K-Ras(G12C) inhibitor 9

Catalog No.S7332

K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).

Price Stock Quantity  
USD 197 In stock
USD 497 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

K-Ras(G12C) inhibitor 9 Chemical Structure

K-Ras(G12C) inhibitor 9 Chemical Structure
Molecular Weight: 513.78

Validation & Quality Control

Quality Control & MSDS

Product Information

  • Compare Rho Inhibitors
    Compare Rho Products
  • Research Area

Product Description

Biological Activity

Description K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).
Targets K-Ras(G12C) [1]
In vitro K-Ras(G12C) inhibitor 9 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines. [1]
In vivo
Features

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Ostrem JM, et al. Nature. 2013, 503(7477), 548-551.

Chemical Information

Download K-Ras(G12C) inhibitor 9 SDF
Molecular Weight (MW) 513.78
Formula

C16H21ClIN3O4

CAS No. 1469337-91-4
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 53 mg/mL (103.15 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Rho Products

Recently Viewed Items

Tags: buy K-Ras(G12C) inhibitor 9 | K-Ras(G12C) inhibitor 9 supplier | purchase K-Ras(G12C) inhibitor 9 | K-Ras(G12C) inhibitor 9 cost | K-Ras(G12C) inhibitor 9 manufacturer | order K-Ras(G12C) inhibitor 9 | K-Ras(G12C) inhibitor 9 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us