Catalog No.S2491

Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.

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Nitrendipine Chemical Structure

Nitrendipine Chemical Structure
Molecular Weight: 360.3699

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Nitrendipine is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Description Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.
Targets Calcium channel [1] Calcium channel [1]
IC50 95 nM
In vitro
In vivo

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


Clinical Trial Information( data from, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02217852 Not yet recruiting Hypertension West China Hospital August 2014 Phase 4
NCT00892892 Withdrawn Chronic Kidney Disease|Hypertension University of Erlangen-Nürnberg Medical School November 2009 Phase 4
NCT01074281 Completed Hypertension Merck KGaA June 2008 --
NCT00751829 Completed Isolated Systolic Hypertension Daiichi Sankyo Europe, GmbH|Daiichi Sankyo Inc. July 2003 Phase 3
NCT02088450 Terminated Isolated Systolic Hypertension Katholieke Universiteit Leuven February 1990 Phase 2

Chemical Information

Download Nitrendipine SDF
Molecular Weight (MW) 360.3699


CAS No. 39562-70-4
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms Bayotensin
Solubility (25°C) * In vitro DMSO 72 mg/mL (199.79 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1,​4-​dihydro-​2,​6-​dimethyl-​4-​(3-​nitrophenyl)​-3,​5-​pyridinedicarboxylic acid 3-​ethyl 5-​methyl ester

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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