FTY720(Fingolimod)

M.Wt: 343.9
Formula: C₁₉H₃₃NO₂.HCl
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 162359-56-0

Price and Availability of FTY720(Fingolimod):

Applications & Customer's Feedback of FTY720(Fingolimod):

Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model.  ------ Radi ZA,Heuvelman DM,et al. Dig Dis Sci. 2011 Aug;56:2283-91.

Biological Activity of FTY720(Fingolimod):

FTY720(Fingolimod) is a potent sphingosine-1-phosphate (S1P) receptors agonist with IC50 of 0.137, 10.98 nM for (S)- and (R)- FTY720-phosphate, respectively and reverses the effects of BCR-ABL kinase. It is a novel immunomodulating agent and can sequester lymphocytes in lymph nodes, preventing them from moving to the central nervous system for auto-immune responses in multiple sclerosis and was originally proposed as a anti-rejection medication indicated post-transplantation. ^[1] It can be phosphorylated by sphingosine kinase and prevents disease in a mouse model of many leukemias caused by BCR-ABL. It does not directly target the BCR-ABL kinase, but instead activates phosphatase 2A (PP2A) which is a tumor suppressor that is inactivated by BCR-ABL. ^[2] FTY720(Fingolimod) also mediated antitumor effects in hepatocellular carcinoma (HCC) cells by activating PKC . The three HCC cell lines examined, Hep3B, Huh7, and PLC5, exhibited differential susceptibility to FTY720-mediated suppression of cell viability, with IC50 values of 4.5, 6.3, and 11 μM, respectively. ^[3]

References on FTY720(Fingolimod):

[1] http://en.wikipedia.org/wiki/Fingolimod

[2] Neviani P et al. J Clin Invest. 2007 Sep;117(9):2408-21.

[3] Hung JH et al. Cancer Res. 2008 Feb 15;68(4):1204-12.

MSDS
Batch S500201: H-NMR  HPLC  COA
Batch S500202: H-NMR  HPLC  COA

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