Catalog No.S7587 Synonyms: INCB14943
Molecular Weight(MW): 271.64
INCB024360 analogue is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM. Phase 2.
Purity & Quality Control
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|Description||INCB024360 analogue is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM. Phase 2.|
In HeLa cells, INCB024360 shows higher inhibitory activity on IDO1 with IC50 of 19 nM.  In coculture systems of human allogeneic lymphocytes with dendritic cells or tumor cells, INCB024360, via IDO1 inhibition, reverses T-cell suppression mediated by IDO-expressing HeLa cells or DCs, and increases the proliferation and functional activity of CD4+ T cells, CD8+ T cells, and NK cells. 
|In vivo||In mice bearing GM-CSF-secreting B16 tumors, INCB024360 (75 mg/kg b.i.d) causes dose dependent inhibition of tumor growth.  INCB024360 significantly suppresses tumor growth in immunocompetent, but not immunodeficient, mice. |
|In vitro||DMSO||54 mg/mL warmed (198.79 mM)|
|Ethanol||54 mg/mL warmed (198.79 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+45% PEG 300+ddH2O
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02862457||Recruiting||Neoplasms||Merck Sharp & Dohme Corp.||August 2016||Phase 1|
|NCT02785250||Recruiting||Recurrent Epithelial Ovarian Cancer|Recurrent Fallopian Tube Cancer|Recurrent Peritoneal Cancer||ImmunoVaccine Technologies, Inc.|Incyte Corporation||April 2016||Phase 1|
|NCT02575807||Recruiting||Platinum-resistant Ovarian Cancer|Platinum-resistant Fallopian Cancer|Platinum-resistant Peritoneal Cancer||Aduro Biotech, Inc.|Incyte Corporation||January 2016||Phase 1|Phase 2|
|NCT02318277||Recruiting||Selected Advanced Solid Tumors|Non-small Cell Lung Cancer|Melanoma|Head and Neck Cancer|Gastric Cancer|Gastroesophageal Cancer|Urothelial Cancer|Triple Negative Breast Cancer||Incyte Corporation|MedImmune LLC||December 2014||Phase 1|Phase 2|
|NCT02178722||Recruiting||Malignant Solid Tumor|Lymphoma, Large B-Cell, Diffuse|Carcinoma, Non-Small-Cell Lung|Transitional Cell Carcinoma of Urinary Tract|Triple Negative Breast Cancer|Carcinoma, Squamous Cell of Head and Neck|Ovarian Neoplasms|Adenocarcinoma of the Endometrium|Renal Cell Carcinoma|Microsatellite-instability (MSI) High Colorectal Cancer||Incyte Corporation|Merck Sharp & Dohme Corp.||June 2014||Phase 1|Phase 2|
|NCT02118285||Suspended||Ovarian Cancer|Fallopian Tube Carcinoma|Primary Peritoneal Carcinoma||Masonic Cancer Center, University of Minnesota|Incyte Corporation||April 2014||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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