Sodium Monensin (NSC 343257)

Catalog No.S2324 Batch:S232401

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Technical Data

Formula

C36H61NaO11

Molecular Weight 692.85 CAS No. 22373-78-0
Solubility (25°C)* In vitro Ethanol 100 mg/mL (144.33 mM)
DMSO Insoluble
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Sodium Monensin (NSC 343257), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.
In vitro Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. [1] Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. [2] The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes. [3]
In vivo LD50: Mice 335mg/kg (i.g.) [4]; Rats 36.5mg/kg (i.g.); Chickens 185mg/kg (i.g.). [5]

Protocol (from reference)

Customer Product Validation

Data from [Tuberc Respir Dis, 2013, 75(1), 9-17]

Selleck's Sodium Monensin (NSC 343257) has been cited by 14 publications

Inhibition of Wnt/β-catenin signaling by monensin in cervical cancer [ Korean J Physiol Pharmacol, 2024, 28(1):21-30] PubMed: 38154961
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer [ Signal Transduct Target Ther, 2022, 7(1):35] PubMed: 35115484
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly [ Nat Commun, 2022, 13(1):4848] PubMed: 35977928
Crosstalk between IL-15Rα+ tumor-associated macrophages and breast cancer cells reduces CD8+ T cell recruitment [ Cancer Commun (Lond), 2022, 10.1002/cac2.12311] PubMed: 35615815
GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair [ Immunity, 2021, 54(6):1123-1136.e8] PubMed: 34107271
Monensin suppresses cell proliferation and invasion in ovarian cancer by enhancing MEK1 SUMOylation [ Exp Ther Med, 2021, 22(6):1390] PubMed: 34650638
Autophagy-based-unconventional-secretion-of-HMGB1-by-keratinocytes-plays-a-pivotal-role-in-psoriatic-skin-inflammation. [ Autophagy, 2020, 16:1-24] PubMed: 32019420
FOXM1D Potentiates PKM2-mediated tumor glycolysis and angiogenesis [ Mol Oncol, 2020, 10.1002/1878-0261.12879] PubMed: 33314660
The Regulatory Effect of the Kinase Inhibitor PD98059 on Autophagic Flux During Trypsinogen Activation in Pancreatic Acinar Cells. [ Pancreas, 2020, 49(2):290-299] PubMed: 32011537
Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19 [ bioRxiv, 2020, 2020/9/20.4.7.30734] PubMed: 32511305

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.