NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.

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4 Customer Reviews

  • Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

    Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.
Targets
DNA-PK [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
PI3K [1]
(Cell-free assay)
ATM [1]
(Cell-free assay)
ATR [1]
(Cell-free assay)
14 nM 1.7 μM 5 μM >100 μM >100 μM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 Mke0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofITWM2OD1yLkCyNVQ{KM7:TR?= MVzTRW5ITVJ?
A172 NFfuXXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq0TWM2OD1yLkG1N|E3KM7:TR?= MVfTRW5ITVJ?
NCI-H526 NVjhTYdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1myNWlEPTB;MD6yPFQxPyEQvF2= NU\LeZhkW0GQR1XS
HDLM-2 M{Tofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHXTWM2OD1yLkOyN|Q2KM7:TR?= MYDTRW5ITVJ?
HuO-3N1 M4rQXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwNE[2N|Yh|ryP MUTTRW5ITVJ?
NCI-SNU-1 M3[1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\Kcol[UUN3ME2wMlYxQTl2IN88US=> NGjPS5dUSU6JRWK=
SK-N-AS MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Li[mlEPTB;MD62NlIyPiEQvF2= NYjR[VNQW0GQR1XS
LoVo M1HSPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfZTWM2OD1yLki2O|Q6KM7:TR?= Mo\LV2FPT0WU
LAMA-84 MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfMfWRUUUN3ME2wMlk5QDN|IN88US=> M3fCWnNCVkeHUh?=
CTB-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjKTWM2OD1zLkGxOVQ3KM7:TR?= MoizV2FPT0WU
KP-N-YS MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7Ze5FKSzVyPUGuNVQzOzFizszN NH;1fnpUSU6JRWK=
HH NVzIcZJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zQeGlEPTB;MT6xPFA6OyEQvF2= NHPhc29USU6JRWK=
CHL-1 NHHkc3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEH1OIFKSzVyPUGuNlE{PjhizszN MmGxV2FPT0WU
NB7 NV[0OoEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXGTWM2OD1zLkK0O|Q2KM7:TR?= M3TlfHNCVkeHUh?=
HL-60 NWLufFRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHsTWM2OD1zLkO4NVkh|ryP MkexV2FPT0WU
639-V MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX70b2MyUUN3ME2xMlQ1OTJ6IN88US=> M1zJd3NCVkeHUh?=
NCI-H1793 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XqPWlEPTB;MT60OVg1KM7:TR?= MlnkV2FPT0WU
NEC8 NVG1e5NJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:zRpZ1UUN3ME2xMlU2OzVizszN MXrTRW5ITVJ?
PA-1 M{fpWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHPU2dKSzVyPUGuOVgzQTRizszN M3\OVXNCVkeHUh?=
D-423MG Mn;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfEc3F{UUN3ME2xMlY6OzZzIN88US=> MlflV2FPT0WU
NCI-H292 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTFwN{SwNVMh|ryP M{fuSHNCVkeHUh?=
SK-MEL-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHlWVVKUUN3ME2xMlc6PDd7IN88US=> NUTwU41SW0GQR1XS
LB2241-RCC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33RVGlEPTB;Mj6xOFE1PiEQvF2= M1;kbnNCVkeHUh?=
SK-MEL-3 NHLyS3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnW[mRKSzVyPUKuNVY1QSEQvF2= MmTlV2FPT0WU
MHH-PREB-1 M3mxSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlS5TWM2OD1{LkG2OlA6KM7:TR?= MkDQV2FPT0WU
BFTC-905 MlnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnVZYVKSzVyPUKuNVY3QDdizszN M4K1e3NCVkeHUh?=
Ramos-2G6-4C10 MkXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPNcWxKSzVyPUKuNVk6ODlizszN NVf5XlJ5W0GQR1XS
G-361 NIPrNVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrm[IN2UUN3ME2yMlIyPjhizszN M1HvSHNCVkeHUh?=
MOLT-4 NFf4S3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljmTWM2OD1{LkKxPFg5KM7:TR?= MVzTRW5ITVJ?
DEL M4CzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXwTWM2OD1{LkO1OVY1KM7:TR?= M3XGWnNCVkeHUh?=
MV-4-11 NIXxfWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJwM{ezPUDPxE1? MVPTRW5ITVJ?
SK-NEP-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW4[|NKSzVyPUKuN|g4QDNizszN NFHENYtUSU6JRWK=
RS4-11 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nvV2lEPTB;Mj61OlAzOyEQvF2= MYfTRW5ITVJ?
HuH-7 NFTMOHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrxcZNKSzVyPUKuOVY4ODJizszN MWjTRW5ITVJ?
A101D M4LHWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIi1XoNKSzVyPUKuOlE{OzhizszN NVKxbod{W0GQR1XS
KG-1 MorIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\HTWM2OD1{Lk[3PVI1KM7:TR?= Mm\oV2FPT0WU
KALS-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnQTWM2OD1{Lk[5OlM{KM7:TR?= MYjTRW5ITVJ?
VMRC-RCZ NGn0SYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnkSoJRUUN3ME2yMlc4OzJ6IN88US=> MnTqV2FPT0WU
SK-UT-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z0RWlEPTB;Mz6xOVMyKM7:TR?= MmH4V2FPT0WU
SW962 NXvtd3RLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfR[FlKSzVyPUOuNlA{PTJizszN NUDLPJRCW0GQR1XS
DBTRG-05MG NVLBOZBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\QdGlEPTB;Mz6yPFA5PSEQvF2= MULTRW5ITVJ?
PANC-08-13 MlrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4q5SWlEPTB;Mz60NVI4QCEQvF2= NUTkPZcyW0GQR1XS
QIMR-WIL MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTNwNEGzOFEh|ryP NHS3fGVUSU6JRWK=
SK-MEL-30 NXfT[3NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTNwNEK1PVgh|ryP NFPGTYZUSU6JRWK=
697 M1jhcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTDTWM2OD1|LkS0PVk{KM7:TR?= M33WUHNCVkeHUh?=
NY NF;B[FVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHZTWM2OD1|LkS1NFIzKM7:TR?= M{T5WnNCVkeHUh?=
ES7 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDlV5VKSzVyPUOuOFY4OjlizszN MWjTRW5ITVJ?
JVM-3 NF7STGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXiOoxiUUN3ME2zMlQ5ODd5IN88US=> NF[wS3dUSU6JRWK=
U031 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTNwNUmzOlgh|ryP Mn7GV2FPT0WU
BHT-101 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzZcFlKSzVyPUOuOVk6QDVizszN MlvRV2FPT0WU
8305C NXvwTFYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXiyUGhZUUN3ME2zMlYyPzN4IN88US=> MkGyV2FPT0WU
MG-63 NWPNO5FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rZV2lEPTB;Mz62NlY4PiEQvF2= MWrTRW5ITVJ?
NOS-1 NXrIUVBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi4OXlKSzVyPUOuOlU{OTJizszN MoTXV2FPT0WU
YH-13 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\F[2ZoUUN3ME2zMlg4OTh7IN88US=> MYXTRW5ITVJ?
LXF-289 M4LTc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH5RnpKSzVyPUOuPVExPDFizszN NF\tNIdUSU6JRWK=
GOTO NV;MVYtIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTNwOUG0PUDPxE1? NVi0dWk1W0GQR1XS
EKVX NE\VOG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PFU2lEPTB;ND6yNlUzPCEQvF2= NVPKS4lIW0GQR1XS
CAL-51 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\VTWM2OD12LkK0PFU1KM7:TR?= NFG4R4ZUSU6JRWK=
AN3-CA NXPpWmtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTRcWN3UUN3ME20MlI2QDF|IN88US=> MXzTRW5ITVJ?
IA-LM M1zFTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTRwMke5N|Uh|ryP M{WycHNCVkeHUh?=
KU-19-19 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r5W2lEPTB;ND6zNlkzOSEQvF2= NXriPVlqW0GQR1XS
A704 NE\CZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki2TWM2OD12LkSwPFg5KM7:TR?= M4PNSXNCVkeHUh?=
RH-18 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInZSmRKSzVyPUSuOFQ6PTNizszN NEfOe4dUSU6JRWK=
IST-MEL1 MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnW3TWM2OD12LkW4NlY{KM7:TR?= NVe0Z5RKW0GQR1XS
LU-134-A NUXhPYM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHJTWM2OD12LkW5Olg2KM7:TR?= Mn3hV2FPT0WU
SF126 NHfPOYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTRwNkC3NVUh|ryP M4Hp[nNCVkeHUh?=
EFO-27 NGrScZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTRwNk[1NlUh|ryP NIraZZRUSU6JRWK=
SN12C NUXTOoNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHmZ4pKSzVyPUSuO|E5QThizszN MYPTRW5ITVJ?
L-363 M3W2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn3TWM2OD12Lke3NVE3KM7:TR?= MnjJV2FPT0WU
MEL-HO MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTRwN{e5PFkh|ryP NVjVeoltW0GQR1XS
TYK-nu NWrJTVhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrYfmNKSzVyPUSuPFAyOjhizszN M2rvfnNCVkeHUh?=
MDA-MB-415 M1XQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLXcIpvUUN3ME21MlAxOzF2IN88US=> NHXLVldUSU6JRWK=
HCC70 NYPHVpdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz4d2hKSzVyPUWuNFM6OzlizszN M33yNnNCVkeHUh?=
IGROV-1 MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfRTWM2OD13LkK1NlkzKM7:TR?= Ml7vV2FPT0WU
NCI-H1355 MkXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37W[GlEPTB;NT6yPVYh|ryP Mn3UV2FPT0WU
23132-87 M1G3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DBZ2lEPTB;NT6zNlAzPCEQvF2= NFSxSGhUSU6JRWK=
NB69 NXTh[3ZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDVXpRKSzVyPUWuN|I1OiEQvF2= MoD2V2FPT0WU
HSC-2 NIrmSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;uc2lEPTB;NT60NVc4OyEQvF2= M3zZUHNCVkeHUh?=
KYSE-410 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjBTWM2OD13LkS3OlM3KM7:TR?= NX7SXo5DW0GQR1XS
GCIY MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HsRWlEPTB;NT61NVM4QCEQvF2= M2flZXNCVkeHUh?=
A427 M3rjUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzLV2pKSzVyPUWuOVM3PjFizszN MljJV2FPT0WU
ChaGo-K-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjtU2xJUUN3ME21MlU3PTl7IN88US=> M3;X[nNCVkeHUh?=
PFSK-1 M4rzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjLTWM2OD13Lk[yNVk1KM7:TR?= NIjxTlZUSU6JRWK=
MLMA M{DCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjXdZk5UUN3ME21Mlg{PjB4IN88US=> M{nrWHNCVkeHUh?=
RVH-421 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:1TWM2OD14LkC3N|M5KM7:TR?= Ml\wV2FPT0WU
LB1047-RCC NIfJ[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3f4U2lEPTB;Nj6xO|UzOiEQvF2= MXPTRW5ITVJ?
MHH-NB-11 MkLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLvTWM2OD14LkOyO|IyKM7:TR?= NGnTRWJUSU6JRWK=
J-RT3-T3-5 NHPOfphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTZwNkOyPVEh|ryP NHj6ZldUSU6JRWK=
UM-UC-3 M{K0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLMfmtEUUN3ME22MlY1OzN2IN88US=> NIHHe2FUSU6JRWK=
IST-SL1 M4noVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;DTVdbUUN3ME22MlY6OzZ7IN88US=> MVTTRW5ITVJ?
NB14 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;iR2lEPTB;Nj63PVc3OSEQvF2= NWqzPHpNW0GQR1XS
NBsusSR NUX4d25kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmL6TWM2OD14LkiyOVAzKM7:TR?= M2[5SXNCVkeHUh?=
D-263MG NVXacnhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTZwOUGwOlgh|ryP M1i3XnNCVkeHUh?=
NCI-H2347 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfMNllDUUN3ME22Mlk{OjF|IN88US=> M1r4WnNCVkeHUh?=
ES8 NYXWOnVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PNSmlEPTB;Nj65O|U5QCEQvF2= M{H6WHNCVkeHUh?=
786-0 Moe0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzITWM2OD15LkC5O|g3KM7:TR?= NUTDfFRDW0GQR1XS
EPLC-272H MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLOdlNDUUN3ME23MlE3OjR4IN88US=> MX3TRW5ITVJ?
CAPAN-1 MmTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTdwMkSzOVkh|ryP Mn7pV2FPT0WU
NCI-H82 NF;CZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTdwMk[2OVkh|ryP MYjTRW5ITVJ?
G-402 M1\US2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XlfGlEPTB;Nz6zNFA2OSEQvF2= M33PWXNCVkeHUh?=
SW982 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWSwU4ExUUN3ME23MlMxOjB|IN88US=> NEHUdGlUSU6JRWK=
OVCAR-4 NVjUdpBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33rOGlEPTB;Nz6zNVMzQCEQvF2= NIH3O2NUSU6JRWK=
KARPAS-299 NFXXN2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfTc3ZlUUN3ME23MlMzPjJ{IN88US=> NYHuZ|Y6W0GQR1XS
MIA-PaCa-2 NVfnd2tMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTdwM{[4NlMh|ryP M1XpfHNCVkeHUh?=
AU565 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGKzTI1KSzVyPUeuOVk5OzNizszN NGf5dWFUSU6JRWK=
GAMG MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTdwNkSxN|Eh|ryP NFjrZmRUSU6JRWK=
HuO9 NULsPYpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfNNmtKSzVyPUeuO|E4PDNizszN MYnTRW5ITVJ?
ACN M3fzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfiVJdxUUN3ME23Mlc1OzNizszN M1nsd3NCVkeHUh?=
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8505C NHLicItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjqNnlKSzVyPUK1MlE5PDVizszN M1f0SXNCVkeHUh?=
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BB30-HNC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2O2V2lEPTB;MkWuNlQ5OyEQvF2= M{O1WHNCVkeHUh?=
KM12 Mn;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fDPGlEPTB;MkWuOVgxPyEQvF2= NEPPOodUSU6JRWK=
NB13 NIPmXI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGL3[5NKSzVyPUK1MlU5QThizszN NHfLSVlUSU6JRWK=
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DK-MG Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLnU3BKSzVyPUK3MlE5OTdizszN M4LkbHNCVkeHUh?=
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RPMI-7951 MoThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTGS41KSzVyPUK4MlI1PTZizszN M4fmTnNCVkeHUh?=
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CHP-212 M3XaOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PvcGlEPTB;MkiuO|QxOSEQvF2= MmLIV2FPT0WU
KYSE-450 M1WxW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHCVnFmUUN3ME2yPE45ODlzIN88US=> MojLV2FPT0WU
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Ca9-22 Mlm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJ7LkSyPVkh|ryP M3PYTnNCVkeHUh?=
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HCE-4 M2TCW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfwTWM2OD1{OT64O|g3KM7:TR?= M4nOVXNCVkeHUh?=
AM-38 MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzBeFNEUUN3ME2zNE4xPjB4IN88US=> MkDlV2FPT0WU
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TE-9 NW\XdmlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnWTWM2OD1|MD64O|M4KM7:TR?= NUPKeZRMW0GQR1XS
HuP-T4 NUPMU3RHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjjW|NJUUN3ME2zNE46PjN6IN88US=> MkOzV2FPT0WU
LB2518-MEL Mme5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTNzLkC3OFQh|ryP MlPsV2FPT0WU
NCI-H1703 NVXyeINYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXhdoh[UUN3ME2zNU4xQTB3IN88US=> NWfTT2d6W0GQR1XS
NCI-H2228 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jJbmlEPTB;M{GuOFY2OSEQvF2= NXPkfVg5W0GQR1XS
SCC-4 NELkTnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXVU4NJUUN3ME2zNU46OThzIN88US=> NVjjTItMW0GQR1XS
KNS-81-FD NX:yXHA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTiU|Y6UUN3ME2zNk4xOTJ6IN88US=> MYrTRW5ITVJ?
NTERA-S-cl-D1 MnrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGn1T29KSzVyPUOyMlA4OzlizszN MW\TRW5ITVJ?
Daoy NU[wZ3djT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTN{LkC4N|gh|ryP NYPYTJp3W0GQR1XS
ES4 NVTVVJV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHUbHR{UUN3ME2zNk4{QTJ{IN88US=> NGTqZmJUSU6JRWK=
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C-33-A NVvLToRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTN{Lke3Nlgh|ryP M3jtSnNCVkeHUh?=
BHY MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPj[opKSzVyPUOyMlk1QTVizszN MWHTRW5ITVJ?
Detroit562 M1O5UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVmyXGpOUUN3ME2zN{43PjV5IN88US=> MkLlV2FPT0WU
EW-1 NHvCSlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXPfZBKSzVyPUOzMlk{OjJizszN MlvxV2FPT0WU
NCI-H1395 MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;PTWM2OD1|ND6wO|k6KM7:TR?= M1jWTXNCVkeHUh?=
KM-H2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[yTWM2OD1|Nj60O|Q{KM7:TR?= MXjTRW5ITVJ?
NCI-H520 M4Lyfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTN4Lke1OFEh|ryP NYTyUppMW0GQR1XS
D-392MG M3HWeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\0TWM2OD1|Nz6zN|Q1KM7:TR?= NF7YfZZUSU6JRWK=
NOMO-1 NI\KS5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fmbWlEPTB;M{euPFA5QSEQvF2= MkjTV2FPT0WU
TE-6 M4LNPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4flTWlEPTB;M{iuNVI1KM7:TR?= M3rI[nNCVkeHUh?=
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RPMI-8226 M4[0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7zXI5ZUUN3ME2zPE46PTF7IN88US=> MorhV2FPT0WU
U251 NFvaT4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTtTWM2OD1|OT6wNVI1KM7:TR?= NFjFc21USU6JRWK=
GCT NEP4UJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrxeJJKSzVyPUO5MlE5PTJizszN Mo\pV2FPT0WU
A431 M{XMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zSOGlEPTB;M{muNVg6PCEQvF2= NYLye3VPW0GQR1XS
TE-12 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3iUlBKSzVyPUO5MlI1PDhizszN NVi2UlU2W0GQR1XS
HMV-II NXnrVJR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTN7LkWwOFch|ryP MVnTRW5ITVJ?
IST-MES1 NFrid3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnETWM2OD12MD6xOVAzKM7:TR?= M3G3[nNCVkeHUh?=
SW13 NXP2OmI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7GXIRKSzVyPUSwMlUyQSEQvF2= NFXrb|lUSU6JRWK=
SF295 NYnBPZViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonvTWM2OD12MD64NFY3KM7:TR?= MYjTRW5ITVJ?
MDA-MB-157 Mle4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;ZWnlKSzVyPUSwMlk1PjJizszN MnHkV2FPT0WU
TE-1 MljDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHob3FKSzVyPUSxMlg4OTRizszN NWH5VYlSW0GQR1XS
HuCCT1 NYO1XphZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;YeWlEPTB;NEKuOVI5QSEQvF2= MnTWV2FPT0WU
KYSE-510 MleyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTR|LkG3OVQh|ryP M37B[nNCVkeHUh?=
NCI-H358 NV\6WWwzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\IUHpKSzVyPUS0MlA{ODRizszN M{HPOXNCVkeHUh?=
SW900 NWXtPZR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NES0[VVKSzVyPUS0MlA4PThizszN MkjWV2FPT0WU
CAS-1 M4mxXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPZU|JKSzVyPUS0MlA6QTFizszN MUTTRW5ITVJ?
TE-8 M1fMXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUG5fYN1UUN3ME20OE42PjV6IN88US=> MVzTRW5ITVJ?
P12-ICHIKAWA M1j2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkS3TWM2OD12ND62NVEzKM7:TR?= MX;TRW5ITVJ?
YKG-1 NETwN|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTLTWM2OD12ND63PFEh|ryP M13ZbXNCVkeHUh?=
SNU-C2B MkDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTqc5o4UUN3ME20OE44QTB|IN88US=> NGD6RZVUSU6JRWK=
LCLC-103H NXztTnA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTR2Lki3NFMh|ryP NGLUOWZUSU6JRWK=
U-87-MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXWxNoJnUUN3ME20OU4yODJ{IN88US=> MmfHV2FPT0WU
HAL-01 MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTR3LkGzO|kh|ryP NETvPZpUSU6JRWK=
OVCAR-8 NWO3eZdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTR3LkO1OlQh|ryP MXvTRW5ITVJ?
KYSE-150 NUn6OXQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrl[GJKSzVyPUS3MlExPTJizszN MlXJV2FPT0WU
OE33 M2n6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Gz[2lEPTB;NEeuNVQzQSEQvF2= NUD0OYkxW0GQR1XS
CAL-62 M1rMc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDwcYdKSzVyPUS3MlQxPjhizszN MX\TRW5ITVJ?
TCCSUP MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnX3TWM2OD12Nz62NlY1KM7:TR?= NVLrbZNCW0GQR1XS
H4 NHKwOWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITmeWdKSzVyPUS3MlY3OjFizszN Mn\XV2FPT0WU
CP66-MEL NXvoNFd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHVTWM2OD12OD6wO|A1KM7:TR?= NFzxXZhUSU6JRWK=
SNB75 NFzFZoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknkTWM2OD12OD6xPFc1KM7:TR?= NW\rNnR7W0GQR1XS
Mo-T MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmqzTWM2OD12OD6yO|kh|ryP NVHkNYZ[W0GQR1XS
BT-549 M1fsXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljFTWM2OD12OD6zO|I6KM7:TR?= MWrTRW5ITVJ?
IGR-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWG4RoM4UUN3ME20PE43PjR3IN88US=> NH3ocGJUSU6JRWK=
NCI-H1299 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHzPIZEUUN3ME20PE44OjR6IN88US=> MVXTRW5ITVJ?
ALL-PO M4nuVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;iTWM2OD12OT65NlY5KM7:TR?= M4qwTXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method: The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID