Research Area
Product Type
United States ( Change Country )
Raltegravir (MK-0518) Chemical Structure
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Biological Activity
Raltegravir (MK-0518) is a novel HIV-1 integrase strand transfer inhibitor with potent in vitro activity against wild-type and multi-class resistant HIV-1 virus (in vitro IC95 for HIV-1 in 50% normal human serum = 33 nM). Inhibition of integrase prevents insertion of HIV DNA into the human DNA genome, thus blocking the ability of HIV to replicate. Raltegravir is administered orally every 12h and does not require boosting with low-dose ritonavir (RTV) to achieve therapeutic concentrations. Raltegravir is not a potent inhibitor or inducer of cytochrome P450 3A4, and it is predominantly metabolized by glucuronidation, specifically by the enzyme UDP-glucuronosyltransferase 1A1. [1]Results from clinical trials indicate that raltegravir is safe and highly effective in the treatment of both antiretroviral-naïve and -experienced patients. [2,3]
Chemical Information
| Molecular Weight (WM): | 444.42 |
|---|---|
| Formula: | C20H21FN6O5 |
| CAS No.: | 871038-72-1 |
| Synonyms: |
Isentress
|
| Dissolve in (25°C): | DMSO ≥89mg/mL |
| Water ≥89mg/mL | |
| Ethanol ≥2mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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