Molecular Weight(MW): 508.61
PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
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|Description||PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.|
PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically labeled two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM). 
|In vivo||PD 123319 has no effect on cerebral blood flow autoregulation. Acute AT2-receptor blockade does not influence CBF autoregulation. Intravenous administration of PD 123319 to conscious hypertensive rats elicites an immediate dose-dependent increase in MAP that is sustained for approximately 7.4 min with 3 mg/kg PD 123319. |
|In vitro||DMSO||100 mg/mL (196.61 mM)|
|Water||100 mg/mL (196.61 mM)|
|Ethanol||100 mg/mL (196.61 mM)|
|In vivo||Saline||30 mg/mL|
* 1 mg/ml means slightly soluble or insoluble.
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