IPA-3

Catalog No.S7093

IPA-3 Chemical Structure

Molecular Weight(MW): 350.45

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

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2 Customer Reviews

  • (e) Immunoblot analysis of p-ERM, p-Pak1 and Pak1 in Ishikawa cells treated with various doses of Pak1 inhibitor IPA-3 for 24 h. Actin serves as a loading control

    Cell Death Differ, 2016, 23(1):169-81. IPA-3 purchased from Selleck.

    The cells were treated with 5 μM of the PAK1-specific inhibitor IPA-3 or 1 μM of the ROCK1/2-specific inhibitor RKI-1447 for 24 h. Total cell lysates were immunoblotted with antibodies against p110β, p110δ, p-PAK1, PAK1, ROCK1, ROCK2, p-LIMK1, LIMK1 or β-actin, which served as an internal control. The results are representative of three independent experiments.

    Anticancer Res, 2017, 37(4):1805-1818. IPA-3 purchased from Selleck.

Purity & Quality Control

Choose Selective PAK Inhibitors

Biological Activity

Description IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Features IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.
Targets
PAK1 [1]
(Cell-free assay)
2.5 μM
In vitro

IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. [1] IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NALM-6 cell NGrpb5ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYXJcohq[mm2aX;uJI9nKGi3bXHuJG5CVE1vNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVc3QTRizszN MUHTRW5ITVJ?
human SW1710 cell M1nSPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlryTY5pcWKrdHnvckBw\iCqdX3hckBUXzF5MUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE4QDN|IN88US=> Mm\kV2FPT0WU
human YT cell NYfrRYtrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkTRTY5pcWKrdHnvckBw\iCqdX3hckB[XCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwM{mwN|Yh|ryP MkDhV2FPT0WU
human BL-70 cell MlLQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIWzbFFKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUewJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xOzd7NjFOwG0> M330b3NCVkeHUh?=
human SIG-M5 cell Mlf4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUjJcohq[mm2aX;uJI9nKGi3bXHuJHNKTy2PNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVAzOTlizszN M{nBWXNCVkeHUh?=
human MCF7 cell Ml:0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUDSdnM3UW6qaXLpeIlwdiCxZjDoeY1idiCPQ1[3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yQDB5IN88US=> NXjweHpPW0GQR1XS
human GB-1 cell MkXsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{C0NmlvcGmkaYTpc44hd2ZiaIXtZY4hT0JvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOlM1QTRizszN MWnTRW5ITVJ?
human KU812 cell M3nQSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH:1bWtKdmirYnn0bY9vKG:oIHj1cYFvKEuXOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44PTl3IN88US=> MkHuV2FPT0WU
human QIMR-WIL cell Ml7QS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUfJcohq[mm2aX;uJI9nKGi3bXHuJHFKVVJvV1nMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46ODh7MTFOwG0> NIH2clVUSU6JRWK=
human BL-41 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmPLTY5pcWKrdHnvckBw\iCqdX3hckBDVC12MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNFk5PDRizszN M2rlXHNCVkeHUh?=
human CMK cell NVr3fHVFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXzLO4xJUW6qaXLpeIlwdiCxZjDoeY1idiCFTVugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlE1PTl7IN88US=> NFvxNZVUSU6JRWK=
human U-698-M cell NULZbm5VT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEn3Tm1KdmirYnn0bY9vKG:oIHj1cYFvKFVvNkm4MW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ|OEW2JO69VQ>? MmLNV2FPT0WU
human Daoy cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{nSU2lvcGmkaYTpc44hd2ZiaIXtZY4hTGGxeTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNlQ3PjJizszN MWLTRW5ITVJ?
human 786-0 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1nwdWlvcGmkaYTpc44hd2ZiaIXtZY4hPzh4LUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlMyQDB3IN88US=> NILLSHNUSU6JRWK=
human REH cell M{nRdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV3NZY1nUW6qaXLpeIlwdiCxZjDoeY1idiCURVigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlM3PjV3IN88US=> MoLvV2FPT0WU
human MHH-PREB-1 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2P6OmlvcGmkaYTpc44hd2ZiaIXtZY4hVUiKLWDSSWIuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwNE[2PFch|ryP MnW0V2FPT0WU
human KE-37 cell growth NEHDPGRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFHJTGdKdmirYnn0bY9vKG:oIHj1cYFvKEuHLUO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{42ODJ|MTFOwG0> NVXsN3B[W0GQR1XS
human CAL-51 cell NGjGc|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWrJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC13MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVQ2OTlizszN MoftV2FPT0WU
human CA46 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWXTXlh[UW6qaXLpeIlwdiCxZjDoeY1idiCFQUS2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{43PjF6IN88US=> NUj5b2J2W0GQR1XS
human HEL cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVjzUJVnUW6qaXLpeIlwdiCxZjDoeY1idiCKRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlczPzZ6IN88US=> M2jIS3NCVkeHUh?=
human NB6 cell NWf6Snc5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVXkV3o{UW6qaXLpeIlwdiCxZjDoeY1idiCQQk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlg{PzVzIN88US=> MWDTRW5ITVJ?
human 8305C cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYjacJFKUW6qaXLpeIlwdiCxZjDoeY1idiB6M{C1R{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOTZ5NUig{txO Ml:wV2FPT0WU
human EW-13 cell MnvzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yNFE1QCEQvF2= MX7TRW5ITVJ?
human NB13 cell NGTMSoRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2XEXGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI2PiEQvF2= NH;sWYRUSU6JRWK=
human EB2 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmXoTY5pcWKrdHnvckBw\iCqdX3hckBGSjJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkS5NVQzKM7:TR?= M4nWN3NCVkeHUh?=
human HOS cell NYrJbI0zT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml;NTY5pcWKrdHnvckBw\iCqdX3hckBJV1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeR?= MYjTRW5ITVJ?
human HLE cell M1r1SGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1zHb2lvcGmkaYTpc44hd2ZiaIXtZY4hUEyHIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND61NlE1QSEQvF2= NX[5c3pRW0GQR1XS
human ST486 cell M335VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVHJcohq[mm2aX;uJI9nKGi3bXHuJHNVPDh4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND64OlU1KM7:TR?= NHH1fGxUSU6JRWK=
human NCI-H2009 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1zOcGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNFA6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS5yNEO1OEDPxE1? NFG4PHpUSU6JRWK=
human NH-12 cell M2fwPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkXJTY5pcWKrdHnvckBw\iCqdX3hckBPUC1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuNVE4PiEQvF2= NI\2d|RUSU6JRWK=
human BFTC-905 cell NIWy[VdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{TTV2lvcGmkaYTpc44hd2ZiaIXtZY4hSk[WQz25NFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjF2N{[4JO69VQ>? MnvWV2FPT0WU
human RKO cell NVHyXJcxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NU\GPGJqUW6qaXLpeIlwdiCxZjDoeY1idiCUS1:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlI5PDdzIN88US=> NVHPUYwyW0GQR1XS
human PF-382 MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn;HTY5pcWKrdHnvckBw\iCqdX3hckBRTi1|OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlM2OjJ4IN88US=> M2LGSnNCVkeHUh?=
human SR cell NX\wZ|hmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUfnfWRzUW6qaXLpeIlwdiCxZjDoeY1idiCVUjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuN|czPTZizszN M3f3NHNCVkeHUh?=
human WSU-NHL cell NIDCRZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWnj[lVYUW6qaXLpeIlwdiCxZjDoeY1idiCZU2WtUmhNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS53MkC2O{DPxE1? NFrGbopUSU6JRWK=
human CAL-12T cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnTJTY5pcWKrdHnvckBw\iCqdX3hckBESUxvMULUJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU43PDF2IN88US=> M2GzbXNCVkeHUh?=
human Daudi cell NFjDdJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2qyVmlvcGmkaYTpc44hd2ZiaIXtZY4hTGG3ZHmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlY5PDd5IN88US=> M4r2d3NCVkeHUh?=
human MC-CAR cell NWPONlRyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2P6RWlvcGmkaYTpc44hd2ZiaIXtZY4hVUNvQ1HSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU44ODZ2NDFOwG0> MX;TRW5ITVJ?
human RPMI-8402 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUnJcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOESwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzZ6N{[g{txO NGjaOG5USU6JRWK=
human CCRF-CEM cell NUjpRVJtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGPaXY5KdmirYnn0bY9vKG:oIHj1cYFvKEOFUl[tR2VOKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS57N{[2O{DPxE1? MmW2V2FPT0WU
human CHP-126 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1zMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22Mlc1OjZ6IN88US=> MYXTRW5ITVJ?
human NB69 cell MlLtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVjJcohq[mm2aX;uJI9nKGi3bXHuJG5DPjliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lke2N|UzKM7:TR?= Ml7oV2FPT0WU
human KS-1 cell MljWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXPJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lki4OVQ6KM7:TR?= NWr2W2dSW0GQR1XS
human J82 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXfHV5hPUW6qaXLpeIlwdiCxZjDoeY1idiCMOEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlA1QTZ3IN88US=> NInhWmxUSU6JRWK=
human SW872 cell NHfkVZhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXrJcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz64N|U2QCEQvF2= MYHTRW5ITVJ?
human HC-1 cell NIXHenZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGhENTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16LkC2PFA2KM7:TR?= M2j1fnNCVkeHUh?=
human DU-145 cell NIfqUFFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIPNeZhKdmirYnn0bY9vKG:oIHj1cYFvKESXLUG0OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvOjF2NkSg{txO MlrPV2FPT0WU
human HL-60 cell Ml;hS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUTJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD64OFYxPSEQvF2= NWLoepRkW0GQR1XS
human MV-4-11 cell NW\wVZJuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mk\ITY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4yPjR7IN88US=> MWjTRW5ITVJ?
human SK-N-DZ cell M3rwZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXniVYJ3UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OMWRbKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QS5{MESyN{DPxE1? MoPGV2FPT0WU
human HT-1197 cell NY\kPIxST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWTJcohq[mm2aX;uJI9nKGi3bXHuJGhVNTFzOUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE4{ODd|IN88US=> M2DyVXNCVkeHUh?=
human NOS-1 cell M4\RTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2TWcGlvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU44OTV{IN88US=> MXzTRW5ITVJ?
human HT-1080 cell NGnYOVdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGhVNTFyOECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xPE43Ojh|IN88US=> NFzLUY1USU6JRWK=
human SK-LU-1 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYjKd|ZCUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3MWU0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwOEezNUDPxE1? M1T0UHNCVkeHUh?=
human SW48 cell NV3zVWZ7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlTVTY5pcWKrdHnvckBw\iCqdX3hckBUXzR6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkGuPFg6PyEQvF2= NVzQR21{W0GQR1XS
human A2780 cell MlHzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVe4VZp3UW6qaXLpeIlwdiCxZjDoeY1idiCDMke4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI5NjN5MTFOwG0> M4S2NXNCVkeHUh?=

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Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.74 mM)
Ethanol 7 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.45
Formula

C20H14O2S2

CAS No. 42521-82-4
Storage powder
Synonyms N/A

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    If this product is cell membrane permeable and would it be suitable for PAK1 inhibition on a pancreatic beta cell line?

  • Answer:

    Based on the reference, I think IPA-3 is able to penetrate the cell membrane, it's likely to inhibit PAK1 on a pancreatic beta cell line although there is no reference confirming it: Figure 3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963893/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635/

PAK Signaling Pathway Map

Tags: buy IPA-3 | IPA-3 supplier | purchase IPA-3 | IPA-3 cost | IPA-3 manufacturer | order IPA-3 | IPA-3 distributor
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID