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R406(free base) Chemical Structure
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R406
R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.
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Biological Activity
R406 is an orally available spleen tyrosine kinase inhibitor with a Ki of 30 nM.
R406 blocked Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 was selective as assessed using a large panel of Syk-independent cell-based assays representing both specific and general signaling pathways. Consistent with Syk inhibition, oral administration of R406 to mice reduced immune complex-mediated inflammation in a reverse-passive Arthus reaction and two antibody-induced arthritis models. [1][2]
References on R406(free base)
- [1] JPET 2006;319:998–1008
- [2] J Thromb Haemost 2009;7: 1192–1199
Chemical Information
| Molecular Weight (WM): | 470.45 |
|---|---|
| Formula: | C22H23FN6O5 |
| CAS No.: | 841290-80-0 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥29mg/mL |
| Water <1mg/mL | |
| Ethanol ≥94mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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