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Adiphenine HCl

Name: Adiphenine HCl
Brand: Selleck Chemicals
SKU: S2082
Rating: 5 (1 reviews)

Synonyms: NSC 129224

Catalog No.S2082 Purity: 99.83%

Adiphenine HCl(NSC 129224) is a nicotinic receptor inhibitor, used as an antispasmodic drug.

Adiphenine HCl Chemical Structure

CAS: 50-42-0

Purity & Quality Control

Batch: S208201 Water] 70 mg/mL] false] DMSO] 30 mg/mL] false] Ethanol] 18 mg/mL] false Purity: 99.83%

99.83

Adiphenine HCl Related Products

Related Targets	mAChR nAChR AChE	Click to Expand
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Signaling Pathway

AChR Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description

Adiphenine HCl(NSC 129224) is a nicotinic receptor inhibitor, used as an antispasmodic drug.

Targets

α3β4 nAChR ^[1] (Cell-free assay)	α1 nAChR ^[1] (Cell-free assay)	α4β2 nAChR ^[1] (Cell-free assay)	α4β4 nAChR ^[1] (Cell-free assay)
1.8 μM	1.9 μM	3.7 μM	6.3 μM

References

[1] C L Gentry, R J Lukas. J Pharmacol Exp Ther . 2001 Dec;299(3):1038-48.

Chemical Information & Solubility

Molecular Weight	347.88	Formula	C₂₀H₂₅NO₂.HCl
CAS No.	50-42-0	SDF	Download Adiphenine HCl SDF
Smiles	CCN(CC)CCOC(=O)C(C1=CC=CC=C1)C2=CC=CC=C2.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 70 mg/mL

DMSO : 30 mg/mL ( (86.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 18 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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