Home Metabolism PKM activator DL-Serine For research use only.

DL-Serine

Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.

DL-Serine Chemical Structure

DL-Serine Chemical Structure

CAS: 302-84-1

Purity & Quality Control

Batch: S554501 Water] 8 mg/mL] false] DMSO] Insoluble] false] ] ] false Purity: 98%
98

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Biological Activity

Description Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
In vitro
In vitro The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for antioxidant defence[2]. Serine activates recombinant PKM2 with a half maximal activation concentration (AC50) of 1.3 mM. Isothermal titration calorimetry was used to determine the dissociation constant (Kd) of the PKM2-serine interaction as 0.20 mM. Serine can bind to and activate human PKM2 and that following serine deprivation, PKM2 activity in cells is reduced. This reduction in PKM2 activity shifts cells to a fuel-efficient mode where more pyruvate is diverted to the mitochondria and more glucose derived carbon is channelled into serine biosynthesis to support cell proliferation[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05485155 Recruiting
Eosinophilic Esophagitis
Children''s Hospital Medical Center Cincinnati|CSL Behring|National Institutes of Health (NIH)
 March 1 2024 Phase 2
NCT05157217 Recruiting
COVID-19
Cairo University|Misr International University
 December 15 2021 --
NCT05186285 Unknown status
Healthy
Keymed Biosciences Co.Ltd
 December 11 2021 Phase 1
NCT05098327 Withdrawn
Prostate Cancer|Insulin Resistance|Diabetes Mellitus Type 2|Androgen Deficiency
State University of New York at Buffalo|National Center for Advancing Translational Sciences (NCATS)
 August 1 2021 Phase 3

Chemical Information & Solubility

Molecular Weight 105.09 Formula

C3H7NO3
CAS No. 302-84-1 SDF --
Smiles C(C(C(=O)O)N)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 8 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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