S1P Receptor

  • Compare S1P Receptor Products
  • Research Area

S1P Receptor Inhibitors | Antagonists | Modulators (6)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S5002 Fingolimod (FTY720) HCl Fingolimod (FTY720) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells.
  • Blood, 2012, 119(9):2176-7
  • Ann Neurol, 2014, 76(3):325-37
  • Proc Natl Acad Sci USA, 2014, 111(31):11515-20
S7176 SKI II SKI II is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.
S7177 PF-543 PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform.
S7179 BAF312 (Siponimod) BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.
S7174 ABC294640 ABC294640 is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.
S7952 Ozanimod (RPC1063) Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.

Hover Mouse over '+' to display IC50

Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S5002 Fingolimod (FTY720) HCl 69 mg/mL 69 mg/mL 69 mg/mL
S7176 SKI II <1 mg/mL 61 mg/mL 61 mg/mL
S7177 PF-543 <1 mg/mL 93 mg/mL 93 mg/mL
S7179 BAF312 (Siponimod) <1 mg/mL 100 mg/mL 44 mg/mL
S7174 ABC294640 <1 mg/mL 76 mg/mL 28 mg/mL
S7952 Ozanimod (RPC1063) <1 mg/mL 81 mg/mL 10 mg/mL
Contact Us