Molecular Weight(MW): 307.28
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)
Purity & Quality Control
|Description||Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)|
Nitazoxanide reduces parasite growth in cell culture by more than 90% with little evidence of drug-associated cytotoxicity.  Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths.  Nitazoxanide and its metabolite tizoxanide are more active in vitro than metronidazole against G. intestinalis, E. histolytica and T. vaginalis.  Nitazoxanide exhibits potent inhibition of both HBV and HCV replication. Nitazoxanide potentiates the effect of subsequent treatment with Nitazoxanide plus IFN, but not Nitazoxanide plus 2'CmeC, in HCV replicon-containing cells. Nitazoxanide induces reductions in several HBV proteins (HBsAg, HBeAg, HBcAg) produced by 2.2.15 cells, but does not affect HBV RNA transcription.  Nitazoxanide exhibits IC50, and IC90 values of 0.017 and 0.776 mg/mL respectively, against E. histolytica, 0.004 and 0.067 mg/mL against G. intestinalis, and 0.034 and 2.046 mg/mL against T. vaginalis. Nitazoxanide is more toxic than metronidazole and albendazole against E. histolytica. 
|In vivo||Nitazoxanide is partially effective at reducing the parasite burden in a gnotobiotic piglet diarrhea model when given orally for 11 days at 250 mg/kg/day but not at 125 mg/kg/day. Nitazoxanide induces a drug-related diarrhea in piglets that might have influenced its therapeutic efficacy. |
-  Theodos CM, et al. Antimicrob Agents Chemother, 1998, 42(8), 1959-1965.
-  Fox LM, et al. Clin Infect Dis, 2005, 40(8), 1173-1180.
-  Adagu IS, et al. J Antimicrob Chemother, 2002, 49(1), 103-111.
|In vitro||DMSO||62 mg/mL (201.77 mM)|
* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02452905||Not yet recruiting||Bronchiolitis||Telethon Kids Institute||December 2016||Phase 2|
|NCT02684240||Not yet recruiting||Tuberculosis||Weill Medical College of Cornell University||February 2016||Phase 2|
|NCT02612922||Recruiting||Influenza||Romark Laboratories L.C.||December 2015||Phase 3|
|NCT02464124||Recruiting||Encephalopathy, Hepatic||Sherief Abd-Elsalam|Tanta University||May 2015||Phase 2|Phase 3|
|NCT02422706||Recruiting||Helicobacter-associated Gastritis||Sherief Abd-Elsalam|Tanta University||January 2015||Phase 3|
|NCT02621359||Recruiting||Dyspepsia||Tanta University||January 2015||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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