Nitrendipine

Catalog No.S2491

Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.

Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Nitrendipine Chemical Structure

Nitrendipine Chemical Structure
Molecular Weight: 360.3699

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Nitrendipine is available in the following compound libraries:

Product Information

  • Compare Calcium Channel Chemicals
    Compare Calcium Channel Products
  • Research Area

Product Description

Biological Activity

Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is an investigational dihydropyridine calcium-channel antagonist for the treatment of hypertension. Nitrendipine and BRL 38227 cause concentration-related inhibitions of the inositol phosphate response to histamine (100 µM). Similar maximal inhibitions were caused by each agent (55-58%). Inhibitory effect of BRL 38227 was reduced in potency (IC50 = 5.5 µM), but not magnitude, in the presence of glibenclamide (0.5 µM). [1][2]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2015-05-23)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02217852 Not yet recruiting Hypertension West China Hospital August 2014 Phase 4
NCT02217852 Not yet recruiting Hypertension West China Hospital August 2014 Phase 4
NCT00892892 Withdrawn Chronic Kidney Disease|Hypertension University of Erlangen-Nürnberg Medical School November 2009 Phase 4
NCT00892892 Withdrawn Chronic Kidney Disease|Hypertension University of Erlangen-Nürnberg Medical School November 2009 Phase 4
NCT01074281 Completed Hypertension Merck KGaA June 2008 --

view more

Chemical Information

Download Nitrendipine SDF
Molecular Weight (MW) 360.3699
Formula

C18H20N2O6

CAS No. 39562-70-4
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms Bayotensin
Solubility (25°C) * In vitro DMSO 72 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1,​4-​dihydro-​2,​6-​dimethyl-​4-​(3-​nitrophenyl)​-3,​5-​pyridinedicarboxylic acid 3-​ethyl 5-​methyl ester

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Calcium Channel Products

  • Digoxin

    Digoxin is a sodium-potassium pump inhibitor, used in the treatment of atrial fibrillation and heart failure.

  • Elacridar (GF120918)

    Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

  • Verdinexor (KPT-335)

    Verdinexor (KPT-335) is an orally bioavailable, selective XPO1/CRM1 inhibitor.

  • Verapamil HCl

    Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.

  • Tetrandrine

    Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.

  • Cilnidipine

    Cilnidipine is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.

  • Ranolazine 2HCl

    Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.

  • Nimodipine

    Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.

  • Ranolazine

    Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.

  • Felodipine

    Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.

    Features:Unlike many Ca2+ channel blockers, Felodipine does not have cardiac side effects due to high selectivity for vascular smooth muscle vs. myocardial tissue.

Recently Viewed Items

Tags: buy Nitrendipine | Nitrendipine ic50 | Nitrendipine price | Nitrendipine cost | Nitrendipine solubility dmso | Nitrendipine purchase | Nitrendipine manufacturer | Nitrendipine research buy | Nitrendipine order | Nitrendipine mouse | Nitrendipine chemical structure | Nitrendipine mw | Nitrendipine molecular weight | Nitrendipine datasheet | Nitrendipine supplier | Nitrendipine in vitro | Nitrendipine cell line | Nitrendipine concentration | Nitrendipine nmr
Contact Us