NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

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6 Customer Reviews

  • (C) Microirradiation live-cell microscopy of U2OS cells stably expressing mEGFP-MacroD2 full-length construct and treated with KU55933 10 μM, VE-821 1 μM, NU7441 1 μM or DMSO. Scale bar, 10 μm.

    Nucleic Acids Res, 2017, 45(1):244-254. NU7441 (KU-57788) purchased from Selleck.

    Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

  • Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

    (C) Immunohistochemically detection of Cleaved Caspase-3 48 h after treatment to measure apoptosis in vivo, induced levels of apoptosis in xenografts treated with radiation in combination with DNA-PKcsi and HT compared to radiation alone. Necrotic areas were observed in xenograft of triple treatment. DNA-PKcsi:NU7441

    Oncotarget, 2016, 7(40): 65504-65513. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6] It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[7].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 MkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILJcm5KSzVyPUCuNFIyPDNizszN NVnhOmgzW0GQR1XS
A172 M4LWZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMUWzNVYh|ryP NUDkUXB3W0GQR1XS
NCI-H526 NUfwdJQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMki0NFch|ryP Mm\HV2FPT0WU
HDLM-2 NXHaS5hGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFniepNKSzVyPUCuN|I{PDVizszN M1y3WXNCVkeHUh?=
HuO-3N1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwNE[2N|Yh|ryP MUPTRW5ITVJ?
NCI-SNU-1 NXHW[otTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXKXWpKSzVyPUCuOlA6QTRizszN Ml7LV2FPT0WU
SK-N-AS NHrMcW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTxTWM2OD1yLk[yNlE3KM7:TR?= NXLJZmtkW0GQR1XS
LoVo NX7T[5o{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTBTWM2OD1yLki2O|Q6KM7:TR?= MXLTRW5ITVJ?
LAMA-84 M37SSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfSTWM2OD1yLkm4PFM{KM7:TR?= MW\TRW5ITVJ?
CTB-1 NGHk[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTFwMUG1OFYh|ryP NYn0bI1iW0GQR1XS
KP-N-YS NEPvO2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHVVGJKSzVyPUGuNVQzOzFizszN M1TlVnNCVkeHUh?=
HH MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFwMUiwPVMh|ryP NHTVWodUSU6JRWK=
CHL-1 MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXO3VWV{UUN3ME2xMlIyOzZ6IN88US=> NYnmSpBYW0GQR1XS
NB7 M1zpOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX1TWM2OD1zLkK0O|Q2KM7:TR?= M4fWSHNCVkeHUh?=
HL-60 M2THXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTFwM{ixPUDPxE1? MlzGV2FPT0WU
639-V MlzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHETlBKSzVyPUGuOFQyOjhizszN NX3TdI4yW0GQR1XS
NCI-H1793 MlPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K4WmlEPTB;MT60OVg1KM7:TR?= Ml;rV2FPT0WU
NEC8 NIniZmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfoTWM2OD1zLkW1N|Uh|ryP NXLaNG5rW0GQR1XS
PA-1 NUTtcVZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTFwNUiyPVQh|ryP NHHlUoxUSU6JRWK=
D-423MG NFnpZllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3zc3k4UUN3ME2xMlY6OzZzIN88US=> MoPpV2FPT0WU
NCI-H292 NHvaNIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nVSGlEPTB;MT63OFAyOyEQvF2= NVjtdYpHW0GQR1XS
SK-MEL-1 NH3rT|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzvOIxKSzVyPUGuO|k1PzlizszN MVLTRW5ITVJ?
LB2241-RCC NVSwb2poT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJwMUSxOFYh|ryP M3qySHNCVkeHUh?=
SK-MEL-3 NY\hXYxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fmeWlEPTB;Mj6xOlQ6KM7:TR?= MXzTRW5ITVJ?
MHH-PREB-1 M3L2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW4fZhMUUN3ME2yMlE3PjB7IN88US=> MW\TRW5ITVJ?
BFTC-905 NYLMSnhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H4R2lEPTB;Mj6xOlY5PyEQvF2= MnHpV2FPT0WU
Ramos-2G6-4C10 NULvUFQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DM[GlEPTB;Mj6xPVkxQSEQvF2= M1ftNXNCVkeHUh?=
G-361 MoLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3JTWM2OD1{LkKxOlgh|ryP NELFOZlUSU6JRWK=
MOLT-4 MkPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYH2V4k2UUN3ME2yMlIyQDh6IN88US=> MWPTRW5ITVJ?
DEL M3[3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPKTWM2OD1{LkO1OVY1KM7:TR?= M3flfnNCVkeHUh?=
MV-4-11 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PaUmlEPTB;Mj6zO|M6KM7:TR?= NW\WXXVTW0GQR1XS
SK-NEP-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTzfmIxUUN3ME2yMlM5Pzh|IN88US=> NHu0WI5USU6JRWK=
RS4-11 MnjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJwNU[wNlMh|ryP NYj0fmdZW0GQR1XS
HuH-7 MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHaTWM2OD1{LkW2O|AzKM7:TR?= MlvKV2FPT0WU
A101D MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1mzdGlEPTB;Mj62NVM{QCEQvF2= NXPndYJNW0GQR1XS
KG-1 MoPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofOTWM2OD1{Lk[3PVI1KM7:TR?= NHjKbYpUSU6JRWK=
KALS-1 NGPQUpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3PTWM2OD1{Lk[5OlM{KM7:TR?= NEXTO2ZUSU6JRWK=
VMRC-RCZ NXXnO3ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX5U|ZKSzVyPUKuO|c{OjhizszN NHewVYNUSU6JRWK=
SK-UT-1 NH3aTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITrTGVKSzVyPUOuNVU{OSEQvF2= NELSUnRUSU6JRWK=
SW962 M4jVbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS4OWhKSzVyPUOuNlA{PTJizszN MYrTRW5ITVJ?
DBTRG-05MG MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;MNmlEPTB;Mz6yPFA5PSEQvF2= NE\Md2xUSU6JRWK=
PANC-08-13 NXj2UHd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTNwNEGyO|gh|ryP NWm0SlVLW0GQR1XS
QIMR-WIL NXn3V4tWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvSTWM2OD1|LkSxN|QyKM7:TR?= NHvoRm9USU6JRWK=
SK-MEL-30 NX7rNI5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTNwNEK1PVgh|ryP M4PDcnNCVkeHUh?=
697 NVHTWpQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHWTWM2OD1|LkS0PVk{KM7:TR?= NV;1VJFVW0GQR1XS
NY NYjqSWo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTNwNEWwNlIh|ryP MoHHV2FPT0WU
ES7 M2\PXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIizNGtKSzVyPUOuOFY4OjlizszN MoLuV2FPT0WU
JVM-3 M{LEfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWm1[JdTUUN3ME2zMlQ5ODd5IN88US=> Mo\ZV2FPT0WU
U031 M1O1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\OWVBIUUN3ME2zMlU6OzZ6IN88US=> NVn0UG9zW0GQR1XS
BHT-101 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz1TWM2OD1|LkW5PVg2KM7:TR?= NWfRNGpGW0GQR1XS
8305C NWjzbGVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPrSopuUUN3ME2zMlYyPzN4IN88US=> MnqxV2FPT0WU
MG-63 NVzFSFR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;VTWM2OD1|Lk[yOlc3KM7:TR?= NVXFVJNCW0GQR1XS
NOS-1 NHjqXYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTNwNkWzNVIh|ryP NV3ZdlRmW0GQR1XS
YH-13 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTNwOEexPFkh|ryP NHX4RWpUSU6JRWK=
LXF-289 NIfG[YpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTNwOUGwOFEh|ryP MVrTRW5ITVJ?
GOTO MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r1OGlEPTB;Mz65NVQ6KM7:TR?= M3vTRnNCVkeHUh?=
EKVX MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\oZ2lEPTB;ND6yNlUzPCEQvF2= MYjTRW5ITVJ?
CAL-51 NU\FRYJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfHT3VKSzVyPUSuNlQ5PTRizszN M1XMcXNCVkeHUh?=
AN3-CA NFH2WVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHle5VLUUN3ME20MlI2QDF|IN88US=> NWL3cZg5W0GQR1XS
IA-LM MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\hXGlEPTB;ND6yO|k{PSEQvF2= NELy[lVUSU6JRWK=
KU-19-19 NIHPbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTsbVVjUUN3ME20MlMzQTJzIN88US=> NHPzUFNUSU6JRWK=
A704 NIrjZpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITwRoVKSzVyPUSuOFA5QDhizszN MXLTRW5ITVJ?
RH-18 NIrhVINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTRwNES5OVMh|ryP M33HW3NCVkeHUh?=
IST-MEL1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHhOo1RUUN3ME20MlU5OjZ|IN88US=> NYK0dpNoW0GQR1XS
LU-134-A MnXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\vTWM2OD12LkW5Olg2KM7:TR?= MkHmV2FPT0WU
SF126 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTRwNkC3NVUh|ryP NWDXT4Z{W0GQR1XS
EFO-27 MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFe2cnNKSzVyPUSuOlY2OjVizszN M33pZXNCVkeHUh?=
SN12C MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ToUWlEPTB;ND63NVg6QCEQvF2= M4TQRXNCVkeHUh?=
L-363 MoS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXiTWM2OD12Lke3NVE3KM7:TR?= MmHvV2FPT0WU
MEL-HO MnHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXmO3lxUUN3ME20Mlc4QTh7IN88US=> NGL6dZdUSU6JRWK=
TYK-nu NHfQXYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\4elFlUUN3ME20MlgxOTJ6IN88US=> NFnzT21USU6JRWK=
MDA-MB-415 NEO3bHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTVwMECzNVQh|ryP MUjTRW5ITVJ?
HCC70 M2DQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\uZY5KSzVyPUWuNFM6OzlizszN M1jibnNCVkeHUh?=
IGROV-1 NVG4RXRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTVwMkWyPVIh|ryP NYfmZWhzW0GQR1XS
NCI-H1355 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXHNYR[UUN3ME21MlI6PiEQvF2= NWT4dZZUW0GQR1XS
23132-87 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NID2WmxKSzVyPUWuN|IxOjRizszN MmjUV2FPT0WU
NB69 MkDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXNcoY1UUN3ME21MlMzPDJizszN Ml7rV2FPT0WU
HSC-2 MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NISzV2JKSzVyPUWuOFE4PzNizszN MXrTRW5ITVJ?
KYSE-410 NI\rcpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL4R4FEUUN3ME21MlQ4PjN4IN88US=> MkPPV2FPT0WU
GCIY MnPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTVwNUGzO|gh|ryP MnzHV2FPT0WU
A427 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq0TWM2OD13LkWzOlYyKM7:TR?= MWPTRW5ITVJ?
ChaGo-K-1 M3u3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\CTWM2OD13LkW2OVk6KM7:TR?= NWLC[ZVyW0GQR1XS
PFSK-1 NEPZfIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3ST3F2UUN3ME21MlYzOTl2IN88US=> MXnTRW5ITVJ?
MLMA MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTVwOEO2NFYh|ryP NX;weWZMW0GQR1XS
RVH-421 NVq3SHA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLDXnBiUUN3ME22MlA4OzN6IN88US=> NETVN2ZUSU6JRWK=
LB1047-RCC NWfOdGg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NID3UlZKSzVyPU[uNVc2OjJizszN MYjTRW5ITVJ?
MHH-NB-11 Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFyyVlBKSzVyPU[uN|I4OjFizszN NXvUV4I1W0GQR1XS
J-RT3-T3-5 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmqzTWM2OD14Lk[zNlkyKM7:TR?= Mmn4V2FPT0WU
UM-UC-3 Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUi0ZY5ZUUN3ME22MlY1OzN2IN88US=> NY\aSYNqW0GQR1XS
IST-SL1 M1PJUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDkVJBKSzVyPU[uOlk{PjlizszN MXrTRW5ITVJ?
NB14 NVvVNoRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHWTWM2OD14Lke5O|YyKM7:TR?= M{TJfHNCVkeHUh?=
NBsusSR M4PteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTZwOEK1NFIh|ryP NV\TT5pVW0GQR1XS
D-263MG NGH2R3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTZwOUGwOlgh|ryP NH3EO2pUSU6JRWK=
NCI-H2347 M{HGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jTfWlEPTB;Nj65N|IyOyEQvF2= MnTNV2FPT0WU
ES8 NV7JW4hTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmC0TWM2OD14Lkm3OVg5KM7:TR?= M1jnU3NCVkeHUh?=
786-0 MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DEdWlEPTB;Nz6wPVc5PiEQvF2= NEjJNpJUSU6JRWK=
EPLC-272H M{XZPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjpXoJKSzVyPUeuNVYzPDZizszN M4rvS3NCVkeHUh?=
CAPAN-1 Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXtbG9KSzVyPUeuNlQ{PTlizszN NUnyXYhYW0GQR1XS
NCI-H82 NVGxOGtoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTdwMk[2OVkh|ryP NYDH[pdyW0GQR1XS
G-402 NU\PNGY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoD0TWM2OD15LkOwNFUyKM7:TR?= M4m2SHNCVkeHUh?=
SW982 M{DLfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHSOZNKSzVyPUeuN|AzODNizszN Mkf3V2FPT0WU
OVCAR-4 NI\qeHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTdwM{GzNlgh|ryP M4PRdHNCVkeHUh?=
KARPAS-299 NEDEe2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTdwM{K2NlIh|ryP M2PyXXNCVkeHUh?=
MIA-PaCa-2 NFzBVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LiUmlEPTB;Nz6zOlgzOyEQvF2= M4n4ZnNCVkeHUh?=
AU565 NVLWfHB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXHTWM2OD15LkW5PFM{KM7:TR?= MU\TRW5ITVJ?
GAMG NG\YcXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTdwNkSxN|Eh|ryP MoXQV2FPT0WU
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CAL-12T M3r0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTdwOUSzOVIh|ryP M3L0bHNCVkeHUh?=
FADU NHq3NJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;KToZKSzVyPUiuNFM3PTRizszN MnHTV2FPT0WU
NCI-H28 M2jsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PCTWlEPTB;OD6xOlk3OiEQvF2= MXzTRW5ITVJ?
LCLC-97TM1 MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjYOlA6UUN3ME24MlIyOTJ{IN88US=> NXHXXXdDW0GQR1XS
CHP-134 M3nXe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnr3TWM2OD16LkK0NVg2KM7:TR?= M3HHN3NCVkeHUh?=
HT-1080 MljxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXCTWM2OD16LkK1NFk{KM7:TR?= MmT0V2FPT0WU
PC-3 NWG5Xno{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7aTWM2OD16LkK3N|kzKM7:TR?= Mn3rV2FPT0WU
SNU-449 M2HrW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPsbGZKSzVyPUiuNlc6OyEQvF2= NWPEXFlvW0GQR1XS
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HT MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XjOWlEPTB;OD6zOlQ6KM7:TR?= MYnTRW5ITVJ?
HOS NFjlTGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRThwM{e1PFkh|ryP NX3KVnlsW0GQR1XS
KNS-62 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf4R|lmUUN3ME24MlM4PzZ{IN88US=> MkTFV2FPT0WU
OAW-42 NIDGc2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWK5SWM6UUN3ME24Mlk2QTZ2IN88US=> M172Z3NCVkeHUh?=
A549 NH;DTYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnHTWM2OD17LkC5OlEzKM7:TR?= MlrMV2FPT0WU
CAKI-1 NWnz[4toT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;VTWM2OD17LkG2OlEh|ryP MkDwV2FPT0WU
HCC1937 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYGze5hTUUN3ME25MlY6QDZ3IN88US=> NHfOXopUSU6JRWK=
GI-ME-N MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jpZWlEPTB;OT63NFE{PyEQvF2= NFnwNGNUSU6JRWK=
DU-4475 NELERXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHocY5KSzVyPUmuPVY6OzlizszN MlLBV2FPT0WU
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NCI-H1755 MoD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfJTWM2OD1zMD6yOFI5KM7:TR?= M2X4eXNCVkeHUh?=
NCI-H1437 M1rOUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\Le5lOUUN3ME2xNE42PzJ3IN88US=> NWn6W4V{W0GQR1XS
VM-CUB-1 NGC4[2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4mxVWlEPTB;MUCuOlE3PCEQvF2= Ml3IV2FPT0WU
A2058 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfETWM2OD1zMD62OFA1KM7:TR?= MonKV2FPT0WU
BPH-1 NUezdY05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTFyLkexOFUh|ryP NHGyeGxUSU6JRWK=
NB5 NHz3VGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrZUFZKSzVyPUGwMlc2PTlizszN NVnFV5BnW0GQR1XS
G-401 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnCfmtKSzVyPUGwMlc3OjZizszN MlLjV2FPT0WU
CAL-72 NVP3R5BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi1U5AyUUN3ME2xNE45ODl2IN88US=> M{D3bnNCVkeHUh?=
SK-MEL-28 MmfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTFyLkiyNFIh|ryP MmrPV2FPT0WU
C32 MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7v[nc3UUN3ME2xNE45OzR5IN88US=> NGDWb4xUSU6JRWK=
NCI-H1155 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrZOFFKSzVyPUGwMlg{PzZizszN MWTTRW5ITVJ?
BB49-HNC MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXjNYdKSzVyPUGwMlg2QDZizszN M3nPZnNCVkeHUh?=
GMS-10 NHfYXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vwfmlEPTB;MUCuPFk4OSEQvF2= NVThRWlDW0GQR1XS
K5 NV:4RYY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH3bo5pUUN3ME2xNE46ODdzIN88US=> M2DOWXNCVkeHUh?=
OS-RC-2 NHi2ToxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\uTWM2OD1zMT6wOVU6KM7:TR?= NH;JSpZUSU6JRWK=
HTC-C3 M1TjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmryTWM2OD1zMT6wO|E1KM7:TR?= MnfoV2FPT0WU
LB996-RCC NFHpdWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTkTWM2OD1zMT6wO|I{KM7:TR?= M1noUnNCVkeHUh?=
NCI-H1563 NIXOXIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnZfFh4UUN3ME2xNU4yODFzIN88US=> MlzkV2FPT0WU
CAL-54 NIn1VoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfJTHlVUUN3ME2xNU41QDFzIN88US=> NVzURYZuW0GQR1XS
WM-115 NIjVbZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknkTWM2OD1zMT62PFI1KM7:TR?= M1PQSXNCVkeHUh?=
COLO-684 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm3TWM2OD1zMT63NlY4KM7:TR?= NVPzWJJHW0GQR1XS
HOP-62 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfWbmFKSzVyPUGxMlc2ODhizszN NX3uZ4RtW0GQR1XS
NCI-H650 MlXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3SwcWlEPTB;MUGuPFk3OSEQvF2= NWOzeFl7W0GQR1XS
TE-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFzLkmzNVUh|ryP NV;a[21oW0GQR1XS
COLO-679 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzyTmx3UUN3ME2xNU46PDZizszN NEPzW4xUSU6JRWK=
FTC-133 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLnUHZKSzVyPUGyMlAxPzZizszN M165[XNCVkeHUh?=
D-283MED Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVuzSFZGUUN3ME2xNk4xPTZ7IN88US=> MlPqV2FPT0WU
SK-PN-DW MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTF{LkG5NFIh|ryP NWHhdI1EW0GQR1XS
BALL-1 M1nTbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rEZ2lEPTB;MUKuNlY3OiEQvF2= MXPTRW5ITVJ?
GT3TKB NFvFd3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\OTWM2OD1zMj6zNFc1KM7:TR?= MVfTRW5ITVJ?
HOP-92 MkDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3O3W2lEPTB;MUKuOVI{OyEQvF2= NHO1NJRUSU6JRWK=
M14 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DNW2lEPTB;MUOuNFM{PSEQvF2= M2\0U3NCVkeHUh?=
SKG-IIIa M1;k[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDrcW1QUUN3ME2xN{4xPTV2IN88US=> NXe3e4dbW0GQR1XS
Becker M1TsWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz3TWM2OD1zMz6wOVgh|ryP MmG3V2FPT0WU
ES5 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj1c29KSzVyPUGzMlE{PTZizszN M3nFRnNCVkeHUh?=
NCI-H2030 M4DacGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGxXGRVUUN3ME2xN{4zODZ{IN88US=> MoHZV2FPT0WU
SNU-423 NIrUc3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjTTIN3UUN3ME2xN{4{QDFizszN NVu0NZFSW0GQR1XS
CP50-MEL-B NHHlXXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHr[3l2UUN3ME2xN{43OjN{IN88US=> NXK4dXhxW0GQR1XS
NCI-H1092 M{C5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjXSm55UUN3ME2xN{44PDd3IN88US=> M1fITnNCVkeHUh?=
8-MG-BA NXy4W3JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXS[nVyUUN3ME2xN{44PTF|IN88US=> MYXTRW5ITVJ?
CAL-27 MnPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vPeGlEPTB;MUSuNFczPyEQvF2= MWfTRW5ITVJ?
AGS NULrc3pET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLnTWM2OD1zND6xN|E6KM7:TR?= NGnEd|hUSU6JRWK=
MZ2-MEL NXrVZ4l2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHftdm5KSzVyPUG0MlE1QDhizszN MVPTRW5ITVJ?
BFTC-909 NWn3TJk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTF2LkWwOVUh|ryP NI\UVI5USU6JRWK=
D-566MG MlrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDCVFF{UUN3ME2xOE44PzB4IN88US=> M{PKPXNCVkeHUh?=
MZ7-mel MlrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF3LkGwOlch|ryP MkjnV2FPT0WU
TE-5 NE\KcoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vMbGlEPTB;MUWuNlM{OyEQvF2= M{TmcXNCVkeHUh?=
647-V MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\CXop3UUN3ME2xOU4zPzB3IN88US=> NUTTXGdEW0GQR1XS
DMS-114 NUTjOZlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLGNXBKUUN3ME2xOU4{OjlzIN88US=> NWr1enBqW0GQR1XS
ME-180 M4\sWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLyTWM2OD1zNT60O|g{KM7:TR?= MU\TRW5ITVJ?
MS-1 NEf6OmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT6TWM2OD1zNT61OlI{KM7:TR?= M3PTTHNCVkeHUh?=
NUGC-3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;vNJI4UUN3ME2xOU43OjR3IN88US=> NV7HT49zW0GQR1XS
GB-1 NUXZZmFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;QTWM2OD1zNT62OFM4KM7:TR?= MYDTRW5ITVJ?
LOXIMVI MmTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHCTWM2OD1zNT64PVE6KM7:TR?= M3LIc3NCVkeHUh?=
NCI-H1304 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTF3Lki5Nlgh|ryP MlTKV2FPT0WU
KURAMOCHI MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjZTWM2OD1zNT65O|Eh|ryP MmfNV2FPT0WU
SW1783 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfKRZdKSzVyPUG2MlA6QTNizszN MnPlV2FPT0WU
EGI-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTF4LkWzOlUh|ryP NXuxUok5W0GQR1XS
KGN MnKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf4TWM2OD1zNj61OVg3KM7:TR?= NWT0U5VOW0GQR1XS
PANC-03-27 NVG4VGNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTF4Lke2OlIh|ryP MlvlV2FPT0WU
RH-1 Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrrfllRUUN3ME2xOk45OjVizszN M1nTcnNCVkeHUh?=
HT-1376 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLzVZdKSzVyPUG2Mlg1PDZizszN NHP1XmdUSU6JRWK=
ZR-75-30 M2Hn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTF4LkmzOlEh|ryP MnLvV2FPT0WU
TI-73 M{fVTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTF4Lkm0NFgh|ryP M4faRnNCVkeHUh?=
TK10 M{DVcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jINGlEPTB;MUeuNFA4QSEQvF2= NV25NZJvW0GQR1XS
SW684 M3nqXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrHVGJjUUN3ME2xO{4xOTV2IN88US=> MWTTRW5ITVJ?
RPMI-8866 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTF5LkC2PVkh|ryP NEj3bYJUSU6JRWK=
LNCaP-Clone-FGC NXmyO3J4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnHfoNqUUN3ME2xO{42OjBzIN88US=> M2nPdnNCVkeHUh?=
NCI-H2291 MofvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfpTnpiUUN3ME2xPE41OzR3IN88US=> NWPnfYhqW0GQR1XS
T47D NVHzb4hLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;LTFZKSzVyPUG4MlQ5QCEQvF2= MnriV2FPT0WU
A204 MmDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTJTnY{UUN3ME2xPE42PDV{IN88US=> NFu1[JFUSU6JRWK=
HT-144 M1\tOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPzZpRKSzVyPUG4Mlc1OjdizszN MlfTV2FPT0WU
MDA-MB-361 MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTDd4pKSzVyPUG5MlA4OTRizszN MVfTRW5ITVJ?
HCC1806 M4DJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjDTWM2OD1zOT6xOVkyKM7:TR?= NFnO[4tUSU6JRWK=
NCI-H596 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XNRWlEPTB;MUmuOlM6OSEQvF2= NID0dZdUSU6JRWK=
K-562 NVr5[nZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTPTWM2OD1zOT64PVI3KM7:TR?= NY\qXGhFW0GQR1XS
D-336MG MmrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTF7LkmzNlIh|ryP NU\2VW5mW0GQR1XS
SK-MEL-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzWdIJkUUN3ME2yNE4yPTV7IN88US=> MX7TRW5ITVJ?
HEC-1 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXqUIxKSzVyPUKwMlQ6PzhizszN MnywV2FPT0WU
EW-13 MlzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDDXHVZUUN3ME2yNE42PDR|IN88US=> NIDu[49USU6JRWK=
Hs-578-T MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\1[nlKSzVyPUKwMlU2QDNizszN NFPX[2dUSU6JRWK=
SJSA-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHviNndKSzVyPUKwMlU3QDhizszN NH7iOFlUSU6JRWK=
RCC10RGB M3vwU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLMTWM2OD1{MD62O|E6KM7:TR?= M2fpUnNCVkeHUh?=
LAN-6 M3vucGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEGzPYxKSzVyPUKxMlA{QTZizszN MlvGV2FPT0WU
NCI-H1048 NXv0UGhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkO0TWM2OD1{MT6yNlU5KM7:TR?= M{jrPHNCVkeHUh?=
CW-2 NV\s[Hh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XMW2lEPTB;MkGuNlcxPSEQvF2= NUXhR4FIW0GQR1XS
HCC2157 NHH5UlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTJzLkO2JO69VQ>? MlnUV2FPT0WU
EW-22 M{TSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mli2TWM2OD1{MT6zO|Yh|ryP MVvTRW5ITVJ?
A253 M2XQOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJzLkS0PFEh|ryP Mn;1V2FPT0WU
BE-13 MmXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJzLk[xNVMh|ryP MUTTRW5ITVJ?
KINGS-1 MkLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJzLk[zNVYh|ryP NVXIT|Y2W0GQR1XS
ETK-1 NITQOpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv5TWM2OD1{MT64NVUzKM7:TR?= M3uwdXNCVkeHUh?=
NCI-H2452 M4jlWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PJOmlEPTB;MkGuPFY1PyEQvF2= NXzpSGJuW0GQR1XS
HPAF-II MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDXTWM2OD1{MT64PVI{KM7:TR?= NGDLUHFUSU6JRWK=
D-542MG MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnf0TWM2OD1{MT65NFY6KM7:TR?= MUXTRW5ITVJ?
NCI-H630 M{T2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\LUGxKSzVyPUKyMlAzQTZizszN NYmxZmM{W0GQR1XS
TGBC11TKB MmHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJ{LkC0PUDPxE1? MV\TRW5ITVJ?
BCPAP MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:xWGlEPTB;MkKuOlEyKM7:TR?= MonZV2FPT0WU
HLE MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJ{Lk[5O{DPxE1? Mn[zV2FPT0WU
NCI-H727 M4HxSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\WTWM2OD1{Mj63N|Uh|ryP M2L4ZnNCVkeHUh?=
RD NWT0bnZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPPfY5KSzVyPUKyMlc2OThizszN NWrBbFJFW0GQR1XS
NCI-H522 NVLqb3FuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\IWWlEPTB;MkKuPFQ{OSEQvF2= NIeyclRUSU6JRWK=
CGTH-W-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7STVJ6UUN3ME2yN{4xPjRzIN88US=> NUeyeZN4W0GQR1XS
SK-LU-1 NIjnNXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\vdZhLUUN3ME2yN{41Pjh|IN88US=> NYrMVIxrW0GQR1XS
BB65-RCC NIXnfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJ|Lke4OlMh|ryP MUnTRW5ITVJ?
HSC-3 M4q5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[wTWM2OD1{Mz64OVI4KM7:TR?= MYLTRW5ITVJ?
SK-MES-1 NXPTdW9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPUWpBKSzVyPUK0MlAyPjFizszN M{XFUnNCVkeHUh?=
DB M1GzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljZTWM2OD1{ND6xNFI5KM7:TR?= Ml7UV2FPT0WU
HO-1-N-1 NWDzXpBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTJ2LkOwPVMh|ryP NY\lSIJuW0GQR1XS
MKN1 NIjxWHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnyTWM2OD1{ND62PEDPxE1? MUDTRW5ITVJ?
MN-60 M2Lmbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDrTIlKSzVyPUK0Mlg2OTlizszN NIrUWXZUSU6JRWK=
8505C NFTZbWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLzZZVKSzVyPUK1MlE5PDVizszN NYPGV3dWW0GQR1XS
COLO-320-HSR NV\DUZFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUSz[4RPUUN3ME2yOU4zOjB6IN88US=> NYrS[Y5iW0GQR1XS
BB30-HNC NVfGPXNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPEWJBLUUN3ME2yOU4zPDh|IN88US=> NUf0XpJQW0GQR1XS
KM12 NWW5XWVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[xTWM2OD1{NT61PFA4KM7:TR?= M{C2T3NCVkeHUh?=
NB13 NWHDOVlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HEPGlEPTB;MkWuOVg6QCEQvF2= M4G3ZnNCVkeHUh?=
HCC2998 MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jyTmlEPTB;Mk[uNFI5OyEQvF2= Mn3pV2FPT0WU
U-118-MG MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJ4LkC4NFgh|ryP NVW2cpBKW0GQR1XS
NB10 NEX0N2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLEN|RnUUN3ME2yOk4zOzRizszN MXHTRW5ITVJ?
SK-LMS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj6dWJ7UUN3ME2yO{4xPzB2IN88US=> NWSyOVRwW0GQR1XS
SW1573 NGnEOo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEftPXFKSzVyPUK3MlEyKM7:TR?= M1n5UHNCVkeHUh?=
LB373-MEL-D MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXxTWM2OD1{Nz6xNlk1KM7:TR?= MlnPV2FPT0WU
DK-MG NFS2NHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJ5LkG4NVch|ryP NXew[m8yW0GQR1XS
RMG-I NUDMU|FXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW5TWM2OD1{Nz6yNFI6KM7:TR?= NUHOXWw2W0GQR1XS
SW1088 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvzTWM2OD1{Nz61NFQzKM7:TR?= NXrjVVZEW0GQR1XS
SK-OV-3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVq1[5N{UUN3ME2yO{44PTl|IN88US=> M3rCXXNCVkeHUh?=
KP-N-YN NXn2d|JlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYGw[Y1tUUN3ME2yO{45ODR|IN88US=> NXH6O|Z{W0GQR1XS
RPMI-7951 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfNbW5FUUN3ME2yPE4zPDV4IN88US=> MlSwV2FPT0WU
CaR-1 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rMe2lEPTB;MkiuOVU5OiEQvF2= NWXE[IZTW0GQR1XS
MKN7 NFvRT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTJ6LkW5OlQh|ryP NF;CZm1USU6JRWK=
CHP-212 NU\Ge3lzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHMTWM2OD1{OD63OFAyKM7:TR?= NWq1ZZFIW0GQR1XS
KYSE-450 Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGToXWVKSzVyPUK4MlgxQTFizszN NGfYNnlUSU6JRWK=
RXF393 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXRTWM2OD1{OT6yPVA3KM7:TR?= NXTlU45CW0GQR1XS
P30-OHK NYfhelNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfuTWM2OD1{OT6zNFQ5KM7:TR?= Ml;5V2FPT0WU
Ca9-22 MmXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7JTWM2OD1{OT60Nlk6KM7:TR?= M4TSNnNCVkeHUh?=
RT-112 NUj3TmJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjydWlSUUN3ME2yPU41PjFzIN88US=> MV\TRW5ITVJ?
ES1 MnG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\Ecm5KSzVyPUK5Mlg2PDRizszN MUfTRW5ITVJ?
HCE-4 Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjGcG1mUUN3ME2yPU45Pzh4IN88US=> NF\CeHRUSU6JRWK=
AM-38 NGnIeZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT3TWM2OD1|MD6wOlA3KM7:TR?= MVLTRW5ITVJ?
AsPC-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTNyLkiwOVMh|ryP NELrUG5USU6JRWK=
TE-9 NX6zd2p1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHITWM2OD1|MD64O|M4KM7:TR?= MXXTRW5ITVJ?
HuP-T4 NVPMeWhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\xTWM2OD1|MD65OlM5KM7:TR?= MWnTRW5ITVJ?
LB2518-MEL MkfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\3fZltUUN3ME2zNU4xPzR2IN88US=> NYe1R5B1W0GQR1XS
NCI-H1703 NXLHe3FnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTEeWpvUUN3ME2zNU4xQTB3IN88US=> MnPtV2FPT0WU
NCI-H2228 MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrUTWM2OD1|MT60OlUyKM7:TR?= MVPTRW5ITVJ?
SCC-4 NFPifZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2wTWM2OD1|MT65NVgyKM7:TR?= NVi5bnNiW0GQR1XS
KNS-81-FD Mkj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe4cmNKSzVyPUOyMlAyOjhizszN NYC4bmVvW0GQR1XS
NTERA-S-cl-D1 NWPPTFBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrLTWM2OD1|Mj6wO|M6KM7:TR?= M2TGWHNCVkeHUh?=
Daoy NH3yWFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTN{LkC4N|gh|ryP Ml\QV2FPT0WU
ES4 NX;QcmJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTN{LkO5NlIh|ryP NITK[3FUSU6JRWK=
MHH-ES-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\qfWZKSzVyPUOyMlQ5PzJizszN NXzwdo5[W0GQR1XS
C-33-A MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTqZ4t5UUN3ME2zNk44PzJ6IN88US=> M3S4bXNCVkeHUh?=
BHY MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvIcYJyUUN3ME2zNk46PDl3IN88US=> Mom4V2FPT0WU
Detroit562 MkfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\iTWM2OD1|Mz62OlU4KM7:TR?= NWTxV5lqW0GQR1XS
EW-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHKwOYdKSzVyPUOzMlk{OjJizszN MmjJV2FPT0WU
NCI-H1395 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTN2LkC3PVkh|ryP M33GO3NCVkeHUh?=
KM-H2 NGLiTnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXOUJJzUUN3ME2zOk41PzR|IN88US=> M2LDbHNCVkeHUh?=
NCI-H520 NEfISVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDDTWM2OD1|Nj63OVQyKM7:TR?= NYTSTI9TW0GQR1XS
D-392MG MlrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTN5LkOzOFQh|ryP MoLRV2FPT0WU
NOMO-1 MlnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn1VWhKSzVyPUO3MlgxQDlizszN NYnoVHBXW0GQR1XS
TE-6 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTN6LkGyOEDPxE1? NULLeYdxW0GQR1XS
HT-3 MkS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTN6LkS0N|Yh|ryP NHjneodUSU6JRWK=
RPMI-8226 M{jSOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjSTWM2OD1|OD65OVE6KM7:TR?= NGDqe2dUSU6JRWK=
U251 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPMTWM2OD1|OT6wNVI1KM7:TR?= NF;STYRUSU6JRWK=
GCT NX7wVmsyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33lO2lEPTB;M{muNVg2OiEQvF2= M3r6UnNCVkeHUh?=
A431 MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\ITWM2OD1|OT6xPFk1KM7:TR?= MkXWV2FPT0WU
TE-12 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi5eXFiUUN3ME2zPU4zPDR6IN88US=> NUDGTXdzW0GQR1XS
HMV-II MlTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M334RWlEPTB;M{muOVA1PyEQvF2= M{izfnNCVkeHUh?=
IST-MES1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\RfpNKSzVyPUSwMlE2ODJizszN MojvV2FPT0WU
SW13 M4q0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:1[mlEPTB;NECuOVE6KM7:TR?= MXLTRW5ITVJ?
SF295 M{ixNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzDbIZKSzVyPUSwMlgxPjZizszN NEjOW3FUSU6JRWK=
MDA-MB-157 NVnkTZY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rzdWlEPTB;NECuPVQ3OiEQvF2= MonBV2FPT0WU
TE-1 M2rtb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDjO5hKSzVyPUSxMlg4OTRizszN MlmyV2FPT0WU
HuCCT1 NX6zc|BTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmmzTWM2OD12Mj61Nlg6KM7:TR?= MVTTRW5ITVJ?
KYSE-510 MmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTR|LkG3OVQh|ryP M3m4PXNCVkeHUh?=
NCI-H358 MlnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XCe2lEPTB;NESuNFMxPCEQvF2= M{\SbXNCVkeHUh?=
SW900 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLJTWM2OD12ND6wO|U5KM7:TR?= NUO2WIZJW0GQR1XS
CAS-1 NEXrNIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f4XWlEPTB;NESuNFk6OSEQvF2= MWTTRW5ITVJ?
TE-8 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzTTWM2OD12ND61OlU5KM7:TR?= MVTTRW5ITVJ?
P12-ICHIKAWA NETCcmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnYTWM2OD12ND62NVEzKM7:TR?= NVLBNYxTW0GQR1XS
YKG-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33wd2lEPTB;NESuO|gyKM7:TR?= NUX1Zlh[W0GQR1XS
SNU-C2B M3nZfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{mzd2lEPTB;NESuO|kxOyEQvF2= NHe2fWhUSU6JRWK=
LCLC-103H MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGC2dIZKSzVyPUS0Mlg4ODNizszN M3u1eHNCVkeHUh?=
U-87-MG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rnTWlEPTB;NEWuNVAzOiEQvF2= M37iWXNCVkeHUh?=
HAL-01 MkOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDETmI2UUN3ME20OU4yOzd7IN88US=> MlfKV2FPT0WU
OVCAR-8 M2DDRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HPSmlEPTB;NEWuN|U3PCEQvF2= MXPTRW5ITVJ?
KYSE-150 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojETWM2OD12Nz6xNFUzKM7:TR?= NIXKNJdUSU6JRWK=
OE33 NGTSVXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXlTWM2OD12Nz6xOFI6KM7:TR?= MlXNV2FPT0WU
CAL-62 NF\jfnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjvPGhlUUN3ME20O{41ODZ6IN88US=> MnnIV2FPT0WU
TCCSUP NHrLTpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HOTGlEPTB;NEeuOlI3PCEQvF2= Mmr3V2FPT0WU
H4 NFvONI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\LWGlEPTB;NEeuOlYzOSEQvF2= MmnpV2FPT0WU
CP66-MEL MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3aTWM2OD12OD6wO|A1KM7:TR?= MoTGV2FPT0WU
SNB75 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHB[WRMUUN3ME20PE4yQDd2IN88US=> NEjLcYRUSU6JRWK=
Mo-T NIHqTYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnJfGc3UUN3ME20PE4zPzlizszN MWHTRW5ITVJ?
BT-549 MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLjVGpKSzVyPUS4MlM4OjlizszN MnnKV2FPT0WU
IGR-1 MoqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrRToxKSzVyPUS4MlY3PDVizszN M4rOUnNCVkeHUh?=
NCI-H1299 NH;2W3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Tv[GlEPTB;NEiuO|I1QCEQvF2= NHOxUnhUSU6JRWK=
ALL-PO MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDiU21KSzVyPUS5MlkzPjhizszN M2\ZZXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method:

    The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID