Home Transmembrane Transporters Calcium Channel inhibitor CarboxyaMidotriazole orotate For research use only.

CarboxyaMidotriazole orotate

Synonyms: L-651582 Orotate, CAI Orotate

Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate inhibits angiogenesis, tumor growth, invasion, and metastasis.

CarboxyaMidotriazole orotate Chemical Structure

CarboxyaMidotriazole orotate Chemical Structure

CAS: 187739-60-2

Purity & Quality Control

Batch: S297501 DMSO] 25 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.97%
99.97

CarboxyaMidotriazole orotate Related Products

Signaling Pathway

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Calcium Channel Signaling Pathway

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Biological Activity

Description Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate inhibits angiogenesis, tumor growth, invasion, and metastasis.
Targets
Calcium channel [1]

Chemical Information & Solubility

Molecular Weight 580.76 Formula

C22H16Cl3N7O6
CAS No. 187739-60-2 SDF --
Smiles NC(=O)C1=C(N)[N](CC2=CC(=C(C(=C2)Cl)C(=O)C3=CC=C(Cl)C=C3)Cl)N=N1.OC(=O)C4=CC(=O)NC(=O)N4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 25 mg/mL ( (43.04 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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