Digoxin

Catalog No.S4290

Digoxin   Chemical Structure

Molecular Weight(MW): 780.94

Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.

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Biological Activity

Description Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.
Targets
α2β3 [1] α2β1 [1] α1β1 [1]
42.8 nM(Ki) 58.7 nM(Ki) 268 nM(Ki)
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
TK10 cells MXHDfZRwfG:6aXPpeJkh[XO|YYm= NW\nfW1KPDhiaB?= MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUT|ExKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MD6wNVQ3KM7:TR?= NUjKTmNCOTZ|MEmzNVU>
MCF7 cells NUflPFM4S3m2b4TvfIlkcXS7IHHzd4F6 MV20PEBp NFH4TotEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xOjRzIN88US=> MorrNVY{ODl|MUW=
UACC62 cells NGHOb2JEgXSxdH;4bYNqfHliYYPzZZk> M3nEWlQ5KGh? NXjZOXJRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXUGFQ{[yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OC5yMkm1JO69VQ>? MXKxOlMxQTNzNR?=
K562 cells NIC0coFEgXSxdH;4bYNqfHliYYPzZZk> MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIJ6KFiWVDDhd5NigSxiSVO1NF0xNjJ6MjFOwG0> MmDyNVY{ODl|MUW=
CC20 cells MXHDfZRwfG:6aXPpeJkh[XO|YYm= M2ftSlczKGh? NX3rRmFQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0N{MDDj[YxteyCjZoTldkA4OiCqcoOgZpkhTk2FQTDt[ZRpd2RuIFnDOVA:OC5{NDFOwG0> MknpNVk5QTR5M{O=
HCT116 cells NWXSbnVVS3m2b4TvfIlkcXS7IHHzd4F6 NEjpPYc4OiCq M2nYPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhTk2FQTDt[ZRpd2RuIFnDOVA:OC5{NzFOwG0> NFLsTYMyQTh7NEezNy=>
HT-29 cells NX3OdYRkS3m2b4TvfIlkcXS7IHHzd4F6 Mly2O|IhcA>? MnnSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGZOS0FibXX0bI9lNCCLQ{WwQVEvPCEQvF2= MWWxPVg6PDd|Mx?=
human colon cancer cells M2HhemN6fG:2b4jpZ4l1gSCjc4PhfS=> MUS3NkBp NUi0[FFPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h[2:ub36gZ4Fv[2W{IHPlcIx{KGGodHXyJFczKGi{czDifUBHVUODIH3leIhw\CxiSVO1NF0xNjFizszN NVnifXJ1OTl6OUS3N|M>
MCF7 cells MWHDfZRwfG:6aXPpeJkh[XO|YYm= M33Q[VczKGh? M3LTZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9iYYPzZZktKEmFNUC9OE44KM7:TR?= MljuNlI{OTZzNki=
human T47D cells M1jkemN6fG:2b4jpZ4l1gSCjc4PhfS=> NFjZZ5U4OiCq NWPPb4dqS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXDR5RDDj[YxteyCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDhd5NigSxiSVO1NF0xNjZ4IN88US=> NW\SV49uOjJ|MU[xOlg>
SK-BR-3 cells MoP3R5l1d3SxeHnjbZR6KGG|c3H5 NULRW4h6PzJiaB?= MkTyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2suSlJvMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDhd5NigSxiSVO1NF0yNjB6IN88US=> MViyNlMyPjF4OB?=
Hs578Bst cells MoHER5l1d3SxeHnjbZR6KGG|c3H5 MWC3NkBp NUHZVnZ1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHN3N{jCd5Qh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8h[XO|YYmsJGlEPTB;MD6wOEDPxE1? Mn:xNlI{OTZzNki=
human Hs578Bst cells NGPX[nFEgXSxdH;4bYNqfHliYYPzZZk> M1m3SFQxKHWP MXe3NkBp MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDId|U4QEK|dDDj[YxteyCjdDC0NEB2VSCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDhd5NigSC{ZXzheIl3\SC2bzD1cpRz\WG2ZXSgZ49vfHKxbDygTWM2OD12Nz63JO69VQ>? M2DrNlIzOzF4MU[4
SK-MEL-28 cells M{[0emN6fG:2b4jpZ4l1gSCjc4PhfS=> M3[wNVMh\GG7cx?= MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT{1OTUxvMkigZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjJ4NjFOwG0> NIHx[5QzOzdyNkCwOS=>
human U373 cells M1[4XGN6fG:2b4jpZ4l1gSCjc4PhfS=> MkPUN{Bl[Xm| NWDDUXg3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTN5MzDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvOTR4IN8ccS=> NWPxVo1TOjN5ME[wNFU>
human A549 cells NXTJcmpCS3m2b4TvfIlkcXS7IHHzd4F6 M1rFSVMh\GG7cx?= NUW1RoFrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODVizszN NX3TNHZCOjN5ME[wNFU>
human PC3 cells Mn62R5l1d3SxeHnjbZR6KGG|c3H5 NUDrNVNvOyCmYYnz NIXmcFREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlA4PSEQvF2= MnPyNlM4ODZyMEW=
MCF7 cells MorrR5l1d3SxeHnjbZR6KGG|c3H5 NF\6cWY{KGSjeYO= M1jkSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlQzPiEQvF2= NYjuSmFYOjN5ME[wNFU>
Hs683 cells MYjDfZRwfG:6aXPpeJkh[XO|YYm= M{XrblMh\GG7cx?= MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDId|Y5OyClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNFQh|ryP M1nr[lI{PzB4MEC1
CHO cells MWHGeY5kfGmxbjDhd5NigQ>? M1TIeJBKSzVyII\hcJVmeyCob4Kgd49lcXWvIH\seY9z\XOlZXnuJEgyOCC3TTmgeZB1[WunIHnuJG9CXFBzQkGteJJidnOoZXP0[YQhS0iRIHPlcIx{NCCLQ{WwQVMvOjN3OUSg{txO MXOyN|U4OTRzNR?=
rat hepatocytes NYLBN45lTnWwY4Tpc44h[XO|YYm= MUPEdpVoKHWydHHr[UBqdiC{YYSgbIVx[XSxY4n0[ZMtKEuvPUCuNVgh|ryP NIHGU|EzODl{Nk[xPS=>
human hepatocytes NWHZPXFkTnWwY4Tpc44h[XO|YYm= MXKwMlA2KHSxIEGwJJVO M1LtXGRzfWdidYD0ZYtmKGmwIIPhcoR4cWOqLXP1cJR2emWmIHj1cYFvKGincHH0c4N6fGW|IHH0JFAvODVidH:gNVAhfU1iYYSgN|ch\GWpQzDifUBOcWOqYXXsbZMuVWWwdHXuJItqdmW2aXPzM5NkcW62aXzsZZRqd25ic4DlZ5Rzd3Olb4D5MEBMdT1{LkO5JO69VQ>? MYOyNFkzPjZzOR?=
CHO cells M3TwRmZ2dmO2aX;uJIF{e2G7 MnLFdGlEPTBidnHseYV{KG[xcjDzc4RqfW1iZnz1c5Jme2OnaX6gLFExKHWPKTD1dJRic2ViaX6gU2FVWDGEMz30doFve2[nY4Tl[EBEUE9iY3XscJMtKEmFNUC9NVMvOTh{NjFOwG0> MnXmNlM2PzF2MUW=
human HeLa cells Mn\ER5l1d3SxeHnjbZR6KGG|c3H5 NEj3d|A1QCCq NGGxcXBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9Nk4zKM7:TR?= MmHENlYyOjJ5N{K=
RKO-AS45-1 cells MmLUR5l1d3SxeHnjbZR6KGG|c3H5 MnvDOFghcA>? MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDST28uSVN2NT2xJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC52MjFOwG0> MVqyOlEzOjd5Mh?=
Hs578T cells MnfXR5l1d3SxeHnjbZR6KGG|c3H5 NInKV4o4OiCq NEnGVZpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJezV5OGSgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gZZN{[XluIFnDOVA:OC5{NUGg{txO NVqwWXlVOjJ|MU[xOlg>
Drosophila Schneider cells MknCSpVv[3Srb36gZZN{[Xl? M1jp[GFvfGGpb37pd5Qh[WO2aY\peJkh[XRidILhcpNi[3SrdnH0bY9vKGSxbXHpckBw\iCUT2LnZY1u[XRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gSJJwe2:yaHnsZUBU[2iwZXnk[ZIh[2WubIOgZ48u\XiycnXzd4lv\yCJYXy0MWRPSSCkaX7kbY5oKGSxbXHpckwhUUN3ME2yJO69VQ>? M4nr[|I1ODRyNEi2

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (128.05 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
2% DMSO+corn oil
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 780.94
Formula

C41H64O14

CAS No. 20830-75-5
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02472236 Completed Healthy Jiangsu Hansoh Pharmaceutical Co., Ltd. June 8, 2015 Phase 1
NCT03008616 Not yet recruiting Severe Preeclampsia Velo Bio, LLC February 2017 Phase 2
NCT03043248 Recruiting Healthy Toray Industries, Inc February 2017 Phase 1
NCT02906800 Recruiting Head and Neck Cancer Assistance Publique - Hôpitaux de Paris|Cancer Research and Personalized Medicine (Carpem)|Laboratoire d’excellence en immuno-oncologie (Labex) January 2017 Phase 1|Phase 2
NCT02915666 Recruiting Melanoma University of Texas Southwestern Medical Center October 2016 Phase 1
NCT02775240 Completed Cytomegalovirus (CMV) Shire August 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID