IPA-3

Catalog No.S7093

IPA-3 Chemical Structure

Molecular Weight(MW): 350.45

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

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1 Customer Review

  • (e) Immunoblot analysis of p-ERM, p-Pak1 and Pak1 in Ishikawa cells treated with various doses of Pak1 inhibitor IPA-3 for 24 h. Actin serves as a loading control

    Cell Death Differ, 2016, 23(1):169-81. IPA-3 purchased from Selleck.

Purity & Quality Control

Choose Selective PAK Inhibitors

Biological Activity

Description IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Features IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.
Targets
PAK1 [1]
(Cell-free assay)
2.5 μM
In vitro

IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. [1] IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NALM-6 cell M1vDXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGLJTJNKdmirYnn0bY9vKG:oIHj1cYFvKE6DTF2tOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTd4OUSg{txO MofnV2FPT0WU
human SW1710 cell M1nJW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEPHSYFKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUexNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTd6M{Og{txO M37vZ3NCVkeHUh?=
human YT cell M3fIcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2\GO2lvcGmkaYTpc44hd2ZiaIXtZY4hYVRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkO5NFM3KM7:TR?= MlzKV2FPT0WU
human BL-70 cell NGXzPXdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mm\wTY5pcWKrdHnvckBw\iCqdX3hckBDVC15MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFM4QTZizszN NVnXe29sW0GQR1XS
human SIG-M5 cell M1vkemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUjJcohq[mm2aX;uJI9nKGi3bXHuJHNKTy2PNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVAzOTlizszN M{\4dnNCVkeHUh?=
human MCF7 cell MlfNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2[wNWlvcGmkaYTpc44hd2ZiaIXtZY4hVUOINzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVgxPyEQvF2= MYDTRW5ITVJ?
human GB-1 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mny4TY5pcWKrdHnvckBw\iCqdX3hckBISi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj62N|Q6PCEQvF2= M1rWSnNCVkeHUh?=
human KU812 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEDGcJhKdmirYnn0bY9vKG:oIHj1cYFvKEuXOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44PTl3IN88US=> NEPUfHhUSU6JRWK=
human QIMR-WIL cell M{Kwe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mk\5TY5pcWKrdHnvckBw\iCqdX3hckBSUU2ULWfJUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQTB6OUGg{txO MkHSV2FPT0WU
human BL-41 cell M3LzO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYHJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTRzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wPVg1PCEQvF2= NW\mO5lYW0GQR1XS
human CMK cell NGO2W|VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2L0VWlvcGmkaYTpc44hd2ZiaIXtZY4hS02NIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6xOFU6QSEQvF2= NFqyRnFUSU6JRWK=
human U-698-M cell MlfuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGiycG9KdmirYnn0bY9vKG:oIHj1cYFvKFVvNkm4MW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ|OEW2JO69VQ>? NH\mUlNUSU6JRWK=
human Daoy cell M17zOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFPCc49KdmirYnn0bY9vKG:oIHj1cYFvKESjb4mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI1PjZ{IN88US=> NFnvT4pUSU6JRWK=
human 786-0 cell M1zxWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mm\NTY5pcWKrdHnvckBw\iCqdX3hckA4QDZvMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|E5ODVizszN NGD6RnJUSU6JRWK=
human REH cell NX3nZnNLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NELKT45KdmirYnn0bY9vKG:oIHj1cYFvKFKHSDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|Y3PTVizszN MnuzV2FPT0WU
human MHH-PREB-1 cell NXzvUYs6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGXjWVJKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3QVmVDNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkS2Olg4KM7:TR?= NHf0NZlUSU6JRWK=
human KE-37 cell growth M1yzU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3viWmlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlUxOjNzIN88US=> MUTTRW5ITVJ?
human CAL-51 cell NWjUO5pMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGDm[FZKdmirYnn0bY9vKG:oIHj1cYFvKEODTD21NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPTR3MUmg{txO MmnVV2FPT0WU
human CA46 cell NX3oXoJLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXzRR5RWUW6qaXLpeIlwdiCxZjDoeY1idiCFQUS2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{43PjF6IN88US=> M4rYUXNCVkeHUh?=
human HEL cell NYHrepBlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn:3TY5pcWKrdHnvckBw\iCqdX3hckBJTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkeyO|Y5KM7:TR?= NEG5dYVUSU6JRWK=
human NB6 cell M4DxXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGjIUmpKdmirYnn0bY9vKG:oIHj1cYFvKE6ENjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuPFM4PTFizszN MYfTRW5ITVJ?
human 8305C cell NHv6cHdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3[xZmlvcGmkaYTpc44hd2ZiaIXtZY4hQDNyNVOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE3PzV6IN88US=> MnP2V2FPT0WU
human EW-13 cell M1TDU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mmq5TY5pcWKrdHnvckBw\iCqdX3hckBGXy1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlAyPDhizszN NGHFVZlUSU6JRWK=
human NB13 cell MnXES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGXpTmhKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlIzPTZizszN NGexeGdUSU6JRWK=
human EB2 cell NUnUV2piT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn7pTY5pcWKrdHnvckBw\iCqdX3hckBGSjJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkS5NVQzKM7:TR?= MmnjV2FPT0WU
human HOS cell NUi1T5NLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGfQRmNKdmirYnn0bY9vKG:oIHj1cYFvKEiRUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5 NXjLXo93W0GQR1XS
human HLE cell M2nVWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NInlcIFKdmirYnn0bY9vKG:oIHj1cYFvKEiORTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOVIyPDlizszN NGHEZ3JUSU6JRWK=
human ST486 cell Ml\DS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1T6V2lvcGmkaYTpc44hd2ZiaIXtZY4hW1R2OE[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Mlg3PTRizszN NFf4SIhUSU6JRWK=
human NCI-H2009 cell NH7YPY5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXPCOldTUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxODliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkC0N|U1KM7:TR?= MnTFV2FPT0WU
human NH-12 cell MnjXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYq3TJlPUW6qaXLpeIlwdiCxZjDoeY1idiCQSD2xNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvOTF5NjFOwG0> NI\rR5pUSU6JRWK=
human BFTC-905 cell NH6xVYZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUTJcohq[mm2aX;uJI9nKGi3bXHuJGJHXENvOUC1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4yPDd4ODFOwG0> NX\JU2NGW0GQR1XS
human RKO cell NFvTXGRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnG3TY5pcWKrdHnvckBw\iCqdX3hckBTU09iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkK4OFcyKM7:TR?= M2DKOnNCVkeHUh?=
human PF-382 M1vGPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlnpTY5pcWKrdHnvckBw\iCqdX3hckBRTi1|OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlM2OjJ4IN88US=> NH;aXFNUSU6JRWK=
human SR cell M{naVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV;Jcohq[mm2aX;uJI9nKGi3bXHuJHNTKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS5|N{K1OkDPxE1? NYjsbVZSW0GQR1XS
human WSU-NHL cell M4rzdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4mxSWlvcGmkaYTpc44hd2ZiaIXtZY4hX1OXLV7IUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPTJyNkeg{txO M1flW3NCVkeHUh?=
human CAL-12T cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3nQT2lvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUGyWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPjRzNDFOwG0> NFq4dopUSU6JRWK=
human Daudi cell NFfvbolIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M37wcmlvcGmkaYTpc44hd2ZiaIXtZY4hTGG3ZHmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlY5PDd5IN88US=> MonNV2FPT0WU
human MC-CAR cell MofaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M13kWmlvcGmkaYTpc44hd2ZiaIXtZY4hVUNvQ1HSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU44ODZ2NDFOwG0> MWHTRW5ITVJ?
human RPMI-8402 cell NUjMRpJCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOESwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzZ6N{[g{txO NGPtO2JUSU6JRWK=
human CCRF-CEM cell M2LaUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWPJcohq[mm2aX;uJI9nKGi3bXHuJGNEWkZvQ1XNJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU46PzZ4NzFOwG0> NHKxdmZUSU6JRWK=
human CHP-126 cell NFLKcIJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1zMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22Mlc1OjZ6IN88US=> NV7vd3c{W0GQR1XS
human NB69 cell M{TjTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3fkcGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uO|Y{PTJizszN M{f4Z3NCVkeHUh?=
human KS-1 cell NVHTd5hsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXfJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lki4OVQ6KM7:TR?= NGHK[pVUSU6JRWK=
human J82 cell M4XJ[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYfJcohq[mm2aX;uJI9nKGi3bXHuJGo5OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMES5OlUh|ryP MWXTRW5ITVJ?
human SW872 cell NW\oZ|MzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnjMTY5pcWKrdHnvckBw\iCqdX3hckBUXzh5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuPFM2PThizszN NX7yc4ZUW0GQR1XS
human HC-1 cell MknwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVLpNHo{UW6qaXLpeIlwdiCxZjDoeY1idiCKQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPjhyNTFOwG0> MV7TRW5ITVJ?
human DU-145 cell NVv0fmI{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1K1VmlvcGmkaYTpc44hd2ZiaIXtZY4hTFVvMUS1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4zOTR4NDFOwG0> M3:xRXNCVkeHUh?=
human HL-60 cell M12y[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4P0NGlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24Mlg1PjB3IN88US=> NEnkZ4ZUSU6JRWK=
human MV-4-11 cell NXPZRWZLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlLoTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4yPjR7IN88US=> M3rvNXNCVkeHUh?=
human SK-N-DZ cell NVLtS2xGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkjITY5pcWKrdHnvckBw\iCqdX3hckBUUy2QLVTaJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4zODR{MzFOwG0> MnHTV2FPT0WU
human HT-1197 cell NYjkNotFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHLNPFZKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUGxPVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5|MEezJO69VQ>? MXzTRW5ITVJ?
human NOS-1 cell MkDlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUHtenJkUW6qaXLpeIlwdiCxZjDoeY1idiCQT2OtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjdzNUKg{txO NYXBUZpKW0GQR1XS
human HT-1080 cell NYjKZWNQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlHWTY5pcWKrdHnvckBw\iCqdX3hckBJXC1zMEiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVgvPjJ6MzFOwG0> M{fYVnNCVkeHUh?=
human SK-LU-1 cell MmnxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnroTY5pcWKrdHnvckBw\iCqdX3hckBUUy2OVT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVgvQDd|MTFOwG0> NIDscIJUSU6JRWK=
human SW48 cell M{H2bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGfSZ|JKdmirYnn0bY9vKG:oIHj1cYFvKFOZNEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNU45QDl5IN88US=> M3fuPHNCVkeHUh?=
human A2780 cell MmjzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn\yTY5pcWKrdHnvckBw\iCqdX3hckBCOjd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK4MlM4OSEQvF2= NFTNPXBUSU6JRWK=

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Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.74 mM)
Ethanol 7 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.45
Formula

C20H14O2S2

CAS No. 42521-82-4
Storage powder
Synonyms N/A

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    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    If this product is cell membrane permeable and would it be suitable for PAK1 inhibition on a pancreatic beta cell line?

  • Answer:

    Based on the reference, I think IPA-3 is able to penetrate the cell membrane, it's likely to inhibit PAK1 on a pancreatic beta cell line although there is no reference confirming it: Figure 3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963893/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635/

PAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID