IPA-3

Catalog No.S7093

IPA-3 Chemical Structure

Molecular Weight(MW): 350.45

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

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2 Customer Reviews

  • (e) Immunoblot analysis of p-ERM, p-Pak1 and Pak1 in Ishikawa cells treated with various doses of Pak1 inhibitor IPA-3 for 24 h. Actin serves as a loading control

    Cell Death Differ, 2016, 23(1):169-81. IPA-3 purchased from Selleck.

    The cells were treated with 5 μM of the PAK1-specific inhibitor IPA-3 or 1 μM of the ROCK1/2-specific inhibitor RKI-1447 for 24 h. Total cell lysates were immunoblotted with antibodies against p110β, p110δ, p-PAK1, PAK1, ROCK1, ROCK2, p-LIMK1, LIMK1 or β-actin, which served as an internal control. The results are representative of three independent experiments.

    Anticancer Res, 2017, 37(4):1805-1818. IPA-3 purchased from Selleck.

Purity & Quality Control

Choose Selective PAK Inhibitors

Biological Activity

Description IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Features IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.
Targets
PAK1 [1]
(Cell-free assay)
2.5 μM
In vitro

IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. [1] IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NALM-6 cell NF3hXmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHzy[WhKdmirYnn0bY9vKG:oIHj1cYFvKE6DTF2tOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTd4OUSg{txO NI\tVI1USU6JRWK=
human SW1710 cell MlO5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mor2TY5pcWKrdHnvckBw\iCqdX3hckBUXzF5MUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE4QDN|IN88US=> NWn6UIQxW0GQR1XS
human YT cell M1TPfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIfGTXhKdmirYnn0bY9vKG:oIHj1cYFvKFmWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zPVA{PiEQvF2= MVzTRW5ITVJ?
human BL-70 cell NFnRRnNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{PHW2lvcGmkaYTpc44hd2ZiaIXtZY4hSkxvN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlA{Pzl4IN88US=> MnzJV2FPT0WU
human SIG-M5 cell NGLrUmlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWrJcohq[mm2aX;uJI9nKGi3bXHuJHNKTy2PNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVAzOTlizszN M2W1VnNCVkeHUh?=
human MCF7 cell Ml7LS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJG1ETjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkG4NFch|ryP MlXaV2FPT0WU
human GB-1 cell M2XFVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWjJcohq[mm2aX;uJI9nKGi3bXHuJGdDNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[zOFk1KM7:TR?= M{XDZ3NCVkeHUh?=
human KU812 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV3ScXRzUW6qaXLpeIlwdiCxZjDoeY1idiCNVUixNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzV7NTFOwG0> M4TxWHNCVkeHUh?=
human QIMR-WIL cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWHtTI5XUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwOUC4PVEh|ryP NWO4XHpGW0GQR1XS
human BL-41 cell NVfwdW1{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml7ETY5pcWKrdHnvckBw\iCqdX3hckBDVC12MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNFk5PDRizszN M1n4Z3NCVkeHUh?=
human CMK cell NGjHTZFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NELSXYZKdmirYnn0bY9vKG:oIHj1cYFvKEOPSzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNVQ2QTlizszN MWDTRW5ITVJ?
human U-698-M cell NYHUfFZWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkDYTY5pcWKrdHnvckBw\iCqdX3hckBWNTZ7OD3NJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4zOzh3NjFOwG0> NUDncXd4W0GQR1XS
human Daoy cell MnnuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHrUdVlKdmirYnn0bY9vKG:oIHj1cYFvKESjb4mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI1PjZ{IN88US=> MoK2V2FPT0WU
human 786-0 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVvVSlZCUW6qaXLpeIlwdiCxZjDoeY1idiB5OE[tNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOzF6MEWg{txO MYLTRW5ITVJ?
human REH cell M2LDZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXHJcohq[mm2aX;uJI9nKGi3bXHuJHJGUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwM{[2OVUh|ryP NWDiV|lxW0GQR1XS
human MHH-PREB-1 cell M3Pl[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MojGTY5pcWKrdHnvckBw\iCqdX3hckBOUEhvUGLFRk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy52Nk[4O{DPxE1? NFy3d29USU6JRWK=
human KE-37 cell growth MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUPJcohq[mm2aX;uJI9nKGi3bXHuJGtGNTN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz61NFI{OSEQvF2= MYTTRW5ITVJ?
human CAL-51 cell NIXwW2FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2C5NWlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{42PDVzOTFOwG0> NWrOeJhwW0GQR1XS
human CA46 cell NGH5bJdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWP3U4o1UW6qaXLpeIlwdiCxZjDoeY1idiCFQUS2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{43PjF6IN88US=> MkDUV2FPT0WU
human HEL cell MnnCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1vJOGlvcGmkaYTpc44hd2ZiaIXtZY4hUEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz63Nlc3QCEQvF2= M3zRZnNCVkeHUh?=
human NB6 cell NW\0WJhUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIXyS|lKdmirYnn0bY9vKG:oIHj1cYFvKE6ENjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuPFM4PTFizszN M4jWbnNCVkeHUh?=
human 8305C cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEXOfJRKdmirYnn0bY9vKG:oIHj1cYFvKDh|MEXDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yPjd3ODFOwG0> NUnYRWxZW0GQR1XS
human EW-13 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWTJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yNFE1QCEQvF2= NF[0e4ZUSU6JRWK=
human NB13 cell NHTzXFVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3HBVmlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI2PiEQvF2= MnP2V2FPT0WU
human EB2 cell NHe5RoJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUXNflVoUW6qaXLpeIlwdiCxZjDoeY1idiCHQkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ6OTR{IN88US=> M3XlTnNCVkeHUh?=
human HOS cell NGCzOGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFnU[nNKdmirYnn0bY9vKG:oIHj1cYFvKEiRUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5 NYS3Vmk4W0GQR1XS
human HLE cell M{PSeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3nVVmlvcGmkaYTpc44hd2ZiaIXtZY4hUEyHIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND61NlE1QSEQvF2= NI\ZPIpUSU6JRWK=
human ST486 cell M1qyN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1:zWWlvcGmkaYTpc44hd2ZiaIXtZY4hW1R2OE[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Mlg3PTRizszN M2DybXNCVkeHUh?=
human NCI-H2009 cell MlHxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGTWcGlKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlAxQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMESzOVQh|ryP MoezV2FPT0WU
human NH-12 cell Mlv0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmHtTY5pcWKrdHnvckBw\iCqdX3hckBPUC1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuNVE4PiEQvF2= Mo\GV2FPT0WU
human BFTC-905 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVvmOnpmUW6qaXLpeIlwdiCxZjDoeY1idiCERmTDMVkxPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMUS3Olgh|ryP M1vKSHNCVkeHUh?=
human RKO cell MmLxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MojvTY5pcWKrdHnvckBw\iCqdX3hckBTU09iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkK4OFcyKM7:TR?= NETtdIVUSU6JRWK=
human PF-382 M{f0Xmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWfJcohq[mm2aX;uJI9nKGi3bXHuJHBHNTN6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuN|UzOjZizszN NX6yZnlmW0GQR1XS
human SR cell MoGzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXPJcohq[mm2aX;uJI9nKGi3bXHuJHNTKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS5|N{K1OkDPxE1? MnrJV2FPT0WU
human WSU-NHL cell MmWwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYfjXmRuUW6qaXLpeIlwdiCxZjDoeY1idiCZU2WtUmhNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS53MkC2O{DPxE1? NUDKTolFW0GQR1XS
human CAL-12T cell NUfWVXVWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoPWTY5pcWKrdHnvckBw\iCqdX3hckBESUxvMULUJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU43PDF2IN88US=> NW\2cGR[W0GQR1XS
human Daudi cell M{fkR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M13jTmlvcGmkaYTpc44hd2ZiaIXtZY4hTGG3ZHmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlY5PDd5IN88US=> MXHTRW5ITVJ?
human MC-CAR cell MmfpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlrZTY5pcWKrdHnvckBw\iCqdX3hckBOSy2FQWKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlcxPjR2IN88US=> MX3TRW5ITVJ?
human RPMI-8402 cell M{j5Umdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHLvcIJKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtPFQxOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwN{[4O|Yh|ryP MlTqV2FPT0WU
human CCRF-CEM cell M3\qe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmfHTY5pcWKrdHnvckBw\iCqdX3hckBES1KILVPFUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQTd4Nkeg{txO NUL1UppIW0GQR1XS
human CHP-126 cell NVq3e3BVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXvzfoprUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi55NEK2PEDPxE1? NHfvbXVUSU6JRWK=
human NB69 cell M1LHPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUTJcohq[mm2aX;uJI9nKGi3bXHuJG5DPjliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lke2N|UzKM7:TR?= M4TodHNCVkeHUh?=
human KS-1 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIDmWoVKdmirYnn0bY9vKG:oIHj1cYFvKEuVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22Mlg5PTR7IN88US=> NULPWFlDW0GQR1XS
human J82 cell NUPsfVlET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmPETY5pcWKrdHnvckBw\iCqdX3hckBLQDJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkC0PVY2KM7:TR?= MoS2V2FPT0WU
human SW872 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXTwdJh3UW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvQDN3NUig{txO NY[4SVYxW0GQR1XS
human HC-1 cell NVraSYR{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUjtXYxjUW6qaXLpeIlwdiCxZjDoeY1idiCKQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPjhyNTFOwG0> NXzLNlVMW0GQR1XS
human DU-145 cell NXj1cZpPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NW\re2RzUW6qaXLpeIlwdiCxZjDoeY1idiCGVT2xOFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjJzNE[0JO69VQ>? MXzTRW5ITVJ?
human HL-60 cell M4noSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVrJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD64OFYxPSEQvF2= NInjV4FUSU6JRWK=
human MV-4-11 cell NF[0eFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFvyZ2RKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjF4NEmg{txO NEmxbopUSU6JRWK=
human SK-N-DZ cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnnaTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QLVTaJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4zODR{MzFOwG0> MoG4V2FPT0WU
human HT-1197 cell NU[4V|MyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUDJcohq[mm2aX;uJI9nKGi3bXHuJGhVNTFzOUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE4{ODd|IN88US=> NUjFOJE6W0GQR1XS
human NOS-1 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEiweo9KdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPzF3MjFOwG0> NGTpS45USU6JRWK=
human HT-1080 cell M{\ubGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4fkR2lvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMUC4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5NjZ{OEOg{txO M1q2eHNCVkeHUh?=
human SK-LU-1 cell MmjNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHjwZZRKdmirYnn0bY9vKG:oIHj1cYFvKFONLVzVMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC56N{OxJO69VQ>? M4PMfHNCVkeHUh?=
human SW48 cell MmTxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVfJTllFUW6qaXLpeIlwdiCxZjDoeY1idiCVV{S4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvQDh7NzFOwG0> NV3zd3RiW0GQR1XS
human A2780 cell MoqzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlvjTY5pcWKrdHnvckBw\iCqdX3hckBCOjd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK4MlM4OSEQvF2= NVPSZnVqW0GQR1XS

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Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.74 mM)
Ethanol 7 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.45
Formula

C20H14O2S2

CAS No. 42521-82-4
Storage powder
Synonyms N/A

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    If this product is cell membrane permeable and would it be suitable for PAK1 inhibition on a pancreatic beta cell line?

  • Answer:

    Based on the reference, I think IPA-3 is able to penetrate the cell membrane, it's likely to inhibit PAK1 on a pancreatic beta cell line although there is no reference confirming it: Figure 3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963893/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635/

PAK Signaling Pathway Map

Tags: buy IPA-3 | IPA-3 supplier | purchase IPA-3 | IPA-3 cost | IPA-3 manufacturer | order IPA-3 | IPA-3 distributor
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID