NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.

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4 Customer Reviews

  • Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

    Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.
Targets
DNA-PK [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
PI3K [1]
(Cell-free assay)
ATM [1]
(Cell-free assay)
ATR [1]
(Cell-free assay)
14 nM 1.7 μM 5 μM >100 μM >100 μM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 M37zdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPh[YJKSzVyPUCuNFIyPDNizszN MX3TRW5ITVJ?
A172 NYXneoJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvqUZBPUUN3ME2wMlE2OzF4IN88US=> MULTRW5ITVJ?
NCI-H526 M3j3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{C3[GlEPTB;MD6yPFQxPyEQvF2= NXW3SFVKW0GQR1XS
HDLM-2 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELtRmlKSzVyPUCuN|I{PDVizszN MVPTRW5ITVJ?
HuO-3N1 NVfqc41XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn62TWM2OD1yLkS2OlM3KM7:TR?= NH3KSmRUSU6JRWK=
NCI-SNU-1 MlTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwNkC5PVQh|ryP NYrKNW1MW0GQR1XS
SK-N-AS MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7UTWM2OD1yLk[yNlE3KM7:TR?= MUPTRW5ITVJ?
LoVo NX7EU3ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHseGtCUUN3ME2wMlg3PzR7IN88US=> NXXoO4FzW0GQR1XS
LAMA-84 NHHMbYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwOUi4N|Mh|ryP M1L4U3NCVkeHUh?=
CTB-1 M2WxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDSTJhUUUN3ME2xMlEyPTR4IN88US=> Mn34V2FPT0WU
KP-N-YS NIrJTGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTFwMUSyN|Eh|ryP NVnvdnJmW0GQR1XS
HH NGnTOmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXK4XnhEUUN3ME2xMlE5ODl|IN88US=> MUDTRW5ITVJ?
CHL-1 M{Dh[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFwMkGzOlgh|ryP NHzUcHZUSU6JRWK=
NB7 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHaTWM2OD1zLkK0O|Q2KM7:TR?= MVjTRW5ITVJ?
HL-60 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPnOWk2UUN3ME2xMlM5OTlizszN NVn4W5NzW0GQR1XS
639-V M3vWU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHrcnp[UUN3ME2xMlQ1OTJ6IN88US=> NHLidGtUSU6JRWK=
NCI-H1793 M2nMPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYr4e5pyUUN3ME2xMlQ2QDRizszN MXfTRW5ITVJ?
NEC8 M3SxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTFwNUWzOUDPxE1? M{L4ZnNCVkeHUh?=
PA-1 M13ocmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXme2N5UUN3ME2xMlU5Ojl2IN88US=> M4[yN3NCVkeHUh?=
D-423MG NILMfHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwNkmzOlEh|ryP MnriV2FPT0WU
NCI-H292 M2qybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu1TY4zUUN3ME2xMlc1ODF|IN88US=> MULTRW5ITVJ?
SK-MEL-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTFwN{m0O|kh|ryP M4rJdnNCVkeHUh?=
LB2241-RCC M{j5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzMSGFCUUN3ME2yMlE1OTR4IN88US=> MXjTRW5ITVJ?
SK-MEL-3 M1j5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPGRmxKSzVyPUKuNVY1QSEQvF2= M1PCbnNCVkeHUh?=
MHH-PREB-1 NX7PbmkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTJ[HFKSzVyPUKuNVY3ODlizszN MVnTRW5ITVJ?
BFTC-905 NYTRNmFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTJwMU[2PFch|ryP NUG2fGdWW0GQR1XS
Ramos-2G6-4C10 NYD5S4l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTJwMUm5NFkh|ryP NVrBPGZ7W0GQR1XS
G-361 NFn5OG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\MTWM2OD1{LkKxOlgh|ryP MVnTRW5ITVJ?
MOLT-4 M1e4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXTTWM2OD1{LkKxPFg5KM7:TR?= NGX3[YRUSU6JRWK=
DEL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jTZ2lEPTB;Mj6zOVU3PCEQvF2= MYTTRW5ITVJ?
MV-4-11 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXEUHh6UUN3ME2yMlM4OzlizszN NVfQc2h6W0GQR1XS
SK-NEP-1 MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DubGlEPTB;Mj6zPFc5OyEQvF2= MV7TRW5ITVJ?
RS4-11 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJwNU[wNlMh|ryP NYDqTYtsW0GQR1XS
HuH-7 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTJwNU[3NFIh|ryP M17OXXNCVkeHUh?=
A101D M1v4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzmeIxKSzVyPUKuOlE{OzhizszN M2m2eHNCVkeHUh?=
KG-1 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3PVXdKSzVyPUKuOlc6OjRizszN M2PZenNCVkeHUh?=
KALS-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojKTWM2OD1{Lk[5OlM{KM7:TR?= MXLTRW5ITVJ?
VMRC-RCZ MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJwN{ezNlgh|ryP M3ywVnNCVkeHUh?=
SK-UT-1 MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPZZ|JKSzVyPUOuNVU{OSEQvF2= MWnTRW5ITVJ?
SW962 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TCZWlEPTB;Mz6yNFM2OiEQvF2= M3;uUXNCVkeHUh?=
DBTRG-05MG MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELlV|VKSzVyPUOuNlgxQDVizszN M1roRXNCVkeHUh?=
PANC-08-13 NHmwbHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITYdWJKSzVyPUOuOFEzPzhizszN Mn[xV2FPT0WU
QIMR-WIL NInsdItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rmNGlEPTB;Mz60NVM1OSEQvF2= MUTTRW5ITVJ?
SK-MEL-30 NEXKdINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf3NI1DUUN3ME2zMlQzPTl6IN88US=> MXfTRW5ITVJ?
697 M4\ibmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTNwNES5PVMh|ryP MmTzV2FPT0WU
NY NEjrPI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTNwNEWwNlIh|ryP M{L2OHNCVkeHUh?=
ES7 NILsXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjDZoYzUUN3ME2zMlQ3PzJ7IN88US=> MmLOV2FPT0WU
JVM-3 MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTNTWM2OD1|LkS4NFc4KM7:TR?= NHexRnRUSU6JRWK=
U031 NUfmS5ljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTNwNUmzOlgh|ryP NYjaWYQyW0GQR1XS
BHT-101 Mn\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHUTWM2OD1|LkW5PVg2KM7:TR?= MnTWV2FPT0WU
8305C MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXLUXNKSzVyPUOuOlE4OzZizszN MWDTRW5ITVJ?
MG-63 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTNwNkK2O|Yh|ryP Mk\aV2FPT0WU
NOS-1 NXfaVYRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3xeFVKSzVyPUOuOlU{OTJizszN MlnxV2FPT0WU
YH-13 NWHoNmtoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvoNZlKSzVyPUOuPFcyQDlizszN NH:w[mdUSU6JRWK=
LXF-289 NH:4N4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TKUGlEPTB;Mz65NVA1OSEQvF2= NGrYZlhUSU6JRWK=
GOTO MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV31VGhJUUN3ME2zMlkyPDlizszN M{O3THNCVkeHUh?=
EKVX NUjTSYRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTRwMkK1NlQh|ryP MWPTRW5ITVJ?
CAL-51 NFPRS25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTRwMkS4OVQh|ryP NWq3SIwzW0GQR1XS
AN3-CA NV\XU41ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLMTWM2OD12LkK1PFE{KM7:TR?= MWTTRW5ITVJ?
IA-LM MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLnbm1JUUN3ME20MlI4QTN3IN88US=> MnjIV2FPT0WU
KU-19-19 NHzLZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXlTWM2OD12LkOyPVIyKM7:TR?= MkTPV2FPT0WU
A704 NHLodYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvWTWM2OD12LkSwPFg5KM7:TR?= MUXTRW5ITVJ?
RH-18 Mlj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPjPI13UUN3ME20MlQ1QTV|IN88US=> MYXTRW5ITVJ?
IST-MEL1 NXPZW4d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDa[FNKSzVyPUSuOVgzPjNizszN MVHTRW5ITVJ?
LU-134-A Ml[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLnTJlpUUN3ME20MlU6Pjh3IN88US=> MoK5V2FPT0WU
SF126 NILJZmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\uZoQ1UUN3ME20MlYxPzF3IN88US=> NVLn[Ww{W0GQR1XS
EFO-27 NGTqTmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXKTWM2OD12Lk[2OVI2KM7:TR?= MX\TRW5ITVJ?
SN12C MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTRwN{G4PVgh|ryP M2LUNHNCVkeHUh?=
L-363 NXywfVJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:4SGlEPTB;ND63O|EyPiEQvF2= NVPvems3W0GQR1XS
MEL-HO NXjGToszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTRwN{e5PFkh|ryP NGSxfZNUSU6JRWK=
TYK-nu MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjTTWM2OD12LkiwNVI5KM7:TR?= M13zdXNCVkeHUh?=
MDA-MB-415 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP1OINKSzVyPUWuNFA{OTRizszN M1r3NXNCVkeHUh?=
HCC70 MmrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTVwMEO5N|kh|ryP MoC4V2FPT0WU
IGROV-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTVwMkWyPVIh|ryP NHzPcnBUSU6JRWK=
NCI-H1355 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTVwMkm2JO69VQ>? MV3TRW5ITVJ?
23132-87 NVzsNWpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\SNFI6UUN3ME21MlMzODJ2IN88US=> M2jhRXNCVkeHUh?=
NB69 M3X4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonNTWM2OD13LkOyOFIh|ryP M{DLe3NCVkeHUh?=
HSC-2 M{TrdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTVwNEG3O|Mh|ryP NUezVJprW0GQR1XS
KYSE-410 MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVyzTXdbUUN3ME21MlQ4PjN4IN88US=> NFvJc5pUSU6JRWK=
GCIY MnTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEGxcHlKSzVyPUWuOVE{PzhizszN Mmm4V2FPT0WU
A427 Mnf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnJZo9KSzVyPUWuOVM3PjFizszN M2LDdXNCVkeHUh?=
ChaGo-K-1 MoDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf4Zo5XUUN3ME21MlU3PTl7IN88US=> M4flZXNCVkeHUh?=
PFSK-1 MlvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TicmlEPTB;NT62NlE6PCEQvF2= M3:yT3NCVkeHUh?=
MLMA NXy0dYlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIm4XmdKSzVyPUWuPFM3ODZizszN MnTPV2FPT0WU
RVH-421 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF2xdZdKSzVyPU[uNFc{OzhizszN MX\TRW5ITVJ?
LB1047-RCC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorpTWM2OD14LkG3OVIzKM7:TR?= NFnUNWdUSU6JRWK=
MHH-NB-11 MkjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPXVHdKSzVyPU[uN|I4OjFizszN NF;OWHZUSU6JRWK=
J-RT3-T3-5 NW\PcZN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTZwNkOyPVEh|ryP NUm2ZnFFW0GQR1XS
UM-UC-3 M3jmZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjqcHlWUUN3ME22MlY1OzN2IN88US=> M{LiTnNCVkeHUh?=
IST-SL1 NHfKbJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTZwNkmzOlkh|ryP NImxOGRUSU6JRWK=
NB14 NULSbG16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7YUohXUUN3ME22Mlc6PzZzIN88US=> NUjJU|hCW0GQR1XS
NBsusSR NWHreJM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\SVmlEPTB;Nj64NlUxOiEQvF2= MWLTRW5ITVJ?
D-263MG NVn2W4M3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17GNWlEPTB;Nj65NVA3QCEQvF2= Ml;tV2FPT0WU
NCI-H2347 M2jLS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:wZ4ZuUUN3ME22Mlk{OjF|IN88US=> MV;TRW5ITVJ?
ES8 M{nZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrtTWM2OD14Lkm3OVg5KM7:TR?= MYXTRW5ITVJ?
786-0 M{DJZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\1bXBKSzVyPUeuNFk4QDZizszN NHHI[lJUSU6JRWK=
EPLC-272H NXnTU2FUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\MPWlEPTB;Nz6xOlI1PiEQvF2= Mkn6V2FPT0WU
CAPAN-1 M{G3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLVTWM2OD15LkK0N|U6KM7:TR?= MX7TRW5ITVJ?
NCI-H82 M2TaUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETiR5dKSzVyPUeuNlY3PTlizszN MkfUV2FPT0WU
G-402 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PhdmlEPTB;Nz6zNFA2OSEQvF2= MknoV2FPT0WU
SW982 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXm2[mVVUUN3ME23MlMxOjB|IN88US=> NGCzS45USU6JRWK=
OVCAR-4 M3nCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPs[mVKSzVyPUeuN|E{OjhizszN M2XNdXNCVkeHUh?=
KARPAS-299 NVjvZ|NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrweI9YUUN3ME23MlMzPjJ{IN88US=> Mn7oV2FPT0WU
MIA-PaCa-2 M1ntWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTdwM{[4NlMh|ryP NFL2SHZUSU6JRWK=
AU565 NGfuTVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fiNWlEPTB;Nz61PVg{OyEQvF2= NEizXGdUSU6JRWK=
GAMG M{HpNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoroTWM2OD15Lk[0NVMyKM7:TR?= MoHJV2FPT0WU
HuO9 M3nZXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;YTWM2OD15LkexO|Q{KM7:TR?= MWLTRW5ITVJ?
ACN NF;ReWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTdwN{SzN{DPxE1? M1T2WnNCVkeHUh?=
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CGTH-W-1 MkTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36xWWlEPTB;MkOuNFY1OSEQvF2= MoPEV2FPT0WU
SK-LU-1 NF[yR|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrzTmpjUUN3ME2yN{41Pjh|IN88US=> NFPs[plUSU6JRWK=
BB65-RCC M{nkVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXMcI5KSzVyPUKzMlc5PjNizszN NFjHS4NUSU6JRWK=
HSC-3 NYOwXFIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUT3bJRbUUN3ME2yN{45PTJ5IN88US=> NHG1VFdUSU6JRWK=
SK-MES-1 NXfGSGJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{f0bGlEPTB;MkSuNFE3OSEQvF2= MlzuV2FPT0WU
DB MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnqxTWM2OD1{ND6xNFI5KM7:TR?= M3O2[HNCVkeHUh?=
HO-1-N-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXjeYgyUUN3ME2yOE4{ODl|IN88US=> MVfTRW5ITVJ?
MKN1 MknHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrtbFh2UUN3ME2yOE43QCEQvF2= MmjhV2FPT0WU
MN-60 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljmTWM2OD1{ND64OVE6KM7:TR?= MX;TRW5ITVJ?
8505C MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPrTWM2OD1{NT6xPFQ2KM7:TR?= M{O5fXNCVkeHUh?=
COLO-320-HSR MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\3SGlEPTB;MkWuNlIxQCEQvF2= MVTTRW5ITVJ?
BB30-HNC NX7qPHhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ThOGlEPTB;MkWuNlQ5OyEQvF2= MXLTRW5ITVJ?
KM12 M3vMfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfwTWM2OD1{NT61PFA4KM7:TR?= M2PSO3NCVkeHUh?=
NB13 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJ3LkW4PVgh|ryP MUjTRW5ITVJ?
HCC2998 M2LJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLFb3RKSzVyPUK2MlAzQDNizszN MnjSV2FPT0WU
U-118-MG NGPPbZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJ4LkC4NFgh|ryP NFy4PIhUSU6JRWK=
NB10 NF\uenBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrafFJKSzVyPUK2MlI{PCEQvF2= Ml31V2FPT0WU
SK-LMS-1 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJ5LkC3NFQh|ryP M2fROXNCVkeHUh?=
SW1573 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITrNWxKSzVyPUK3MlEyKM7:TR?= NInLSGtUSU6JRWK=
LB373-MEL-D MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvFZpN1UUN3ME2yO{4yOjl2IN88US=> NVf2[29ZW0GQR1XS
DK-MG NGn1ZYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PjfGlEPTB;MkeuNVgyPyEQvF2= MYHTRW5ITVJ?
RMG-I MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK3[VhKSzVyPUK3MlIxOjlizszN NFvIbmtUSU6JRWK=
SW1088 NF7jRWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nTfmlEPTB;MkeuOVA1OiEQvF2= MmnEV2FPT0WU
SK-OV-3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF32XWVKSzVyPUK3Mlc2QTNizszN NF:2V3FUSU6JRWK=
KP-N-YN M4njfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJ5LkiwOFMh|ryP MXLTRW5ITVJ?
RPMI-7951 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HsPGlEPTB;MkiuNlQ2PiEQvF2= NWOwNndWW0GQR1XS
CaR-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTJ6LkW1PFIh|ryP MYXTRW5ITVJ?
MKN7 NYPidZlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;hTnlpUUN3ME2yPE42QTZ2IN88US=> MkLXV2FPT0WU
CHP-212 Ml;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJ6Lke0NFEh|ryP NIO4WGZUSU6JRWK=
KYSE-450 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTJ6LkiwPVEh|ryP NFLleZJUSU6JRWK=
RXF393 MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLP[2tKSzVyPUK5MlI6ODZizszN NWDFUIMxW0GQR1XS
P30-OHK NF;kOlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[1VXBrUUN3ME2yPU4{ODR6IN88US=> MWjTRW5ITVJ?
Ca9-22 NX;rVZZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJ7LkSyPVkh|ryP M3rhVHNCVkeHUh?=
RT-112 MlT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLMTWM2OD1{OT60OlEyKM7:TR?= MmLLV2FPT0WU
ES1 M{PBRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjkPXhKSzVyPUK5Mlg2PDRizszN Mn25V2FPT0WU
HCE-4 MlO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJ7Lki3PFYh|ryP NF;OO4FUSU6JRWK=
AM-38 M4XOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3wbJNKSzVyPUOwMlA3ODZizszN MV7TRW5ITVJ?
AsPC-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHITWM2OD1|MD64NFU{KM7:TR?= M2DyeXNCVkeHUh?=
TE-9 NH\NRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jIUGlEPTB;M{CuPFc{PyEQvF2= NFrRTmNUSU6JRWK=
HuP-T4 Mnj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vCOGlEPTB;M{CuPVY{QCEQvF2= NEHoT|VUSU6JRWK=
LB2518-MEL NYrJZoJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTNzLkC3OFQh|ryP Mmr2V2FPT0WU
NCI-H1703 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn2TZp[UUN3ME2zNU4xQTB3IN88US=> MljTV2FPT0WU
NCI-H2228 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXqxOIZHUUN3ME2zNU41PjVzIN88US=> NYfvZmZ{W0GQR1XS
SCC-4 NYnEXW5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTNzLkmxPFEh|ryP MVjTRW5ITVJ?
KNS-81-FD MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DDU2lEPTB;M{KuNFEzQCEQvF2= MUnTRW5ITVJ?
NTERA-S-cl-D1 NXzMWnN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHmxRmxKSzVyPUOyMlA4OzlizszN MX;TRW5ITVJ?
Daoy NWHaT3ZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPRTWM2OD1|Mj6wPFM5KM7:TR?= NWHIcnlHW0GQR1XS
ES4 MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTh[ZdGUUN3ME2zNk4{QTJ{IN88US=> Mlr1V2FPT0WU
MHH-ES-1 NV;SbW1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofVTWM2OD1|Mj60PFczKM7:TR?= NVrFR29qW0GQR1XS
C-33-A MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVy1OItMUUN3ME2zNk44PzJ6IN88US=> NULWWnpyW0GQR1XS
BHY M1zOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7kV|NKSzVyPUOyMlk1QTVizszN M2\tZXNCVkeHUh?=
Detroit562 NXziWXpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3JTWM2OD1|Mz62OlU4KM7:TR?= MYfTRW5ITVJ?
EW-1 NVXLeJVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLTVWhyUUN3ME2zN{46OzJ{IN88US=> MXvTRW5ITVJ?
NCI-H1395 M1zPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH61O5lKSzVyPUO0MlA4QTlizszN NFezSJJUSU6JRWK=
KM-H2 NYHrWmZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnKUod2UUN3ME2zOk41PzR|IN88US=> NFO2U3dUSU6JRWK=
NCI-H520 NGS3[nVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fU[mlEPTB;M{[uO|U1OSEQvF2= NVXRRZRzW0GQR1XS
D-392MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELCeIdKSzVyPUO3MlM{PDRizszN NWXneWRPW0GQR1XS
NOMO-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\RW4tKSzVyPUO3MlgxQDlizszN M{nBWHNCVkeHUh?=
TE-6 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3ONJZKSzVyPUO4MlEzPCEQvF2= M3jIZXNCVkeHUh?=
HT-3 NUO1dIpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDlTWM2OD1|OD60OFM3KM7:TR?= M3vQVXNCVkeHUh?=
RPMI-8226 NHHrZ4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTN6Lkm1NVkh|ryP NW[4VGF6W0GQR1XS
U251 M1jEemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfJ[2gxUUN3ME2zPU4xOTJ2IN88US=> MWjTRW5ITVJ?
GCT M4Xr[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvUd3hxUUN3ME2zPU4yQDV{IN88US=> NGP5cY9USU6JRWK=
A431 NH32U45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGiwb5RKSzVyPUO5MlE5QTRizszN M1TRW3NCVkeHUh?=
TE-12 MlH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTN7LkK0OFgh|ryP M{XCcnNCVkeHUh?=
HMV-II NFjNSZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\zOYdpUUN3ME2zPU42ODR5IN88US=> Ml22V2FPT0WU
IST-MES1 MoSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG4WJFZUUN3ME20NE4yPTB{IN88US=> MYLTRW5ITVJ?
SW13 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYSwVoRQUUN3ME20NE42OTlizszN NXXXbZRYW0GQR1XS
SF295 NFrhUW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLOdZJKSzVyPUSwMlgxPjZizszN M1H4WXNCVkeHUh?=
MDA-MB-157 MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v2NGlEPTB;NECuPVQ3OiEQvF2= M3rsSnNCVkeHUh?=
TE-1 NWH2T4ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDDTWM2OD12MT64O|E1KM7:TR?= NWC5cnJRW0GQR1XS
HuCCT1 M12xcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rnZWlEPTB;NEKuOVI5QSEQvF2= NHP3VXJUSU6JRWK=
KYSE-510 MkKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUW0eWg2UUN3ME20N{4yPzV2IN88US=> MkjLV2FPT0WU
NCI-H358 NHG5VZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkm5TWM2OD12ND6wN|A1KM7:TR?= NVLJc2tSW0GQR1XS
SW900 NFXGVXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj5TWM2OD12ND6wO|U5KM7:TR?= M{\1S3NCVkeHUh?=
CAS-1 NVHVbnlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3nTWM2OD12ND6wPVkyKM7:TR?= M2TyPXNCVkeHUh?=
TE-8 M1vYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XoU2lEPTB;NESuOVY2QCEQvF2= MV\TRW5ITVJ?
P12-ICHIKAWA MoHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTR2Lk[xNVIh|ryP M3\TSHNCVkeHUh?=
YKG-1 M3W4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTR2Lke4NUDPxE1? M{LId3NCVkeHUh?=
SNU-C2B M4i3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7PSnZKSzVyPUS0Mlc6ODNizszN Mn;4V2FPT0WU
LCLC-103H Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fKUWlEPTB;NESuPFcxOyEQvF2= NH30ToNUSU6JRWK=
U-87-MG NGrVUpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjxWVhTUUN3ME20OU4yODJ{IN88US=> Mkf6V2FPT0WU
HAL-01 M4fhS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjaV5pKSzVyPUS1MlE{PzlizszN MlriV2FPT0WU
OVCAR-8 NIexUW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\MZ21KSzVyPUS1MlM2PjRizszN NEDrfGtUSU6JRWK=
KYSE-150 M3XUOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTR5LkGwOVIh|ryP NG\mTWtUSU6JRWK=
OE33 NYfRUJM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTR5LkG0Nlkh|ryP MX\TRW5ITVJ?
CAL-62 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTkfYxKSzVyPUS3MlQxPjhizszN MYLTRW5ITVJ?
TCCSUP MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXzb|JKSzVyPUS3MlYzPjRizszN MWnTRW5ITVJ?
H4 MoPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXxWFlKSzVyPUS3MlY3OjFizszN NWXYVFB{W0GQR1XS
CP66-MEL NYfvcI41T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzqWZY3UUN3ME20PE4xPzB2IN88US=> M1;6c3NCVkeHUh?=
SNB75 NGTieHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPiTWM2OD12OD6xPFc1KM7:TR?= NHnoZoNUSU6JRWK=
Mo-T MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\ZO2lEPTB;NEiuNlc6KM7:TR?= MWDTRW5ITVJ?
BT-549 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHvb41KSzVyPUS4MlM4OjlizszN NV;oe4JOW0GQR1XS
IGR-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXsOZZtUUN3ME20PE43PjR3IN88US=> NVPN[4h6W0GQR1XS
NCI-H1299 M{nXd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvGT3d5UUN3ME20PE44OjR6IN88US=> NWf2WFhoW0GQR1XS
ALL-PO M1rnRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTR7LkmyOlgh|ryP MXHTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method: The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL (9.67 mM) warming
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID