Catalog No.S1627

Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)

Price Stock Quantity  
USD 130 In stock
USD 97 In stock
USD 270 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Nitazoxanide Chemical Structure

Nitazoxanide Chemical Structure
Molecular Weight: 307.28

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Nitazoxanide is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Description Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)
Targets PFOR [2]
In vitro Nitazoxanide reduces parasite growth in cell culture by more than 90% with little evidence of drug-associated cytotoxicity. [1] Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. [2] Nitazoxanide and its metabolite tizoxanide are more active in vitro than metronidazole against G. intestinalis, E. histolytica and T. vaginalis. [3] Nitazoxanide exhibits potent inhibition of both HBV and HCV replication. Nitazoxanide potentiates the effect of subsequent treatment with Nitazoxanide plus IFN, but not Nitazoxanide plus 2'CmeC, in HCV replicon-containing cells. Nitazoxanide induces reductions in several HBV proteins (HBsAg, HBeAg, HBcAg) produced by 2.2.15 cells, but does not affect HBV RNA transcription. [4] Nitazoxanide exhibits IC50, and IC90 values of 0.017 and 0.776 mg/mL respectively, against E. histolytica, 0.004 and 0.067 mg/mL against G. intestinalis, and 0.034 and 2.046 mg/mL against T. vaginalis. Nitazoxanide is more toxic than metronidazole and albendazole against E. histolytica. [5]
In vivo Nitazoxanide is partially effective at reducing the parasite burden in a gnotobiotic piglet diarrhea model when given orally for 11 days at 250 mg/kg/day but not at 125 mg/kg/day. Nitazoxanide induces a drug-related diarrhea in piglets that might have influenced its therapeutic efficacy. [1]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Theodos CM, et al. Antimicrob Agents Chemother, 1998, 42(8), 1959-1965.

[2] Fox LM, et al. Clin Infect Dis, 2005, 40(8), 1173-1180.

view more

Clinical Trial Information( data from, updated on 2015-11-14)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02452905 Not yet recruiting Bronchiolitis Telethon Kids Institute July 2015 Phase 2
NCT02464124 Recruiting Encephalopathy, Hepatic Sherief Abd-Elsalam|Tanta University May 2015 Phase 2|Phase 3
NCT02422706 Recruiting Helicobacter-associated Gastritis Sherief Abd-Elsalam|Tanta University January 2015 Phase 3
NCT02334163 Recruiting Hepatic Encephalopathy Ain Shams University|Al-Azhar University December 2014 Phase 2
NCT02165813 Recruiting Gastroenteritis Telethon Kids Institute|The University of Western Austral  ...more Telethon Kids Institute|The University of Western Australia|Menzies School of Health Research November 2014 Phase 2

view more

Chemical Information

Download Nitazoxanide SDF
Molecular Weight (MW) 307.28


CAS No. 55981-09-4
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 62 mg/mL (201.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 2-​(acetyloxy)​-​N-​(5-​nitro-​2-​thiazolyl)​-benzamide

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Others Products

  • CB-839

    CB-839 is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. Phase 1.

  • GKT137831

    GKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Phase 2.

  • LB-100

    LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.

  • Puromycin 2HCl

    Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

  • Cyclosporin A

    Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

  • Cyclophosphamide Monohydrate

    Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.

  • Calcitriol

    Calcitriol is the hormonally active form of vitamin D.

  • Ganciclovir

    Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.

  • Ribavirin

    Ribavirin, a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.

  • N6-methyladenosine (m6A)

    N6-methyladenosine (m6A) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.

Recently Viewed Items

Tags: buy Nitazoxanide | Nitazoxanide ic50 | Nitazoxanide price | Nitazoxanide cost | Nitazoxanide solubility dmso | Nitazoxanide purchase | Nitazoxanide manufacturer | Nitazoxanide research buy | Nitazoxanide order | Nitazoxanide mouse | Nitazoxanide chemical structure | Nitazoxanide mw | Nitazoxanide molecular weight | Nitazoxanide datasheet | Nitazoxanide supplier | Nitazoxanide in vitro | Nitazoxanide cell line | Nitazoxanide concentration | Nitazoxanide nmr
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us