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Sodium orthovanadate Chemical Structure
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Biological Activity
Sodium orthovanadate is the chemical compound Na3VO4 and contains the tetrahedral VO43-. It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. The VO43- ion binds reversibly to the active sites of most protein tyrosine phosphatases. It is often added to buffer solutions that are used in protein analysis in molecular biology. The aim is to preserve the phosphorylation of proteins of interest by inhibiting endogenous phosphatases present in cell lysate mixture. It is commonly used at a final concentration of 100 - 1000 μM. It is toxic when inhaled, swallowed or in contact with skin. [1]
Chemical Information
| Molecular Weight (WM): | 183.91 |
|---|---|
| Formula: | Na3O4V |
| CAS No.: | 13721-39-6 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO <1mg/mL |
| Water ≥37mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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