Nitazoxanide

Catalog No.S1627

Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)

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In DMSO USD 130 In stock
USD 97 In stock
USD 270 In stock
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Nitazoxanide Chemical Structure

Nitazoxanide Chemical Structure
Molecular Weight: 307.28

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Product Description

Biological Activity

Nitazoxanide(Alinia, Annita) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM) The anti- protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. [1] It has also been shown to have activity against influenza A virus. Nitazoxanide and tizoxanide inhibited virus replication of all canine influenza virus with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively. [2]

Chemical Information

Download Nitazoxanide SDF
Molecular Weight (MW) 307.28
Formula

C12H9N3O5S

CAS No. 55981-09-4
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Syonnyms Daxon, Dexidex, Kidonax, Pacovanton, Paramix, Nitax, Zox, Nitazox, Toza
Solubility (25°C) * In vitro DMSO 62 mg/mL (201 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name

Preparing Stock Solutions

Stock Solution (1ml DMSO) 1mM 10mM 20mM 30mM
Mass(mg) 0.30728 3.0728 6.1456 9.2184

Research Area

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