NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.

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4 Customer Reviews

  • Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

    Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.
Targets
DNA-PK [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
PI3K [1]
(Cell-free assay)
ATM [1]
(Cell-free assay)
ATR [1]
(Cell-free assay)
14 nM 1.7 μM 5 μM >100 μM >100 μM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 MlPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEKxOFMh|ryP MU\TRW5ITVJ?
A172 MlLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLYVW5rUUN3ME2wMlE2OzF4IN88US=> MWXTRW5ITVJ?
NCI-H526 MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PBOGlEPTB;MD6yPFQxPyEQvF2= MY\TRW5ITVJ?
HDLM-2 NWT2eIh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\RUIFRUUN3ME2wMlMzOzR3IN88US=> NHjYb5NUSU6JRWK=
HuO-3N1 MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwNE[2N|Yh|ryP Mk\1V2FPT0WU
NCI-SNU-1 NGXWRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwNkC5PVQh|ryP MkjIV2FPT0WU
SK-N-AS MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fFSGlEPTB;MD62NlIyPiEQvF2= Ml31V2FPT0WU
LoVo M4LtVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PxOmlEPTB;MD64Olc1QSEQvF2= M2PxO3NCVkeHUh?=
LAMA-84 Mnz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnuZ4RKSzVyPUCuPVg5OzNizszN NH7WNoZUSU6JRWK=
CTB-1 NU\tWIY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTFwMUG1OFYh|ryP NFzaUZdUSU6JRWK=
KP-N-YS M2fXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXLbFlXUUN3ME2xMlE1OjNzIN88US=> MUnTRW5ITVJ?
HH MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojkTWM2OD1zLkG4NFk{KM7:TR?= MYXTRW5ITVJ?
CHL-1 MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTjTWM2OD1zLkKxN|Y5KM7:TR?= MXfTRW5ITVJ?
NB7 MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTFwMkS3OFUh|ryP M4LST3NCVkeHUh?=
HL-60 NILtbIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH64SYdKSzVyPUGuN|gyQSEQvF2= M2HkV3NCVkeHUh?=
639-V NG[0W|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTZSWZlUUN3ME2xMlQ1OTJ6IN88US=> NVntcW1KW0GQR1XS
NCI-H1793 MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDkcHRXUUN3ME2xMlQ2QDRizszN MmjaV2FPT0WU
NEC8 M1vRdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTFwNUWzOUDPxE1? NGjCRWhUSU6JRWK=
PA-1 M3nHNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWj5XmxSUUN3ME2xMlU5Ojl2IN88US=> NHLjbnNUSU6JRWK=
D-423MG M3XyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\WPGlEPTB;MT62PVM3OSEQvF2= MYLTRW5ITVJ?
NCI-H292 M1;qPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPjS|NKSzVyPUGuO|QxOTNizszN MnK4V2FPT0WU
SK-MEL-1 M37oeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nCWGlEPTB;MT63PVQ4QSEQvF2= NHfoVJJUSU6JRWK=
LB2241-RCC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n2XmlEPTB;Mj6xOFE1PiEQvF2= M33wPXNCVkeHUh?=
SK-MEL-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjDTWM2OD1{LkG2OFkh|ryP MUTTRW5ITVJ?
MHH-PREB-1 NFHNWWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLZTWRMUUN3ME2yMlE3PjB7IN88US=> M1\oZnNCVkeHUh?=
BFTC-905 NF;ZN49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLIcFBKSzVyPUKuNVY3QDdizszN M3nvbnNCVkeHUh?=
Ramos-2G6-4C10 M1nJ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7CTWM2OD1{LkG5PVA6KM7:TR?= Mn3FV2FPT0WU
G-361 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3HTWM2OD1{LkKxOlgh|ryP NGHt[ZdUSU6JRWK=
MOLT-4 M1XsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJwMkG4PFgh|ryP NYHpcG5MW0GQR1XS
DEL NFLsUmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJwM{W1OlQh|ryP NVjCR2NFW0GQR1XS
MV-4-11 MnXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJwM{ezPUDPxE1? MV\TRW5ITVJ?
SK-NEP-1 NUn0dpNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzsVox6UUN3ME2yMlM5Pzh|IN88US=> MXLTRW5ITVJ?
RS4-11 NXTXWVRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XCU2lEPTB;Mj61OlAzOyEQvF2= MkHpV2FPT0WU
HuH-7 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\ZeWlEPTB;Mj61OlcxOiEQvF2= MVrTRW5ITVJ?
A101D NXXQOWU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLkRWpKSzVyPUKuOlE{OzhizszN NIPQSnpUSU6JRWK=
KG-1 M{fwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV64bW1IUUN3ME2yMlY4QTJ2IN88US=> NIjScXFUSU6JRWK=
KALS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j1W2lEPTB;Mj62PVY{OyEQvF2= NVTPeWdVW0GQR1XS
VMRC-RCZ MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PzcGlEPTB;Mj63O|MzQCEQvF2= NXL1bGlMW0GQR1XS
SK-UT-1 MnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfTTWM2OD1|LkG1N|Eh|ryP MliwV2FPT0WU
SW962 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfBTWM2OD1|LkKwN|UzKM7:TR?= NV[wZXlUW0GQR1XS
DBTRG-05MG NHXMUVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTNwMkiwPFUh|ryP MYfTRW5ITVJ?
PANC-08-13 M1fwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTNwNEGyO|gh|ryP NXfvXIFlW0GQR1XS
QIMR-WIL NXPEU3VtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojWTWM2OD1|LkSxN|QyKM7:TR?= M1LJZnNCVkeHUh?=
SK-MEL-30 NGrOXYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;SSJRKSzVyPUOuOFI2QThizszN NU\IfpdtW0GQR1XS
697 MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfhd29KSzVyPUOuOFQ6QTNizszN MoPQV2FPT0WU
NY M{fh[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm2NZVKSzVyPUOuOFUxOjJizszN M2m0WnNCVkeHUh?=
ES7 M1nubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTNwNE[3Nlkh|ryP MmLnV2FPT0WU
JVM-3 MlLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXiTWM2OD1|LkS4NFc4KM7:TR?= MY\TRW5ITVJ?
U031 NX3wOYlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojWTWM2OD1|LkW5N|Y5KM7:TR?= NWfZc5ZwW0GQR1XS
BHT-101 NXLHZlJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nrV2lEPTB;Mz61PVk5PSEQvF2= M3\nb3NCVkeHUh?=
8305C NWC1[lNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rzOGlEPTB;Mz62NVc{PiEQvF2= MlnJV2FPT0WU
MG-63 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlL0TWM2OD1|Lk[yOlc3KM7:TR?= NIjXcVVUSU6JRWK=
NOS-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPyTWM2OD1|Lk[1N|EzKM7:TR?= M2jHSnNCVkeHUh?=
YH-13 Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTNwOEexPFkh|ryP M{\rUXNCVkeHUh?=
LXF-289 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTNwOUGwOFEh|ryP Mm\YV2FPT0WU
GOTO MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXjWFVKSzVyPUOuPVE1QSEQvF2= NH75RmRUSU6JRWK=
EKVX MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TBcmlEPTB;ND6yNlUzPCEQvF2= M17UeHNCVkeHUh?=
CAL-51 M4DWcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3vTWM2OD12LkK0PFU1KM7:TR?= MlS3V2FPT0WU
AN3-CA NU\rTIU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTRwMkW4NVMh|ryP NGnaZVZUSU6JRWK=
IA-LM NEPmWnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTRwMke5N|Uh|ryP M4\tbXNCVkeHUh?=
KU-19-19 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTRwM{K5NlEh|ryP NYPYbVF7W0GQR1XS
A704 NF;tcGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqwN2JKSzVyPUSuOFA5QDhizszN NVzQPXUyW0GQR1XS
RH-18 NHPrWnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LufmlEPTB;ND60OFk2OyEQvF2= MXjTRW5ITVJ?
IST-MEL1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTRwNUiyOlMh|ryP NXW4PW81W0GQR1XS
LU-134-A MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTRwNUm2PFUh|ryP M3:5eXNCVkeHUh?=
SF126 NHLCSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETiW3ZKSzVyPUSuOlA4OTVizszN MluxV2FPT0WU
EFO-27 NEDrfplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3s[4NNUUN3ME20MlY3PTJ3IN88US=> NIPmPZJUSU6JRWK=
SN12C M1;WUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUCwXI1rUUN3ME20MlcyQDl6IN88US=> M4PmdXNCVkeHUh?=
L-363 NEDtPW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\TZWlEPTB;ND63O|EyPiEQvF2= M1z3XHNCVkeHUh?=
MEL-HO NYe5[m5lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTRwN{e5PFkh|ryP MVnTRW5ITVJ?
TYK-nu M1nNWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTRwOECxNlgh|ryP NFPLfnZUSU6JRWK=
MDA-MB-415 NGLh[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXFTFdqUUN3ME21MlAxOzF2IN88US=> NGfXVGJUSU6JRWK=
HCC70 M{PL[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTVwMEO5N|kh|ryP MoGyV2FPT0WU
IGROV-1 NIfRc|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHvTWM2OD13LkK1NlkzKM7:TR?= M2XCZXNCVkeHUh?=
NCI-H1355 NXfwZ297T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mom1TWM2OD13LkK5OkDPxE1? MnjMV2FPT0WU
23132-87 NEHFTFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[1b2lEPTB;NT6zNlAzPCEQvF2= MUTTRW5ITVJ?
NB69 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPHS3h2UUN3ME21MlMzPDJizszN MorjV2FPT0WU
HSC-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTVwNEG3O|Mh|ryP MkDBV2FPT0WU
KYSE-410 M4TmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTVwNEe2N|Yh|ryP NGXXOFFUSU6JRWK=
GCIY NHL2S2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnjNYxbUUN3ME21MlUyOzd6IN88US=> MXPTRW5ITVJ?
A427 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWOzUWZNUUN3ME21MlU{PjZzIN88US=> MoS2V2FPT0WU
ChaGo-K-1 NUTLZYd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;Ld4FKSzVyPUWuOVY2QTlizszN MnzoV2FPT0WU
PFSK-1 NWLSSJpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS2WHlKSzVyPUWuOlIyQTRizszN NG\kRplUSU6JRWK=
MLMA NX3YUFFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jXNmlEPTB;NT64N|YxPiEQvF2= NH21VYJUSU6JRWK=
RVH-421 NEPmTpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjoV4pKSzVyPU[uNFc{OzhizszN MX;TRW5ITVJ?
LB1047-RCC M2LUWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPyTWM2OD14LkG3OVIzKM7:TR?= NXXScVhlW0GQR1XS
MHH-NB-11 MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13vOmlEPTB;Nj6zNlczOSEQvF2= NWTsOlBuW0GQR1XS
J-RT3-T3-5 NEXPXotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\4doRKSzVyPU[uOlMzQTFizszN M4jHdnNCVkeHUh?=
UM-UC-3 NF7vfZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3wO41bUUN3ME22MlY1OzN2IN88US=> M1zk[HNCVkeHUh?=
IST-SL1 NUXtfW9jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n4ZmlEPTB;Nj62PVM3QSEQvF2= MoHuV2FPT0WU
NB14 M3zGTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL6d3RpUUN3ME22Mlc6PzZzIN88US=> NXjUPFZtW0GQR1XS
NBsusSR NUfCVlVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfOTWM2OD14LkiyOVAzKM7:TR?= MXLTRW5ITVJ?
D-263MG NX61ZVZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rz[GlEPTB;Nj65NVA3QCEQvF2= NUnSUmpIW0GQR1XS
NCI-H2347 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mly2TWM2OD14LkmzNlE{KM7:TR?= NF\ycYVUSU6JRWK=
ES8 M2PKNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\hTppKSzVyPU[uPVc2QDhizszN M4HNUXNCVkeHUh?=
786-0 M{\nNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXjTWM2OD15LkC5O|g3KM7:TR?= NGjJbo5USU6JRWK=
EPLC-272H MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXLe4lKSzVyPUeuNVYzPDZizszN NG\4e4RUSU6JRWK=
CAPAN-1 MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j6RWlEPTB;Nz6yOFM2QSEQvF2= MUXTRW5ITVJ?
NCI-H82 NH7YNGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnmdlJkUUN3ME23MlI3PjV7IN88US=> MYXTRW5ITVJ?
G-402 Mn\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULDWopFUUN3ME23MlMxODVzIN88US=> NGmzNJNUSU6JRWK=
SW982 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHtZmtKSzVyPUeuN|AzODNizszN MXLTRW5ITVJ?
OVCAR-4 M3v6[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFO1fG5KSzVyPUeuN|E{OjhizszN M1jJTXNCVkeHUh?=
KARPAS-299 NHXHUZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTdwM{K2NlIh|ryP M{O2THNCVkeHUh?=
MIA-PaCa-2 NGDEcWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTTNpBKSzVyPUeuN|Y5OjNizszN M{jZTHNCVkeHUh?=
AU565 M3\ER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DCTWlEPTB;Nz61PVg{OyEQvF2= M2nXeHNCVkeHUh?=
GAMG NGX5cJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jFNWlEPTB;Nz62OFE{OSEQvF2= MmXGV2FPT0WU
HuO9 NUSy[2YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mon3TWM2OD15LkexO|Q{KM7:TR?= NXe1UmZiW0GQR1XS
ACN NXnIeW94T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTdwN{SzN{DPxE1? MXLTRW5ITVJ?
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G-401 MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTFyLke2NlYh|ryP M1nvXnNCVkeHUh?=
CAL-72 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TZWmlEPTB;MUCuPFA6PCEQvF2= M2qwcHNCVkeHUh?=
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NCI-H1155 M{LZU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\hTWM2OD1zMD64N|c3KM7:TR?= M1Pw[HNCVkeHUh?=
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LB996-RCC MmXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjIeIJuUUN3ME2xNU4xPzJ|IN88US=> NHjIS5VUSU6JRWK=
NCI-H1563 MmXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFzLkGwNVEh|ryP NITB[opUSU6JRWK=
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NCI-H650 M3HhUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HaN2lEPTB;MUGuPFk3OSEQvF2= NIjpeFhUSU6JRWK=
TE-11 NUX2SXJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfHWHVmUUN3ME2xNU46OzF3IN88US=> MmDjV2FPT0WU
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SK-PN-DW MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\J[GlEPTB;MUKuNVkxOiEQvF2= MnPTV2FPT0WU
BALL-1 NFfhUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPhTWM2OD1zMj6yOlYzKM7:TR?= NXPsXXZiW0GQR1XS
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HOP-92 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDMdGhkUUN3ME2xNk42OjN|IN88US=> MWPTRW5ITVJ?
M14 NWDG[HU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTF|LkCzN|Uh|ryP M13YVnNCVkeHUh?=
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NCI-H2030 MoD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjEc4poUUN3ME2xN{4zODZ{IN88US=> NHv0cVZUSU6JRWK=
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NCI-H1092 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XWZ2lEPTB;MUOuO|Q4PSEQvF2= MYDTRW5ITVJ?
8-MG-BA M{LaTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF|Lke1NVMh|ryP NIewRpdUSU6JRWK=
CAL-27 NGnlRZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTF2LkC3Nlch|ryP Mn;2V2FPT0WU
AGS NX[5SI5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\xUGlEPTB;MUSuNVMyQSEQvF2= MmKyV2FPT0WU
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D-566MG NHjqb3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXaTWM2OD1zND63O|A3KM7:TR?= MWXTRW5ITVJ?
MZ7-mel Mor4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUW1XYRYUUN3ME2xOU4yODZ5IN88US=> M1;BTHNCVkeHUh?=
TE-5 NFH6UoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTF3LkKzN|Mh|ryP MWPTRW5ITVJ?
647-V NXLXSnR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTF3LkK3NFUh|ryP NGX4OlNUSU6JRWK=
DMS-114 NGm1V2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojZTWM2OD1zNT6zNlkyKM7:TR?= M2XJUnNCVkeHUh?=
ME-180 NVPCTnRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;BTWM2OD1zNT60O|g{KM7:TR?= M1zjPHNCVkeHUh?=
MS-1 NEfldZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzrbHhKSzVyPUG1MlU3OjNizszN MWfTRW5ITVJ?
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GB-1 Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTF3Lk[0N|ch|ryP M3XQbHNCVkeHUh?=
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NCI-H1304 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[3TWM2OD1zNT64PVI5KM7:TR?= NF;FSHBUSU6JRWK=
KURAMOCHI Mor5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX65TldmUUN3ME2xOU46PzFizszN NHjSbZdUSU6JRWK=
SW1783 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT3TWM2OD1zNj6wPVk{KM7:TR?= MofHV2FPT0WU
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PANC-03-27 NFfyTHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIq2eZpKSzVyPUG2Mlc3PjJizszN NEDodXRUSU6JRWK=
RH-1 NGfiOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTF4LkiyOUDPxE1? MUTTRW5ITVJ?
HT-1376 Mmq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTqW5pFUUN3ME2xOk45PDR4IN88US=> MVLTRW5ITVJ?
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TK10 MnnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n4V2lEPTB;MUeuNFA4QSEQvF2= M3TrNHNCVkeHUh?=
SW684 NVi3T3NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTF5LkCxOVQh|ryP NUW1WJhuW0GQR1XS
RPMI-8866 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTF5LkC2PVkh|ryP MWjTRW5ITVJ?
LNCaP-Clone-FGC NU\TOo4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPWTWM2OD1zNz61NlAyKM7:TR?= MXvTRW5ITVJ?
NCI-H2291 Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf2RXFKSzVyPUG4MlQ{PDVizszN Ml7KV2FPT0WU
T47D NUPVVlNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;KTWM2OD1zOD60PFgh|ryP M4XEPHNCVkeHUh?=
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HT-144 MkHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XJTmlEPTB;MUiuO|QzPyEQvF2= NInaeI9USU6JRWK=
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HCC1806 NFnsU2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHjRYRHUUN3ME2xPU4yPTlzIN88US=> M{i3[XNCVkeHUh?=
NCI-H596 NX7COXFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTF7Lk[zPVEh|ryP MnXhV2FPT0WU
K-562 NYjUZ4htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PwV2lEPTB;MUmuPFkzPiEQvF2= Mn\FV2FPT0WU
D-336MG M1flO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF7LkmzNlIh|ryP NIrr[JBUSU6JRWK=
SK-MEL-2 NInUZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXiSlNKUUN3ME2yNE4yPTV7IN88US=> NH;qeVNUSU6JRWK=
HEC-1 NHL1ZmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;RcGlEPTB;MkCuOFk4QCEQvF2= MU\TRW5ITVJ?
EW-13 M1XYVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jQOGlEPTB;MkCuOVQ1OyEQvF2= NF\tUmxUSU6JRWK=
Hs-578-T NFnzNoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFriUppKSzVyPUKwMlU2QDNizszN MlXRV2FPT0WU
SJSA-1 NXXvW253T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;EfGhSUUN3ME2yNE42Pjh6IN88US=> NVHBbWt3W0GQR1XS
RCC10RGB NVjuV5BwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jxPGlEPTB;MkCuOlcyQSEQvF2= NIfjUIFUSU6JRWK=
LAN-6 NXi1ellyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7FUmJYUUN3ME2yNU4xOzl4IN88US=> NVLwd44yW0GQR1XS
NCI-H1048 NXrlbZlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJzLkKyOVgh|ryP MVzTRW5ITVJ?
CW-2 M1T6Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlT1TWM2OD1{MT6yO|A2KM7:TR?= NXTGSpZPW0GQR1XS
HCC2157 NF;rU49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi0b4dKSzVyPUKxMlM3KM7:TR?= NYfVPJVDW0GQR1XS
EW-22 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFuyU|RKSzVyPUKxMlM4PiEQvF2= MWLTRW5ITVJ?
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BE-13 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jQdmlEPTB;MkGuOlEyOyEQvF2= MWPTRW5ITVJ?
KINGS-1 NGj3fndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDMTWM2OD1{MT62N|E3KM7:TR?= MnG1V2FPT0WU
ETK-1 MoTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTzTWM2OD1{MT64NVUzKM7:TR?= NF7pblhUSU6JRWK=
NCI-H2452 M1zNW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljjTWM2OD1{MT64OlQ4KM7:TR?= NXWwU4tnW0GQR1XS
HPAF-II Mmn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1H2OWlEPTB;MkGuPFkzOyEQvF2= M1mxNXNCVkeHUh?=
D-542MG M1rub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M12w[2lEPTB;MkGuPVA3QSEQvF2= MVnTRW5ITVJ?
NCI-H630 NH7UcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLUb5FKSzVyPUKyMlAzQTZizszN NUTzUnhLW0GQR1XS
TGBC11TKB MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrHN|RXUUN3ME2yNk4xPDlizszN M1G1R3NCVkeHUh?=
BCPAP MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPOTWM2OD1{Mj62NVEh|ryP NWjjR41XW0GQR1XS
HLE M2qwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfFTWM2OD1{Mj62PVch|ryP NX7obFB5W0GQR1XS
NCI-H727 NVnnUFJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLySoZKSzVyPUKyMlc{PSEQvF2= NH32boNUSU6JRWK=
RD Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnLVVhKSzVyPUKyMlc2OThizszN MoWwV2FPT0WU
NCI-H522 NYLlRnpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfJTWM2OD1{Mj64OFMyKM7:TR?= NHryWHBUSU6JRWK=
CGTH-W-1 M{Djc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXjVJdKUUN3ME2yN{4xPjRzIN88US=> M4fWenNCVkeHUh?=
SK-LU-1 NX;NdWlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX2b2xKSzVyPUKzMlQ3QDNizszN MXPTRW5ITVJ?
BB65-RCC NWrhc3FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfNO3ZKSzVyPUKzMlc5PjNizszN NIDSbIxUSU6JRWK=
HSC-3 NF\RdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTzZ|JKSzVyPUKzMlg2OjdizszN MkLpV2FPT0WU
SK-MES-1 M1zrcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEm0bJZKSzVyPUK0MlAyPjFizszN MYXTRW5ITVJ?
DB M4\r[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2q2WmlEPTB;MkSuNVAzQCEQvF2= NEnzd3hUSU6JRWK=
HO-1-N-1 M4jsOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XBbWlEPTB;MkSuN|A6OyEQvF2= MYTTRW5ITVJ?
MKN1 MoDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTBRm9VUUN3ME2yOE43QCEQvF2= MUHTRW5ITVJ?
MN-60 NGDyO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmroTWM2OD1{ND64OVE6KM7:TR?= MYnTRW5ITVJ?
8505C NV;kdnRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmCxTWM2OD1{NT6xPFQ2KM7:TR?= NUHubnRMW0GQR1XS
COLO-320-HSR NELZV5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJ3LkKyNFgh|ryP NFvoOXVUSU6JRWK=
BB30-HNC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3RVHRFUUN3ME2yOU4zPDh|IN88US=> NFfkfHZUSU6JRWK=
KM12 MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJ3LkW4NFch|ryP MnPaV2FPT0WU
NB13 M2W4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT4VIhuUUN3ME2yOU42QDl6IN88US=> M4\5dHNCVkeHUh?=
HCC2998 NHPrbWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJ4LkCyPFMh|ryP NX62SWptW0GQR1XS
U-118-MG MoDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\WTWM2OD1{Nj6wPFA5KM7:TR?= M3\teXNCVkeHUh?=
NB10 Mm\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJ4LkKzOEDPxE1? MVfTRW5ITVJ?
SK-LMS-1 M{DxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLDdW5KSzVyPUK3MlA4ODRizszN NX7zNmQzW0GQR1XS
SW1573 Mn3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TIWGlEPTB;MkeuNVEh|ryP MYLTRW5ITVJ?
LB373-MEL-D MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHLTWM2OD1{Nz6xNlk1KM7:TR?= M{\Je3NCVkeHUh?=
DK-MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJ5LkG4NVch|ryP MnXYV2FPT0WU
RMG-I M2HyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PWcmlEPTB;MkeuNlAzQSEQvF2= NH7Qe|JUSU6JRWK=
SW1088 Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7vcWVTUUN3ME2yO{42ODR{IN88US=> MWLTRW5ITVJ?
SK-OV-3 Mme5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkGxTWM2OD1{Nz63OVk{KM7:TR?= NUD1VIZYW0GQR1XS
KP-N-YN MmfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLiTWM2OD1{Nz64NFQ{KM7:TR?= MYDTRW5ITVJ?
RPMI-7951 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHXTWM2OD1{OD6yOFU3KM7:TR?= NI\SPVlUSU6JRWK=
CaR-1 Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJ6LkW1PFIh|ryP M4jZenNCVkeHUh?=
MKN7 Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTCdFdKSzVyPUK4MlU6PjRizszN MUDTRW5ITVJ?
CHP-212 NVT1T5pxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\2OXZKSzVyPUK4Mlc1ODFizszN MoHhV2FPT0WU
KYSE-450 M3vGdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJ6LkiwPVEh|ryP MlTRV2FPT0WU
RXF393 M{H4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTJ7LkK5NFYh|ryP Mkn3V2FPT0WU
P30-OHK MnK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJ7LkOwOFgh|ryP NYrLcWJ3W0GQR1XS
Ca9-22 NYXVO3A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfPc2FkUUN3ME2yPU41Ojl7IN88US=> NX;kUIVSW0GQR1XS
RT-112 NEftPIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\sXWZ7UUN3ME2yPU41PjFzIN88US=> NWjsOmFzW0GQR1XS
ES1 M37NTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTRTWM2OD1{OT64OVQ1KM7:TR?= Mn3oV2FPT0WU
HCE-4 M2Pobmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTJ7Lki3PFYh|ryP MlfNV2FPT0WU
AM-38 NXPiTI5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH4bGRKSzVyPUOwMlA3ODZizszN NF3VSmhUSU6JRWK=
AsPC-1 M{L4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDucFZKSzVyPUOwMlgxPTNizszN M1frd3NCVkeHUh?=
TE-9 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1mwPGlEPTB;M{CuPFc{PyEQvF2= M{n0eXNCVkeHUh?=
HuP-T4 M1znbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37NZWlEPTB;M{CuPVY{QCEQvF2= MVLTRW5ITVJ?
LB2518-MEL M{jERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIi2[WFKSzVyPUOxMlA4PDRizszN M2i2[nNCVkeHUh?=
NCI-H1703 MmL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnVVJdKSzVyPUOxMlA6ODVizszN M4jjd3NCVkeHUh?=
NCI-H2228 NHLwZpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;CTWM2OD1|MT60OlUyKM7:TR?= MULTRW5ITVJ?
SCC-4 M3u3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLVUmVKSzVyPUOxMlkyQDFizszN MVrTRW5ITVJ?
KNS-81-FD MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnRTWM2OD1|Mj6wNVI5KM7:TR?= MUXTRW5ITVJ?
NTERA-S-cl-D1 MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfHe|ZKSzVyPUOyMlA4OzlizszN NFqxWoNUSU6JRWK=
Daoy M{fIOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe1RllCUUN3ME2zNk4xQDN6IN88US=> MWnTRW5ITVJ?
ES4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfURnkxUUN3ME2zNk4{QTJ{IN88US=> MW\TRW5ITVJ?
MHH-ES-1 M3\m[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHCSYRMUUN3ME2zNk41QDd{IN88US=> M1WzTnNCVkeHUh?=
C-33-A M1zFdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fQUmlEPTB;M{KuO|czQCEQvF2= NHizcmxUSU6JRWK=
BHY NVS1UlBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjGZ2pKSzVyPUOyMlk1QTVizszN M3rNUXNCVkeHUh?=
Detroit562 NE\WeotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TzcmlEPTB;M{OuOlY2PyEQvF2= NXXBN2NLW0GQR1XS
EW-1 NVnTXpc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTN|LkmzNlIh|ryP NIjkPZdUSU6JRWK=
NCI-H1395 NXvMc|hVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HXdGlEPTB;M{SuNFc6QSEQvF2= Mm[4V2FPT0WU
KM-H2 NHHR[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTN4LkS3OFMh|ryP NXLr[YVkW0GQR1XS
NCI-H520 M{jaVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTN4Lke1OFEh|ryP M4e3c3NCVkeHUh?=
D-392MG NG\VUo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTN5LkOzOFQh|ryP NWPSUnBkW0GQR1XS
NOMO-1 M1vTSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrMT4lSUUN3ME2zO{45ODh7IN88US=> MWjTRW5ITVJ?
TE-6 M{\lXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTLZoJyUUN3ME2zPE4yOjRizszN MYLTRW5ITVJ?
HT-3 NG\i[2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHWzc|dKSzVyPUO4MlQ1OzZizszN Mn25V2FPT0WU
RPMI-8226 NWrLSHV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TvWWlEPTB;M{iuPVUyQSEQvF2= NFXST|ZUSU6JRWK=
U251 NGPGNWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETybXZKSzVyPUO5MlAyOjRizszN MV3TRW5ITVJ?
GCT MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTN7LkG4OVIh|ryP M2jCOnNCVkeHUh?=
A431 MknOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zkT2lEPTB;M{muNVg6PCEQvF2= NIXpcIZUSU6JRWK=
TE-12 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTRTWM2OD1|OT6yOFQ5KM7:TR?= Mn3mV2FPT0WU
HMV-II NYnrOm02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTN7LkWwOFch|ryP M3K0V3NCVkeHUh?=
IST-MES1 M{j1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELMW41KSzVyPUSwMlE2ODJizszN MmfTV2FPT0WU
SW13 NGPOWpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7DWFFKSzVyPUSwMlUyQSEQvF2= MUTTRW5ITVJ?
SF295 NGDOZnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVmxc|JXUUN3ME20NE45ODZ4IN88US=> M2nOPXNCVkeHUh?=
MDA-MB-157 NHzJSIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrQSphmUUN3ME20NE46PDZ{IN88US=> MnPRV2FPT0WU
TE-1 NV;MXmxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPBWGhKSzVyPUSxMlg4OTRizszN M2PZNHNCVkeHUh?=
HuCCT1 MmjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfrZnhHUUN3ME20Nk42Ojh7IN88US=> M2XtfnNCVkeHUh?=
KYSE-510 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTR|LkG3OVQh|ryP MXXTRW5ITVJ?
NCI-H358 NVP6RmhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\IO|ZKSzVyPUS0MlA{ODRizszN MWrTRW5ITVJ?
SW900 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHBR3RnUUN3ME20OE4xPzV6IN88US=> NG\BRVBUSU6JRWK=
CAS-1 MmTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjHW5ZKSzVyPUS0MlA6QTFizszN NH3OZ49USU6JRWK=
TE-8 NILuNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTR2LkW2OVgh|ryP MoPTV2FPT0WU
P12-ICHIKAWA MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofvTWM2OD12ND62NVEzKM7:TR?= NFrCXlFUSU6JRWK=
YKG-1 NY\yfWRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[4TWM2OD12ND63PFEh|ryP M3n6fnNCVkeHUh?=
SNU-C2B NVTJdmRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4SwOGlEPTB;NESuO|kxOyEQvF2= MXPTRW5ITVJ?
LCLC-103H MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG4fGJoUUN3ME20OE45PzB|IN88US=> Mk\0V2FPT0WU
U-87-MG MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz3TWM2OD12NT6xNFIzKM7:TR?= NFzH[JhUSU6JRWK=
HAL-01 MmD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfoN2tKSzVyPUS1MlE{PzlizszN MmfjV2FPT0WU
OVCAR-8 NInwclBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnVSXlsUUN3ME20OU4{PTZ2IN88US=> NV7KO49jW0GQR1XS
KYSE-150 MlnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTR5LkGwOVIh|ryP MX\TRW5ITVJ?
OE33 M2TEVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTR5LkG0Nlkh|ryP NYD3OHhFW0GQR1XS
CAL-62 NIPve3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTR5LkSwOlgh|ryP MmPUV2FPT0WU
TCCSUP MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\6SGlEPTB;NEeuOlI3PCEQvF2= NFjEN|RUSU6JRWK=
H4 M1PTSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TaVWlEPTB;NEeuOlYzOSEQvF2= MX;TRW5ITVJ?
CP66-MEL MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXexOoVCUUN3ME20PE4xPzB2IN88US=> M4iwb3NCVkeHUh?=
SNB75 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLsTWM2OD12OD6xPFc1KM7:TR?= MnixV2FPT0WU
Mo-T MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn6zTWM2OD12OD6yO|kh|ryP M{HXWXNCVkeHUh?=
BT-549 NF;T[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\s[2lEPTB;NEiuN|czQSEQvF2= M3jMXHNCVkeHUh?=
IGR-1 MnL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHzN|JKSzVyPUS4MlY3PDVizszN NH75OohUSU6JRWK=
NCI-H1299 MkHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzqTWM2OD12OD63NlQ5KM7:TR?= MVrTRW5ITVJ?
ALL-PO M4DaOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33XfmlEPTB;NEmuPVI3QCEQvF2= NInQbmJUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research
+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method: The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.
    (Only for Reference)
Animal Research
+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL (9.67 mM) warming
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID