Nitazoxanide

Catalog No.S1627

Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)

Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 270 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Nitazoxanide Chemical Structure

Nitazoxanide Chemical Structure
Molecular Weight: 307.28

Validation & Quality Control

MSDS

Related Compound Libraries

Nitazoxanide is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Description Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)
Targets PFOR [2]
In vitro Nitazoxanide reduces parasite growth in cell culture by more than 90% with little evidence of drug-associated cytotoxicity. [1] Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. [2] Nitazoxanide and its metabolite tizoxanide are more active in vitro than metronidazole against G. intestinalis, E. histolytica and T. vaginalis. [3] Nitazoxanide exhibits potent inhibition of both HBV and HCV replication. Nitazoxanide potentiates the effect of subsequent treatment with Nitazoxanide plus IFN, but not Nitazoxanide plus 2'CmeC, in HCV replicon-containing cells. Nitazoxanide induces reductions in several HBV proteins (HBsAg, HBeAg, HBcAg) produced by 2.2.15 cells, but does not affect HBV RNA transcription. [4] Nitazoxanide exhibits IC50, and IC90 values of 0.017 and 0.776 mg/mL respectively, against E. histolytica, 0.004 and 0.067 mg/mL against G. intestinalis, and 0.034 and 2.046 mg/mL against T. vaginalis. Nitazoxanide is more toxic than metronidazole and albendazole against E. histolytica. [5]
In vivo Nitazoxanide is partially effective at reducing the parasite burden in a gnotobiotic piglet diarrhea model when given orally for 11 days at 250 mg/kg/day but not at 125 mg/kg/day. Nitazoxanide induces a drug-related diarrhea in piglets that might have influenced its therapeutic efficacy. [1]
Features

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Theodos CM, et al. Antimicrob Agents Chemother, 1998, 42(8), 1959-1965.

[2] Fox LM, et al. Clin Infect Dis, 2005, 40(8), 1173-1180.

view more

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2015-03-23)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02334163 Recruiting Hepatic Encephalopathy Ain Shams University|Al-Azhar University December 2014 Phase 2
NCT02165813 Recruiting Gastroenteritis Telethon Kids Institute|The University of Western Austral  ...more Telethon Kids Institute|The University of Western Australia|Menzies School of Health Research November 2014 Phase 2
NCT02057757 Recruiting Severe Acute Respiratory Illness National Institute of Allergy and Infectious Diseases (NI  ...more National Institute of Allergy and Infectious Diseases (NIAID)|Mexican Emerging Infectious Diseases Clinical Research Network (La Red) February 2014 Phase 2
NCT01610245 Completed Influenza Romark Laboratories L.C. March 2013 Phase 3
NCT01559636 Withdrawn Poliomyelitis Seroconversion|Diarrhea Centers for Disease Control and Prevention|Tribhuvan Univ  ...more Centers for Disease Control and Prevention|Tribhuvan University, Nepal May 2012 Phase 3

view more

Chemical Information

Download Nitazoxanide SDF
Molecular Weight (MW) 307.28
Formula

C12H9N3O5S

CAS No. 55981-09-4
Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms
Solubility (25°C) * In vitro DMSO 62 mg/mL (201.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 2-​(acetyloxy)​-​N-​(5-​nitro-​2-​thiazolyl)​-benzamide

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Others Products

  • OTSSP167

    OTSSP167 is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor with IC50 of 0.41 nM.

  • Puromycin 2HCl

    Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

  • BAPTA-AM

    BAPTA-AM is a selective, membrane-permeable calcium chelator.

  • CX-4945 (Silmitasertib)

    CX-4945 (Silmitasertib) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1/2.

    Features:First clinical inhibitor of CK2.

  • Cyclosporin A

    Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.

  • Ganciclovir

    Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM.

  • Calcitriol

    Calcitriol is the hormonally active form of vitamin D.

  • 4μ8C

    4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.

  • Cyclophosphamide Monohydrate

    Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.

  • Ezetimibe

    Ezetimibe is a potent, selective, cholesterol absorption inhibitor, used to lower cholesterol.

Recently Viewed Items

Tags: buy Nitazoxanide | Nitazoxanide ic50 | Nitazoxanide price | Nitazoxanide cost | Nitazoxanide solubility dmso | Nitazoxanide purchase | Nitazoxanide manufacturer | Nitazoxanide research buy | Nitazoxanide order | Nitazoxanide mouse | Nitazoxanide chemical structure | Nitazoxanide mw | Nitazoxanide molecular weight | Nitazoxanide datasheet | Nitazoxanide supplier | Nitazoxanide in vitro | Nitazoxanide cell line | Nitazoxanide concentration | Nitazoxanide nmr
Contact Us