Digoxin

Catalog No.S4290

Digoxin   Chemical Structure

Molecular Weight(MW): 780.94

Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.

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Biological Activity

Description Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.
Targets
α2β3 [1] α2β1 [1] α1β1 [1]
42.8 nM(Ki) 58.7 nM(Ki) 268 nM(Ki)
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
TK10 cells MoHXR5l1d3SxeHnjbZR6KGG|c3H5 MmHVOFghcA>? MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUT|ExKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MD6wNVQ3KM7:TR?= Mn\aNVY{ODl|MUW=
MCF7 cells MUXDfZRwfG:6aXPpeJkh[XO|YYm= NFnhXIE1QCCq NHfjOVlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xOjRzIN88US=> NEjiXZEyPjNyOUOxOS=>
UACC62 cells NYK1TVRCS3m2b4TvfIlkcXS7IHHzd4F6 NVnLcVN4PDhiaB?= NFTkblREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWSUOFNkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0xNjB{OUWg{txO M1;GUlE3OzB7M{G1
K562 cells MlXaR5l1d3SxeHnjbZR6KGG|c3H5 NVWwdHVLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCkeTDYWHQh[XO|YYmsJGlEPTB;MD6yPFIh|ryP MYCxOlMxQTNzNR?=
CC20 cells MkXNR5l1d3SxeHnjbZR6KGG|c3H5 NVrMPVBuPzJiaB?= NIDoV3VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESzJyIHPlcIx{KGGodHXyJFczKGi{czDifUBHVUODIH3leIhw\CxiSVO1NF0xNjJ2IN88US=> NHvxO4gyQTh7NEezNy=>
HCT116 cells MkDoR5l1d3SxeHnjbZR6KGG|c3H5 MmTQO|IhcA>? NVnPfmJYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCITVPBJI1mfGixZDygTWM2OD1yLkK3JO69VQ>? NUj0eWhpOTl6OUS3N|M>
HT-29 cells MXjDfZRwfG:6aXPpeJkh[XO|YYm= NHTY[484OiCq NFLpfXFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhTk2FQTDt[ZRpd2RuIFnDOVA:OS52IN88US=> MUexPVg6PDd|Mx?=
human colon cancer cells NIfZUWREgXSxdH;4bYNqfHliYYPzZZk> NG[4WGE4OiCq M3nN[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJINwdG:wIHPhcoNmeiClZXzsd{Bi\nSncjC3NkBpenNiYomgSm1ESSCvZYToc4QtKEmFNUC9NE4yKM7:TR?= MWSxPVg6PDd|Mx?=
MCF7 cells M{\MUmN6fG:2b4jpZ4l1gSCjc4PhfS=> NWSzcWd4PzJiaB?= NF3Keo5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHHzd4F6NCCLQ{WwQVQvPyEQvF2= M4nCO|IzOzF4MU[4
human T47D cells NV3UWVh{S3m2b4TvfIlkcXS7IHHzd4F6 NVTXdY1OPzJiaB?= NIK4Xm5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVPDeGIHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHHzd4F6NCCLQ{WwQVAvPjZizszN MlfJNlI{OTZzNki=
SK-BR-3 cells MnXCR5l1d3SxeHnjbZR6KGG|c3H5 NILUdlc4OiCq M4S5bWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMNUKULUOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gZZN{[XluIFnDOVA:OS5yODFOwG0> NUDoeHJFOjJ|MU[xOlg>
Hs578Bst cells NEfjO4JEgXSxdH;4bYNqfHliYYPzZZk> NWnNcXljPzJiaB?= NVnjWGxOS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHN3N{jCd5Qh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8h[XO|YYmsJGlEPTB;MD6wOEDPxE1? M1fIblIzOzF4MU[4
human Hs578Bst cells NFqyd2VEgXSxdH;4bYNqfHliYYPzZZk> Mm\mOFAhfU1? M2Hz[|czKGh? NY\YWVExS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHN3N{jCd5Qh[2WubIOgZZQhPDBidV2gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8h[XO|YYmgdoVt[XSrdnWgeI8hfW62cnXheIVlKGOxboTyc4wtKEmFNUC9OFcvPyEQvF2= NVjLdnBwOjJ|MU[xOlg>
SK-MEL-28 cells NXXNSJRtS3m2b4TvfIlkcXS7IHHzd4F6 MWizJIRigXN? M1[4SmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMNU2HTD2yPEBk\WyuczDh[pRmeiB|IHThfZMh[nliTWTUJIF{e2G7LDDJR|UxRTBwMk[2JO69VQ>? NHfMZlUzOzdyNkCwOS=>
human U373 cells M3:2XmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVzrdXNMOyCmYYnz MoH6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVM4OyClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNVQ3KM7ebR?= MkKwNlM4ODZyMEW=
human A549 cells MkPhR5l1d3SxeHnjbZR6KGG|c3H5 M{PORVMh\GG7cx?= MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6wOUDPxE1? NV;ucZVVOjN5ME[wNFU>
human PC3 cells MnnoR5l1d3SxeHnjbZR6KGG|c3H5 NUnGfnhkOyCmYYnz M3HOR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNFc2KM7:TR?= MW[yN|cxPjByNR?=
MCF7 cells Ml;kR5l1d3SxeHnjbZR6KGG|c3H5 MnWyN{Bl[Xm| M{fub2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlQzPiEQvF2= NYnrO5YyOjN5ME[wNFU>
Hs683 cells MY\DfZRwfG:6aXPpeJkh[XO|YYm= M3u5WVMh\GG7cx?= NVHYUVgxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHN4OEOgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjB2IN88US=> NIPFd4EzOzdyNkCwOS=>
CHO cells M33R[mZ2dmO2aX;uJIF{e2G7 NX[1OI9peEmFNUCgeoFtfWW|IH\vdkB{d2SrdX2g[ox2d3Knc3PlbY4hMDFyIIXNLUB2eHSja3WgbY4hV0GWUEHCNU11emGwc3\lZ5Rm\CCFSF:gZ4VtdHNuIFnDOVA:Oy5{M{W5OEDPxE1? MkXwNlM2PzF2MUW=
rat hepatocytes MkDBSpVv[3Srb36gZZN{[Xl? MmXCSJJ2\yC3cIThb4UhcW5icnH0JIhmeGG2b3P5eIV{NCCNbU2wMlE5KM7:TR?= MVOyNFkzPjZzOR?=
human hepatocytes NXm2SGFpTnWwY4Tpc44h[XO|YYm= NXLWOW15OC5yNTD0c{AyOCC3TR?= NVnuV49yTHK3ZzD1dJRic2ViaX6gd4Fv\HerY3itZ5VtfHW{ZXSgbJVu[W5iaHXwZZRw[3m2ZYOgZZQhOC5yNTD0c{AyOCC3TTDheEA{PyCmZXfDJIJ6KE2rY3jh[Yxqey2PZX70[Y4hc2mwZYTpZ5Mwe2OrboTpcIxifGmxbjDzdIVkfHKxc3PvdJktKEuvPUKuN|kh|ryP NH\nbXMzODl{Nk[xPS=>
CHO cells NGfad|FHfW6ldHnvckBie3OjeR?= NGPicm5xUUN3MDD2ZYx2\XNiZn;yJJNw\Gm3bTDmcJVwemW|Y3XpckApOTBidV2pJJVxfGGtZTDpckBQSVSSMVKzMZRz[W6|ZnXjeIVlKEOKTzDj[YxteyxiSVO1NF0yOy5zOEK2JO69VQ>? MVqyN|U4OTRzNR?=
human HeLa cells MYnDfZRwfG:6aXPpeJkh[XO|YYm= MmnJOFghcA>? Mn7JR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKuNkDPxE1? MWSyOlEzOjd5Mh?=
RKO-AS45-1 cells MVTDfZRwfG:6aXPpeJkh[XO|YYm= MUW0PEBp NVrGNow6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWkuRLVHTOFUuOSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuOFIh|ryP NIKwe3czPjF{Mke3Ni=>
Hs578T cells MoH5R5l1d3SxeHnjbZR6KGG|c3H5 NX[1N4FjPzJiaB?= NXn5W4pKS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHN3N{jUJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIF{e2G7LDDJR|UxRTBwMkWxJO69VQ>? MWmyNlMyPjF4OB?=
Drosophila Schneider cells M1;nVWZ2dmO2aX;uJIF{e2G7 NEG4V|FCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IITyZY5{[WO2aY\heIlwdiCmb33hbY4hd2ZiUl;S[4FudWG2IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGRzd3OxcHjpcIEhW2OqbnXp[IVzKGOnbHzzJINwNWW6cILld5NqdmdiR3HsOE1FVkFiYnnu[Ilv\yCmb33hbY4tKEmFNUC9NkDPxE1? MmjBNlQxPDB2OE[=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (128.05 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+corn oil
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 780.94
Formula

C41H64O14

CAS No. 20830-75-5
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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    C2=C1/X C2: LOG(C2):
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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02472236 Completed Healthy Jiangsu Hansoh Pharmaceutical Co., Ltd. June 8, 2015 Phase 1
NCT03008616 Not yet recruiting Severe Preeclampsia Velo Bio, LLC February 2017 Phase 2
NCT03043248 Recruiting Healthy Toray Industries, Inc February 2017 Phase 1
NCT02906800 Recruiting Head and Neck Cancer Assistance Publique - Hôpitaux de Paris|Cancer Research and Personalized Medicine (Carpem)|Laboratoire d’excellence en immuno-oncologie (Labex) January 2017 Phase 1|Phase 2
NCT02915666 Recruiting Melanoma University of Texas Southwestern Medical Center October 2016 Phase 1
NCT02775240 Completed Cytomegalovirus (CMV) Shire August 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Sodium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID