Catalog No.S1905 Synonyms: UK-48340
Molecular Weight(MW): 408.88
Amlodipine is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
Purity & Quality Control
Choose Selective Calcium Channel Inhibitors
|Description||Amlodipine is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.|
Amlodipine causes a dose-dependent increase in nitrite production. Amlodipine also increases nitrite production in large coronary arteries and in aorta.  Amlodipine is attributed to distinct membrane physico-chemical interactions. Amlodipine contributes to distinct membrane biophysical interactions that lead to potent lipid antioxidant effects, independent of calcium channel modulation.  Amlodipine increases plaque smooth muscle cell content (P<0.05), whereas atenolol decreases plaque inflammation.  Amlodipine attenuates intracellular neuronal Ca2+ increases elicited by KCl depolarization but does not affect Ca2+ changes triggered by N-methyl-D-aspartate receptor activation. Amlodipine also inhibits free radical-induced damage to lipid constituents of the membrane in a dose-dependent manner, independent of Ca2+ channel modulation. 
|In vivo||Amlodipine results in regression of cardiovascular hypertrophy and amelioration of endothelial dysfunction in spontaneously hypertensive rats.  Amlodipine significantly reduces aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels in Ang II-infused rats. Amlodipine has antihypertensive and antioxidant activity in vivo, which effectively inhibits many of the oxidative stress-dependent mechanisms involved in Ang II-mediated cardiovascular injury. |
-  Zhang X, et al. Circulation, 1998, 97(6), 576-580.
-  Mason RP, et al. J Mol Cell Cardiol, 1999, 31(1), 275-281.
-  Nussberger J, et al. Hypertension, 2008, 51(5), 1306-1311.
|In vitro||DMSO||82 mg/mL (200.54 mM)|
|Ethanol||82 mg/mL (200.54 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02995720||Active, not recruiting||Hypertension, Hyperlipidemia||Boryung Pharmaceutical Co., Ltd||August 26, 2016||Phase 1|
|NCT02699645||Not yet recruiting||Acute Intracerebral Haemorrhage (ICH)||The George Institute||May 2017||Phase 4|
|NCT02969265||Not yet recruiting||Hypertension||Takeda||May 2017||Phase 3|
|NCT02940548||Recruiting||Hypertension||Jing Liu|Bayer|Peking University Peoples Hospital||December 2016||Phase 4|
|NCT02988362||Not yet recruiting||Hypertension||HanAll BioPharma Co., Ltd.||December 2016||Phase 1|
|NCT02973035||Recruiting||Hypertension||Asan Medical Center|Yuhan Corporation||December 2016||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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