YM155 (Sepantronium Bromide)

Catalog No.S1130

YM155 (Sepantronium Bromide) Chemical Structure

Molecular Weight(MW): 443.29

YM155 (Sepantronium Bromide) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. Phase 2.

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Cited by 41 Publications

12 Customer Reviews

  • Dose response of ALL cell lines to YM155. Asynchronous populations of cells were treated with increasing doses of YM155 for 72 h. Then, viability was measured by MTS and normalized to no drug control. S.e.m. bars are inserted. Dotted line represents 50% viability.

    Leukemia 2012 26, 623-632. YM155 (Sepantronium Bromide) purchased from Selleck.

    Treatment of SUPB15 cells with imatinib or YM155. Top panel shows cells treated with siRNA in the presence of 500 nM imatinib. Cells were treated with siRNA, and then subsequently incubated in 500 nM imatinib for 96 h. Bottom panel shows the partial rescue of SUPB15 cells treated with 100 nM YM155 for 96 h. S.e.m. bars are inserted into each graph.

    Leukemia 2012 26, 623-632. YM155 (Sepantronium Bromide) purchased from Selleck.

  • Inhibition of survivin expression restricts VZV repl ication and sprea d in vitro . ( A ) HEL F were infected w ith VZV-GFP in the presence of YM155 or DMSO, and infectious virus yields were determined at 48 hpi by titration on melanoma cells. ( B) VZV-GFP-infected HELF were treated with DMSO or YM155; plaques were detected by staining with anti-VZV IgG at 48 hpi. Plaque sizes were determined using ImageJ; the graph shows the mean size ?S EM o f 30 plaques . (C )Expression of VZV proteins was assessed in VZV-infected HELF lysat e s (24 hp i) treated with YM155 or DMSO.

    Proc Natl Acad Sci U S A 2012 109, 600-5. YM155 (Sepantronium Bromide) purchased from Selleck.

    MM cell lines UM9 (left panel) or U266 (right panel) were cultured in presence or absence of accessory cells prior to incubation with CTLs alone, YM155 alone or the combination. Survival of UM9 and U266 MM cells was assessed by CS-BLI. Results show % lysis of MM cells after 24 hour incubation and are depicted for three doses.

    Clin Cancer Res 2013 19, 5591-601. YM155 (Sepantronium Bromide) purchased from Selleck.

  • Survivin inhibitor increased apoptosis in burn serum-stimulated cardiomyocytes. a YM155 increased apoptosis in burn serumstimulated cardiomyocytes in a concentration-dependent manner. Neonatal rat cardiomyocytes were treated with YM155 (3-300 nM at the indicated) for 2 h prior to stimulation burn serum for 12 h. The extent of DNA fragmentation was quantified using the Cell Death Detection ELISA. versus 0 nM YM155 plus stimulation with burn serum. b YM155 (100 nM) pretreatment increased the apoptosis production at 2 or 12 h after burn serum stimulation. c Representative blots of survivin and cleaved caspase-3 in YM155 (100 nM) pretreated cardiomyocytes at 2 and 12 h after burn serum stimulation. d Bar graphs show the relative proteins.

    Basic Res Cardiol 2011 106, 1207-1220. YM155 (Sepantronium Bromide) purchased from Selleck.

    Induction of cardiomyocytes apoptosis by survivin inhibitor in vivo. After YM155 was administered (5 mg/kg/day) for 5 days, the rats were exposed to a 40% TBSA burn (burn injury) or 25C water (sham) and killed 6 h after burn injury. The frozen sections of the ventricular tissues or whole cell lysates were prepared. Apoptotic staining was performed using the TUNEL method and immunostained using a-sarcomeric actin. The survivin and cleaved caspase-3 levels were measured by Western blot analysis. a Representative blots of survivin and cleaved caspase-3. b The statistical analysis of the relative proteins .c Figures are representative of two independent TUNEL experiments. Green fluorescence represents apoptotic cells, whereas red stain indicates staining for a-sarcomeric actin specific for cardiac myocytes. d Bar graph summarizes the counted apoptotic cells.



    Basic Res Cardiol 2011 106, 1207-1220. YM155 (Sepantronium Bromide) purchased from Selleck.

  • YM-155 sensitizes ABT-263-induced apoptosis in HCC cells. A. LH86 and B. Huh7 cells were untreated or treated with ABT-263(1 μM), YM-155(1 μM) or combination of ABT-263(1 μM) and YM-155(1 μM) for up to 6 h. Then apoptotic cells were assessed as in Figure 2A and2B (representative apoptotic cells were marked with white arrows). C. LH86 and D. Huh7 cells were untreated or treated with ABT-263(1 μM), YM-155(1 μM) or combination of ABT-263(1 μM) and YM-155(1 μM) for 6 h. Cells with apoptotic nuclei were counted to determine cell death ratio (*p<0.05, **p<0.05). E. LH86 cells and F. Huh7 cells were treated as indicated and cell lysates were prepared and subjected to Western blotting.Apoptosis was evaluated through caspase 3 activation. b-actin was used as an equal protein loading control. G. LH86 cells grown in six-well plate were untreated (control) or treated with different conditions as indicated for 48 h. After rinsed with fresh culture medium for 3 times, cells were cultured for another two weeks. Cell colony formation assays were performed with crystal violet staining. H. colony number were counted to show combination treatment with ABT-263 and YM-155 resulted in reduction of clonogenesis (#p<0.05).

    PLoS One 2011 6, e21980. YM155 (Sepantronium Bromide) purchased from Selleck.

    Survivin down-regulation sensitizes ABT-263-induced apoptosis in HCC cells. A. LH86 cells were treated as indicated and cell lysates were prepared for Western blotting. Pro-apoptotic proteins: Bax, Bad, and Bak and anti-apoptotic proteins Bcl-xL and Mcl-1 were assessed with specific antibodies respectively. b-actin was detected and served as an equal protein loading control. B. LH86 cells were untreated or treated with ABT-263 (1 μM), YM-155 (1 μM) or combination of ABT-263 (1 μM) and YM155 (1 μM) for up to 6 h as indicated. Then cells were harvested and cell lysates were prepared for Western blotting. Anti-survivin and anti-Bcl-xL polyclonal antibodies were used to assess protein levels for survivin and Bcl-xL respectively. b-actin was used as an equal protein loading control. The band intensities of survivin, Bcl-xL, and b-actin was qualified with Image J software. C. LH86 cells were transiently transfected with synthesized random siRNA (control) or survivin specific siRNA duplexes, and 48 h posttransfection, cells were subjected to Western blotting analysis with anti-survivin polyclonal antibody. β-actin was used as an equal protein loading control. D. LH86 cells were transfected with synthesized random control siRNA or survivin specific siRNA, and 48 h post-transfection, cells were untreated or treated with ABT-263 (1 μM) for 24 h and then subjected to Hoechst staining to show apoptotic cells with condensed nuclei (representative apoptotic cells were marked with white arrows). E. LH86 cells were treated as in Figure 4D and apoptosis was measured as in Figure 2A. Statistical analysis was performed for apoptosis ratio by counting the number of cells with apoptotic nuclei (*p<0.05). F. LH86 cells treated as in Figure 4D were harvested and cell lysates were prepared and subjected to Western blotting. Apoptosis was determined through caspase 3 activation. β-actin was used as an equal protein loading control.

    PLoS One 2011 6, e21980. YM155 (Sepantronium Bromide) purchased from Selleck.

  • Effects of YM155 on cell viability (A) and cell cycle (B), and on experiment of survivin mRNA (C) and protein (D) in the MiaPaCa-2 human pancreatic cancer cell line.

    Anticancer Res 2012 32, 1681-8. YM155 (Sepantronium Bromide) purchased from Selleck.


    IPF fibroblasts from 8 different patients were cultured to 60% confluence in DMEM supplemented with 10% fetal bovine serum and growth-arrested for 24 hours in serum-free DMEM prior to treatment for 16 hours with/without the Fas-activating antibody CH11 (FasL; 250 ng/ml) in the presence/absence of the survivin inhibitors CAY10625 (5 µM) or YM155 (10.0 µM), or with the survivin inhibitors alone. (a) Apoptosis was assessed using ELISA-based detection of histone associated DNA fragments. To allow relative comparisons of apoptosis across experiments, the data for each cell line is expressed as the percentage of the assay positive control that was included on each ELISA plate. The scatter plot shows the distribution of responses in individual cell lines along with the mean ± standard error for each treatment group. p = 0.038 overall (ANOVA). p = 0.027 for FasL compared to FasL/CAY10625, and p = 0.046 for FasL compared to FasL/YM155; (b) The correlation of apoptosis between IPF fibroblasts treated with FasL/CAY10625 and FasL/YM155. Each point represents a different IPF cell line. The Spearman correlation (r) = 0.95.

    Adv Biosci Biotechnol 2012 3, 657-664. YM155 (Sepantronium Bromide) purchased from Selleck.

  • Total RNA from livers of these mice were isolated from tissues using TRIZOL (Invitrogen). cDNA synthesis was performed with the M-MLV RTase cDNA Synthesis Kit (Promega). qRT-PCR reactions were performed using SYBR Green (Takara) on ABI 7500 Fast system. Expression levels of Survivin gene were measured by qRT-PCR in livers injected with 0.9% Nacl (91#,92#) or YM155 48 hours after DEN treatment.

    Lihua Min of Chinese Academy of Sciences. YM155 (Sepantronium Bromide) purchased from Selleck.

    Western blot analysis of Survivin. U-251 and PC-3 cell line was treated with 0-100nM YM-155.



    Dr. Chunrong Yu of RoswelI Park Cancer Institute. YM155 (Sepantronium Bromide) purchased from Selleck.

Purity & Quality Control

Choose Selective Survivin Inhibitors

Biological Activity

Description YM155 (Sepantronium Bromide) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. Phase 2.
Survivin [1]
(HeLa-SURP-luc, CHO-SV40-luc cells)
0.54 nM
In vitro

YM155 is not sensitive to survivn gene promoter-driven luciferase reporter activity even at 30 μM. YM155 significantly inhibits endogenous survivin expression in PC-3 and PPC-1 human HRPC cells with deficient p53 through transcriptional inhibition of the survivin gene promoter. On the contrary YM155 shows no sufficient effect on protein expression of c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, α-actin, and β-tubulin at 100 nM. YM155 indicates great apoptosis in human cancer cell lines including PC-3 and PPC-1 with a concomitant increase in caspase-3 activity. YM155 potently inhibits human cancer cell lines (mutated or truncated p53) including PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5 and A375 with IC50 from 2.3 to 11 nM, respectively. [1] YM155 increases the sensitivity of NSCLC cells to γ-radiation. The combination of YM155 and γ-radiation increases both the number of apoptotic cells and the activity of caspase-3. YM155 delays the repair of radiation-induced double-strand breaks in nuclear DNA. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Kasumi-1 MmfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPy[mE4OiCq NGHFT5JFVVOR M1nxZmlEPTB;MD6wNFkhyrFiMD6wNFA6KM7:TR?= MkPUNlU3PTl5M{G=
THP-1 NFnuNopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PWSlczKGh? MkXOSG1UVw>? NWf5PIhlUUN3ME2wMlA2OSEEsTCwMlAyOyEQvF2= NYjZdo9GOjV4NUm3N|E>
AML-193 NXnFcJk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjuU404OiCq MnjrSG1UVw>? NEHQT3dKSzVyPUCuOFYzKMLzIECuNFYxKM7:TR?= M3vZNlI2PjV7N{Ox
HL-60 M4LnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fEVFczKGh? M2\uOmROW09? NIG2OmNKSzVyPUCuNFAyKMLzIECuNFAxOiEQvF2= NHK5PVIzPTZ3OUezNS=>
ML-2 M4nXfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HEelczKGh? M1z0bGROW09? M1\HeGlEPTB;MD6wNFkhyrFiMD6wNFIh|ryP Mn:0NlU3PTl5M{G=
ME-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPNdFg4OiCq NWj2eJd5TE2VTx?= NF;MeHlKSzVyPUCuOlg1KMLzIECuNVc6KM7:TR?= M2\JRVI2PjV7N{Ox
THP-1 NIK4bXlCeG:ydH;zbZMhSXO|YYm= NWjXXGtOOcLizszN MVm3NkBp MoP3SG1UVw>? M2fFb4lv\HWlZYOgZZBweHSxc3nz NGT6SGIzPTZ3OUezNS=>
M-07e M3[3TmZ2dmO2aX;uJGF{e2G7 MViw5qCUOcLizszN NEHRZoI4OiCq NVjIOXE4TE2VTx?= M{HXUIlv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gV5Vzfmm4aX6= MYSyOVY2QTd|MR?=
THP-1 MWDGeY5kfGmxbjDBd5NigQ>? MYmw5qCUOcLizszN NH;5N|M4OiCq M{DadmROW09? NU[xXW9ZcW6mdXPld{Bld3ewcnXneYxifGmxbjDv[kBUfXK4aY\pci=> NFvxfFYzPTZ3OUezNS=>
CMK NYCzW|RQTnWwY4Tpc44hSXO|YYm= MWGw5qCUOcLizszN NWP0V29QPzJiaB?= NUDaNlJ2TE2VTx?= MkfjbY5lfWOnczDkc5dvemWpdXzheIlwdiCxZjDTeZJ3cX[rbh?= MkDtNlU3PTl5M{G=
AML-193 NIrOOFFHfW6ldHnvckBCe3OjeR?= NHPvdZgx6oDVMdMg{txO NH3uO2o4OiCq NHXKTWpFVVOR M1fu[4lv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gV5Vzfmm4aX6= NFG5Uo8zPTZ3OUezNS=>
Kasumi-1 MlnUSpVv[3Srb36gRZN{[Xl? MliyNQKBmzIEoN88US=> M37MdFczKGh? MW\EUXNQ MlW5bY5lfWOnczDkc5dvemWpdXzheIlwdiCxZjDTeZJ3cX[rbh?= NYDZ[GFHOjV4NUm3N|E>
MV4-11 NHziUGFHfW6ldHnvckBCe3OjeR?= M2HEfVDjiJNzwrFOwG0> MlTRO|IhcA>? NFnJXINFVVOR MkH1bY5lfWOnczDkc5dvemWpdXzheIlwdiCxZjDTeZJ3cX[rbh?= NVOwfHdvOjV4NUm3N|E>
MUG-Chor  M1zIdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fV[|AuPSEQvF2= NWfXcG81OjRxNEigbC=> NHPnVo5KSzVyPUeuNFXjiImwTTDmc5IhPDiq NXjXNldIOjV4NECxPFU>
KATOIII MkjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\tZZcyOC9{MDDuUS=> Mlv1OFghcA>? NGfrSHFqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MWCyOVY{PTB3NR?=
AGS  NWDuRoVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1y0XVExNzJyIH7N M{TselQ5KGh? MXvpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MmK4NlU3OzVyNUW=
SACC-83 MYjGeY5kfGmxbjDBd5NigQ>? MXq1JI5O Mn7QOFghcA>? NIW1[Zpl\WO{ZXHz[ZMhdnWlbHXhdkBmgHC{ZYPzbY9vKG:oIFjJSk0y|rF? M4\HZVI2PDh3NkO1
INA-6 NFnNd2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnZWm8xNTVyMDDuUS=> MofBOFghcA>? NFXvVVFqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MkTtNlUzQTZ7N{i=
U-266 MmPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7Zeo0xNTVyMDDuUS=> NF;MS3o1QCCq M4fObIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz M1nybFI2Ojl4OUe4
MOLP-8 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXGwMVUxOCCwTR?= M4DzTVQ5KGh? MmnxbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NX;wNIFROjV{OU[5O|g>
HG-1 MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnuco8xNTVyMDDuUS=> NGLMXIU1QCCq MVXpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MkPoNlUzQTZ7N{i=
NCI-H929 NHTBS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1K4UVAuPTByIH7N M4DpXlQ5KGh? NEfy[YJqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MXqyOVI6Pjl5OB?=
OPM-2 NIjXXVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLhNE02ODBibl2= NEPlNXc1QCCq M2nsN4lvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NVfEdXlmOjV{OU[5O|g>
L-363 M3nTOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPMNE02ODBibl2= M1OyR|Q5KGh? M3\yTIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz M3riUlI2Ojl4OUe4
MOLP-2 NH;MWGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV[wMVUxOCCwTR?= M4LuWFQ5KGh? MXjpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NEfKUo8zPTJ7Nkm3PC=>
KMS-12-BM MofDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3r4bFAuPTByIH7N NWXye5BZPDhiaB?= MWTpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M2jve|I2Ojl4OUe4
SK-MM-2 Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkntNE02ODBibl2= M1WxO|Q5KGh? MkXmbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MoPpNlUzQTZ7N{i=
U-266 NIK5cmhCeG:ydH;zbZMhSXO|YYm= NUfoTG85OC13MDDuUS=> NGTJW2IzPCCq M3TwUolv\HWlZYOgZZBweHSxc3nz NVTOSHBjOjV{OU[5O|g>
INA-6  MmnzRZBweHSxc3nzJGF{e2G7 NFP6OmMxNTVyIH7N NEDWb|czPCCq MnLObY5lfWOnczDhdI9xfG:|aYO= NYG1b|IyOjV{OU[5O|g>
MCF7 M4PEeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojKO|IhcA>? NEHwSZFKSzVyPUGzJOKyKDZibl2= NGTiO|kzPTJ{MEKyOS=>
MCF7-TamR6 MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXK3NkBp NETh[WpKSzVyPUigxtEhPiCwTR?= M{nOb|I2OjJyMkK1
MCF7-TamR7 NUHZSVF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TzeFczKGh? NW\X[5ZiUUN3ME24JOKyKDNibl2= MnLkNlUzOjB{MkW=
MCF7-TamR8 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7sO|IhcA>? M4raW2lEPTB;MUWgxtEhPiCwTR?= NFLHWJkzPTJ{MEKyOS=>
MCF7-TamC3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUW3NkBp NX\uOmVJUUN3ME22JOKyKDNibl2= M{PzfFI2OjJyMkK1
MDA-MB-231 NGTzUXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;WO|IhcA>? NHKxR2VKSzVyPUWgxtEhOSCwTR?= M3\zfFI2OjJyMkK1
SK-BR-3 M3nEOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT6W|lFPzJiaB?= MU\JR|UxRTdiwsGgNE4{KG6P NV[xS3RGOjV{MkCyNlU>
Eca109 Mlj5SpVv[3Srb36gRZN{[Xl? NI[0THAyNTVyIH7N NYjaNIVGPDhiaB?= Mo\4SG1UVw>? NWDsPZpoe3WycILld5NmeyC|dYL2bZZqdiCneIDy[ZN{cW:wIHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ NFfJd5kzPTF|OUO5OS=>
TE13 M1XYbGZ2dmO2aX;uJGF{e2G7 MXixMVUxKG6P MmrSOFghcA>? NVrqZ5U1TE2VTx?= MUXzeZBxemW|c3XzJJN2en[rdnnuJIV5eHKnc4Ppc44hcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> MUCyOVE{QTN7NR?=
Eca109 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1exRlAuOTByIH7N NIDGOnIzPC92ODDo NV\5SZlTTE2VTx?= M13DdYRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NFj2UVkzPTF|OUO5OS=>
TE13 MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTONE0yODBibl2= NYrVUnVLOjRxNEigbC=> MUfEUXNQ NWPDcHp5\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NHPOWWczPTF|OUO5OS=>
MT-3 MoHhT4lv[XOnIFHzd4F6 MmTjO|IhcA>? NFXydFRFVVOR M3[5XGlEPTB;Mj64OkDDuSByLkW0JI5OKG[xcjDEVlQh\XiycnXzd4lwdg>? M4DEW|I1QDZ4NUi1
MDA-MB-468 MUfLbY5ie2ViQYPzZZk> MYi3NkBp M2Xib2ROW09? M3fKfGlEPTB;MD6xNUDDuSByLkCxJI5OKG[xcjDEVlQh\XiycnXzd4lwdg>? M3TzfFI1QDZ4NUi1
SUM-159 M1jKdWtqdmG|ZTDBd5NigQ>? MUm3NkBp NVjQfVl6TE2VTx?= NGX3UHdKSzVyPUGuO|IhyrFiMD6zN{BvVSCob4KgSHI1KGW6cILld5Nqd25? MXiyOFg3PjV6NR?=
MT-3 + NAC NHLqO|VMcW6jc3WgRZN{[Xl? NHHu[5c4OiCq NX;4WnBbTE2VTx?= MYrJR|UxRTV4LkKgxtEhOi5yNzDuUUBnd3JiRGK1JIV5eHKnc4Ppc44> M3HBd|I1QDZ4NUi1
MT-3 + SB203580 M2DRNGtqdmG|ZTDBd5NigQ>? M4HTUVczKGh? MVXEUXNQ MljaTWM2OD1|OD60NUDDuSB3LkCyJI5OKG[xcjDEVlUh\XiycnXzd4lwdg>? M4DzOVI1QDZ4NUi1
DB M2W1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom5NVAhdk1? NHf3XZozPCCq MWHEUXNQ MnjKbY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;u NIGycZgzPDR6NkW5OS=>
SU-DHL-8 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV[xNEBvVQ>? NEDRVW8zPCCq NGLQbmpFVVOR NWPNcWptcW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9v M3qyO|I1PDh4NUm1
WSU-DLCL2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jYW|ExKG6P MV:yOEBp NF7ERmRFVVOR MXfpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36= M1\jcFI1PDh4NUm1
ACC-2 MmT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVOwMVExOCCwTR?= MVGyOEBp NIm2UVVqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MnzQNlQ{PzB7OUW=
ACC-2 MVzBdI9xfG:|aYOgRZN{[Xl? NEHIXoExNTJyIH7N MYSyOEBp M1ntZ4lv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NXnvclJWOjR|N{C5PVU>
ACC-2 NH;aPHNHfW6ldHnvckBCe3OjeR?= MnTvNE0zOCCwTR?= MWCyOEBp NIjs[WxqdmO{ZXHz[ZMhfGinIHPvcpZmenOrb36gc4YhVEN|STD0c{BNSzOLSR?= MXyyOFM4ODl7NR?=
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TSGH8301  MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYewMVExODBibl2= M4e3c|Q5KGkEoB?= MYnEUXNQ NV2zbld1UUN3ME2yNEBvVSxiaX7obYJqfHNiY3XscEBoem:5dHigbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= M{n5TFI1Ojl5NkS0
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U937  NH7qSJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYS3NuKhcA>? MWfEUXNQ NFTYT21KSzVyPUCuPEBvVQ>? MnK1NlM3OTh6NkK=
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U937  NW\Db|R4TnWwY4Tpc44hSXO|YYm= M3r0WlHDqM7:TR?= M3rEZ|YwOTJxMkSgbC=> M3zQVGROW09? M2W3fIlvcGmkaYTzJJRp\SCneIDy[ZN{cW:wIH;mJJN2en[rdnnu MmTBNlM3OTh6NkK=
HL-60 M1y3W2Fxd3C2b4Ppd{BCe3OjeR?= NIDhU|UxNjFxMTFOwG0> NE[yV|c5KGh? MVHEUXNQ NWjxcGdXcW6mdXPld{BieG:ydH;zbZM> M4nQNFI{PjF6OE[y
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TC-71 M{nLO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fZe|AvOS1zMECwJI5O MnjWSWM2OD13Lkegcm0tKGmwaHnibZR{KGOnbHyg[5Jwf3SqIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NITjflEzOjl4MUe2Ny=>
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M059K NEXm[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHKNE02OCCwTR?= NGH6VJc1QCCq MW\pcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MVeyNlc4ODFzMB?=
M059J MUPBdI9xfG:|aYOgRZN{[Xl? NV\RU3doOzBibl2= NUjxR2d1OjRiaB?= M1ewb4lv\HWlZYOgZZBweHSxc3nz NGfaXGwzOjd5MEGxNC=>
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RPMI-7951 NFrlfFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f1V2dKPTB;Mz6yJI5O NF75VnAzOTd|N{WwNi=>
SK-MEL-5 M1rNW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PI[WdKPTB;ND6yJI5O MX[yNVc{PzVyMh?=
A375 NIjzSlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPNS2k2OD14LkOgcm0> Mn2zNlE4Ozd3MEK=
SK-MEL-28 MoX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXYS2k2OD15Lk[gcm0> MWKyNVc{PzVyMh?=
SK-MEL-2 M4G4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvwS2k2OD1zMTDuUS=> MljaNlE4Ozd3MEK=
DB M{LmNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXLdGY1QMLiaB?= NFjGXpZIUTVyPUOuOUBvVQ>? M37wbVIyOjN5NUC4
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SU-DHL-5 Mn32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfqPXhnPDkEoHi= MXPHTVUxRTBwMkOgcm0> M4HCSFIyOjN5NUC4
SU-DHL-8 NHrUdnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlu1OFjDqGh? MUHHTVUxRTFwNDDuUS=> NEXBe4kzOTJ|N{WwPC=>

... Click to View More Cell Line Experimental Data

In vivo YM155 completely inhibits the tumor growth of PC-3 s.c. xenografted prostate tumors at doses of 3 and 10 mg/kg, without body weight loss and blood cell count decrease. Pharmacokinetic analysis shows that YM155 is highly distributed to tumor tissue. Moreover, YM155 shows 80% TGI at a dose of 5 mg/kg in PC-3 orthotopic xenografts. [1] The combination therapy with YM155 and γ-radiation shows great antitumor activity against H460 or Calu6 xenografts in nude mice. [2]


Kinase Assay:


+ Expand

Promoter-luciferase reporter assay:

A 2,767-bp sequence of human survivin gene promoter is isolated from human genomic DNA by PCR using Pyrobest polymerase and the following primers: 5
Cell Research:


+ Expand
  • Cell lines: Hormone refractory prostate cancer cell lines (PC-3, PPC-1, DU145, TSU-Pr1 and 22Rv1) and malignant melanoma cell lines (SK-MEL-5 and A375)
  • Concentrations: ~ 100 nM
  • Incubation Time: 48 hours
  • Method:

    Cells are seeded in 96-well plates at a density of 5-40 × 103. YM155 is dissolved in DMSO and added to cells for 48 hours. Then the cell count is determined by sulforhodamine B assay.

    (Only for Reference)
Animal Research:


+ Expand
  • Animal Models: PC-3 s.c. (orthotopic) xenografts in male nude mice (BALB/c nu/nu)
  • Formulation: Dissolved and diluted in saline immediately before administration
  • Dosages: 5 mg/kg
  • Administration: Subcutaneous injection as a 3-day continuous infusion per week for 3 weeks by an implanted micro-osmotic pump
    (Only for Reference)

Solubility (25°C)

In vitro Water 89 mg/mL (200.77 mM)
DMSO 55 mg/mL (124.07 mM)
Ethanol 6 mg/mL (13.53 mM)
In vivo Add solvents individually and in order:
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 443.29


CAS No. 781661-94-7
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01100931 Completed NSCLC|Solid Tumors National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) February 2010 Phase 1|Phase 2
NCT01038804 Completed Breast Cancer Astellas Pharma Inc December 2009 Phase 2
NCT01023386 Completed Cancer Astellas Pharma Inc November 2009 Phase 1
NCT01009775 Completed Melanoma Astellas Pharma Inc November 2009 Phase 2
NCT01007292 Completed Non-Hodgkins Lymphoma Astellas Pharma Inc November 2009 Phase 2
NCT00498914 Terminated Lymphoma, Large-Cell, Diffuse|Lymphoma, B-Cell Refractory Astellas Pharma Inc June 2007 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Survivin Signaling Pathway Map

Related Survivin Products

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID