Telmisartan

Catalog No.S1738 Synonyms: BIBR 277

Telmisartan  Chemical Structure

Molecular Weight(MW): 514.62

Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 120 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

1 Customer Review

  • (B) Dose-response curves of each drug for acute G protein or barr activation derived from the CellKey assay. LOS: Losartan; EXP: EXP3174; TEL: Telmisartan.

    Sci Rep, 2015, 5:8116.. Telmisartan purchased from Selleck.

Purity & Quality Control

Choose Selective RAAS Inhibitors

Biological Activity

Description Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
Targets
angiotensin II receptor [1]
In vitro

Telmisartan functions as a moderately potent (EC50=4.5 μM), selective PPARγ partial agonist, activating the receptor to 25% to 30% of the maximum level achieved by the full agonists pioglitazone and rosiglitazone. Telmisartan induces adipocyte differentiation of 3T3-L1 cells. Telmisartan causes a 60% to 70% decrease in the expression of ACC2 in murine muscle myotubes. [1] Telmisartan, but not candesartan, another ARB, downregulates RAGE mRNA levels in a dose-dependent manner. Telmisartan decreases basal as well as AGE-induced RAGE protein expression in Hep3B cells. Telmisartan dose-dependently inhibits AGE-induced ROS generation and subsequent CRP gene and protein induction in Hep3B cells. [2] Telmisartan effectively facilitates differentiation of 3T3-L1 preadipocytes. Telmisartan causes a dose-dependent increase in mRNA levels for PPARgamma target genes such as aP2 and adiponectin in both differentiating adipocytes and fully differentiated adipocytes. Telmisartan attenuates 11beta-hydroxysteroid dehydrogenase type 1 mRNA level in differentiated adipocytes. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO cells NVPHNnFqTnWwY4Tpc44h[XO|YYm= M135PWFvfGGpb37pd5Qh[WO2aY\peJkh[XRiaIXtZY4hSVRzIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEUE9iY3XscJMhdWWjc4Xy[YQh[W[2ZYKgc5Zmem6rZ3j0JIlv[3WkYYTpc44h[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuNFAzKM7:TR?= NFfwV20zPDR4Mk[2OS=>
HepG2 cells NHewNWdHfW6ldHnvckBie3OjeR?= MnflTY5pcWKrdHnvckBw\iCuaY\ldkB{fGGpZTDQcIF{dW:maYXtJIJmemeqZXmgbY5n\WO2aX;uJIlvKEincFeyJINmdGy|LDDJR|UxRTBwMEK1JO69VQ>? NWP6OY5LOjJ3OE[xNlQ>
CV1 cells MVLGeY5kfGmxbjDhd5NigQ>? MnPNRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGg[ZhxemW|c3XkJIlvKGGocnnjZY4h\3KnZX6gcY9vc2W7IFPWNUBk\WyuczDifUBI[Wx2IITyZY5{[WO2aY\heIlwdiCjc4PhfUwhTUN3ME2yMlAzKM7:TR?= NFzkWpIzODB5OU[zOi=>
HEK293 cells NXHzV|RITnWwY4Tpc44h[XO|YYm= MXjJcohq[mm2aX;uJI9nKGi3bXHuJG1CXEVzLX3l[IlifGWmIFHTVEshfXC2YXvlJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZYZ1\XJiMT61JI1qdnNiYomg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyPUG3Mlkh|ryP NVfSbGtxOjN{NEGwNlk>

... Click to View More Cell Line Experimental Data

In vivo Telmisartan promotes increases in caloric expenditure and protects against dietary-induced weight gain in rats fed with a high-fat, high-carbohydrate diet. Telmisartan reduces the accumulation of visceral fat and decreases adipocyte size to a much greater extent than valsartan and is also associated with a significant reduction in hepatic triglyceride levels in rats fed with a high-fat, high-carbohydrate diet. [4]

Protocol

Solubility (25°C)

In vitro DMSO 13 mg/mL (25.26 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 514.62
Formula

C33H30N4O2

CAS No. 144701-48-4
Storage powder
Synonyms BIBR 277

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02699645 Not yet recruiting Acute Intracerebral Haemorrhage (ICH) The George Institute May 2017 Phase 4
NCT02968160 Recruiting Metabolic Syndrome Yuhan Corporation|Linical Korea October 2016 Phase 4
NCT02768948 Not yet recruiting Diabetic Nephropathy Centre Hospitalier Universitaire de Nice July 2016 --
NCT02620163 Completed Hypertension Yuhan Corporation December 2015 Phase 3
NCT02734355 Completed Atrial Fibrillation Research Institute for Complex Problems of Cardiovascular Diseases, Russia November 2015 Phase 4
NCT02933658 Completed Hypertension and Dyslipidemia Daewon Pharmaceutical Co., Ltd. November 2015 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

RAAS Signaling Pathway Map

Related RAAS Products

Tags: buy Telmisartan | Telmisartan ic50 | Telmisartan price | Telmisartan cost | Telmisartan solubility dmso | Telmisartan purchase | Telmisartan manufacturer | Telmisartan research buy | Telmisartan order | Telmisartan mouse | Telmisartan chemical structure | Telmisartan mw | Telmisartan molecular weight | Telmisartan datasheet | Telmisartan supplier | Telmisartan in vitro | Telmisartan cell line | Telmisartan concentration | Telmisartan nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID