(-)-Epigallocatechin Gallate

Catalog No.S2250 Synonyms: EGCG

(-)-Epigallocatechin Gallate Chemical Structure

Molecular Weight(MW): 458.37

(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.

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In DMSO USD 160 In stock
USD 50 In stock
USD 70 In stock
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4 Customer Reviews

  • (a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.

    Sci Rep, 2016, 6:27268.. (-)-Epigallocatechin Gallate purchased from Selleck.

    EGCG treatment increases cTnI protein levels in ageing hearts. (A) Western blotting analysis using cTnI and cTnT antibodies. b-Actin was used as protein loading control. (B) A summary of Western blotting results of cTnI. Values are expressed as mean S.D. from four separate experiments. Statistical significance was determined by ANOVA followed by least significant difference (LSD) tests. *P < 0.05 as compared with the 18M + EGCG and 3M groups. EGCG: epigallocatechin-3-gallate

    J Cell Mol Med, 2017. (-)-Epigallocatechin Gallate purchased from Selleck.

  • PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

    PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

Purity & Quality Control

Choose Selective Telomerase Inhibitors

Biological Activity

Description (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
In vitro

(-)-Epigallocatechin gallate functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. (-)-Epigallocatechin gallate shows multiple anticancer effects, such as anti-proliferation, anti-angiogenesis, transformation prevention of various cancer cells, cancer cell cycle arrest and inhibition of tumor metastasis. (-)-Epigallocatechin gallate exerts multi-anticancer effects through regulating several cancer-related cell signal pathways (regulated the function or the expression of key signal proteins, such as nuclear factor-κB, MAPKs and activator protein-1, EGFR, IGF, COX-2 signaling pathway, and so on.), effecting methylation of cancer genes and combination of ligand with membrane receptors. [1] (-)-Epigallocatechin gallate also shows an immunomodulating effects. Several types of immune cells in both the innate and adaptive immune systems are known to be affected in varying degrees by (-)-Epigallocatechin gallate. Among them, the dramatic effect on T cell functions has been repeatedly demonstrated, including T cell activation, proliferation, differentiation, and production of cytokines. Studies using animal models of autoimmune diseases have reported disease improvement in animals treated with green tea/EGCG. [2] (-)-Epigallocatechin gallate displays anti-infective properties. Antiviral activities of (-)-Epigallocatechin gallate with different modes of action have been demonstrated on diverse families of viruses, such as Retroviridae, Orthomyxoviridae and Flaviviridae and include important human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SH-SY5Y cells NWKxTWNmTnWwY4Tpc44h[XO|YYm= NEnMXnZP\XW{b4Dyc5Rm[3Srb36gZYdicW6|dDDi[ZRiNWGveXzvbYQheGWydHnk[UAyNTR{LXnu[JVk\WRidH;4bYNqfHliaX6gbJVu[W5iU1itV3k2YSClZXzsd{Bie3Onc4Pl[EBieyCuYXP0ZZRmKGSnaInkdo9o\W6jc3WgdoVt\WG|ZTygSWM2OD1yLkCzPVg4KM7:TR?= MnHsNVkyOzh6NUm=
human MDA435/LCC6MDR cells M1\u[WZ2dmO2aX;uJIF{e2G7 M1j2[|ExKM7:TR?= NV6zPJJIPSCmYYnz NIjJWIJOd2S3bHH0bY9vKG:oIGCt[5AhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDoeY1idiCPRFG0N|UwVEOFNl3EVkBk\WyuczDhd5Nme3OnZDDhd{Bz\X[ncoPpZoxmKG:oIIDhZ4xqfGG6ZXygdoV{cXO2YX7j[UBu\WG|dYLl[EBieyCLQ{WwJIZweiCyYXPsbZRigGWuIHH0JFExKHWPIHHmeIVzKDViZHH5d{BjgSCFZXzsWIl1\XJiOU[gRZF2\W:3czDhd5NigSxiSVO1NF0xNjF{Mk[g{txO MlrpNlU6QDVzOUW=
Sf9 cells NITMUG5HfW6ldHnvckBie3OjeR?= NHnZOFJKdmirYnn0bY9vKG:oIFjpd|YufGGpZ3XkJIh2dWGwIILlZ49u[mmwYX70JGRPVVRzIHX4dJJme3OnZDDpckBqdnOnY4SgV4Y6KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDEUmEhdWW2aInseJJidnOoZYLhd4Uh[WO2aY\peJkhfXOrbnegOUcu[mmxdHnufYxifGWmIES1MYJxKHWwbXX0bJlt[XSnZDDvdkBp\W2rbXX0bJlt[XSnZDDvcIlod263Y3zlc5Rq\GVic4Xid5Rz[XSnczDhcoQhYzOKXT3B[I9O\XRiYomgcIlyfWmmIIPjbY51cWyuYYTpc44h[2:3boTpcochdWW2aH;kMEBKSzVyPUCuOUDPxE1? MWqyOVQxPjl2NB?=
human U937 cells MUPGeY5kfGmxbjDhd5NigQ>? NXrzTGZrUW6qaXLpeIlwdiCxZjD0[YxwdWW{YYPlJIlvKGi3bXHuJHU6OzdiY3XscJMtKEmFNUC9NUDPxE1? MYCyNlQyOzh2NR?=
human HeLa cells M{C0WWZ2dmO2aX;uJIF{e2G7 MkjuTY5pcWKrdHnvckBw\iC2ZXzvcYVz[XOnIHnuJIh2dWGwIFjlUIEh[2WubIOgeZNqdmdiNTetRWFVKEOFRzDUR2chSUeFIFHHRUBIXFRvMzegZZMhe3Wkc4TyZZRmKGmwY4XiZZRm\CCob4KgNVUhdWmwczDwdolweiC2bzDlfJRmdnOrb36gdoVi[3Srb36g[o9tdG:5ZXSgZpkh[2:vcH;1coQhf2G|aH;1eEBjgSC|cHnuMZRmdG:vZYLpZ{Bz\XCnYYSgZY1xdGmoaXPheIlwdiCycn;0c4NwdCxiSVO1NF0yNjB6IN88US=> NX;xWpZWOjJ2MUO4OFU>
CHO cells M{HDOGN6fG:2b4jpZ:Kh[XO|YYm= MVq0PEBp NF7a[IREgXSxdH;4bYNqfHliYXfhbY5{fCCFSF:gZ4VtdHNiZYjwdoV{e2mwZzDPRXRROUJ|IHjhdIxwfHmyZTCxJIFnfGW{IES4JIhzeyCkeTDmcJVwemW|Y3XuZ4Uh[mG|ZXSgR4VtdFSrdHXyMWdtdyCjc4PhfUwhUUN3ME2zMlIh|ryP MX6yN|MzPzh5Nx?=
MDCK cells NVnGcpRYTnWwY4Tpc44h[XO|YYm= M2i1R|Qh\GG7cx?= M4nVO2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIlv\my3ZX76ZUBCKH[rcoXzJEhCN3O5aX7lM29JNzVzMUS0OU8zODB5KFixUlEqMSCRaEegbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGGodHXyJFQh\GG7czDifUByfWGwdHn0ZZRqfmViUmStVGNTNCCHREWwQVgvOyEQvF2= MmC2NlIyOTV3OUG=
human HL60 cells MofnVJJwdGmoZYLheIlwdiCjc4PhfS=> NUjZ[3V2OyCmYYnz NH23WYtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZYZ1\XJiMzDkZZl{NCCLQ{WwQVkvPCEQvF2= NFrxUlkyQDZ7M{CyNC=>
HSC-T6 cells  MWHGeY5kfGmxbjDhd5NigQ>? NGD6dII1QCCq MnriRY51cW[rYoLveIlkKGGldHn2bZR6KGGpYXnud5QhemG2IFjTR{1VPiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KEK{ZGWgbY5kd3Kyb4LheIlwdiCjc4PhfUwhUUN3ME25Mlkh|ryP NIH1dGUzOTVyNEi0PC=>
mouse 3T3-L1 cells MUDGeY5kfGmxbjDhd5NigQ>? M4rjNGlvcGmkaYTpc44hd2ZiR{\QSE1u\WSrYYTl[EBPSUSSSDDwdo9lfWO2aX;uJIlvKG2xdYPlJFNVOy2OMTDj[YxteyxiSVO1NF0zPSEQvF2= Ml:5NVg{OTN|MEi=
mouse RAW264.7 cells NUnxNpZjTnWwY4Tpc44h[XO|YYm= M2LSXlUh\GG7cx?= MlTkTY5pcWKrdHnvckBw\iCUQV7LUE1qdmS3Y3XkJI9{fGWxY3zhd5Rw\2WwZYPpd{BqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCWUlHQMZBwe2m2aY\lJI12dHSrLX71Z4xm[XSnZDDj[YxteyCjZoTldkA2KGSjeYOsJGlEPTB;MkmuPEDPxE1? NGq1PXAzOTR3NkWyNS=>
HSC-T6 cells M4XSdXBzd2yrZnXyZZRqd25iYYPzZZk> MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IILheEBJW0NvVE[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5MEBKSzVyPUK5Mlgh|ryP NEn3TowzPTN{MkS1OS=>
human A431 cells NWnvTmZ3WHKxbHnm[ZJifGmxbjDhd5NigQ>? NYraSGdKPDhiaB?= MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF2M{GgZ4VtdHNib4\ldoV5eHKnc4PpcochTXKkQjDpckB{\XK3bT3mdoVmKG2nZHn1cUBie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgW3NVNTFiYYPzZZktKEWFNUC9N|gh|ryP M3SxelI1PDV4MEC0
human MDA-MB-231 cells MYXQdo9tcW[ncnH0bY9vKGG|c3H5 M1jNWFI1KGh? MoHLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZk> MlfGNlI1PTl{MEi=
human HepG2 cells NFHFe|FHfW6ldHnvckBie3OjeR?= M3HSbVI1KGh? NV;sSXJlUW6qaXLpeIlwdiCxZjDvcIVq[yCjY3nkMYlv\HWlZXSgeJJq\2y7Y3XybYRmKG:4ZYKtZYNkfW23bHH0bY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJJJmdGG2aY\lJJRwKHWwdILlZZRm\CClb370do9t MX2yNVgzPDZ7MB?=
human HepG2 cells M1XkSGZ2dmO2aX;uJIF{e2G7 M4DtXVI1KGh? NHnTSIpCdnSrb4jp[IFvfCCjY4Tpeol1gSCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2Zib3zlbYMh[WOrZD3pcoR2[2WmIGLPV{Bo\W6ncnH0bY9vKGmwY4XiZZRm\CCob4KgNlQhcHK|IHL5JGRJS0ZvRFGgZoF{\WRiZnz1c5JqdWW2cnnjJIF{e2G7IILlcIF1cX[nIITvJJVvfHKnYYTl[EBkd262cn;s MVqyNVgzPDZ7MB?=
human Caco-2 cells M{n5WGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUTifnlUOjVizszN MljTOkBl[Xm| M{HiNmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGNi[29vMjDj[YxteyCjdDCyOUB2VSCjZoTldkA3KGSjeYO= M3HBV|E5OzJ2N{[z
mouse 3T3 cells NWTRbXFvTnWwY4Tpc44h[XO|YYm= MmTmNU0zOCEQvF2= NYf5boliOTJiaB?= M1zXemFvfGmvaXfyZZRwenliYXP0bZZqfHliYXfhbY5{fCCVd3nzd{BidGKrbn:gcY92e2ViM2SzJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGOnbHygcpVu[mW{czDheEAyKHSxIEKwJJVOKGGodHXyJFEzKGi{czDifUBjgSC|Y4LheINpNXexdX7kJIF{e2G7 MV[yNVA5ODZ2Mh?=
human MDA-MB-231 cells NVnmV4d4WHKxbHnm[ZJifGmxbjDhd5NigQ>? M{e2OVI1KGh? NFfvfIFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigQ>? MWGyNlQ2QTJyOB?=
human Jurkat cells MYXGeY5kfGmxbjDhd5NigQ>? M36xNlExNTV3IN88US=> MU[yOEBp MmDuTY5pcWKrdHnvckBw\iCWTl\hcJBp[S2rbnT1Z4VlKE6ILXvhdJBiSiCjY4TpeoF1cW:wIHnuJIh2dWGwIFr1dotifCClZXzsd{BifCBzMDD0c{A2PSC3TTDh[pRmeiB{NDDodpMh[nliZXzlZ5Rzd3Cqb4LleIlkKG2xYnnsbZR6KHOqaX\0JIF{e2G7 MorhNlExQDB4NEK=
human K562 cells M3jnOmZ2dmO2aX;uJIF{e2G7 NULHc5p1OjRiaB?= Mly3TY5lfWO2aX;uJI9nKDZ5IHvEZUBt[W2rbnnuJJJm[2WydH;yJIV5eHKnc4Ppc44hcW5iaIXtZY4hUzV4MjDj[YxteyCjZoTldkAzPCCqcoOgZpkh\myxdzDjfZRwdWW2comgZY5idHm|aYO= MoO4NlE1OzR4MEO=
human HL60 cells NYTTXZRITnWwY4Tpc44h[XO|YYm= NUHa[IhlOjRiaB?= MVvJcoR2[3Srb36gc4YhPjdia1ThJIxidWmwaX6gdoVk\XC2b4Kg[ZhxemW|c3nvckBqdiCqdX3hckBJVDZyIHPlcIx{KGGodHXyJFI1KGi{czDifUBndG:5IHP5eI9u\XS{eTDhcoFtgXOrcx?= M3TrR|IyPDN2NkCz
human Raji cells M4DYSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4HZbVExKM7:TR?= MoLVOFghcA>? NEToPI9Iem:5dHigbY5pcWKrdHnvckBi\2GrboP0JIh2dWGwIGLhbokh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZZQhOTBidV2gZYZ1\XJiNEigbJJ{KGK7IITyfZBidiCkbIXlJIJie2WmIH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzJIlvKHC{ZYPlcoNmKG:oIIP1dIVzd3irZHWg[Il{dXW2YYPl NEnV[5IzOTR|NE[wNy=>
human PC3 cells NGXH[GlRem:uaX\ldoF1cW:wIHHzd4F6 MU[xNE0yODBizszN NHTNd|M1QCCq NX;UNGprSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZZQhOTBidH:gNVAxKHWPIHHmeIVzKDR6IHjyd{BjgSCqZX3vZ5l1d22ndILpZ{Bk\WyuIHPveY51cW6pIH3leIhw\A>? M{T5PVI{QDZ5MU[3
human A431 cells M1TtSWZ2dmO2aX;uJIF{e2G7 MYSxNFAh|ryP NGHiU3gyOiCq MWPS[YR2[3Srb36gc4Yh[2y3c4Tldolv\yCxZjDHSnAuT1CLIHnuJIxqeGmmIILh[pR{KG:oIHj1cYFvKEF2M{GgZ4VtdHNiYYSgNVAxKHWPIHHmeIVzKDF{IHjyd{BjgSClb37mc4NidCCvaXPyc5Nkd3CrYzDhcoFtgXOrcx?= MViyOFQ2PjByNB?=
human SKBR3 cells M1j6SWZ2dmO2aX;uJIF{e2G7 MYWyNFDPxE1? NYDjboJmOzBibXnudy=> NIPrWJhFd3ewcnXneYxifGmxbjDv[kBGemKEMjDwdo91\WmwIHX4dJJme3Orb36gbY4hcHWvYX6gV2tDWjNiY3XscJMhcW5ic3XyeY0h\nKnZTDt[YRqfW1iYYSgNlAxKHWPIHHmeIVzKDNyIH3pcpMh[nliaX3teY5w\my3b4Lld4NmdmOnIIP0ZYlvcW6pLXLhd4VlKGOxbn\vZ4FtKG2rY4Lvd4NweGmlIHHuZYx6e2m| NFPpW3kzPDR3NkCwOC=>
human 293T cells MWnGeY5kfGmxbjDhd5NigQ>? NHPkN5Q2OCEQvF2= NV7qSoNyOTJiaB?= MoewTY5pcWKrdHnvckBw\iCGWWLLNWEhcW5iaIXtZY4hOjl|VDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YhT0yLMTD0doFve2O{aYD0bY9vKGGldHn2bZR6KGG2IEWwJJVOKGGodHXyJFEzKGi{czDifUBlfWGuLXz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=> MVSyNlE2PDZ4NB?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro Ethanol 83 mg/mL warmed (181.07 mM)
DMSO 72 mg/mL warmed (157.07 mM)
Water 23 mg/mL warmed (50.17 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 458.37
Formula

C22H18O11

CAS No. 989-51-5
Storage powder
Synonyms EGCG

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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    C2=C1/X C2: LOG(C2):
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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02891538 Not yet recruiting Colon Cancer The University of Texas Health Science Center at San Antonio November 2016 --
NCT02832271 Not yet recruiting Endometriosis Chinese University of Hong Kong September 2016 Phase 2
NCT02577393 Enrolling by invitation Lung Neoplasms|Esophagitis|Prevention & Control|Epigallocatechin Gallate Shandong Cancer Hospital and Institute June 2015 Phase 2
NCT02731495 Completed Traumatic Brain Injury National Nutrition and Food Technology Institute|Tehran University of Medical Sciences March 2015 Phase 2|Phase 3
NCT02580279 Enrolling by invitation Breast Neoplasms|Dermatitis|Prevention & Control|Epigallocatechin Gallate Shandong Cancer Hospital and Institute February 2015 Phase 2
NCT02008721 Completed Multiple System Atrophy Dr. Johannes Levin|German Center for Neurodegenerative Diseases (DZNE)|Deutsche Parkinson Vereinigung|Deutsche Stiftung Neurologie|ParkinsonFonds Deutschland gGmbH|Ludwig-Maximilians - University of Munich January 2014 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Related Antibodies

Telomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID