Research Area
Product Type
United States ( Change Country )
BIBR 1532 Chemical Structure
Costunolide
Costunolide has wide-ranging biological effects, including anti-inflammatory, anti-viral, anti-fungal, antimycobacterial, pro-differentiation, hypolipidemic, and caner activities (cell IC50 = 65 μM).
ABT-888 (Veliparib)
ABT-888 (Veliparib) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor of PARP-1 and PARP-2 with Ki of 5.2 nM and 2.9 nM, respectively.
Olaparib (AZD2281)
Olaparib(AZD2281, KU0059436) is a selective inhibitor of PARP-1 and PARP-2 enzymes with IC50 of 5 nM and 1 nM, respectively.
Y-27632 2HCl
Y-27632 2HCl is ROCK inhibitor, as a novel bronchodilator. Y27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively.
Rucaparib (AG-014699 , PF-01367338)
AG-014699 (Rucaparib, PF-01367338) is an inhibitor of PARP with a Ki of 1.4 nM.
BI 2536
BI 2536 is a Plk1 inhibitor with an IC50 of 0.83 nM.
PD 0332991 HCl
PD 0332991 is a highly selective inhibitor of Cdk4/cyclin D1 and Cdk6/cyclin D2 with IC50 of 11 nM and 16 nM, respectively.
BSI-401
PARP-1 inhibitor with an IC50<15μm
INO-1001
INO-1001 is a novel potent PARP inhibitor with an IC50 of 3 nM.
SNS-032 (BMS-387032)
SNS-032 (BMS-387032) is a potent and selective cyclin-dependent kinases (CDK) 9, 7 and 2 inhibitor with IC50 of 4, 62 and 38 nM for CDK9, CDK2/cyclin A and CDK7/Cyclin H.
Biological Activity
BIBR 1532, (2-[(E)-3-naphtalen-2-yl-but-2-enoylamino]-benzoic acid), is a selective telomerase inhibitor.[1,2]This reagent inhibits the in vitro processivity of telomerase in a dose-dependent manner, with IC50 of 93 nM. The selectivity of BIBR1532 was assessed in a panel of DNA and RNA polymerases, showing that none of these enzymes was inhibited in concentrations up to 100 uM. BIBR1532 has a direct cytotoxic effect on leukemia cells but not in normal hematopoietic stem cells.[1]
References on BIBR 1532
- [1] Blood 2005;105: 1742-1749
- [2] THE JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277:15566–15572
Product Information
| Molecular Weight (WM): | 331.36 |
|---|---|
| Formula: | C21H17NO3 |
| CAS No.: | 321674-73-1 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥66mg/mL |
| Water <1mg/mL | |
| Ethanol ≥3mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
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