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United States ( Change Country )
Omecamtiv mecarbil (CK-1827452) Chemical Structure
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Biological Activity
Omecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an E50 of 0.6 μM. Omecamtiv mecarbil (CK-1827452) represents a novel myosin activator that acts independently of Ca2+, with an advantage compared with inotropic agents that elevate cAMP, enhance Ca2+ fluxes and have the potential to induce arrhythmias. Omecamtiv mecarbil (CK-1827452) accelerates productive phosphate release. Omecamtiv mecarbil (CK-1827452) improves systolic function by increasing the systolic ejection duration/stroke volume, without consuming more ATP energy, oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency. [1][2]
References on Omecamtiv mecarbil (CK-1827452)
- [1] IDrugs. 2009 Apr;12(4):243-51.
- [2] http://en.wikipedia.org/wiki/Omecamtiv_Mecarbil_(CK-1827452) ;
Chemical Information
| Molecular Weight (WM): | 401.43 |
|---|---|
| Formula: | C20H24FN5O3 |
| CAS No.: | 873697-71-3 |
| Synonyms: |
CK-1827452, CK1827452
|
| Dissolve in (25°C): | DMSO ≥80mg/mL |
| Water <1mg/mL | |
| Ethanol ≥14mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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