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Imatinib Mesylate
(SynonymsGleevec, Glivec, CGP-57148B, STI-571
)Add to Favor
M.Wt: 589.71
Formula: C29H31N7O.CH4SO3
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 220127-57-1
Price and Availability of Imatinib Mesylate:
Applications & Customer's Feedback of Imatinib Mesylate:
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Imatinib Mesylate was supplied by Selleck.Data was provided by Dr Thomas Kruwel of Fraunhofer-Institute for Toxicology and Experimental Medicine.
Cell Viability assay results. A2C12, BetaD5, GammaA3, GammaD12, A549, CaCo2, HepG2 cell lines were treated with imatinib mesylate for 24h and 96h.
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Imatinib was purchased from Selleck.Data from FASEB J 2011.June; 25:Ahead of print.
Ba/F3-p210T315I cells were treated with indicated concentrations of imatinib with or without PDMP for 24 h. Apoptosis was determined as in A. Data are shown as percentage of sub-G1 for apoptosis in triplicate cultures. *P 0.05.
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Imatinib was purchased from Selleck.Data was provided by Dr Helen Rizos from the university of Sydney.
A. Viability curve for the c-Kit mutant MelMS melanoma cell line treated with increasing concentrations of imatinib for 72h (relative to DMSO-treated controls; mean ± sd; n=3) B. MelMS melanoma cells were treated with 50nM imatinib for 24h. The effects on c-Kit, ERK and AKT activation were determined by immunoblotting.
Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers. ------ Ryohei Katayama,Tahsin M. Khan et al. PNAS 2011.May;108:7535-40.
Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. ------ Huang WC,Tsai CC,et al. FASEB J. 2011 Oct;25:3661-73.
Biological Activity of Imatinib Mesylate:
Imatinib Mesylate is a multitargeted c-kit, PDGF-R and c-ABL inhibitor with IC50 of 3.9 and 2.9 μM for the inhibition of T-cell proliferation stimulated by DCs and PHA, respectively. A reversible tyrosine kinase inhibitor effective in treatment of chronic myelogenous leukemia1 (CML), gastrointestinal stromal tumors, eosinophilic disorders, and systemic mast cell disease. Imatinib Mesylate binds preferentially to ATP–binding sites of the c-kit protooncogene product, platelet-derived growth factor receptor (PDGF-R), and Abelson kinase (c-ABL) impeding the ensuing signal transduction. [1][2][3]
References on Imatinib Mesylate:
[1] Heinrich MC et al. Blood. 2000 Aug 1;96(3):925-32.
[2] Dietz AB et al. Blood. 2004 Aug 15;104(4):1094-9.
[3] Dietz AB et al. J Hematother Stem Cell Res. 2000 Feb;9(1):95-101.
MSDS
Batch S102602: H-NMR HPLC COA
Batch S102603: H-NMR COA
Batch S102604: H-NMR HPLC COA
Batch S102605: H-NMR COA
Batch S102606: H-NMR HPLC COA
VEGFR-PDGFRc-KitWe give free samples and rewards to people who would like to provide us useful scientific data(western blot, etc.) See Details
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