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MAPK/Erk kinase
| Cat.No. | Product Name | Feedback | Added |
|---|---|---|---|
| S1475 | AS703026 | Aug 2010 | |
| AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor (cell IC50 ranging from 0.005 to 2 µM). | |||
| S1008 | AZD6244 (Selumetinib) |  | Apr 2009 |
| AZD6244 (Selumetinib) is highly potent to inhibit MEK1 with IC50 of 14nmol. | |||
| S2134 | AZD8330 | Dec 2010 | |
| AZD8330 is an orally active, selective MEK inhibitor with an IC50 of 7 nM. | |||
| S1530 | BIX 02188 | Oct 2010 | |
| BIX02188 is a MEK5-selective inhibitor with an IC50 of 0.8 ± 1.0 μM. | |||
| S1531 | BIX 02189 | | Oct 2010 |
| BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. | |||
| S1020 | CI-1040 (PD184352) | | Apr 2009 |
| CI-1040 is a MEK 1/2 inhibitor. Ki of 300nM | |||
| S2676 | D-87503 | Aug 2011 | |
| D-87503 is a potent PI3K/Akt/mTOR signaling pathway inhibitor with IC50 of 62nM and 0.76μM for PI3K and Erk2, respectively. | |||
| S2673 | GSK1120212 (JTP-74057) | Sep 2011 | |
| GSK1120212 (JTP-74057) is a reversible, selective, allosteric MEK1/MEK2 kinase activity inhibitor with IC50 of 0.7 and 0.9 nM for MEK1 and MEK2. | |||
| S1036 | PD0325901 | | Apr 2009 |
| PD0325901 is selective and non ATP-competitive mitogen activated protein kinase kinase (MEK or MAPKK) MEK inhibitor with an IC50 of 0.33 nM for inhibiton of MEK activity in mouse colon 26 cells. | |||
| S1568 | PD318088 | Nov 2010 | |
| PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor. | |||
| S1177 | PD98059 | | Apr 2010 |
| PD 98059 is an inhibitor of MEK1 and MEK2 with IC50 values of 4 µM and 50 µM. | |||
| S1089 | RDEA119(BAY 869766) | Jul 2009 | |
| MEK inhibitor with EC50 of 73 nM. | |||
| S2617 | TAK-733 | Jul 2011 | |
| TAK-733 is highly potent and selective novel MEK allosteric site inhibitor with an IC50 of 3.2 nM. | |||
| S1102 | U0126 | | Aug 2009 |
| U0126 is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively. | |||
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Customer's Feedback
| Dongfeng Chen, The Rausing Lab |
| "Your product U0126(Cat.NO S1102) works well in our experiments. I hope I can get more excellent products from your company in future." |
| R.B. Cambridge |
| "I have used the chemical that I bought from you(Selleck,PTC-124) and it worked well.So we will eventually be ordering more." |
| Zhenghe John Wang Assistant Professor, Case Western Reserve University |
| "We have purchased LBH-589, Saha and MS-275 from you and they all worked well." |
| Jenny Sun |
| "We used the LBH-589 in our experiments. The compound is easy to use with excellent reproducibility." |
| Yu Wang, Harvard University |
| "The GDC0449 compound worked very well. The results in my hands are equally good as what's been published. Thanks for this great resource for our research." |
| Dung-Fang Lee |
| "Based on our preliminary data, I found MLN8237 and VX-680 have good effects in inhibiting Aurka-maintaining ESC self-renewal in mouse ES cells." |
Latest Catalog
| May 2010 Selleck Latest Catalog |  |
