DMOG

Catalog No.S7483 Synonyms: Dimethyloxalylglycine

DMOG Chemical Structure

Molecular Weight(MW): 175.14

DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase.

Size Price Stock Quantity  
In DMSO USD 120 In stock
USD 97 In stock
USD 194 In stock
USD 327 In stock
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1 Customer Review

  • Western blot analysis of the indicated proteins after the treatment with DMOG (K).

    Theranostics, 2017, 7(13): 3293-3305. DMOG purchased from Selleck.

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Biological Activity

Description DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase.
Targets
HIF prolyl hydroxylase [1]
()
In vitro

DMOG shows only weakly active in the microsomal system, but efficiently suppresses hydroxyproline synthesis in intact cells. [1] DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human SR cell NGDlT|dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4XnUmlvcGmkaYTpc44hd2ZiaIXtZY4hW1JiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkW3PVQ3KM7:TR?= NWG0Ro82W0GQR1XS
human LB996-RCC cell NGfZ[GhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NInyW2hKdmirYnn0bY9vKG:oIHj1cYFvKEyEOUm2MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNki3O{DPxE1? NYPvPZZjW0GQR1XS
human LOUCY cell NVe0dWlGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3ex[2lvcGmkaYTpc44hd2ZiaIXtZY4hVE:XQ2mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE4{PDl|IN88US=> MmD5V2FPT0WU
human KS-1 cell NYLXV4dlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MULJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMT6yOVU4KM7:TR?= MkX3V2FPT0WU
human U-698-M cell NFTYN4FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYfJcohq[mm2aX;uJI9nKGi3bXHuJHUuPjl6LV2gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{4{OzB4IN88US=> MoL2V2FPT0WU
human A3-KAW cell MlvPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYThTZF5UW6qaXLpeIlwdiCxZjDoeY1idiCDMz3LRXch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS56MUe0JO69VQ>? NFfr[5NUSU6JRWK=
human BL-70 cell NFPxO41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4rzU2lvcGmkaYTpc44hd2ZiaIXtZY4hSkxvN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU46PDJ|IN88US=> M2X3T3NCVkeHUh?=
human DMS-273 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmKxTY5pcWKrdHnvckBw\iCqdX3hckBFVVNvMkezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVUvQTZ3IN88US=> MVvTRW5ITVJ?
human CAL-39 cell NVnBdWY{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXrDenp{UW6qaXLpeIlwdiCxZjDoeY1idiCFQVytN|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQS5|Mke3JO69VQ>? M1rNdnNCVkeHUh?=
human KYSE-410 cell NUHLNJA4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXH0do1XUW6qaXLpeIlwdiCxZjDoeY1idiCNWWPFMVQyOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJyLkixPVch|ryP MYHTRW5ITVJ?
human YT cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkO2TY5pcWKrdHnvckBw\iCqdX3hckB[XCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ|LkO5PFQh|ryP MUjTRW5ITVJ?
human LC-2-ad cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEHEfpdKdmirYnn0bY9vKG:oIHj1cYFvKEyFLUKtZYQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPC53NUezJO69VQ>? MWHTRW5ITVJ?
human COR-L105 cell M{KxbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEfI[ZpKdmirYnn0bY9vKG:oIHj1cYFvKEORUj3MNVA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjZwNESzOkDPxE1? M4ra[XNCVkeHUh?=
human CAL-12T cell M1HUemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4e3WmlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUGyWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI3NjV3MEKg{txO NIqwSYNUSU6JRWK=
human KU812 cell NWDo[ZFVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYXrOmpsUW6qaXLpeIlwdiCxZjDoeY1idiCNVUixNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI5NjR3N{mg{txO NV;GbGZoW0GQR1XS
human OPM-2 cell NU\VUoc4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrJcohq[mm2aX;uJI9nKGi3bXHuJG9RVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuPFIzPyEQvF2= MnH0V2FPT0WU
human SW982 cell NGTZdFVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGXES5dKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUiyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|MvPzByNzFOwG0> MY\TRW5ITVJ?
human HH cell MnHIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mnm5TY5pcWKrdHnvckBw\iCqdX3hckBJUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN2LkCyN|Uh|ryP M1G2fXNCVkeHUh?=
human RS4-11 cell NYDwW2NpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF64[GZKdmirYnn0bY9vKG:oIHj1cYFvKFKVND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM1NjF6ME[g{txO NIXzZVFUSU6JRWK=
human BEN cell NXjON21iT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWfJcohq[mm2aX;uJI9nKGi3bXHuJGJGViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN4LkixPFch|ryP NEm5RWVUSU6JRWK=
human CCRF-CEM cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3m2[GlvcGmkaYTpc44hd2ZiaIXtZY4hS0OURj3DSW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Py55N{K5JO69VQ>? MnHKV2FPT0WU
human EW-13 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYHJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{muNFQ5OSEQvF2= NVLlSJBlW0GQR1XS
human NCI-H2228 cell Ml23S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkKyPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQzNjhzODFOwG0> Mn3BV2FPT0WU
human KE-37 cell NH\1PFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MomxTY5pcWKrdHnvckBw\iCqdX3hckBMTS1|NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSzMlI6OTVizszN MW\TRW5ITVJ?
human A4-Fuk cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYjJcohq[mm2aX;uJI9nKGi3bXHuJGE1NU[3azDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS1MlA{PjRizszN MkT1V2FPT0WU
human MZ1-PC cell NXq3bFhIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX;HXI84UW6qaXLpeIlwdiCxZjDoeY1idiCPWkGtVGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01PS57OEi4JO69VQ>? M{PmUHNCVkeHUh?=
human MLMA cell M1zmN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NI\UR3VKdmirYnn0bY9vKG:oIHj1cYFvKE2OTVGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Ok4{Ojl{IN88US=> MkfYV2FPT0WU
human EB-3 cell M2D5eWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mo\ETY5pcWKrdHnvckBw\iCqdX3hckBGSi1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NEmuOVc6OiEQvF2= NHzwbHNUSU6JRWK=
human 293T cells  MVfGeY5kfGmxbjDhd5NigQ>? MnTONk42KG2P MnTJTY5pcWKrdHnvckBw\iCMTVrENk1u\WSrYYTl[EBJO0t|NjDk[Y1mfGi7bHH0bY9vKGmwIHj1cYFvKDJ7M2SgZ4VtdHNiYYSgNk42KG2P NIfVSVcyQTN3OUG2Oy=>

... Click to View More Cell Line Experimental Data

In vivo DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. [2] Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. [4]

Protocol

Cell Research:

[3]

+ Expand
  • Cell lines: VSMC cells
  • Concentrations: ~100 μM
  • Incubation Time: 72-96 hours
  • Method:

    To analyze DNA synthesis as an index of cellular proliferation, VSMC are plated in 48-well plates (5,000 per square centimeter) in growth medium, incubated overnight, and serum-deprived (1% FCS) for 24 h. Replicate wells are then stored at −70°C for baseline (day 0) cell counts, and fresh medium with or without growth factors is added to the remaining wells, which are incubated 72-96 h in 20 or 5% O2. Days 0 and 3 or 4 cell counts are determined by lysing cells in a buffer containing a fluorescent dye, which has minimal fluorescence by itself but fluoresces when bound to DNA or RNA. Absolute cell numbers are calculated by comparing the fluorescence of specimens with that of a standard curve similarly prepared using a known number of cells.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Mice (C57Bl6)
  • Formulation: 8 mg/mouse
  • Dosages: 8 mg in 0.5 ml saline
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 35 mg/mL (199.84 mM)
Water 35 mg/mL (199.84 mM)
Ethanol 35 mg/mL (199.84 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 175.14
Formula

C6H9NO5

CAS No. 89464-63-1
Storage powder
Synonyms Dimethyloxalylglycine

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID