Catalog No.S1445 Synonyms: CI-912

Zonisamide Chemical Structure

Molecular Weight(MW): 212.23

Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 170 In stock
USD 370 In stock
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Biological Activity

Description Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.
Sodium channel [1]
In vitro

Zonisamide inhibits monoamine oxidase B (MAO-B) activity in vitro with an IC(50) of 25 μM. [1]

In vivo Zonisamide modifies dopamine (DA) activity, provides protection in ischemia mice models and influences antioxidant systems. Zonisamide attenuates the reduction in striatal contents of DA, its metabolite DOPAC and tyrosine hydroxylase (TH). [1] Zonisamide (10 and 30 mg/kg) produces antihyperalgesic and antiallodynic effects in a dose-dependent manner, these effects are manifested by elevation of the withdrawal threshold in response to a thermal (plantar test) or mechanical (von Frey) stimulus, respectively.. Zonisamide produces antinociceptive effects against acute thermal and mechanical nociception in non-ligated mice. [2] Zonisamide reduces the cortical infarction volume to 6% from 68% in vehicle-treated controls and the striatal volume to 8% from 78% in rats. Zonisamide also reduces neuronal necrosis in 5 hippocampal regions (the dentate gyrus, CA4, CA3, CA1, and the subiculum) in rats. [3] Zonisamide causes increase in the quantity of EAAC-1 protein in hippocampus and cortex and down regulation of the GABA transporter GAT-1 in rats with hippocampal seizures. [4] Zonisamide inhibits both the 50 mM KCl-evoked hippocampal glutamate release (AUC for 60 min) from 9.2 mM to 5.8 mM in urethane-anaesthetized rats, as well as the stimulatory effects of Ca2+ on KCl-evoked hippocampal glutamate release. [5]


Solubility (25°C)

In vitro DMSO 42 mg/mL (197.89 mM)
Ethanol 5 mg/mL (23.55 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 212.23


CAS No. 68291-97-4
Storage powder
in solvent
Synonyms CI-912

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02049073 Not yet recruiting Noise-induced Hearing Loss Washington University School of Medicine June 2017 Phase 1|Phase 2
NCT02900352 Recruiting Alcohol Use Disorder Yale University October 2016 Phase 1
NCT02901041 Not yet recruiting Alcohol Dependence Boston University|Mclean Hospital|University of Houston September 2016 Phase 3
NCT02707965 Not yet recruiting Epilepsy Food and Drug Administration (FDA)|University of Maryland March 2016 --
NCT02368431 Recruiting Alcohol Use Disorder VA Office of Research and Development March 2015 Phase 3
NCT01847469 Recruiting Alcohol Dependence|Post-Traumatic Stress Disorder (PTSD) Yale University|United States Department of Defense June 2013 Phase 2

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Sodium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID