Nitazoxanide

Catalog No.S1627

Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)

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In DMSO USD 130 In stock
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Nitazoxanide Chemical Structure

Nitazoxanide Chemical Structure
Molecular Weight: 307.28

Validation & Quality Control

MSDS

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Product Description

Biological Activity

Nitazoxanide(Alinia, Annita) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM) The anti- protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. [1] It has also been shown to have activity against influenza A virus. Nitazoxanide and tizoxanide inhibited virus replication of all canine influenza virus with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively. [2]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2014-08-23)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02165813 Not yet recruiting Gastroenteritis Telethon Kids Institute|The University of Western Australia|Menzies School of Health Research July 2014 Phase 2
NCT02057757 Recruiting Severe Acute Respiratory Illness National Institute of Allergy and Infectious Diseases (NIAID)|Mexican Emerging Infectious Diseases Clinical Research Network (La Red) February 2014 Phase 2
NCT01610245 Recruiting Influenza Romark Laboratories L.C. March 2013 Phase 3
NCT01559636 Withdrawn Poliomyelitis Seroconversion|Diarrhea Centers for Disease Control and Prevention|Tribhuvan University, Nepal May 2012 Phase 3
NCT01529073 Active, not recruiting HCV Coinfection|HIV Infection Andaluz Health Service|Juan Macías|Spanish National Health System February 2012 Phase 2

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Chemical Information

Download Nitazoxanide SDF
Molecular Weight (MW) 307.28
Formula

C12H9N3O5S

CAS No. 55981-09-4
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 62 mg/mL (201 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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