Product Categories

MEK Inhibitors

MEK Inhibitors (14)
water-soluble

Cat.No.	Product Name	Information	Product Citations	Customer Reviews
S1008	AZD6244 (Selumetinib)	AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM.	Nature, 2012, 487(7408):505-9 Nature, 2010, 468(7326), 973-977 Nature, 2010, 468(7326), 968-972
S1036	PD0325901	PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.	Cell, 2012, 151(5):937-50 Cell Stem Cell, 2012, 10(2):210-7 Nat Methods, 2011, 8(6):487-93
S2673	GSK1120212 (JTP-74057)	GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.	Proc Natl Acad Sci U S A, 2012, 109(31), E2127-2133 J Neurosci, 2012, 32(14):4887-900
S1102	U0126-EtOH	U0126-EtOH is a highly selective inhibitor of MEK1 and MEK2 with IC50 of 0.07 μM and 0.06 μM, respectively.	Nat Genet, 2011, 44(2):133-9 Cell Death Differ, 2012, 19(12):1908-16 J Invest Dermatol, 2012, 132(12):2780-90
S1177	PD98059	PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM.	J Natl Cancer Inst, 2012, 104(21):1673-9 Sci Signal, 2011, 4(192), ra62 J Biol Chem, 2010, 285(43), 32824-32833
S1020	CI-1040 (PD184352)	CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM.	Nat Genet, 2011, 44(2):133-9 Science, 2011, 331(6019), 912-916 J Exp Med, 2011, 208(9):1889-900
S1531	BIX 02189	BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.	J Biol Chem, 2012, 287(48):40722-31 Anat Cell Biol, 2011, 44(4), 265-273 Biochem Biophys Res Commun, 2012, 421(3):490-3
S2617	TAK-733	TAK-733 is a potent, selective, non ATP-competitive MEK inhibitor with IC50 of 3.2 nM.
S2310	Honokiol	Honokiol is a biphyl neolignan present in the cones, bark, and leaves of Magnolia grandifloris that displays antiangiogenic, antiinflammatory, and antitumor properties due to the inhibitory effect on the PI3K/Akt pathway.
S2134	AZD8330	AZD8330 (ARRY-424704) is a MEK 1/2 inhibitor with IC50 of 7 nM.	Oncogene, 2012, ahead of print
S1568	PD318088	PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor.
S1530	BIX 02188	BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM.	Exp Neurol, 2012, 238(2), 209-217
S1475	AS703026 (pimasertib)	AS703026 is a highly selective and potent non-competitive inhibitor of MEK1/2 with IC50 of 5-11 nM.
S1066	SL327	SL327 is a selective inhibitor for MEK1 and MEK2 with IC50 of 0.18 μM and 0.22 μM, respectively.

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1008	AZD6244 (Selumetinib)	<1 mg/mL	92 mg/mL	<1 mg/mL
S1036	PD0325901	<1 mg/mL	96 mg/mL	40 mg/mL
S2673	GSK1120212 (JTP-74057)	<1 mg/mL	5 mg/mL	<1 mg/mL
S1102	U0126-EtOH	<1 mg/mL	85 mg/mL	<1 mg/mL
S1177	PD98059	<1 mg/mL	19 mg/mL	<1 mg/mL
S1020	CI-1040 (PD184352)	<1 mg/mL	96 mg/mL	14 mg/mL
S1531	BIX 02189	<1 mg/mL	88 mg/mL	88 mg/mL
S2617	TAK-733	<1 mg/mL	101 mg/mL	<1 mg/mL
S2310	Honokiol	53 mg/mL	53 mg/mL	<1 mg/mL
S2134	AZD8330	<1 mg/mL	92 mg/mL	92 mg/mL
S1568	PD318088	<1 mg/mL	112 mg/mL	14 mg/mL
S1530	BIX 02188	<1 mg/mL	43 mg/mL	3 mg/mL
S1475	AS703026 (pimasertib)	<1 mg/mL	86 mg/mL	<1 mg/mL
S1066	SL327	<1 mg/mL	4 mg/mL	7 mg/mL

Tags: MEK Inhibitors | mek1 inhibitor | mek2 inhibitor | erk inhibitor | MEK inhibitor | MEK1 inhibitor | MEK2 inhibitor | MEK5 inhibitor | MAP2K1 inhibitor | MAP2K2 inhibitor | MAP2K5 inhibitor | oral MEK inhibitor | pan MEK inhibitor | ATP-competitive MEK inhibitor | irreversible MEK inhibitor