IPA-3

Catalog No.S7093

IPA-3 Chemical Structure

Molecular Weight(MW): 350.45

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

Size Price Stock Quantity  
USD 70 In stock
USD 370 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

2 Customer Reviews

  • (e) Immunoblot analysis of p-ERM, p-Pak1 and Pak1 in Ishikawa cells treated with various doses of Pak1 inhibitor IPA-3 for 24 h. Actin serves as a loading control

    Cell Death Differ, 2016, 23(1):169-81. IPA-3 purchased from Selleck.

    The cells were treated with 5 μM of the PAK1-specific inhibitor IPA-3 or 1 μM of the ROCK1/2-specific inhibitor RKI-1447 for 24 h. Total cell lysates were immunoblotted with antibodies against p110β, p110δ, p-PAK1, PAK1, ROCK1, ROCK2, p-LIMK1, LIMK1 or β-actin, which served as an internal control. The results are representative of three independent experiments.

    Anticancer Res, 2017, 37(4):1805-1818. IPA-3 purchased from Selleck.

Purity & Quality Control

Choose Selective PAK Inhibitors

Biological Activity

Description IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Features IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.
Targets
PAK1 [1]
(Cell-free assay)
2.5 μM
In vitro

IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. [1] IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NALM-6 cell MonhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJG5CVE1vNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVc3QTRizszN Mnf6V2FPT0WU
human SW1710 cell M2Tp[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4HPXWlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzN{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPzh|MzFOwG0> MYrTRW5ITVJ?
human YT cell M{K0U2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIHlOpBKdmirYnn0bY9vKG:oIHj1cYFvKFmWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zPVA{PiEQvF2= MUXTRW5ITVJ?
human BL-70 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4i3emlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlA{Pzl4IN88US=> NEXMXo9USU6JRWK=
human SIG-M5 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3HMPGlvcGmkaYTpc44hd2ZiaIXtZY4hW0mJLV21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yODJzOTFOwG0> NGfaW|BUSU6JRWK=
human MCF7 cell NFu1V5BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVfJcohq[mm2aX;uJI9nKGi3bXHuJG1ETjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkG4NFch|ryP M2rycHNCVkeHUh?=
human GB-1 cell NGDXdHBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYX3OmdMUW6qaXLpeIlwdiCxZjDoeY1idiCJQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk43OzR7NDFOwG0> NGHaZYRUSU6JRWK=
human KU812 cell Mnn4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjLbFR[UW6qaXLpeIlwdiCxZjDoeY1idiCNVUixNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzV7NTFOwG0> MUXTRW5ITVJ?
human QIMR-WIL cell NFXtWXBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVPJcohq[mm2aX;uJI9nKGi3bXHuJHFKVVJvV1nMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46ODh7MTFOwG0> NWXoXHJpW0GQR1XS
human BL-41 cell NInTO3RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFLUNWZKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xQTh2NDFOwG0> M2LPcHNCVkeHUh?=
human CMK cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoDITY5pcWKrdHnvckBw\iCqdX3hckBEVUtiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkG0OVk6KM7:TR?= MmjPV2FPT0WU
human U-698-M cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlLBTY5pcWKrdHnvckBw\iCqdX3hckBWNTZ7OD3NJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4zOzh3NjFOwG0> MXnTRW5ITVJ?
human Daoy cell M2G0W2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4fjRmlvcGmkaYTpc44hd2ZiaIXtZY4hTGGxeTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNlQ3PjJizszN NV7JUHMzW0GQR1XS
human 786-0 cell NY\N[FVPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGDTNZpKdmirYnn0bY9vKG:oIHj1cYFvKDd6Nj2wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4{OThyNTFOwG0> MoG1V2FPT0WU
human REH cell NI\2[lJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1rlSWlvcGmkaYTpc44hd2ZiaIXtZY4hWkWKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zOlY2PSEQvF2= MVLTRW5ITVJ?
human MHH-PREB-1 cell NHXpVopIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWXVTWRZUW6qaXLpeIlwdiCxZjDoeY1idiCPSFitVHJGSi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz60OlY5PyEQvF2= NIThZnNUSU6JRWK=
human KE-37 cell growth NGq1c45Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M12yZmlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlUxOjNzIN88US=> MYTTRW5ITVJ?
human CAL-51 cell M2LVcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVPJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC13MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVQ2OTlizszN Mmj6V2FPT0WU
human CA46 cell NVzEblBpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVrITXBOUW6qaXLpeIlwdiCxZjDoeY1idiCFQUS2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{43PjF6IN88US=> MVrTRW5ITVJ?
human HEL cell MnvpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mne2TY5pcWKrdHnvckBw\iCqdX3hckBJTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkeyO|Y5KM7:TR?= NHuwZ3lUSU6JRWK=
human NB6 cell MoqxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MULJcohq[mm2aX;uJI9nKGi3bXHuJG5DPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwOEO3OVEh|ryP NF\idVlUSU6JRWK=
human 8305C cell NEXkN3hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mo\VTY5pcWKrdHnvckBw\iCqdX3hckA5OzB3QzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNVY4PThizszN MlntV2FPT0WU
human EW-13 cell NVTOT3pPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFLE[mxKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4zODF2ODFOwG0> MUDTRW5ITVJ?
human NB13 cell M1LZRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3;MR2lvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI2PiEQvF2= M3fvWHNCVkeHUh?=
human EB2 cell Ml3sS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUPUcIpLUW6qaXLpeIlwdiCxZjDoeY1idiCHQkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ6OTR{IN88US=> NX:wWmdPW0GQR1XS
human HOS cell NHnwSYxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGrVbpVKdmirYnn0bY9vKG:oIHj1cYFvKEiRUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5 MUDTRW5ITVJ?
human HLE cell NYn0U|d[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoPnTY5pcWKrdHnvckBw\iCqdX3hckBJVEViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkWyNVQ6KM7:TR?= MV3TRW5ITVJ?
human ST486 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlrqTY5pcWKrdHnvckBw\iCqdX3hckBUXDR6NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPFY2PCEQvF2= MWfTRW5ITVJ?
human NCI-H2009 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX7DN40xUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxODliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkC0N|U1KM7:TR?= MXnTRW5ITVJ?
human NH-12 cell MnTiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlLSTY5pcWKrdHnvckBw\iCqdX3hckBPUC1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuNVE4PiEQvF2= MojhV2FPT0WU
human BFTC-905 cell M2\nVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYLJcohq[mm2aX;uJI9nKGi3bXHuJGJHXENvOUC1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4yPDd4ODFOwG0> NFHtUmVUSU6JRWK=
human RKO cell NXq1PVFUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYTJcohq[mm2aX;uJI9nKGi3bXHuJHJMVyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMki0O|Eh|ryP Mk\GV2FPT0WU
human PF-382 NIO2fGhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIPpZmxKdmirYnn0bY9vKG:oIHj1cYFvKFCILUO4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvOzV{Mk[g{txO M3LiXXNCVkeHUh?=
human SR cell MlPmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFHCfYZKdmirYnn0bY9vKG:oIHj1cYFvKFOUIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT6zO|I2PiEQvF2= MWnTRW5ITVJ?
human WSU-NHL cell NXjhN2wzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVHJcohq[mm2aX;uJI9nKGi3bXHuJHdUXS2QSFygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlUzODZ5IN88US=> MYXTRW5ITVJ?
human CAL-12T cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2fiZmlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUGyWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPjRzNDFOwG0> Ml\5V2FPT0WU
human Daudi cell NYjYXItkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlnLTY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuOlg1PzdizszN NVO1NWV2W0GQR1XS
human MC-CAR cell MlvvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWLFeJo1UW6qaXLpeIlwdiCxZjDoeY1idiCPQz3DRXIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjdyNkS0JO69VQ>? NFi0VldUSU6JRWK=
human RPMI-8402 cell M3nlTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYDJcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOESwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzZ6N{[g{txO MXjTRW5ITVJ?
human CCRF-CEM cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MorrTY5pcWKrdHnvckBw\iCqdX3hckBES1KILVPFUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQTd4Nkeg{txO NFH1S3NUSU6JRWK=
human CHP-126 cell NUnQOVM{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGrO[VJKdmirYnn0bY9vKG:oIHj1cYFvKEOKUD2xNlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03Njd2Mk[4JO69VQ>? MYDTRW5ITVJ?
human NB69 cell MnPvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFy1eHBKdmirYnn0bY9vKG:oIHj1cYFvKE6ENkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22Mlc3OzV{IN88US=> M3XH[HNCVkeHUh?=
human KS-1 cell NHmyOohIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUDJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lki4OVQ6KM7:TR?= MmTPV2FPT0WU
human J82 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlfCTY5pcWKrdHnvckBw\iCqdX3hckBLQDJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkC0PVY2KM7:TR?= M{PCc3NCVkeHUh?=
human SW872 cell NFzJZ29Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{\YT2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d6N{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23Mlg{PTV6IN88US=> NVTITlV7W0GQR1XS
human HC-1 cell NIK3WopIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFLqcW5KdmirYnn0bY9vKG:oIHj1cYFvKEiFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA3QDB3IN88US=> M4K5fXNCVkeHUh?=
human DU-145 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3r2PWlvcGmkaYTpc44hd2ZiaIXtZY4hTFVvMUS1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4zOTR4NDFOwG0> MmLIV2FPT0WU
human HL-60 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF;1SoNKdmirYnn0bY9vKG:oIHj1cYFvKEiOLU[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE45PDZyNTFOwG0> M2XVU3NCVkeHUh?=
human MV-4-11 cell M4D1d2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoLPTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4yPjR7IN88US=> NIrRPG5USU6JRWK=
human SK-N-DZ cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmfXTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QLVTaJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4zODR{MzFOwG0> MYrTRW5ITVJ?
human HT-1197 cell MlzxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NECzVoZKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUGxPVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5|MEezJO69VQ>? NVv0VpVCW0GQR1XS
human NOS-1 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2LObGlvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU44OTV{IN88US=> M{\NdnNCVkeHUh?=
human HT-1080 cell NVHHbnhmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFjQRXhKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUGwPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC54MkizJO69VQ>? MonSV2FPT0WU
human SK-LU-1 cell M4rkbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NE\HPYdKdmirYnn0bY9vKG:oIHj1cYFvKFONLVzVMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC56N{OxJO69VQ>? NVz1OnJqW0GQR1XS
human SW48 cell NXvncYpOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGCz[oJKdmirYnn0bY9vKG:oIHj1cYFvKFOZNEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNU45QDl5IN88US=> NXnMOGZCW0GQR1XS
human A2780 cell NYfKW4JsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlL4TY5pcWKrdHnvckBw\iCqdX3hckBCOjd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK4MlM4OSEQvF2= MmCzV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.74 mM)
Ethanol 7 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.45
Formula

C20H14O2S2

CAS No. 42521-82-4
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    If this product is cell membrane permeable and would it be suitable for PAK1 inhibition on a pancreatic beta cell line?

  • Answer:

    Based on the reference, I think IPA-3 is able to penetrate the cell membrane, it's likely to inhibit PAK1 on a pancreatic beta cell line although there is no reference confirming it: Figure 3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963893/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635/

PAK Signaling Pathway Map

Tags: buy IPA-3 | IPA-3 supplier | purchase IPA-3 | IPA-3 cost | IPA-3 manufacturer | order IPA-3 | IPA-3 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID