DMOG

Catalog No.S7483 Synonyms: Dimethyloxalylglycine

DMOG Chemical Structure

Molecular Weight(MW): 175.14

DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.

Size Price Stock Quantity  
In DMSO USD 120 In stock
USD 97 In stock
USD 194 In stock
USD 327 In stock
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Biological Activity

Description DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.
Targets
HIF prolyl hydroxylase [1]
In vitro

DMOG shows only weakly active in the microsomal system, but efficiently suppresses hydroxyproline synthesis in intact cells. [1] DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human SR cell M4TVOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mk\BTY5pcWKrdHnvckBw\iCqdX3hckBUWiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwNUe5OFYh|ryP M{fjXnNCVkeHUh?=
human LB996-RCC cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUPJcohq[mm2aX;uJI9nKGi3bXHuJGxDQTl4LWLDR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPjh5NzFOwG0> M{jOS3NCVkeHUh?=
human LOUCY cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2\WR2lvcGmkaYTpc44hd2ZiaIXtZY4hVE:XQ2mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE4{PDl|IN88US=> NGXYV4RUSU6JRWK=
human KS-1 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVjuNVNqUW6qaXLpeIlwdiCxZjDoeY1idiCNUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOjV3NzFOwG0> MXLTRW5ITVJ?
human U-698-M cell NIXSPWxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2PxUGlvcGmkaYTpc44hd2ZiaIXtZY4hXS14OUitUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjN|ME[g{txO NF30dWRUSU6JRWK=
human A3-KAW cell NUnsbWM1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWrJcohq[mm2aX;uJI9nKGi3bXHuJGE{NUuDVzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlgyPzRizszN NIDzXpdUSU6JRWK=
human BL-70 cell NGXJb4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFPQU5RKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUewJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVUvQTR{MzFOwG0> NVG1UJZZW0GQR1XS
human DMS-273 cell NFTSNJdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX;PO3hoUW6qaXLpeIlwdiCxZjDoeY1idiCGTWOtNlc{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTVwOU[1JO69VQ>? NXTFeJpnW0GQR1XS
human CAL-39 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3SydmlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUO5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVkvOzJ5NzFOwG0> M{jkWXNCVkeHUh?=
human KYSE-410 cell Mom0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUTFO4dUUW6qaXLpeIlwdiCxZjDoeY1idiCNWWPFMVQyOCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJyLkixPVch|ryP MXHTRW5ITVJ?
human YT cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjCTY5pcWKrdHnvckBw\iCqdX3hckB[XCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ|LkO5PFQh|ryP MYrTRW5ITVJ?
human LC-2-ad cell M{TKZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWnJcohq[mm2aX;uJI9nKGi3bXHuJGxENTJvYXSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yOE42PTd|IN88US=> MX3TRW5ITVJ?
human COR-L105 cell NEi2WIxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlXPTY5pcWKrdHnvckBw\iCqdX3hckBEV1JvTEGwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI3NjR2M{[g{txO Mk\GV2FPT0WU
human CAL-12T cell M1nvSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnLCTY5pcWKrdHnvckBw\iCqdX3hckBESUxvMULUJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlYvPTVyMjFOwG0> NYexdGZYW0GQR1XS
human KU812 cell M{O2dWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGXTb5ZKdmirYnn0bY9vKG:oIHj1cYFvKEuXOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlgvPDV5OTFOwG0> NWnEb3JvW0GQR1XS
human OPM-2 cell MnLqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJG9RVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuPFIzPyEQvF2= MlrSV2FPT0WU
human SW982 cell NY\sW3Y6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX\DeolSUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM{NjdyMEeg{txO NEnGT4xUSU6JRWK=
human HH cell NXrDeW5pT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGjUV2tKdmirYnn0bY9vKG:oIHj1cYFvKEiKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{SuNFI{PSEQvF2= M4n6THNCVkeHUh?=
human RS4-11 cell MoeyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHnHWnJKdmirYnn0bY9vKG:oIHj1cYFvKFKVND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM1NjF6ME[g{txO NUHaT3dZW0GQR1XS
human BEN cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXLM[IRXUW6qaXLpeIlwdiCxZjDoeY1idiCERV6gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk45OTh5IN88US=> NXvQdFl{W0GQR1XS
human CCRF-CEM cell MmjJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{Hwc2lvcGmkaYTpc44hd2ZiaIXtZY4hS0OURj3DSW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Py55N{K5JO69VQ>? MYjTRW5ITVJ?
human EW-13 cell NFi0d2FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NESxbHhKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|kvODR6MTFOwG0> NF:zZ3NUSU6JRWK=
human NCI-H2228 cell MnHtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHvZW4FKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlIzQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTR{LkixPEDPxE1? MlHqV2FPT0WU
human KE-37 cell M37ERmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWTGcG1KUW6qaXLpeIlwdiCxZjDoeY1idiCNRT2zO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ{NjJ7MUWg{txO M17kWnNCVkeHUh?=
human A4-Fuk cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVr5U45DUW6qaXLpeIlwdiCxZjDoeY1idiCDND3GeYsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01PS5yM{[0JO69VQ>? M1jGZ3NCVkeHUh?=
human MZ1-PC cell NY\ydHd1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3yycWlvcGmkaYTpc44hd2ZiaIXtZY4hVVpzLWDDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFUvQTh6ODFOwG0> NX7pXHZKW0GQR1XS
human MLMA cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3PaWGlvcGmkaYTpc44hd2ZiaIXtZY4hVUyPQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS2MlMzQTJizszN NWmzb4dDW0GQR1XS
human EB-3 cell M4ntN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXTCO2xIUW6qaXLpeIlwdiCxZjDoeY1idiCHQj2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFkvPTd7MjFOwG0> MoPtV2FPT0WU
human 293T cells  MlnOSpVv[3Srb36gZZN{[Xl? MlnnNk42KG2P NXvKNmdCUW6qaXLpeIlwdiCxZjDKUWpFOi2vZXTpZZRm\CCKM1uzOkBl\W2ndHj5cIF1cW:wIHnuJIh2dWGwIEK5N3Qh[2WubIOgZZQhOi53IH3N NX[yUJlMOTl|NUmxOlc>

... Click to View More Cell Line Experimental Data

In vivo DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. [2] Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. [4]

Protocol

Cell Research:

[3]

+ Expand
  • Cell lines: VSMC cells
  • Concentrations: ~100 μM
  • Incubation Time: 72-96 hours
  • Method:

    To analyze DNA synthesis as an index of cellular proliferation, VSMC are plated in 48-well plates (5,000 per square centimeter) in growth medium, incubated overnight, and serum-deprived (1% FCS) for 24 h. Replicate wells are then stored at −70°C for baseline (day 0) cell counts, and fresh medium with or without growth factors is added to the remaining wells, which are incubated 72-96 h in 20 or 5% O2. Days 0 and 3 or 4 cell counts are determined by lysing cells in a buffer containing a fluorescent dye, which has minimal fluorescence by itself but fluoresces when bound to DNA or RNA. Absolute cell numbers are calculated by comparing the fluorescence of specimens with that of a standard curve similarly prepared using a known number of cells.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Mice (C57Bl6)
  • Formulation: 8 mg/mouse
  • Dosages: 8 mg in 0.5 ml saline
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 35 mg/mL (199.84 mM)
Water 35 mg/mL (199.84 mM)
Ethanol 35 mg/mL (199.84 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 175.14
Formula

C6H9NO5

CAS No. 89464-63-1
Storage powder
in solvent
Synonyms Dimethyloxalylglycine

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID