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Ramelteon (TAK-375) Chemical Structure
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Biological Activity
Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ± 8.55 pM)and MT2 (20.1 ± 9.25 pM)receptors and selectivity over the MT3 receptor. [1]
The activity of ramelteon at the MT1 and MT2 receptors is believed to contribute to its sleep-promoting properties. Ramelteon has no appreciable affinity for the GABA receptor complex or for receptors that bind neuropeptides, cytokines, serotonin, dopamine, noradrenaline, acetylcholine, and opiates. [2]
Chemical Information
| Molecular Weight (WM): | 259.34 |
|---|---|
| Formula: | C16H21NO2 |
| CAS No.: | 196597-26-9 |
| Synonyms: |
Rozerem, TAK-375
|
| Dissolve in (25°C): | DMSO ≥52mg/mL |
| Water <1mg/mL | |
| Ethanol ≥52mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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