DMOG

Catalog No.S7483 Synonyms: Dimethyloxalylglycine

DMOG Chemical Structure

Molecular Weight(MW): 175.14

DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase.

Size Price Stock Quantity  
In DMSO USD 120 In stock
USD 97 In stock
USD 194 In stock
USD 327 In stock
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1 Customer Review

  • Western blot analysis of the indicated proteins after the treatment with DMOG (K).

    Theranostics, 2017, 7(13): 3293-3305. DMOG purchased from Selleck.

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Biological Activity

Description DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase.
Targets
HIF prolyl hydroxylase [1]
()
In vitro

DMOG shows only weakly active in the microsomal system, but efficiently suppresses hydroxyproline synthesis in intact cells. [1] DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human SR cell M1T3Zmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1;XWmlvcGmkaYTpc44hd2ZiaIXtZY4hW1JiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkW3PVQ3KM7:TR?= MV;TRW5ITVJ?
human LB996-RCC cell M13BVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVzJcohq[mm2aX;uJI9nKGi3bXHuJGxDQTl4LWLDR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPjh5NzFOwG0> MofkV2FPT0WU
human LOUCY cell NGLZZWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWLEfml6UW6qaXLpeIlwdiCxZjDoeY1idiCOT2XDXUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjN2OUOg{txO NUPjTm9wW0GQR1XS
human KS-1 cell NVLrRWlVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVHJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMT6yOVU4KM7:TR?= M1XmRnNCVkeHUh?=
human U-698-M cell NHTV[mlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{jwRWlvcGmkaYTpc44hd2ZiaIXtZY4hXS14OUitUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjN|ME[g{txO NEXXe2xUSU6JRWK=
human A3-KAW cell NEXsPVZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXHJcohq[mm2aX;uJI9nKGi3bXHuJGE{NUuDVzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlgyPzRizszN MnL0V2FPT0WU
human BL-70 cell NUD0R3dZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3;3N2lvcGmkaYTpc44hd2ZiaIXtZY4hSkxvN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU46PDJ|IN88US=> NWnqemdWW0GQR1XS
human DMS-273 cell NWnBdZJQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFeyfJhKdmirYnn0bY9vKG:oIHj1cYFvKESPUz2yO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS57NkWg{txO MkX0V2FPT0WU
human CAL-39 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH\TUXdKdmirYnn0bY9vKG:oIHj1cYFvKEODTD2zPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE6NjN{N{eg{txO M4fGOnNCVkeHUh?=
human KYSE-410 cell NV\1W2dvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFfTSo5KdmirYnn0bY9vKG:oIHj1cYFvKEu\U1WtOFExKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjBwOEG5O{DPxE1? MlrkV2FPT0WU
human YT cell M{POPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV7Jcohq[mm2aX;uJI9nKGi3bXHuJHlVKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjNwM{m4OEDPxE1? NW\SUlVvW0GQR1XS
human LC-2-ad cell NETZO5JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NInuVmRKdmirYnn0bY9vKG:oIHj1cYFvKEyFLUKtZYQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPC53NUezJO69VQ>? MmDjV2FPT0WU
human COR-L105 cell M4C3OWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmjWTY5pcWKrdHnvckBw\iCqdX3hckBEV1JvTEGwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI3NjR2M{[g{txO NIHOdHFUSU6JRWK=
human CAL-12T cell NHHlS3hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXHidY9[UW6qaXLpeIlwdiCxZjDoeY1idiCFQVytNVJVKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjZwNUWwNkDPxE1? MUDTRW5ITVJ?
human KU812 cell MlrwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVf2PZd3UW6qaXLpeIlwdiCxZjDoeY1idiCNVUixNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI5NjR3N{mg{txO MVfTRW5ITVJ?
human OPM-2 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIHpPYNKdmirYnn0bY9vKG:oIHj1cYFvKE:STT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlgvQDJ{NzFOwG0> NX3vS4tRW0GQR1XS
human SW982 cell NYLTTnB5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MorCTY5pcWKrdHnvckBw\iCqdX3hckBUXzl6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOzMlcxODdizszN MVzTRW5ITVJ?
human HH cell M{nXOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3Hi[2lvcGmkaYTpc44hd2ZiaIXtZY4hUEhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|ND6wNlM2KM7:TR?= MkjXV2FPT0WU
human RS4-11 cell NULCPJRHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkDqTY5pcWKrdHnvckBw\iCqdX3hckBTWzRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOE4yQDB4IN88US=> Mo[wV2FPT0WU
human BEN cell MmO1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF;tc4FKdmirYnn0bY9vKG:oIHj1cYFvKEKHTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO2MlgyQDdizszN MW\TRW5ITVJ?
human CCRF-CEM cell M{fCR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mni0TY5pcWKrdHnvckBw\iCqdX3hckBES1KILVPFUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM4Njd5Mkmg{txO NI\Mb5VUSU6JRWK=
human EW-13 cell MoHQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1u1ZWlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zPU4xPDhzIN88US=> NG\2R4xUSU6JRWK=
human NCI-H2228 cell M1ixfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mk\OTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKyNlgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Oi56MUig{txO NXr6e2Y2W0GQR1XS
human KE-37 cell M3jVbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYHmSW54UW6qaXLpeIlwdiCxZjDoeY1idiCNRT2zO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ{NjJ7MUWg{txO MY\TRW5ITVJ?
human A4-Fuk cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWjWU21MUW6qaXLpeIlwdiCxZjDoeY1idiCDND3GeYsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01PS5yM{[0JO69VQ>? NVHrUINsW0GQR1XS
human MZ1-PC cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJG1bOS2SQzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS1Mlk5QDhizszN MXnTRW5ITVJ?
human MLMA cell Mke4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MULJcohq[mm2aX;uJI9nKGi3bXHuJG1NVUFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12Nj6zNlkzKM7:TR?= M2LEZXNCVkeHUh?=
human EB-3 cell M3KxXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGVDNTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12OT61O|kzKM7:TR?= NYD6Soh3W0GQR1XS
human 293T cells  MnPiSpVv[3Srb36gZZN{[Xl? MoPLNk42KG2P NFrjV45KdmirYnn0bY9vKG:oIFrNTmQzNW2nZHnheIVlKEh|S{O2JIRmdWW2aInsZZRqd25iaX6gbJVu[W5iMkmzWEBk\WyuczDheEAzNjVibV2= NF21dIcyQTN3OUG2Oy=>

... Click to View More Cell Line Experimental Data

In vivo DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. [2] Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. [4]

Protocol

Cell Research:

[3]

+ Expand
  • Cell lines: VSMC cells
  • Concentrations: ~100 μM
  • Incubation Time: 72-96 hours
  • Method:

    To analyze DNA synthesis as an index of cellular proliferation, VSMC are plated in 48-well plates (5,000 per square centimeter) in growth medium, incubated overnight, and serum-deprived (1% FCS) for 24 h. Replicate wells are then stored at −70°C for baseline (day 0) cell counts, and fresh medium with or without growth factors is added to the remaining wells, which are incubated 72-96 h in 20 or 5% O2. Days 0 and 3 or 4 cell counts are determined by lysing cells in a buffer containing a fluorescent dye, which has minimal fluorescence by itself but fluoresces when bound to DNA or RNA. Absolute cell numbers are calculated by comparing the fluorescence of specimens with that of a standard curve similarly prepared using a known number of cells.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Mice (C57Bl6)
  • Formulation: 8 mg/mouse
  • Dosages: 8 mg in 0.5 ml saline
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 35 mg/mL (199.84 mM)
Water 35 mg/mL (199.84 mM)
Ethanol 35 mg/mL (199.84 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 175.14
Formula

C6H9NO5

CAS No. 89464-63-1
Storage powder
in solvent
Synonyms Dimethyloxalylglycine

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID