Digoxin

Catalog No.S4290

Digoxin   Chemical Structure

Molecular Weight(MW): 780.94

Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.

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Biological Activity

Description Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.
Targets
α2β3 [1] α2β1 [1] α1β1 [1]
42.8 nM(Ki) 58.7 nM(Ki) 268 nM(Ki)
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
TK10 cells M2XoV2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnjMOFghcA>? MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUT|ExKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MD6wNVQ3KM7:TR?= NX7ScYVLOTZ|MEmzNVU>
MCF7 cells MnixR5l1d3SxeHnjbZR6KGG|c3H5 MlrUOFghcA>? NIHZeYtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xOjRzIN88US=> MoHFNVY{ODl|MUW=
UACC62 cells M4TMeWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnjaOFghcA>? MnXQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWWFESzZ{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xOjl3IN88US=> NEH3NmwyPjNyOUOxOS=>
K562 cells NUXyb4c2S3m2b4TvfIlkcXS7IHHzd4F6 M4jEe2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[nliWGTUJIF{e2G7LDDJR|UxRTBwMkiyJO69VQ>? MmDxNVY{ODl|MUW=
CC20 cells NGS0e45EgXSxdH;4bYNqfHliYYPzZZk> NILLWGU4OiCq M3fhTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNEOjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGZOS0FibXX0bI9lNCCLQ{WwQVAvOjRizszN NF\uU|UyQTh7NEezNy=>
HCT116 cells M160b2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4XuRlczKGh? M4TOO2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkhTk2FQTDt[ZRpd2RuIFnDOVA:OC5{NzFOwG0> NHWxNYsyQTh7NEezNy=>
HT-29 cells NGXCPIlEgXSxdH;4bYNqfHliYYPzZZk> NWTDSGp4PzJiaB?= M1LETWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFczKGi{czDifUBHVUODIH3leIhw\CxiSVO1NF0yNjRizszN M1fDeFE6QDl2N{Oz
human colon cancer cells NHfvWZZEgXSxdH;4bYNqfHliYYPzZZk> M1;oc|czKGh? MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDjc4xwdiClYX7j[ZIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF\NR2EhdWW2aH;kMEBKSzVyPUCuNUDPxE1? MXqxPVg6PDd|Mx?=
MCF7 cells NGD0OJlEgXSxdH;4bYNqfHliYYPzZZk> MWW3NkBp NIH6SFFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHHzd4F6NCCLQ{WwQVQvPyEQvF2= M2XNPFIzOzF4MU[4
human T47D cells M3;hTGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVL5cmF7PzJiaB?= M3nPV2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHQ1P0RiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9iYYPzZZktKEmFNUC9NE43PiEQvF2= MkLFNlI{OTZzNki=
SK-BR-3 cells MnfGR5l1d3SxeHnjbZR6KGG|c3H5 NUnKWWZYPzJiaB?= Mne2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2suSlJvMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDhd5NigSxiSVO1NF0yNjB6IN88US=> MV:yNlMyPjF4OB?=
Hs578Bst cells NXfWbo05S3m2b4TvfIlkcXS7IHHzd4F6 MVG3NkBp NE\iRVdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJezV5OFLzeEBk\WyuczDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{Bie3OjeTygTWM2OD1yLkC0JO69VQ>? MXuyNlMyPjF4OB?=
human Hs578Bst cells NYDEWFlmS3m2b4TvfIlkcXS7IHHzd4F6 M{HTTFQxKHWP MonEO|IhcA>? NIriXo9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJezV5OFLzeEBk\WyuczDheEA1OCC3TTDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{Bie3OjeTDy[YxifGm4ZTD0c{B2dnS{ZXH0[YQh[2:wdILvcEwhUUN3ME20O{44KM7:TR?= MnezNlI{OTZzNki=
SK-MEL-28 cells MVjDfZRwfG:6aXPpeJkh[XO|YYm= NHjOSpQ{KGSjeYO= MlvSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2suVUWOLUK4JINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XluIFnDOVA:OC5{Nk[g{txO NHjQW5EzOzdyNkCwOS=>
human U373 cells MkfFR5l1d3SxeHnjbZR6KGG|c3H5 NETwdIU{KGSjeYO= M1PMWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU{PzNiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlE1PiEQnH2= NEjMTlczOzdyNkCwOS=>
human A549 cells M3z4V2N6fG:2b4jpZ4l1gSCjc4PhfS=> MkLlN{Bl[Xm| M17UUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlA2KM7:TR?= NWGzcpl5OjN5ME[wNFU>
human PC3 cells NH7FZ25EgXSxdH;4bYNqfHliYYPzZZk> MYKzJIRigXN? MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3OjeTygTWM2OD1yLkC3OUDPxE1? M4f0[|I{PzB4MEC1
MCF7 cells M3\LZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> NUC1VplFOyCmYYnz NY\UWJk{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvPDJ4IN88US=> NEjGbGYzOzdyNkCwOS=>
Hs683 cells M{DqTWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGLKc2I{KGSjeYO= MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDId|Y5OyClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNFQh|ryP MUOyN|cxPjByNR?=
CHO cells MYDGeY5kfGmxbjDhd5NigQ>? Mn3jdGlEPTBidnHseYV{KG[xcjDzc4RqfW1iZnz1c5Jme2OnaX6gLFExKHWPKTD1dJRic2ViaX6gU2FVWDGEMT30doFve2[nY4Tl[EBEUE9iY3XscJMtKEmFNUC9N{4zOzV7NDFOwG0> MU[yN|U4OTRzNR?=
rat hepatocytes NWq3fnJyTnWwY4Tpc44h[XO|YYm= MVnEdpVoKHWydHHr[UBqdiC{YYSgbIVx[XSxY4n0[ZMtKEuvPUCuNVgh|ryP MoTqNlA6OjZ4MUm=
human hepatocytes NWTmU2dlTnWwY4Tpc44h[XO|YYm= M{TMWlAvODVidH:gNVAhfU1? NHPYU5FFenWpIIXweIFs\SCrbjDzZY5lf2mlaD3jeYx1fXKnZDDoeY1idiCqZYDheI9kgXSnczDheEAxNjB3IITvJFExKHWPIHH0JFM4KGSnZ1OgZpkhVWmlaHHlcIl{NU2nboTlckBscW6ndHnjd{9{[2mwdHnscIF1cW:wIIPw[YN1em:|Y3;wfUwhU21;Mj6zPUDPxE1? NYq5VJdQOjB7Mk[2NVk>
CHO cells M1fk[GZ2dmO2aX;uJIF{e2G7 NYjtNlE{eEmFNUCgeoFtfWW|IH\vdkB{d2SrdX2g[ox2d3Knc3PlbY4hMDFyIIXNLUB2eHSja3WgbY4hV0GWUEHCN{11emGwc3\lZ5Rm\CCFSF:gZ4VtdHNuIFnDOVA:OTNwMUiyOkDPxE1? NX[2dYhpOjN3N{G0NVU>
human HeLa cells MnjtR5l1d3SxeHnjbZR6KGG|c3H5 NHv0NVc1QCCq NIXIcIxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9Nk4zKM7:TR?= NVfmd4FoOjZzMkK3O|I>
RKO-AS45-1 cells NHnPSJREgXSxdH;4bYNqfHliYYPzZZk> M4DoPFQ5KGh? M1y2fmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJMVy2DU{S1MVEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkSyJO69VQ>? MmDvNlYyOjJ5N{K=
Hs578T cells NGK4SnhEgXSxdH;4bYNqfHliYYPzZZk> MYC3NkBp M13MbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh{PTd6VDDj[YxteyCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDhd5NigSxiSVO1NF0xNjJ3MTFOwG0> M4jmclIzOzF4MU[4
Drosophila Schneider cells NHjvU5hHfW6ldHnvckBie3OjeR?= NHPMOIpCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IITyZY5{[WO2aY\heIlwdiCmb33hbY4hd2ZiUl;S[4FudWG2IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGRzd3OxcHjpcIEhW2OqbnXp[IVzKGOnbHzzJINwNWW6cILld5NqdmdiR3HsOE1FVkFiYnnu[Ilv\yCmb33hbY4tKEmFNUC9NkDPxE1? MXyyOFA1ODR6Nh?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (128.05 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
2% DMSO+corn oil
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 780.94
Formula

C41H64O14

CAS No. 20830-75-5
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02472236 Completed Healthy Jiangsu Hansoh Pharmaceutical Co., Ltd. June 8, 2015 Phase 1
NCT03008616 Not yet recruiting Severe Preeclampsia Velo Bio, LLC February 2017 Phase 2
NCT03043248 Recruiting Healthy Toray Industries, Inc February 2017 Phase 1
NCT02906800 Recruiting Head and Neck Cancer Assistance Publique - Hôpitaux de Paris|Cancer Research and Personalized Medicine (Carpem)|Laboratoire d’excellence en immuno-oncologie (Labex) January 2017 Phase 1|Phase 2
NCT02915666 Recruiting Melanoma University of Texas Southwestern Medical Center October 2016 Phase 1
NCT02775240 Completed Cytomegalovirus (CMV) Shire August 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Sodium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID