IPA-3

Catalog No.S7093

IPA-3 Chemical Structure

Molecular Weight(MW): 350.45

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

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2 Customer Reviews

  • (e) Immunoblot analysis of p-ERM, p-Pak1 and Pak1 in Ishikawa cells treated with various doses of Pak1 inhibitor IPA-3 for 24 h. Actin serves as a loading control

    Cell Death Differ, 2016, 23(1):169-81. IPA-3 purchased from Selleck.

    The cells were treated with 5 μM of the PAK1-specific inhibitor IPA-3 or 1 μM of the ROCK1/2-specific inhibitor RKI-1447 for 24 h. Total cell lysates were immunoblotted with antibodies against p110β, p110δ, p-PAK1, PAK1, ROCK1, ROCK2, p-LIMK1, LIMK1 or β-actin, which served as an internal control. The results are representative of three independent experiments.

    Anticancer Res, 2017, 37(4):1805-1818. IPA-3 purchased from Selleck.

Purity & Quality Control

Choose Selective PAK Inhibitors

Biological Activity

Description IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Features IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.
Targets
PAK1 [1]
(Cell-free assay)
2.5 μM
In vitro

IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. [1] IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NALM-6 cell M{jMWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHW5TmVKdmirYnn0bY9vKG:oIHj1cYFvKE6DTF2tOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTd4OUSg{txO NEG4RXpUSU6JRWK=
human SW1710 cell M4\SOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MknsTY5pcWKrdHnvckBw\iCqdX3hckBUXzF5MUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE4QDN|IN88US=> MXLTRW5ITVJ?
human YT cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{DyUWlvcGmkaYTpc44hd2ZiaIXtZY4hYVRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkO5NFM3KM7:TR?= MWXTRW5ITVJ?
human BL-70 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoTHTY5pcWKrdHnvckBw\iCqdX3hckBDVC15MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFM4QTZizszN M2L5bHNCVkeHUh?=
human SIG-M5 cell NIf2TFBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFi3NXRKdmirYnn0bY9vKG:oIHj1cYFvKFOLRz3NOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTB{MUmg{txO NYHEUYJTW0GQR1XS
human MCF7 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4j2bmlvcGmkaYTpc44hd2ZiaIXtZY4hVUOINzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVgxPyEQvF2= MW\TRW5ITVJ?
human GB-1 cell NFq2cpNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGn1[ZVKdmirYnn0bY9vKG:oIHj1cYFvKEeELUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlY{PDl2IN88US=> NHTtVolUSU6JRWK=
human KU812 cell NWXkNGxyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHLRe5VKdmirYnn0bY9vKG:oIHj1cYFvKEuXOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44PTl3IN88US=> NEe3No1USU6JRWK=
human QIMR-WIL cell MonyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJHFKVVJvV1nMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46ODh7MTFOwG0> NGLDNIVUSU6JRWK=
human BL-41 cell NGL3dJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVn5PVN{UW6qaXLpeIlwdiCxZjDoeY1idiCETD20NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODl6NESg{txO M4nPd3NCVkeHUh?=
human CMK cell NWrkN4EyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV3aeYpGUW6qaXLpeIlwdiCxZjDoeY1idiCFTVugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlE1PTl7IN88US=> NGfYWmJUSU6JRWK=
human U-698-M cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEjGcmZKdmirYnn0bY9vKG:oIHj1cYFvKFVvNkm4MW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ|OEW2JO69VQ>? NYrmWmE2W0GQR1XS
human Daoy cell MlnzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHzFdZVKdmirYnn0bY9vKG:oIHj1cYFvKESjb4mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI1PjZ{IN88US=> NFjIR5dUSU6JRWK=
human 786-0 cell NGTmOFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFrMepZKdmirYnn0bY9vKG:oIHj1cYFvKDd6Nj2wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4{OThyNTFOwG0> NELzNYJUSU6JRWK=
human REH cell M3zR[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEHaZXNKdmirYnn0bY9vKG:oIHj1cYFvKFKHSDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|Y3PTVizszN NVXRT3c2W0GQR1XS
human MHH-PREB-1 cell M3q1emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXfJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2SUlXCMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjR4Nki3JO69VQ>? NIe4bXdUSU6JRWK=
human KE-37 cell growth NV;6TmlVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NU\vTFlbUW6qaXLpeIlwdiCxZjDoeY1idiCNRT2zO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPTB{M{Gg{txO M33rVXNCVkeHUh?=
human CAL-51 cell NV7nfW5vT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGNCVC13MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVQ2OTlizszN MV3TRW5ITVJ?
human CA46 cell MofsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2\OfWlvcGmkaYTpc44hd2ZiaIXtZY4hS0F2NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOlYyQCEQvF2= M3fFO3NCVkeHUh?=
human HEL cell NWryR2RCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3vIcmlvcGmkaYTpc44hd2ZiaIXtZY4hUEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz63Nlc3QCEQvF2= MYLTRW5ITVJ?
human NB6 cell NVzBXFRVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYrJcohq[mm2aX;uJI9nKGi3bXHuJG5DPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwOEO3OVEh|ryP NEjoUWVUSU6JRWK=
human 8305C cell NFmyPYlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYjudZVRUW6qaXLpeIlwdiCxZjDoeY1idiB6M{C1R{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOTZ5NUig{txO MmS3V2FPT0WU
human EW-13 cell NF7GVW9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX2xUWU1UW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOjBzNEig{txO M1PERnNCVkeHUh?=
human NB13 cell NEG4ZZFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVzJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkKyOVYh|ryP NVrQSo5bW0GQR1XS
human EB2 cell NIrxbGFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MornTY5pcWKrdHnvckBw\iCqdX3hckBGSjJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkS5NVQzKM7:TR?= NYPwUGM6W0GQR1XS
human HOS cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFjqcJRKdmirYnn0bY9vKG:oIHj1cYFvKEiRUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5 MXTTRW5ITVJ?
human HLE cell NWfnbGdkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUTJcohq[mm2aX;uJI9nKGi3bXHuJGhNTSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwNUKxOFkh|ryP MXfTRW5ITVJ?
human ST486 cell M4Wz[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlW4TY5pcWKrdHnvckBw\iCqdX3hckBUXDR6NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPFY2PCEQvF2= M3[1U3NCVkeHUh?=
human NCI-H2009 cell NXz5RopKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGnr[|BKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlAxQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMESzOVQh|ryP NYPIW|cxW0GQR1XS
human NH-12 cell MkKzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYLmRXV2UW6qaXLpeIlwdiCxZjDoeY1idiCQSD2xNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvOTF5NjFOwG0> NWnWZVJEW0GQR1XS
human BFTC-905 cell NHu5TIJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmO4TY5pcWKrdHnvckBw\iCqdX3hckBDTlSFLUmwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvOTR5Nkig{txO M{fXT3NCVkeHUh?=
human RKO cell NFTrboJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHTQN|JKdmirYnn0bY9vKG:oIHj1cYFvKFKNTzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuNlg1PzFizszN NXHF[FN1W0GQR1XS
human PF-382 M{S4eGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmjETY5pcWKrdHnvckBw\iCqdX3hckBRTi1|OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlM2OjJ4IN88US=> NXzjPG5iW0GQR1XS
human SR cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV7Jcohq[mm2aX;uJI9nKGi3bXHuJHNTKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS5|N{K1OkDPxE1? M4nUcHNCVkeHUh?=
human WSU-NHL cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIrDUHJKdmirYnn0bY9vKG:oIHj1cYFvKFeVVT3OTGwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjV{ME[3JO69VQ>? MmXoV2FPT0WU
human CAL-12T cell M1GwSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXLJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC1zMmSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlY1OTRizszN NHH3[WRUSU6JRWK=
human Daudi cell MlnpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGRifWSrIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT62PFQ4PyEQvF2= MXvTRW5ITVJ?
human MC-CAR cell M1;XUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVzJcohq[mm2aX;uJI9nKGi3bXHuJG1ENUODUjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuO|A3PDRizszN MWTTRW5ITVJ?
human RPMI-8402 cell M{juOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MU\Jcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOESwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzZ6N{[g{txO M2DGWnNCVkeHUh?=
human CCRF-CEM cell M4nVOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmXQTY5pcWKrdHnvckBw\iCqdX3hckBES1KILVPFUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQTd4Nkeg{txO MnvpV2FPT0WU
human CHP-126 cell Mm\KS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVzwWI9tUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi55NEK2PEDPxE1? MofsV2FPT0WU
human NB69 cell NH;MTZZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoHiTY5pcWKrdHnvckBw\iCqdX3hckBPSjZ7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj63OlM2OiEQvF2= NVraUGZWW0GQR1XS
human KS-1 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lki4OVQ6KM7:TR?= M4LXWHNCVkeHUh?=
human J82 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3i3NmlvcGmkaYTpc44hd2ZiaIXtZY4hUjh{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz6wOFk3PSEQvF2= MoLZV2FPT0WU
human SW872 cell NEfrXo1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV[yVIlmUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvQDN3NUig{txO NWXMV|hsW0GQR1XS
human HC-1 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXXJcohq[mm2aX;uJI9nKGi3bXHuJGhENTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16LkC2PFA2KM7:TR?= Ml:0V2FPT0WU
human DU-145 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUXJcohq[mm2aX;uJI9nKGi3bXHuJGRWNTF2NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuNlE1PjRizszN MYLTRW5ITVJ?
human HL-60 cell NF\sSo9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1PuSWlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24Mlg1PjB3IN88US=> NEf4eFlUSU6JRWK=
human MV-4-11 cell MnHOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHfzTZVKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjF4NEmg{txO M3;INXNCVkeHUh?=
human SK-N-DZ cell M3PjcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWG3b2tFUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OMWRbKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QS5{MESyN{DPxE1? MWnTRW5ITVJ?
human HT-1197 cell M1TKWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NULw[HdyUW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xNVk4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwM{C3N{DPxE1? MmPOV2FPT0WU
human NOS-1 cell NXX5NmQyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4L0cWlvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU44OTV{IN88US=> NFPXflVUSU6JRWK=
human HT-1080 cell M1y2Vmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUnjXmlRUW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xNFgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwNkK4N{DPxE1? NXzn[XI5W0GQR1XS
human SK-LU-1 cell NHTYWYVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3vBWWlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTGWtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5Njh5M{Gg{txO Mn65V2FPT0WU
human SW48 cell NVLYNWh{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIi2dWpKdmirYnn0bY9vKG:oIHj1cYFvKFOZNEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNU45QDl5IN88US=> MkXKV2FPT0WU
human A2780 cell MlHsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVPJcohq[mm2aX;uJI9nKGi3bXHuJGEzPzhyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuN|cyKM7:TR?= MkW4V2FPT0WU

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Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.74 mM)
Ethanol 7 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.45
Formula

C20H14O2S2

CAS No. 42521-82-4
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    If this product is cell membrane permeable and would it be suitable for PAK1 inhibition on a pancreatic beta cell line?

  • Answer:

    Based on the reference, I think IPA-3 is able to penetrate the cell membrane, it's likely to inhibit PAK1 on a pancreatic beta cell line although there is no reference confirming it: Figure 3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963893/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635/

PAK Signaling Pathway Map

Tags: buy IPA-3 | IPA-3 supplier | purchase IPA-3 | IPA-3 cost | IPA-3 manufacturer | order IPA-3 | IPA-3 distributor
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID