Catalog No.S7756 Synonyms: 1-Methyl-D-tryptophan
Molecular Weight(MW): 218.25
Indoximod (NLG-8189), a methylated tryptophan, acts as an IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor, and reverses IDO-mediated immune suppression. Phase 2.
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|Description||Indoximod (NLG-8189), a methylated tryptophan, acts as an IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor, and reverses IDO-mediated immune suppression. Phase 2.|
Indoximod significantly reverses the suppression of T cells created by IDO-expressing dendritic cells, using both human monocyte-derived dendritic cells and murine dendritic cells isolated directly from tumor-draining lymph nodes.  Indoximod activates a Trp sufficiency signal that stimulates mTOR, and relieves IDO-induced Trp deprivation as well as an autophagic response. 
|In vivo||In mouse models of transplantable melanoma and transplantable and autochthonous breast cancer, Indoximod (400 mg/kg p.o.) enhances antitumor immunity in the setting of combined chemo-immunotherapy regimens. |
|In vitro||DMSO||1 mg/mL warmed (4.58 mM)|
|In vivo||Add solvents to the product individually and in order:
5% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02835729||Recruiting||Acute Myeloid Leukemia||NewLink Genetics Corporation||July 2016||Phase 1|Phase 2|
|NCT02460367||Recruiting||Non-small Cell Lung Cancer|Progression of Non-small Cell Lung Cancer|Non-small Cell Lung Cancer Recurrent||NewLink Genetics Corporation||January 2016||Phase 1|Phase 2|
|NCT02502708||Recruiting||Glioblastoma Multiforme|Glioma|Gliosarcoma|Malignant Brain Tumor|Ependymoma|Medulloblastoma||NewLink Genetics Corporation||October 2015||Phase 1|
|NCT02077881||Recruiting||Metastatic Pancreatic Adenocarcinoma|Metastatic Pancreatic Cancer||NewLink Genetics Corporation||August 2014||Phase 1|Phase 2|
|NCT02073123||Recruiting||Metastatic Melanoma|Stage III Melanoma|Stage IV Melanoma||NewLink Genetics Corporation||July 2014||Phase 1|Phase 2|
|NCT02052648||Recruiting||Glioblastoma Multiforme|Glioma|Gliosarcoma|Malignant Brain Tumor||NewLink Genetics Corporation||March 2014||Phase 1|Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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