IPA-3

Catalog No.S7093

IPA-3 Chemical Structure

Molecular Weight(MW): 350.45

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).

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2 Customer Reviews

  • (e) Immunoblot analysis of p-ERM, p-Pak1 and Pak1 in Ishikawa cells treated with various doses of Pak1 inhibitor IPA-3 for 24 h. Actin serves as a loading control

    Cell Death Differ, 2016, 23(1):169-81. IPA-3 purchased from Selleck.

    The cells were treated with 5 μM of the PAK1-specific inhibitor IPA-3 or 1 μM of the ROCK1/2-specific inhibitor RKI-1447 for 24 h. Total cell lysates were immunoblotted with antibodies against p110β, p110δ, p-PAK1, PAK1, ROCK1, ROCK2, p-LIMK1, LIMK1 or β-actin, which served as an internal control. The results are representative of three independent experiments.

    Anticancer Res, 2017, 37(4):1805-1818. IPA-3 purchased from Selleck.

Purity & Quality Control

Choose Selective PAK Inhibitors

Biological Activity

Description IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Features IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42.
Targets
PAK1 [1]
(Cell-free assay)
2.5 μM
In vitro

IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. [1] IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human NALM-6 cell M{DC[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX;Jcohq[mm2aX;uJI9nKGi3bXHuJG5CVE1vNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVc3QTRizszN NE\BeXpUSU6JRWK=
human SW1710 cell NUT3NYFRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoDNTY5pcWKrdHnvckBw\iCqdX3hckBUXzF5MUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE4QDN|IN88US=> M{TkTnNCVkeHUh?=
human YT cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWDJcohq[mm2aX;uJI9nKGi3bXHuJHlVKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5|OUCzOkDPxE1? M3;IbHNCVkeHUh?=
human BL-70 cell M1rsfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHnSUIdKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUewJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xOzd7NjFOwG0> M4n4e3NCVkeHUh?=
human SIG-M5 cell M2r6Omdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml\NTY5pcWKrdHnvckBw\iCqdX3hckBUUUdvTUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlExOjF7IN88US=> MVvTRW5ITVJ?
human MCF7 cell M{X0XWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVe4NpVxUW6qaXLpeIlwdiCxZjDoeY1idiCPQ1[3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yQDB5IN88US=> MYLTRW5ITVJ?
human GB-1 cell NY[0elM1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVnaeJB5UW6qaXLpeIlwdiCxZjDoeY1idiCJQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk43OzR7NDFOwG0> M{\ZTHNCVkeHUh?=
human KU812 cell NXTrR4lrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{nWWWlvcGmkaYTpc44hd2ZiaIXtZY4hU1V6MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlc2QTVizszN MkLrV2FPT0WU
human QIMR-WIL cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXS2fYRIUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwOUC4PVEh|ryP MXvTRW5ITVJ?
human BL-41 cell M4LpR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYnJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTRzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wPVg1PCEQvF2= NFfUeldUSU6JRWK=
human CMK cell M3e3dWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHe4bZZKdmirYnn0bY9vKG:oIHj1cYFvKEOPSzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNVQ2QTlizszN NGGxNJpUSU6JRWK=
human U-698-M cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWDrZ21mUW6qaXLpeIlwdiCxZjDoeY1idiCXLU[5PE1OKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy5{M{i1OkDPxE1? MkXpV2FPT0WU
human Daoy cell M1jSTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkfITY5pcWKrdHnvckBw\iCqdX3hckBF[W:7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6yOFY3OiEQvF2= MmG3V2FPT0WU
human 786-0 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkCzTY5pcWKrdHnvckBw\iCqdX3hckA4QDZvMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|E5ODVizszN NHHmdoJUSU6JRWK=
human REH cell M4HuO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYfYOHpZUW6qaXLpeIlwdiCxZjDoeY1idiCURVigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlM3PjV3IN88US=> MkTaV2FPT0WU
human MHH-PREB-1 cell NYftNFJmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2SUlXCMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjR4Nki3JO69VQ>? M3zpSHNCVkeHUh?=
human KE-37 cell growth Ml;wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{j0[GlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlUxOjNzIN88US=> M4O2bnNCVkeHUh?=
human CAL-51 cell NE\uUWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYrPNmJYUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytOVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjV2NUG5JO69VQ>? M1yxbHNCVkeHUh?=
human CA46 cell M3fHVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEO0PZVKdmirYnn0bY9vKG:oIHj1cYFvKEODNE[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlY3OThizszN MmjsV2FPT0WU
human HEL cell MkL0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1fNeWlvcGmkaYTpc44hd2ZiaIXtZY4hUEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz63Nlc3QCEQvF2= MkHOV2FPT0WU
human NB6 cell NFvlTIZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{LHXGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz64N|c2OSEQvF2= M1\3V3NCVkeHUh?=
human 8305C cell M1G1Umdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVvJcohq[mm2aX;uJI9nKGi3bXHuJFg{ODWFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xOlc2QCEQvF2= NWTCXoZDW0GQR1XS
human EW-13 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYjRfppbUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOjBzNEig{txO NHrGVm5USU6JRWK=
human NB13 cell M1PqbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{fqXGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI2PiEQvF2= M2LVPXNCVkeHUh?=
human EB2 cell M4rIeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGrM[YNKdmirYnn0bY9vKG:oIHj1cYFvKEWEMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOFkyPDJizszN MV7TRW5ITVJ?
human HOS cell NYX6SGFMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGhQWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7 MmPSV2FPT0WU
human HLE cell MoH5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX;kSm9HUW6qaXLpeIlwdiCxZjDoeY1idiCKTFWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlUzOTR7IN88US=> MUjTRW5ITVJ?
human ST486 cell M1zl[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkfoTY5pcWKrdHnvckBw\iCqdX3hckBUXDR6NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPFY2PCEQvF2= M3\s[nNCVkeHUh?=
human NCI-H2009 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUL5XHRKUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxODliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkC0N|U1KM7:TR?= M37BeHNCVkeHUh?=
human NH-12 cell NHHaSpJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJG5JNTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT6xNVc3KM7:TR?= NVPCXYlZW0GQR1XS
human BFTC-905 cell NG\lOo9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkHLTY5pcWKrdHnvckBw\iCqdX3hckBDTlSFLUmwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvOTR5Nkig{txO MXTTRW5ITVJ?
human RKO cell NFK5Xm5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXvjRYJFUW6qaXLpeIlwdiCxZjDoeY1idiCUS1:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlI5PDdzIN88US=> NYPUenlXW0GQR1XS
human PF-382 NGqwfpNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIjlPXZKdmirYnn0bY9vKG:oIHj1cYFvKFCILUO4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvOzV{Mk[g{txO M1PwSnNCVkeHUh?=
human SR cell NFjjfJhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkDrTY5pcWKrdHnvckBw\iCqdX3hckBUWiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwM{eyOVYh|ryP M4rGU3NCVkeHUh?=
human WSU-NHL cell NX;wU5k3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn;QTY5pcWKrdHnvckBw\iCqdX3hckBYW1VvTljMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU42OjB4NzFOwG0> NUf3W|BOW0GQR1XS
human CAL-12T cell NFXrRWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MonQTY5pcWKrdHnvckBw\iCqdX3hckBESUxvMULUJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU43PDF2IN88US=> NYnoRoV2W0GQR1XS
human Daudi cell NVTTTJJET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYjTeWN5UW6qaXLpeIlwdiCxZjDoeY1idiCGYYXkbUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPjh2N{eg{txO NGrtZoVUSU6JRWK=
human MC-CAR cell NVfTNG1uT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJG1ENUODUjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuO|A3PDRizszN NXTKOItWW0GQR1XS
human RPMI-8402 cell Mn7lS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYTJcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOESwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzZ6N{[g{txO NFLXNI1USU6JRWK=
human CCRF-CEM cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1fGN2lvcGmkaYTpc44hd2ZiaIXtZY4hS0OURj3DSW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njl5Nk[3JO69VQ>? NVHqe3lKW0GQR1XS
human CHP-126 cell M2Laemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXTJcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1zMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22Mlc1OjZ6IN88US=> NH\kdHhUSU6JRWK=
human NB69 cell NHjUXXdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVTJcohq[mm2aX;uJI9nKGi3bXHuJG5DPjliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lke2N|UzKM7:TR?= M2XhTHNCVkeHUh?=
human KS-1 cell NXu4Vos5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVLJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14Lki4OVQ6KM7:TR?= M2PRVHNCVkeHUh?=
human J82 cell NV7XdFg3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYTJcohq[mm2aX;uJI9nKGi3bXHuJGo5OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMES5OlUh|ryP MYrTRW5ITVJ?
human SW872 cell NVLRRpppT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUjJcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz64N|U2QCEQvF2= M{XPcXNCVkeHUh?=
human HC-1 cell M4fPWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHf5XXpKdmirYnn0bY9vKG:oIHj1cYFvKEiFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA3QDB3IN88US=> NEjUOmdUSU6JRWK=
human DU-145 cell NILhV|lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkjlTY5pcWKrdHnvckBw\iCqdX3hckBFXS1zNEWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlIyPDZ2IN88US=> NFH5cZVUSU6JRWK=
human HL-60 cell NYO1cpE4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYTEeXRbUW6qaXLpeIlwdiCxZjDoeY1idiCKTD22NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvQDR4MEWg{txO M3XqTXNCVkeHUh?=
human MV-4-11 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnTHTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4yPjR7IN88US=> NV;QUJpwW0GQR1XS
human SK-N-DZ cell M3qwNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFLUXWRKdmirYnn0bY9vKG:oIHj1cYFvKFONLV6tSHoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjJyNEKzJO69VQ>? NULpTHpXW0GQR1XS
human HT-1197 cell NH\hTWdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlPaTY5pcWKrdHnvckBw\iCqdX3hckBJXC1zMUm3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvOzB5MzFOwG0> M4XFUXNCVkeHUh?=
human NOS-1 cell M3HBR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{ewfGlvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU44OTV{IN88US=> NXjaSVFGW0GQR1XS
human HT-1080 cell NVrQcYlTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGhVNTFyOECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xPE43Ojh|IN88US=> NWXifYdlW0GQR1XS
human SK-LU-1 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH7jSYlKdmirYnn0bY9vKG:oIHj1cYFvKFONLVzVMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC56N{OxJO69VQ>? M{LLUnNCVkeHUh?=
human SW48 cell NX3YTmdZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkfUTY5pcWKrdHnvckBw\iCqdX3hckBUXzR6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkGuPFg6PyEQvF2= M1vnXnNCVkeHUh?=
human A2780 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlLDTY5pcWKrdHnvckBw\iCqdX3hckBCOjd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK4MlM4OSEQvF2= NHOwVoxUSU6JRWK=

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Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL (199.74 mM)
Ethanol 7 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.45
Formula

C20H14O2S2

CAS No. 42521-82-4
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    If this product is cell membrane permeable and would it be suitable for PAK1 inhibition on a pancreatic beta cell line?

  • Answer:

    Based on the reference, I think IPA-3 is able to penetrate the cell membrane, it's likely to inhibit PAK1 on a pancreatic beta cell line although there is no reference confirming it: Figure 3: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963893/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353635/

PAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID