Hydroxylase

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Hydroxylase Inhibitors | Activators (7)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2695 Nepicastat (SYN-117) HCl Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.
S1379 Isotretinoin It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
S4130 Mildronate Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
S2367 Tetrahydropapaverine HCl Tetrahydropapaverine, one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons.
S7483 DMOG DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.
S4926 (R)-Nepicastat HCl (R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
S2173 Telotristat Etiprate (LX 1606 Hippurate) Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S2695 Nepicastat (SYN-117) HCl <1 mg/mL 66 mg/mL <1 mg/mL
S1379 Isotretinoin <1 mg/mL 60 mg/mL 1 mg/mL
S4130 Mildronate 29 mg/mL <1 mg/mL 29 mg/mL
S2367 Tetrahydropapaverine HCl 76 mg/mL 7 mg/mL <1 mg/mL
S7483 DMOG 35 mg/mL 35 mg/mL 35 mg/mL
S4926 (R)-Nepicastat HCl <1 mg/mL 66 mg/mL <1 mg/mL
S2173 Telotristat Etiprate (LX 1606 Hippurate) <1 mg/mL 100 mg/mL <1 mg/mL
Tags: Hydroxylase activity | Dopamine-β-Hydroxylase activity | Hydroxylase inhibitor review
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