Nimodipine

Catalog No.S1747 Synonyms: BAY E 9736

Nimodipine Chemical Structure

Molecular Weight(MW): 418.44

Nimodipine is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
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1 Customer Review

  • Assessment of the role of Ca2+ channels during RSV replication. HEp-2 cells were infected with RSV strain long at an MOI of 0.1, and treated with calcium channel blockers nifedipine, nimodipine, and tetrandrine (A), at indicated concentrations. Supernatants were collected at 48 h postinfection and viral titers were determined by immunoplaque assay. Grey bars represent cytotoxicity of the compounds. The data presented were obtained from two independent experiments. Error bars represent the standard deviations from two independent experiments. NS, no differences at a significance level of 0.05.

    Antiviral Res, 2016, 132:38-45.. Nimodipine purchased from Selleck.

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Biological Activity

Description Nimodipine is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.
Targets
Calcium channel [1]
In vitro

Nimodipine decreases both the peak amplitude and the integrated area of the AHP in an age- and concentration-dependent manner. Nimodipine (100 nM) significantly reduces the AHP in aging CA1 neurons. Nimodipine increases excitability in an age- and concentration-dependent manner by decreasing spike frequency accommodation (increasing the number of action potentials during prolonged depolarizing current injection). Nimodipine decreases accommodation only at higher concentrations in young CA1 neurons. [1] Nimodipine decreases the plateau phase of the calcium AP at concentrations as low as 100 nM in aging neurons and 10 mM in young rat neurons. [2]

In vivo Nimodipine results in reversible, dose-related suppression of the compound action potential of the auditory nerve (CAP; N1-P1), a prolongation of N1 latency at suprathreshold levels, an elevated CAP threshold, a decrease in N1 latency at a constant amplitude measured at CAP threshold, a reduction in cochlear microphonics (CM), and a reduction of the negative summating potential (SP) to a point where it becomes positive. [3] Nimodipine (10 mg/kg, SC), an L-type dihydropyridine Ca2+ channel antagonist, appears to completely block the establishment of conditioning of cocaine's effects, but only partially blocks sensitization to cocaine. [4] Nimodipine (5-20 mg/kg, SC) inhibits in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response. [5]

Protocol

Solubility (25°C)

In vitro DMSO 84 mg/mL (200.74 mM)
Ethanol 84 mg/mL (200.74 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 418.44
Formula

C21H26N2O7

CAS No. 66085-59-4
Storage powder
Synonyms BAY E 9736

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02991157 Active, not recruiting Subarachnoid Hemorrhage, Aneurysmal National Institute of Mental Health and Neuro Sciences, India December 2016 --
NCT02893826 Recruiting Subarachnoid Hemorrhage, Aneurysmal Edge Therapeutics Inc September 2016 Phase 1
NCT02790632 Recruiting Subarachnoid Hemorrhage, Aneurysmal Edge Therapeutics Inc July 2016 Phase 3
NCT02537080 Terminated Mild Cognitive Impairment University Hospital Hradec Kralove September 2015 --
NCT02165644 Withdrawn Acute Cerebrovascular Accident|Vasospasm University of Florida September 2015 Phase 2
NCT02248233 Unknown status Cerebral Infarction Fengtian Hospital October 2014 Phase 4

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Calcium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID