Catalog No.S1738 Synonyms: BIBR 277

Telmisartan  Chemical Structure

Molecular Weight(MW): 514.62

Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

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In DMSO USD 90 In stock
USD 70 In stock
USD 120 In stock
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  • (B) Dose-response curves of each drug for acute G protein or barr activation derived from the CellKey assay. LOS: Losartan; EXP: EXP3174; TEL: Telmisartan.

    Sci Rep, 2015, 5:8116.. Telmisartan purchased from Selleck.

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Biological Activity

Description Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
angiotensin II receptor [1]
In vitro

Telmisartan functions as a moderately potent (EC50=4.5 μM), selective PPARγ partial agonist, activating the receptor to 25% to 30% of the maximum level achieved by the full agonists pioglitazone and rosiglitazone. Telmisartan induces adipocyte differentiation of 3T3-L1 cells. Telmisartan causes a 60% to 70% decrease in the expression of ACC2 in murine muscle myotubes. [1] Telmisartan, but not candesartan, another ARB, downregulates RAGE mRNA levels in a dose-dependent manner. Telmisartan decreases basal as well as AGE-induced RAGE protein expression in Hep3B cells. Telmisartan dose-dependently inhibits AGE-induced ROS generation and subsequent CRP gene and protein induction in Hep3B cells. [2] Telmisartan effectively facilitates differentiation of 3T3-L1 preadipocytes. Telmisartan causes a dose-dependent increase in mRNA levels for PPARgamma target genes such as aP2 and adiponectin in both differentiating adipocytes and fully differentiated adipocytes. Telmisartan attenuates 11beta-hydroxysteroid dehydrogenase type 1 mRNA level in differentiated adipocytes. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO cells NHLYNYpHfW6ldHnvckBie3OjeR?= MVjBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGFVOSC{ZXPldJRweiCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzJI1m[XO3cnXkJIFnfGW{IH;2[ZJvcWeqdDDpcoN2[mG2aX;uJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1yLkCwNkDPxE1? MorNNlQ1PjJ4NkW=
HepG2 cells NHKzbHRHfW6ldHnvckBie3OjeR?= MVvJcohq[mm2aX;uJI9nKGyrdnXyJJN1[WenIGDsZZNud2SrdX2gZoVz\2inaTDpcoZm[3Srb36gbY4hUGWyR{KgZ4VtdHNuIFnDOVA:OC5yMkWg{txO MVKyNlU5PjF{NB?=
CV1 cells M{HOfWZ2dmO2aX;uJIF{e2G7 NWi0PIlRSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIHHmdolk[W5iZ4Ll[Y4hdW:wa3X5JGNXOSClZXzsd{BjgSCJYXy0JJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NF0zNjB{IN88US=> NVPweG0yOjByN{m2N|Y>
HEK293 cells NU\ycIU3TnWwY4Tpc44h[XO|YYm= M37sW2lvcGmkaYTpc44hd2ZiaIXtZY4hVUGWRUGtcYVlcWG2ZXSgRXNRMyC3cIThb4Uh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bi\nSncjCxMlUhdWmwczDifUBndHWxcnXzZ4Vv[2ViYYPzZZktKEmFNUC9NVcvQSEQvF2= NYH4XllPOjN{NEGwNlk>

... Click to View More Cell Line Experimental Data

In vivo Telmisartan promotes increases in caloric expenditure and protects against dietary-induced weight gain in rats fed with a high-fat, high-carbohydrate diet. Telmisartan reduces the accumulation of visceral fat and decreases adipocyte size to a much greater extent than valsartan and is also associated with a significant reduction in hepatic triglyceride levels in rats fed with a high-fat, high-carbohydrate diet. [4]


Solubility (25°C)

In vitro DMSO 13 mg/mL (25.26 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 514.62


CAS No. 144701-48-4
Storage powder
in solvent
Synonyms BIBR 277

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02699645 Not yet recruiting Acute Intracerebral Haemorrhage (ICH) The George Institute May 2017 Phase 4
NCT02968160 Recruiting Metabolic Syndrome Yuhan Corporation|Linical Korea October 2016 Phase 4
NCT02768948 Not yet recruiting Diabetic Nephropathy Centre Hospitalier Universitaire de Nice July 2016 --
NCT02620163 Completed Hypertension Yuhan Corporation December 2015 Phase 3
NCT02734355 Completed Atrial Fibrillation Research Institute for Complex Problems of Cardiovascular Diseases, Russia November 2015 Phase 4
NCT02933658 Completed Hypertension and Dyslipidemia Daewon Pharmaceutical Co., Ltd. November 2015 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID