Research Area
Product Type
United States ( Change Country )
AZD8330 Chemical Structure
AZD6244 (Selumetinib)
AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM.
CI-1040 (PD184352)
CI-1040 (PD184352) is a MEK 1/2 inhibitor. Ki of 300nM
PD0325901
PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
RDEA119 (BAY 869766)
MEK inhibitor with EC50 of 73 nM.
U0126-EtOH
U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
PD98059
PD 98059 is an inhibitor of MEK1 and MEK2 with IC50 values of 4 μM and 50 μM respectively.
AS703026
AS703026 is a highly selective and potent noncompetitive inhibitor of MEK1/2 with an IC50 range of 5-11 nM.
BIX 02188
BIX02188 is a MEK5-selective inhibitor with an IC50 of 0.8 ± 1.0 μM.
BIX 02189
BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM.
PD318088
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor.
Biological Activity
AZD8330 is an orally active, selective MEK inhibitor with an IC50 of 7 nM. AZD8330 has potential antineoplastic activity. AZD8330 specifically inhibits mitogen- activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. Constitutive activation of this pathway has been implicated in many cancers. [1][2]
References on AZD8330
- [2] Journal of Hematology & Oncology 2010;3:8
Product Information
| Molecular Weight (WM): | 461.23 |
|---|---|
| Formula: | C16H17FIN3O4 |
| CAS No.: | 869357-68-6 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥92mg/mL |
| Water <1mg/mL | |
| Ethanol ≥92mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
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After starved in serum-free medium for 24h, T47D cells incubated with the indicated concentrations of AZD8330 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
After starved in serum-free medium for 24h, T47D cells incubated with the indicated concentrations of AZD8330 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
Data independently produced by Dr. Zhang of Tianjin Medical University AZD8330 purchased from Selleck
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After starved in serum-free medium for 24h, T47D cells incubated with the indicated concentrations of AZD8330 for 3h,followed by 20-minute stimolation of 100ng/ml EGF. |
Data independently produced by Dr. Zhang of Tianjin Medical University
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