Digoxin

Catalog No.S4290

Digoxin is a sodium-potassium pump inhibitor, used in the treatment of atrial fibrillation and heart failure.

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Digoxin   Chemical Structure

Digoxin Chemical Structure
Molecular Weight: 780.94

Validation & Quality Control

Quality Control & MSDS

Product Information

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Product Description

Biological Activity

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-06-25)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02391337 Not yet recruiting Permanent Atrial Fibrillation University of Birmingham July 2016 Phase 4
NCT02775240 Not yet recruiting Cytomegalovirus (CMV) Shire July 2016 Phase 1
NCT02797145 Recruiting Heart Failure Hospital Ana Nery May 2016 Phase 2|Phase 3
NCT02762123 Recruiting Rheumatoid Arthritis Bristol-Myers Squibb May 2016 Phase 1
NCT02743260 Recruiting Healthy University of Cologne|Umm Al-Qura University|Institute fo  ...more University of Cologne|Umm Al-Qura University|Institute for Biomedical and Pharmaceutical Research (IBMP), Nürnberg-Heroldsberg, Germany April 2016 Phase 4

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Chemical Information

Download Digoxin SDF
Molecular Weight (MW) 780.94
Formula

C41H64O14

CAS No. 20830-75-5
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 100 mg/mL (128.05 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (3β,5β,12β)- 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

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