DNA-PK

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DNA-PK Inhibitors (6)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1038 PI-103 PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM.
  • Cell, 2013, 153(4):840-54
  • Leukemia, 2013, 27(3):650-60
  • Leukemia, 2012, 26(5):927-33
S2638 NU7441 (KU-57788) NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.
  • Genes Dev, 2014, 28(8):875-87
  • Nucleic Acids Res, 2014, 42(12):7776-92
  • Nucleic Acids Res, 2014, 42(9):5616-32
S1205 PIK-75 PIK-75 is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.
  • Cell Death Differ, 2013, 21(3):491-502
  • Stem Cells, 2015, 10.1002/stem.1986
  • Mol Carcinog, 2012, 52(9):667-75
S2893 NU7026 NU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.
  • Nucleic Acids Res, 2013, 41(15):7378-86
  • Clin Cancer Res, 2014, 20(13):3496-506
  • Br J Pharmacol, 2014, 10.1111/bph.13046
S2622 PP121 PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM.
  • Tumour Biol, 2014, 35(9):8659-64
  • Biochem Biophys Res Commun, 2015, 465(1):137-44
  • Int J Clin Exp Pathol, 2013, 6(10):2082-91
S8045 KU-0060648 KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1038 PI-103 <1 mg/mL 24 mg/mL <1 mg/mL
S2638 NU7441 (KU-57788) <1 mg/mL 4 mg/mL <1 mg/mL
S1205 PIK-75 <1 mg/mL 4 mg/mL <1 mg/mL
S2893 NU7026 <1 mg/mL 1 mg/mL <1 mg/mL
S2622 PP121 <1 mg/mL 64 mg/mL 2 mg/mL
S8045 KU-0060648 <1 mg/mL 0.4 mg/mL <1 mg/mL
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