Syk

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2194 R406 <1 mg/mL 100 mg/mL 0 mg/mL
S2206 R788 (Fostamatinib) Disodium <1 mg/mL 6 mg/mL <1 mg/mL
S1533 R406 (free base) <1 mg/mL 21 mg/mL <1 mg/mL
S8032 PRT062607 (P505-15, BIIB057) HCl 86 mg/mL 86 mg/mL <1 mg/mL
S2625 Fostamatinib (R788) <1 mg/mL 116 mg/mL <1 mg/mL
S8442 TAK-659 4 mg/mL <1 mg/mL <1 mg/mL
S7286 RO9021 <1 mg/mL 5 mg/mL 7 mg/mL
S3026 Piceatannol <1 mg/mL 48 mg/mL 48 mg/mL
S4921 MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN) <1 mg/mL 39 mg/mL <1 mg/mL
S7738 PRT-060318 2HCl 75 mg/mL 75 mg/mL <1 mg/mL
S7523 Entospletinib (GS-9973) <1 mg/mL 26 mg/mL <1 mg/mL
S7006 BAY-61-3606 <1 mg/mL 14 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations
S2194

R406

R406 is a potent Syk inhibitor with IC50 of 41 nM in cell-free assays, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 1.

S2206

R788 (Fostamatinib) Disodium

R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.

S1533

R406 (free base)

R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 1.

S8032

PRT062607 (P505-15, BIIB057) HCl

PRT062607 (P505-15, BIIB057) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.

S2625

Fostamatinib (R788)

Fostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.

S8442New

TAK-659

TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.

S7286New

RO9021

RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling.

S3026

Piceatannol

Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn.

S4921

MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)

MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.

S7738

PRT-060318 2HCl

PRT-060318 2HCl is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.

S7523

Entospletinib (GS-9973)

Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM in a cell-free assay and showed 13- to >1000-fold cellular selectivity for Syk over other kinases(including Jak2, ckit, Flt3, Ret, KDR) as assessed by target protein phosphorylation or functional response.

S7006

BAY-61-3606

BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).

Tags: Syk inhibition | Syk signaling | Syk pathway | Syk activation | Syk cancer | Syk phosphorylation | Syk inhibitors in development | Syk signaling pathway | spleen tyrosine kinase pathway | Syk inhibitor review