Secnidazole

Catalog No.S2537

Secnidazole (Flagentyl) is a nitroimidazole anti-infective.

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Secnidazole  Chemical Structure

Secnidazole Chemical Structure
Molecular Weight: 185.18

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Secnidazole is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Secnidazole (Flagentyl) is a nitroimidazole anti-infective. Secnidazole (Flagentyl) is effective in the treatment of dientamoebiasis. Secnidazole (Flagentyl) has also been tested against Atopobium vaginae. An MIC range for secnidazole (Flagentyl) is 4-128 mg/L. The MIC50 for secnidazole (Flagentyl) is 16 mg/L. The MIC90 for secnidazole (Flagentyl) is 64 mg/L. Secnidazole (Flagentyl) is highly effective in achieving parasitologic. [1][2][3]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2015-05-23)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02111629 Completed Vaginal Discharge Universidad Nacional de Colombia May 2012 Phase 3
NCT02111629 Completed Vaginal Discharge Universidad Nacional de Colombia May 2012 Phase 3
NCT01733966 Terminated Diverticular Sigmoïditis Quanta Medical|Laboratoires Iprad-Vegebom May 2010 Phase 3
NCT01733966 Terminated Diverticular Sigmoïditis Quanta Medical|Laboratoires Iprad-Vegebom May 2010 Phase 3
NCT01019083 Completed Cholera|Typhoid International Centre for Diarrhoeal Disease Research, Ban  ...more International Centre for Diarrhoeal Disease Research, Bangladesh|Göteborg University February 2008 Phase 1|Phase 2

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Chemical Information

Download Secnidazole SDF
Molecular Weight (MW) 185.18
Formula

C7H11N3O3

CAS No. 3366-95-8
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms PM 185184, RP 14539
Solubility (25°C) * In vitro DMSO 37 mg/mL (199.8 mM)
Water 37 mg/mL (199.8 mM)
Ethanol 37 mg/mL (199.8 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name α,​2-​dimethyl-​5-​nitro-1H-​imidazole-​1-​ethanol

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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