Lacidipine
Catalog No.S1994 Synonyms: GX-1048,GR-43659X,SN-305
Molecular Weight(MW): 455.54
Lacidipine is a L-type calcium channel blocker, used for treating high blood pressure.
Purity & Quality Control
Choose Selective Calcium Channel Inhibitors
Biological Activity
| Description | Lacidipine is a L-type calcium channel blocker, used for treating high blood pressure. | |
|---|---|---|
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| In vitro |
Lacidipine, an L-type Ca(2+) channel blocker that also inhibits [Ca(2+)](ER) efflux, enhances folding, trafficking, and activity of degradation-prone glucocerebrosidase (GC) variants. Lacidipine remodels mutated GC proteostasis by simultaneously activating a series of distinct molecular mechanisms, namely modulation of Ca(2+) homeostasis, upregulation of the ER chaperone BiP, and moderate induction of the unfolded protein response. [1] Lacidipine almost completely inhibits cholesterol esterification in cholesterol loaded mouse cultured peritoneal macrophages. [2] |
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| In vivo | Lacidipine has non-significant effects on blood pressure but inhibits the paradoxical increases in plasma renin activity (PRA) and in renin mRNA in kidney that are found in salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP). Lacidipine restores the physiological downregulation of renin production by high salt and reduces left ventricular hypertrophy and mRNA levels of atrial natriuretic factor and transforming growth factor-beta1. [3] Lacidipine (1 and 3 mg/kg) also effectively increases calcium concentrations significantly in ovariectomized rats. [4] Lacidipine, a dihydropyridine-type calcium antagonist, reduces the cardiac hypertrophy and the cardiacendothelin-1 (ET-1) gene overexpression occurring in salt-loaded stroke-prone spontaneously hypertensive rats (SL-SHRSP), an effect occurring without systolic blood pressure (SBP) change. Lacidipine exerts a dose-related inhibition of ventricle hypertrophy and preproET-1-mRNA expression in SHRSP and indicate that this effect is unrelated to SBP changes. [5] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 91 mg/mL (199.76 mM) |
|---|---|---|
| Ethanol | 22 mg/mL (48.29 mM) | |
| Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 455.54 |
|---|---|
| Formula | C26H33NO6 |
| CAS No. | 103890-78-4 |
| Storage | powder |
| Synonyms | GX-1048,GR-43659X,SN-305 |
Bio Calculators
Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT00533858 | Unknown status | Hypertension | Seoul National University Hospital | September 2007 | Phase 4 |
| NCT00460915 | Completed | Hypertension | Korea University Guro Hospital|GlaxoSmithKline | January 2007 | Phase 4 |
| NCT00338338 | Completed | Uncomplicated Hypertension|Hypertension|Essential | GlaxoSmithKline | November 2005 | Phase 4 |
| NCT00328965 | Completed | Diabetes Mellitus, Type 2|Essential Hypertension | GlaxoSmithKline | November 2004 | Phase 4 |
| NCT02264158 | Completed | Healthy | Boehringer Ingelheim | September 2001 | Phase 1 |
| NCT02209649 | Completed | Healthy | Boehringer Ingelheim | October 1999 | Phase 1 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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