IPA-3

Catalog No.S7093

IPA-3 Chemical Structure

Molecular Weight(MW): 350.45

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

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2 Customer Reviews

  • (e) Immunoblot analysis of p-ERM, p-Pak1 and Pak1 in Ishikawa cells treated with various doses of Pak1 inhibitor IPA-3 for 24 h. Actin serves as a loading control

    Cell Death Differ, 2016, 23(1):169-81. IPA-3 purchased from Selleck.

    The cells were treated with 5 μM of the PAK1-specific inhibitor IPA-3 or 1 μM of the ROCK1/2-specific inhibitor RKI-1447 for 24 h. Total cell lysates were immunoblotted with antibodies against p110β, p110δ, p-PAK1, PAK1, ROCK1, ROCK2, p-LIMK1, LIMK1 or β-actin, which served as an internal control. The results are representative of three independent experiments.

    Anticancer Res, 2017, 37(4):1805-1818. IPA-3 purchased from Selleck.

Purity & Quality Control

Choose Selective PAK Inhibitors

Biological Activity

Description IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Features IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.
Targets
PAK1 [1]
(Cell-free assay)
2.5 μM
In vitro

IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. [1] IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NALM-6 cell M1HseGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3S0dWlvcGmkaYTpc44hd2ZiaIXtZY4hVkGOTT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46PzZ7NDFOwG0> M3;JS3NCVkeHUh?=
human SW1710 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NU[zdolXUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G3NVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjF5OEOzJO69VQ>? NVSyRnRQW0GQR1XS
human YT cell NVv2VZF2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkDGTY5pcWKrdHnvckBw\iCqdX3hckB[XCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwM{mwN|Yh|ryP NUjZc3BRW0GQR1XS
human BL-70 cell M{nJNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{LVUmlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlA{Pzl4IN88US=> MUTTRW5ITVJ?
human SIG-M5 cell MlK0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIDEbGdKdmirYnn0bY9vKG:oIHj1cYFvKFOLRz3NOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTB{MUmg{txO NIfrTIRUSU6JRWK=
human MCF7 cell M2DTeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYnJcohq[mm2aX;uJI9nKGi3bXHuJG1ETjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkG4NFch|ryP Mo\aV2FPT0WU
human GB-1 cell NWHod|JZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkL3TY5pcWKrdHnvckBw\iCqdX3hckBISi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj62N|Q6PCEQvF2= MYjTRW5ITVJ?
human KU812 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NULoPXBiUW6qaXLpeIlwdiCxZjDoeY1idiCNVUixNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzV7NTFOwG0> NGXVZ|BUSU6JRWK=
human QIMR-WIL cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV;wZopUUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwOUC4PVEh|ryP NHK2NohUSU6JRWK=
human BL-41 cell NGP0NpFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGJNNTRzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wPVg1PCEQvF2= NGDEdoRUSU6JRWK=
human CMK cell M4XWXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2PteGlvcGmkaYTpc44hd2ZiaIXtZY4hS02NIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6xOFU6QSEQvF2= NHH2W5JUSU6JRWK=
human U-698-M cell M3jQ[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MorHTY5pcWKrdHnvckBw\iCqdX3hckBWNTZ7OD3NJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4zOzh3NjFOwG0> MnGzV2FPT0WU
human Daoy cell M4WyeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml3lTY5pcWKrdHnvckBw\iCqdX3hckBF[W:7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6yOFY3OiEQvF2= MXrTRW5ITVJ?
human 786-0 cell M4Pv[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYDJcohq[mm2aX;uJI9nKGi3bXHuJFc5Pi1yIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zNVgxPSEQvF2= MUjTRW5ITVJ?
human REH cell MlTKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NETGcWNKdmirYnn0bY9vKG:oIHj1cYFvKFKHSDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|Y3PTVizszN NG\3Xo5USU6JRWK=
human MHH-PREB-1 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlL2TY5pcWKrdHnvckBw\iCqdX3hckBOUEhvUGLFRk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy52Nk[4O{DPxE1? NGXDS5hUSU6JRWK=
human KE-37 cell growth NHG4WnRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4DQXGlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlUxOjNzIN88US=> Mn;0V2FPT0WU
human CAL-51 cell NGW5fJpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1TwZ2lvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{42PDVzOTFOwG0> NFfsbm1USU6JRWK=
human CA46 cell NH3NS|hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXjWNVd1UW6qaXLpeIlwdiCxZjDoeY1idiCFQUS2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{43PjF6IN88US=> NV7YUpZDW0GQR1XS
human HEL cell NFniWZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoTrTY5pcWKrdHnvckBw\iCqdX3hckBJTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkeyO|Y5KM7:TR?= NX;DZ4xzW0GQR1XS
human NB6 cell MmPFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnrnTY5pcWKrdHnvckBw\iCqdX3hckBPSjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkizO|UyKM7:TR?= M3K0d3NCVkeHUh?=
human 8305C cell NELrbWhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVfJcohq[mm2aX;uJI9nKGi3bXHuJFg{ODWFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xOlc2QCEQvF2= MkjUV2FPT0WU
human EW-13 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmPTTY5pcWKrdHnvckBw\iCqdX3hckBGXy1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlAyPDhizszN NX3ZR414W0GQR1XS
human NB13 cell NV;HTmZjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmH2TY5pcWKrdHnvckBw\iCqdX3hckBPSjF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yNlU3KM7:TR?= Mn;LV2FPT0WU
human EB2 cell M1jQe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWPWTW1IUW6qaXLpeIlwdiCxZjDoeY1idiCHQkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ6OTR{IN88US=> M{XrW3NCVkeHUh?=
human HOS cell NEP0O5RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGfIdFZKdmirYnn0bY9vKG:oIHj1cYFvKEiRUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5 NFTT[I5USU6JRWK=
human HLE cell NWfvVXlmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV7CdFJyUW6qaXLpeIlwdiCxZjDoeY1idiCKTFWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlUzOTR7IN88US=> NWnsdVZUW0GQR1XS
human ST486 cell NFz3[5BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnnQTY5pcWKrdHnvckBw\iCqdX3hckBUXDR6NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPFY2PCEQvF2= NUfCdlhoW0GQR1XS
human NCI-H2009 cell NV;UbJQ2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkCwPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvODR|NUSg{txO NYPKNopmW0GQR1XS
human NH-12 cell NGHycZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVG5c5NTUW6qaXLpeIlwdiCxZjDoeY1idiCQSD2xNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvOTF5NjFOwG0> NIPUbnRUSU6JRWK=
human BFTC-905 cell M4PJbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4nle2lvcGmkaYTpc44hd2ZiaIXtZY4hSk[WQz25NFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjF2N{[4JO69VQ>? NX3Fd4k{W0GQR1XS
human RKO cell NWjVU2JZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYXJcohq[mm2aX;uJI9nKGi3bXHuJHJMVyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMki0O|Eh|ryP MXrTRW5ITVJ?
human PF-382 M{DpZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmDhTY5pcWKrdHnvckBw\iCqdX3hckBRTi1|OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlM2OjJ4IN88US=> NHvsbJdUSU6JRWK=
human SR cell NVLrOHlVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mmi1TY5pcWKrdHnvckBw\iCqdX3hckBUWiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwM{eyOVYh|ryP M1vXXXNCVkeHUh?=
human WSU-NHL cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmnVTY5pcWKrdHnvckBw\iCqdX3hckBYW1VvTljMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU42OjB4NzFOwG0> NFrwUpJUSU6JRWK=
human CAL-12T cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXXJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC1zMmSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlY1OTRizszN MV;TRW5ITVJ?
human Daudi cell NULINHE6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2XwR2lvcGmkaYTpc44hd2ZiaIXtZY4hTGG3ZHmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlY5PDd5IN88US=> M1LxZ3NCVkeHUh?=
human MC-CAR cell NULUUJhjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MULJcohq[mm2aX;uJI9nKGi3bXHuJG1ENUODUjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuO|A3PDRizszN M136O3NCVkeHUh?=
human RPMI-8402 cell M4fWVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3rlTWlvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST24OFAzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS55Nki3OkDPxE1? NVTjS3k1W0GQR1XS
human CCRF-CEM cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrJWHFrUW6qaXLpeIlwdiCxZjDoeY1idiCFQ2LGMWNGVSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwOUe2Olch|ryP MXfTRW5ITVJ?
human CHP-126 cell NFW1Z5hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXjJcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1zMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22Mlc1OjZ6IN88US=> MUPTRW5ITVJ?
human NB69 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{LmSmlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uO|Y{PTJizszN MV7TRW5ITVJ?
human KS-1 cell NHLzclJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH3HbpdKdmirYnn0bY9vKG:oIHj1cYFvKEuVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22Mlg5PTR7IN88US=> MVfTRW5ITVJ?
human J82 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4\kbGlvcGmkaYTpc44hd2ZiaIXtZY4hUjh{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz6wOFk3PSEQvF2= NGHTWZBUSU6JRWK=
human SW872 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYLJcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz64N|U2QCEQvF2= MlTTV2FPT0WU
human HC-1 cell MnyyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoXsTY5pcWKrdHnvckBw\iCqdX3hckBJSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD6wOlgxPSEQvF2= MUPTRW5ITVJ?
human DU-145 cell M2TsTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnTJTY5pcWKrdHnvckBw\iCqdX3hckBFXS1zNEWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlIyPDZ2IN88US=> MYrTRW5ITVJ?
human HL-60 cell M1;oW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoPWTY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuPFQ3ODVizszN NHHtZldUSU6JRWK=
human MV-4-11 cell M1fIPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1q3U2lvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvOTZ2OTFOwG0> NGrUV4ZUSU6JRWK=
human SK-N-DZ cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUfJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU5vRGqgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlIxPDJ|IN88US=> NFniO5VUSU6JRWK=
human HT-1197 cell MnHXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFrNeo5KdmirYnn0bY9vKG:oIHj1cYFvKEiWLUGxPVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5|MEezJO69VQ>? NFHNTJlUSU6JRWK=
human NOS-1 cell NVr4W5lOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{m2XGlvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU44OTV{IN88US=> MnnrV2FPT0WU
human HT-1080 cell Mkj0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWr4N4ZmUW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xNFgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwNkK4N{DPxE1? M2rBbHNCVkeHUh?=
human SK-LU-1 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJHNMNUyXLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xPE45PzNzIN88US=> NXPWeWFKW0GQR1XS
human SW48 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2TK[WlvcGmkaYTpc44hd2ZiaIXtZY4hW1d2ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKxMlg5QTdizszN NXvV[IN7W0GQR1XS
human A2780 cell MnXFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWHFTVBZUW6qaXLpeIlwdiCxZjDoeY1idiCDMke4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI5NjN5MTFOwG0> M4rhN3NCVkeHUh?=

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Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.74 mM)
Ethanol 7 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.45
Formula

C20H14O2S2

CAS No. 42521-82-4
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    If this product is cell membrane permeable and would it be suitable for PAK1 inhibition on a pancreatic beta cell line?

  • Answer:

    Based on the reference, I think IPA-3 is able to penetrate the cell membrane, it's likely to inhibit PAK1 on a pancreatic beta cell line although there is no reference confirming it: Figure 3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963893/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635/

PAK Signaling Pathway Map

Tags: buy IPA-3 | IPA-3 supplier | purchase IPA-3 | IPA-3 cost | IPA-3 manufacturer | order IPA-3 | IPA-3 distributor
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID