Omecamtiv mecarbil (CK-1827452)
Molecular Weight(MW): 401.43
Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.
Cited by 6 Publications
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Normal and Mutation human iPSC-CMs Structure when Treated with Omecamtiv Mecarbil. Human iPSC-CMs were plated on 100 kPa flat PDMS and grown for five days and left untreated, treated acutely on day 5, or treated continuously from the time of plating with the myosin activator Omecamtiv Mecarbil. iPSC-CMs were then fixed and stained for actin filaments (phalloidin, red) and nucleus (DAPI, blue). (a, c, e) Normal and (b, d, f) Mutation untreated, acutely treated, and continuously treated iPSC-CMs.
University of Illinois at Chicago 2014 Omecamtiv mecarbil (CK-1827452) purchased from Selleck.
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|Description||Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.|
In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate.  In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway. 
|In vivo||Omecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure.  In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters. |
|In vitro||DMSO||80 mg/mL (199.28 mM)|
|Ethanol||6 mg/mL (14.94 mM)|
|In vivo||1% DMSO+30% polyethylene glycol+1% Tween 80||30 mg/mL|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02929329||Recruiting||Heart Failure||Amgen|Cytokinetics|Servier||January 2017||Phase 3|
|NCT02695420||Active, not recruiting||Heart Failure With Reduced Ejection Fraction||Amgen||April 2016||Phase 2|
|NCT01786512||Completed||Modified Release Oral Formulation|Left Ventricular Systolic Dysfunction|Chronic Heart Failure|History of Chronic Heart Failure|Left Ventricular Ejection Fraction|Pharmacokinetics|Echocardiogram||Amgen|Cytokinetics||February 2013||Phase 2|
|NCT01300013||Completed||Heart Failure||Amgen|Cytokinetics||April 2011||Phase 2|
|NCT01077167||Withdrawn||Heart Failure||Amgen||July 2010||Phase 2|
|NCT00941681||Completed||Heart Failure||Cytokinetics||April 2009||Phase 2|
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