MEK Antagonist

Cat.No. Product Name Information Product Use Citations Product Validations
S8355 APS-2-79 HCl APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK. IC50=120 ± 23 nM.
Science Advances, 2019, eaax4249
Sci Adv, 2019, 5(11):eaax4249
Experimental and Therapeutic Medicine, 2018, 5269-5274
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