Zonisamide
Catalog No.S1445 Synonyms: CI-912
Molecular Weight(MW): 212.23
Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.
Purity & Quality Control
Choose Selective Sodium Channel Inhibitors
Biological Activity
| Description | Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug. | |
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| Targets |
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| In vitro |
Zonisamide inhibits monoamine oxidase B (MAO-B) activity in vitro with an IC(50) of 25 μM. [1] |
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| In vivo | Zonisamide modifies dopamine (DA) activity, provides protection in ischemia mice models and influences antioxidant systems. Zonisamide attenuates the reduction in striatal contents of DA, its metabolite DOPAC and tyrosine hydroxylase (TH). [1] Zonisamide (10 and 30 mg/kg) produces antihyperalgesic and antiallodynic effects in a dose-dependent manner, these effects are manifested by elevation of the withdrawal threshold in response to a thermal (plantar test) or mechanical (von Frey) stimulus, respectively.. Zonisamide produces antinociceptive effects against acute thermal and mechanical nociception in non-ligated mice. [2] Zonisamide reduces the cortical infarction volume to 6% from 68% in vehicle-treated controls and the striatal volume to 8% from 78% in rats. Zonisamide also reduces neuronal necrosis in 5 hippocampal regions (the dentate gyrus, CA4, CA3, CA1, and the subiculum) in rats. [3] Zonisamide causes increase in the quantity of EAAC-1 protein in hippocampus and cortex and down regulation of the GABA transporter GAT-1 in rats with hippocampal seizures. [4] Zonisamide inhibits both the 50 mM KCl-evoked hippocampal glutamate release (AUC for 60 min) from 9.2 mM to 5.8 mM in urethane-anaesthetized rats, as well as the stimulatory effects of Ca2+ on KCl-evoked hippocampal glutamate release. [5] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 42 mg/mL (197.89 mM) |
|---|---|---|
| Ethanol | 5 mg/mL (23.55 mM) | |
| Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 212.23 |
|---|---|
| Formula | C8H8N2O3S |
| CAS No. | 68291-97-4 |
| Storage | powder |
| Synonyms | CI-912 |
Bio Calculators
Molarity Calculator
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02049073 | Not yet recruiting | Noise-induced Hearing Loss | Washington University School of Medicine | June 2017 | Phase 1|Phase 2 |
| NCT02900352 | Recruiting | Alcohol Use Disorder | Yale University | October 2016 | Phase 1 |
| NCT02901041 | Not yet recruiting | Alcohol Dependence | Boston University|Mclean Hospital|University of Houston | September 2016 | Phase 3 |
| NCT02707965 | Not yet recruiting | Epilepsy | Food and Drug Administration (FDA)|University of Maryland | March 2016 | -- |
| NCT02368431 | Recruiting | Alcohol Use Disorder | VA Office of Research and Development | March 2015 | Phase 3 |
| NCT01847469 | Recruiting | Alcohol Dependence|Post-Traumatic Stress Disorder (PTSD) | Yale University|United States Department of Defense | June 2013 | Phase 2 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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