LDN-212854

Catalog No.S7147 Synonyms: BMP Inhibitor III

LDN-212854	 Chemical Structure

Molecular Weight(MW): 406.48

LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.

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Biological Activity

Description LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.
Targets
ALK2 [1]
(Cell-free assay)
ALK1 [1]
(Cell-free assay)
ALK3 [1]
(Cell-free assay)
ALK4 [1]
(Cell-free assay)
ALK5 [1]
(Cell-free assay)
1.3 nM 2.4 nM 85.8 nM 2133 nM 9276 nM
In vitro

In myofibroblast C2C12 cells, LDN-212854 exhibits greater selectivity for BMP6- versus BMP4-induced osteogenic differentiation. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse C2C12BRA cells MWDGeY5kfGmxbjDhd5NigQ>? MX2xOEBp NWP6Wo1pUW6qaXLpeIlwdiCxZjDCUXA1KGmwIH3veZNmKEN{Q{GyRnJCKGOnbHzzJIFnfGW{IEG0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NE4yOTdizszN NHu2c5EzOzZ|OUW0NC=>

... Click to View More Cell Line Experimental Data

In vivo LDN-212854 (6 mg/kg, i.p.) effectively neutralize ALK2 signaling in vivo, and potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. [1]

Protocol

Animal Research:

[1]

+ Expand
  • Animal Models: Murine inducible transgenic ALK2Q207D model of heterotopic ossification.
  • Formulation: --
  • Dosages: 6 mg/kg, twice daily
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 81 mg/mL warmed (199.27 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 406.48
Formula

C25 H22 N6

CAS No. 1432597-26-6
Storage powder
Synonyms BMP Inhibitor III

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID