Digoxin

Catalog No.S4290

Digoxin   Chemical Structure

Molecular Weight(MW): 780.94

Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.

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Biological Activity

Description Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.
Targets
α2β3 [1] α2β1 [1] α1β1 [1]
42.8 nM(Ki) 58.7 nM(Ki) 268 nM(Ki)
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
TK10 cells NYHvb5JUS3m2b4TvfIlkcXS7IHHzd4F6 NIP3b2c1QCCq MoLMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGsyOCClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUCuNFE1PiEQvF2= MYmxOlMxQTNzNR?=
MCF7 cells NWDaWYtNS3m2b4TvfIlkcXS7IHHzd4F6 NWjB[WZ3PDhiaB?= MljER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUCuNFI1OSEQvF2= NV6zUWlsOTZ|MEmzNVU>
UACC62 cells NHzYNIhEgXSxdH;4bYNqfHliYYPzZZk> MonWOFghcA>? MoP6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWWFESzZ{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xOjl3IN88US=> M4L5[VE3OzB7M{G1
K562 cells NF7RPJZEgXSxdH;4bYNqfHliYYPzZZk> NHLnOWVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGK7IGjUWEBie3OjeTygTWM2OD1yLkK4NkDPxE1? MYexOlMxQTNzNR?=
CC20 cells M3GwWGN6fG:2b4jpZ4l1gSCjc4PhfS=> NEnWfG04OiCq NFTSTWtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESzJyIHPlcIx{KGGodHXyJFczKGi{czDifUBHVUODIH3leIhw\CxiSVO1NF0xNjJ2IN88US=> M2mwT|E6QDl2N{Oz
HCT116 cells M1XXemN6fG:2b4jpZ4l1gSCjc4PhfS=> MVe3NkBp MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGZOS0FibXX0bI9lNCCLQ{WwQVAvOjdizszN NXO3VHFNOTl6OUS3N|M>
HT-29 cells MVzDfZRwfG:6aXPpeJkh[XO|YYm= M4r2d|czKGh? NEPE[XFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhTk2FQTDt[ZRpd2RuIFnDOVA:OS52IN88US=> MUOxPVg6PDd|Mx?=
human colon cancer cells NFrad2dEgXSxdH;4bYNqfHliYYPzZZk> NGi1TJY4OiCq M3y3SmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJINwdG:wIHPhcoNmeiClZXzsd{Bi\nSncjC3NkBpenNiYomgSm1ESSCvZYToc4QtKEmFNUC9NE4yKM7:TR?= M4T4[lE6QDl2N{Oz
MCF7 cells MnrWR5l1d3SxeHnjbZR6KGG|c3H5 NIDqWlM4OiCq M4HhWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9iYYPzZZktKEmFNUC9OE44KM7:TR?= M1vlS|IzOzF4MU[4
human T47D cells M1XwUWN6fG:2b4jpZ4l1gSCjc4PhfS=> MlroO|IhcA>? MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUOFdFKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGG|c3H5MEBKSzVyPUCuOlYh|ryP Mk\xNlI{OTZzNki=
SK-BR-3 cells NUTSNldCS3m2b4TvfIlkcXS7IHHzd4F6 NHPQ[4c4OiCq NUT4XoZES3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0tvQmKtN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{Bie3OjeTygTWM2OD1zLkC4JO69VQ>? MXmyNlMyPjF4OB?=
Hs578Bst cells M2LkT2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2DmV|czKGh? MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDId|U4QEK|dDDj[YxteyCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDhd5NigSxiSVO1NF0xNjB2IN88US=> M{TFPVIzOzF4MU[4
human Hs578Bst cells NF;YNHFEgXSxdH;4bYNqfHliYYPzZZk> NIDOXZI1OCC3TR?= NIfRVZI4OiCq NIDRemVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJezV5OFLzeEBk\WyuczDheEA1OCC3TTDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{Bie3OjeTDy[YxifGm4ZTD0c{B2dnS{ZXH0[YQh[2:wdILvcEwhUUN3ME20O{44KM7:TR?= MYWyNlMyPjF4OB?=
SK-MEL-28 cells MUDDfZRwfG:6aXPpeJkh[XO|YYm= MXGzJIRigXN? NYHmTIJGS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0tvTVXMMVI5KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6yOlYh|ryP NWjCTIR6OjN5ME[wNFU>
human U373 cells MXjDfZRwfG:6aXPpeJkh[XO|YYm= NFrFeWo{KGSjeYO= NVzoSW5oS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTN5MzDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvOTR4IN8ccS=> M1rHXlI{PzB4MEC1
human A549 cells NGTnUWJEgXSxdH;4bYNqfHliYYPzZZk> M1HFUVMh\GG7cx?= M4jyWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlA2KM7:TR?= MXKyN|cxPjByNR?=
human PC3 cells NUi1PYVuS3m2b4TvfIlkcXS7IHHzd4F6 MW[zJIRigXN? Mn;uR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6wO|Uh|ryP MXGyN|cxPjByNR?=
MCF7 cells M1;RRmN6fG:2b4jpZ4l1gSCjc4PhfS=> NXGzZ4ppOyCmYYnz MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDNWHQh[XO|YYmsJGlEPTB;MD60NlYh|ryP NXTMbFFVOjN5ME[wNFU>
Hs683 cells NHrsSphEgXSxdH;4bYNqfHliYYPzZZk> NETFXIQ{KGSjeYO= NXrLZ2lrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHN4OEOgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjB2IN88US=> NYjLS5NrOjN5ME[wNFU>
CHO cells NYiy[|Y2TnWwY4Tpc44h[XO|YYm= M2nNcJBKSzVyII\hcJVmeyCob4Kgd49lcXWvIH\seY9z\XOlZXnuJEgyOCC3TTmgeZB1[WunIHnuJG9CXFBzQkGteJJidnOoZXP0[YQhS0iRIHPlcIx{NCCLQ{WwQVMvOjN3OUSg{txO NEjEclkzOzV5MUSxOS=>
rat hepatocytes M1S2N2Z2dmO2aX;uJIF{e2G7 MYfEdpVoKHWydHHr[UBqdiC{YYSgbIVx[XSxY4n0[ZMtKEuvPUCuNVgh|ryP M4LydFIxQTJ4NkG5
human hepatocytes NH62bnFHfW6ldHnvckBie3OjeR?= M2j6eFAvODVidH:gNVAhfU1? NVW4dFRvTHK3ZzD1dJRic2ViaX6gd4Fv\HerY3itZ5VtfHW{ZXSgbJVu[W5iaHXwZZRw[3m2ZYOgZZQhOC5yNTD0c{AyOCC3TTDheEA{PyCmZXfDJIJ6KE2rY3jh[Yxqey2PZX70[Y4hc2mwZYTpZ5Mwe2OrboTpcIxifGmxbjDzdIVkfHKxc3PvdJktKEuvPUKuN|kh|ryP NWrvdItnOjB7Mk[2NVk>
CHO cells MYfGeY5kfGmxbjDhd5NigQ>? M1y2ZpBKSzVyII\hcJVmeyCob4Kgd49lcXWvIH\seY9z\XOlZXnuJEgyOCC3TTmgeZB1[WunIHnuJG9CXFBzQkOteJJidnOoZXP0[YQhS0iRIHPlcIx{NCCLQ{WwQVE{NjF6Mk[g{txO NVfsOoQ5OjN3N{G0NVU>
human HeLa cells MX;DfZRwfG:6aXPpeJkh[XO|YYm= NIPOfJg1QCCq MkTVR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKuNkDPxE1? MVyyOlEzOjd5Mh?=
RKO-AS45-1 cells M3KzT2N6fG:2b4jpZ4l1gSCjc4PhfS=> MWC0PEBp NXvGTVhvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWkuRLVHTOFUuOSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuOFIh|ryP M{P6N|I3OTJ{N{ey
Hs578T cells MVfDfZRwfG:6aXPpeJkh[XO|YYm= NX[wV4tnPzJiaB?= NXPaTWFCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHN3N{jUJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIF{e2G7LDDJR|UxRTBwMkWxJO69VQ>? MkXDNlI{OTZzNki=
Drosophila Schneider cells NHTIdZFHfW6ldHnvckBie3OjeR?= NYi3SJQ{SW62YXfvcol{fCCjY4Tpeol1gSCjdDD0doFve2GldHn2ZZRqd25iZH;tZYlvKG:oIGLPVodidW2jdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBFem:|b4DobYxiKFOlaH7lbYRmeiClZXzsd{Bkdy2neIDy[ZN{cW6pIFfhcFQuTE6DIHLpcoRqdmdiZH;tZYlvNCCLQ{WwQVIh|ryP MVSyOFA1ODR6Nh?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (128.05 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
2% DMSO+corn oil
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 780.94
Formula

C41H64O14

CAS No. 20830-75-5
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02472236 Completed Healthy Jiangsu Hansoh Pharmaceutical Co., Ltd. June 8, 2015 Phase 1
NCT03008616 Not yet recruiting Severe Preeclampsia Velo Bio, LLC February 2017 Phase 2
NCT03043248 Recruiting Healthy Toray Industries, Inc February 2017 Phase 1
NCT02906800 Recruiting Head and Neck Cancer Assistance Publique - Hôpitaux de Paris|Cancer Research and Personalized Medicine (Carpem)|Laboratoire d’excellence en immuno-oncologie (Labex) January 2017 Phase 1|Phase 2
NCT02915666 Recruiting Melanoma University of Texas Southwestern Medical Center October 2016 Phase 1
NCT02775240 Completed Cytomegalovirus (CMV) Shire August 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID