Nitrendipine

Catalog No.S2491

Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.

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In DMSO USD 130 In stock
USD 97 In stock
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Nitrendipine Chemical Structure

Nitrendipine Chemical Structure
Molecular Weight: 360.3699

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Nitrendipine is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is an investigational dihydropyridine calcium-channel antagonist for the treatment of hypertension. Nitrendipine and BRL 38227 cause concentration-related inhibitions of the inositol phosphate response to histamine (100 µM). Similar maximal inhibitions were caused by each agent (55-58%). Inhibitory effect of BRL 38227 was reduced in potency (IC50 = 5.5 µM), but not magnitude, in the presence of glibenclamide (0.5 µM). [1][2]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2014-09-01)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02217852 Not yet recruiting Hypertension West China Hospital August 2014 Phase 4
NCT00892892 Completed Chronic Kidney Disease|Hypertension University of Erlangen-Nürnberg Medical School November 2009 Phase 4
NCT01074281 Completed Hypertension Merck KGaA June 2008 --
NCT00751829 Completed Isolated Systolic Hypertension Daiichi Sankyo Inc.|Daiichi Sankyo Europe, GmbH July 2003 Phase 3
NCT02088450 Terminated Isolated Systolic Hypertension Katholieke Universiteit Leuven February 1990 Phase 2

Chemical Information

Download Nitrendipine SDF
Molecular Weight (MW) 360.3699
Formula

C18H20N2O6

CAS No. 39562-70-4
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 72 mg/mL (199 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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