Catalog No.S1738 Synonyms: BIBR 277

Telmisartan  Chemical Structure

Molecular Weight(MW): 514.62

Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

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In DMSO USD 90 In stock
USD 70 In stock
USD 120 In stock
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  • (B) Dose-response curves of each drug for acute G protein or barr activation derived from the CellKey assay. LOS: Losartan; EXP: EXP3174; TEL: Telmisartan.

    Sci Rep, 2015, 5:8116.. Telmisartan purchased from Selleck.

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Biological Activity

Description Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
angiotensin II receptor [1]
In vitro

Telmisartan functions as a moderately potent (EC50=4.5 μM), selective PPARγ partial agonist, activating the receptor to 25% to 30% of the maximum level achieved by the full agonists pioglitazone and rosiglitazone. Telmisartan induces adipocyte differentiation of 3T3-L1 cells. Telmisartan causes a 60% to 70% decrease in the expression of ACC2 in murine muscle myotubes. [1] Telmisartan, but not candesartan, another ARB, downregulates RAGE mRNA levels in a dose-dependent manner. Telmisartan decreases basal as well as AGE-induced RAGE protein expression in Hep3B cells. Telmisartan dose-dependently inhibits AGE-induced ROS generation and subsequent CRP gene and protein induction in Hep3B cells. [2] Telmisartan effectively facilitates differentiation of 3T3-L1 preadipocytes. Telmisartan causes a dose-dependent increase in mRNA levels for PPARgamma target genes such as aP2 and adiponectin in both differentiating adipocytes and fully differentiated adipocytes. Telmisartan attenuates 11beta-hydroxysteroid dehydrogenase type 1 mRNA level in differentiated adipocytes. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO cells NVPHNnFqTnWwY4Tpc44h[XO|YYm= M135PWFvfGGpb37pd5Qh[WO2aY\peJkh[XRiaIXtZY4hSVRzIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEUE9iY3XscJMhdWWjc4Xy[YQh[W[2ZYKgc5Zmem6rZ3j0JIlv[3WkYYTpc44h[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuNFAzKM7:TR?= NFfwV20zPDR4Mk[2OS=>
HepG2 cells NHewNWdHfW6ldHnvckBie3OjeR?= MnflTY5pcWKrdHnvckBw\iCuaY\ldkB{fGGpZTDQcIF{dW:maYXtJIJmemeqZXmgbY5n\WO2aX;uJIlvKEincFeyJINmdGy|LDDJR|UxRTBwMEK1JO69VQ>? NWP6OY5LOjJ3OE[xNlQ>
CV1 cells MVLGeY5kfGmxbjDhd5NigQ>? MnPNRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGg[ZhxemW|c3XkJIlvKGGocnnjZY4h\3KnZX6gcY9vc2W7IFPWNUBk\WyuczDifUBI[Wx2IITyZY5{[WO2aY\heIlwdiCjc4PhfUwhTUN3ME2yMlAzKM7:TR?= NFzkWpIzODB5OU[zOi=>
HEK293 cells NXHzV|RITnWwY4Tpc44h[XO|YYm= MXjJcohq[mm2aX;uJI9nKGi3bXHuJG1CXEVzLX3l[IlifGWmIFHTVEshfXC2YXvlJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZYZ1\XJiMT61JI1qdnNiYomg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyPUG3Mlkh|ryP NVfSbGtxOjN{NEGwNlk>

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In vivo Telmisartan promotes increases in caloric expenditure and protects against dietary-induced weight gain in rats fed with a high-fat, high-carbohydrate diet. Telmisartan reduces the accumulation of visceral fat and decreases adipocyte size to a much greater extent than valsartan and is also associated with a significant reduction in hepatic triglyceride levels in rats fed with a high-fat, high-carbohydrate diet. [4]


Solubility (25°C)

In vitro DMSO 13 mg/mL (25.26 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 514.62


CAS No. 144701-48-4
Storage powder
Synonyms BIBR 277

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02699645 Not yet recruiting Acute Intracerebral Haemorrhage (ICH) The George Institute May 2017 Phase 4
NCT02968160 Recruiting Metabolic Syndrome Yuhan Corporation|Linical Korea October 2016 Phase 4
NCT02768948 Not yet recruiting Diabetic Nephropathy Centre Hospitalier Universitaire de Nice July 2016 --
NCT02620163 Completed Hypertension Yuhan Corporation December 2015 Phase 3
NCT02734355 Completed Atrial Fibrillation Research Institute for Complex Problems of Cardiovascular Diseases, Russia November 2015 Phase 4
NCT02933658 Completed Hypertension and Dyslipidemia Daewon Pharmaceutical Co., Ltd. November 2015 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID