NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.

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5 Customer Reviews

  • (C) Microirradiation live-cell microscopy of U2OS cells stably expressing mEGFP-MacroD2 full-length construct and treated with KU55933 10 μM, VE-821 1 μM, NU7441 1 μM or DMSO. Scale bar, 10 μm.

    Nucleic Acids Res, 2017, 45(1):244-254. NU7441 (KU-57788) purchased from Selleck.

    Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

  • Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

    Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 NIOwPI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\EcWRnUUN3ME2wMlAzOTR|IN88US=> MYXTRW5ITVJ?
A172 M1zkPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;rWlZ1UUN3ME2wMlE2OzF4IN88US=> MonoV2FPT0WU
NCI-H526 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zhdmlEPTB;MD6yPFQxPyEQvF2= NXfU[ldtW0GQR1XS
HDLM-2 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwM{KzOFUh|ryP MoXPV2FPT0WU
HuO-3N1 M{frRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XCUGlEPTB;MD60OlY{PiEQvF2= M2faSHNCVkeHUh?=
NCI-SNU-1 NGHaW|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlyxTWM2OD1yLk[wPVk1KM7:TR?= MX;TRW5ITVJ?
SK-N-AS NVjHW3FDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwNkKyNVYh|ryP NUTnfVlRW0GQR1XS
LoVo Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7lfYlkUUN3ME2wMlg3PzR7IN88US=> NYjEcFJOW0GQR1XS
LAMA-84 Mk\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1qyZ2lEPTB;MD65PFg{OyEQvF2= MmLuV2FPT0WU
CTB-1 M37CVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n0bWlEPTB;MT6xNVU1PiEQvF2= MmL5V2FPT0WU
KP-N-YS Mki5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;3RWlEPTB;MT6xOFI{OSEQvF2= NVfO[mN1W0GQR1XS
HH NI\ZTG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTFwMUiwPVMh|ryP M2TqW3NCVkeHUh?=
CHL-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD0TWM2OD1zLkKxN|Y5KM7:TR?= M{n3[XNCVkeHUh?=
NB7 M4nyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTibHVmUUN3ME2xMlI1PzR3IN88US=> MU\TRW5ITVJ?
HL-60 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTFwM{ixPUDPxE1? M{n4THNCVkeHUh?=
639-V M4\Xb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[4TWM2OD1zLkS0NVI5KM7:TR?= NHvVTG1USU6JRWK=
NCI-H1793 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjmOGFKSzVyPUGuOFU5PCEQvF2= NGW3bnFUSU6JRWK=
NEC8 NEP6N|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPxTWM2OD1zLkW1N|Uh|ryP MoLDV2FPT0WU
PA-1 NVTBTo5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFwNUiyPVQh|ryP MVTTRW5ITVJ?
D-423MG MoHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrDfId7UUN3ME2xMlY6OzZzIN88US=> MkiyV2FPT0WU
NCI-H292 NX[yV5U1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTFwN{SwNVMh|ryP MVTTRW5ITVJ?
SK-MEL-1 NYnTZnNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjYNpdvUUN3ME2xMlc6PDd7IN88US=> M1TLUHNCVkeHUh?=
LB2241-RCC NVjSWoJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJwMUSxOFYh|ryP NWr3S2ZyW0GQR1XS
SK-MEL-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJwMU[0PUDPxE1? MUfTRW5ITVJ?
MHH-PREB-1 M3LzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrXWldOUUN3ME2yMlE3PjB7IN88US=> NVjucHN3W0GQR1XS
BFTC-905 NF73dHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJwMU[2PFch|ryP MVXTRW5ITVJ?
Ramos-2G6-4C10 NVGwXIRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTJwMUm5NFkh|ryP MYrTRW5ITVJ?
G-361 NYnyW45OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7QTWM2OD1{LkKxOlgh|ryP M{\GVXNCVkeHUh?=
MOLT-4 NVvFc3JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vifWlEPTB;Mj6yNVg5QCEQvF2= M2HVUHNCVkeHUh?=
DEL MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJwM{W1OlQh|ryP MX\TRW5ITVJ?
MV-4-11 NVTGUWZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPNOFFVUUN3ME2yMlM4OzlizszN MV3TRW5ITVJ?
SK-NEP-1 NH3RT5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPUTWM2OD1{LkO4O|g{KM7:TR?= NXr2Slh5W0GQR1XS
RS4-11 NXLHSGFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3G5RmlEPTB;Mj61OlAzOyEQvF2= NXTXPXU6W0GQR1XS
HuH-7 Ml\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HQfmlEPTB;Mj61OlcxOiEQvF2= MknFV2FPT0WU
A101D NGPre2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LCeWlEPTB;Mj62NVM{QCEQvF2= MXzTRW5ITVJ?
KG-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJwNke5NlQh|ryP Ml22V2FPT0WU
KALS-1 NVzNZoZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LrdGlEPTB;Mj62PVY{OyEQvF2= MmrsV2FPT0WU
VMRC-RCZ MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DVSGlEPTB;Mj63O|MzQCEQvF2= M2e5W3NCVkeHUh?=
SK-UT-1 MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjZeG1RUUN3ME2zMlE2OzFizszN MofqV2FPT0WU
SW962 M4r5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzvTWM2OD1|LkKwN|UzKM7:TR?= M1HSO3NCVkeHUh?=
DBTRG-05MG NUj1V2xZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTNwMkiwPFUh|ryP M1TYcHNCVkeHUh?=
PANC-08-13 MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jVWGlEPTB;Mz60NVI4QCEQvF2= MVfTRW5ITVJ?
QIMR-WIL Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LxTmlEPTB;Mz60NVM1OSEQvF2= NHjtNG1USU6JRWK=
SK-MEL-30 NGfyTJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHzU4t7UUN3ME2zMlQzPTl6IN88US=> NYLLVo4xW0GQR1XS
697 NWHvZZNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTvTWM2OD1|LkS0PVk{KM7:TR?= M33QSXNCVkeHUh?=
NY NFrYNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2D0TmlEPTB;Mz60OVAzOiEQvF2= NGG1WotUSU6JRWK=
ES7 MlPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPISY5KSzVyPUOuOFY4OjlizszN MVrTRW5ITVJ?
JVM-3 NX\nZ41ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoGzTWM2OD1|LkS4NFc4KM7:TR?= M3[4ZnNCVkeHUh?=
U031 NEPufXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH6xe2xKSzVyPUOuOVk{PjhizszN M4C2cnNCVkeHUh?=
BHT-101 NHX0TFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLp[5lKSzVyPUOuOVk6QDVizszN MkW0V2FPT0WU
8305C NELEe3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTNwNkG3N|Yh|ryP Ml;qV2FPT0WU
MG-63 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPMR2NKSzVyPUOuOlI3PzZizszN NIq5XlRUSU6JRWK=
NOS-1 MkO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVKxVJppUUN3ME2zMlY2OzF{IN88US=> MnfiV2FPT0WU
YH-13 MnPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vtWmlEPTB;Mz64O|E5QSEQvF2= MmfHV2FPT0WU
LXF-289 NVPXcnk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXjOYJ5UUN3ME2zMlkyODRzIN88US=> Mln5V2FPT0WU
GOTO NUnzS2F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH2TWM2OD1|LkmxOFkh|ryP NULWcFlZW0GQR1XS
EKVX NFjTOFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;VTWM2OD12LkKyOVI1KM7:TR?= MnTKV2FPT0WU
CAL-51 NXjUR2UyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHRTWM2OD12LkK0PFU1KM7:TR?= NIXLZZRUSU6JRWK=
AN3-CA M4rkXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjTTWM2OD12LkK1PFE{KM7:TR?= NWP6enRmW0GQR1XS
IA-LM NHj1UVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnMTndKSzVyPUSuNlc6OzVizszN NUPBdXhiW0GQR1XS
KU-19-19 NUnFeVFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;sdJhNUUN3ME20MlMzQTJzIN88US=> MkH5V2FPT0WU
A704 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\sSINoUUN3ME20MlQxQDh6IN88US=> NHLucGhUSU6JRWK=
RH-18 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTRwNES5OVMh|ryP MX3TRW5ITVJ?
IST-MEL1 M2T6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33mfWlEPTB;ND61PFI3OyEQvF2= MknDV2FPT0WU
LU-134-A Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7ReHlKSzVyPUSuOVk3QDVizszN MojwV2FPT0WU
SF126 NGPSTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnsTWM2OD12Lk[wO|E2KM7:TR?= NVfKO|hiW0GQR1XS
EFO-27 NX;DR|E2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGq3U2ZKSzVyPUSuOlY2OjVizszN MWnTRW5ITVJ?
SN12C NYPEd5BIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTiTWM2OD12LkexPFk5KM7:TR?= M2TVOXNCVkeHUh?=
L-363 MkLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTRwN{exNVYh|ryP MnvLV2FPT0WU
MEL-HO NX6xNWRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDEeI5JUUN3ME20Mlc4QTh7IN88US=> NF;4WZlUSU6JRWK=
TYK-nu MlKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3DR2Z[UUN3ME20MlgxOTJ6IN88US=> MoO0V2FPT0WU
MDA-MB-415 NUnOUYJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\xeIczUUN3ME21MlAxOzF2IN88US=> Mmm3V2FPT0WU
HCC70 MnrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDubVNKSzVyPUWuNFM6OzlizszN NF\pcphUSU6JRWK=
IGROV-1 NGrZPXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;HTWM2OD13LkK1NlkzKM7:TR?= NGDve5JUSU6JRWK=
NCI-H1355 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUK0OYZIUUN3ME21MlI6PiEQvF2= NYDKcmxPW0GQR1XS
23132-87 NXyxenZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq2VIV6UUN3ME21MlMzODJ2IN88US=> MYrTRW5ITVJ?
NB69 NE\yNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NISwPXVKSzVyPUWuN|I1OiEQvF2= NHP2dlRUSU6JRWK=
HSC-2 NVXuUlFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIn5SopKSzVyPUWuOFE4PzNizszN MXfTRW5ITVJ?
KYSE-410 NHjDeGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXF[YltUUN3ME21MlQ4PjN4IN88US=> M4HsbHNCVkeHUh?=
GCIY NFrHVYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXmdpA{UUN3ME21MlUyOzd6IN88US=> MWLTRW5ITVJ?
A427 M3G5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTVwNUO2OlEh|ryP NYT5boxRW0GQR1XS
ChaGo-K-1 NWfTN4x5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXaSnhKSzVyPUWuOVY2QTlizszN M2exN3NCVkeHUh?=
PFSK-1 NYf1fmpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vrVWlEPTB;NT62NlE6PCEQvF2= M2nDV3NCVkeHUh?=
MLMA MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTVwOEO2NFYh|ryP MWrTRW5ITVJ?
RVH-421 NH;MeZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTZwMEezN|gh|ryP M3fXV3NCVkeHUh?=
LB1047-RCC NX23PGQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[0coYyUUN3ME22MlE4PTJ{IN88US=> NWHGRVBSW0GQR1XS
MHH-NB-11 NVzC[plWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmryTWM2OD14LkOyO|IyKM7:TR?= M1fXRXNCVkeHUh?=
J-RT3-T3-5 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTZwNkOyPVEh|ryP NUfUSWJ2W0GQR1XS
UM-UC-3 MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTZwNkSzN|Qh|ryP M1u2bXNCVkeHUh?=
IST-SL1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTZwNkmzOlkh|ryP NGqyeGNUSU6JRWK=
NB14 M3;0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTZwN{m3OlEh|ryP MVPTRW5ITVJ?
NBsusSR M3;MUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkH4TWM2OD14LkiyOVAzKM7:TR?= MXnTRW5ITVJ?
D-263MG MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHvVmRKSzVyPU[uPVExPjhizszN M{DRWHNCVkeHUh?=
NCI-H2347 MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHsc|JJUUN3ME22Mlk{OjF|IN88US=> MkexV2FPT0WU
ES8 MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTZwOUe1PFgh|ryP MUjTRW5ITVJ?
786-0 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnq1TWM2OD15LkC5O|g3KM7:TR?= MYnTRW5ITVJ?
EPLC-272H NGOzXm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTdwMU[yOFYh|ryP MlnCV2FPT0WU
CAPAN-1 M1myWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[4NpRKSzVyPUeuNlQ{PTlizszN M1XSeXNCVkeHUh?=
NCI-H82 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\0VXh4UUN3ME23MlI3PjV7IN88US=> NEfQZ3VUSU6JRWK=
G-402 NH\0VYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTdwM{CwOVEh|ryP NWTHWoJqW0GQR1XS
SW982 M2\WNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nHemlEPTB;Nz6zNFIxOyEQvF2= NHTucYdUSU6JRWK=
OVCAR-4 M4XYZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;VN|h[UUN3ME23MlMyOzJ6IN88US=> M1\zN3NCVkeHUh?=
KARPAS-299 M4nzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoruTWM2OD15LkOyOlIzKM7:TR?= NIf6Zm5USU6JRWK=
MIA-PaCa-2 M{DUUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTdwM{[4NlMh|ryP MU\TRW5ITVJ?
AU565 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjBWZhKUUN3ME23MlU6QDN|IN88US=> NWLhcW1iW0GQR1XS
GAMG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33HWGlEPTB;Nz62OFE{OSEQvF2= NVrKU3JZW0GQR1XS
HuO9 M2HNVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPOdZZKSzVyPUeuO|E4PDNizszN NU\yT2l2W0GQR1XS
ACN MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrROGVKSzVyPUeuO|Q{OyEQvF2= MkjwV2FPT0WU
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BB65-RCC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L6UGlEPTB;MkOuO|g3OyEQvF2= NYrxUWx{W0GQR1XS
HSC-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJ|Lki1Nlch|ryP MUTTRW5ITVJ?
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DB NIntNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrjU5dxUUN3ME2yOE4yODJ6IN88US=> MY\TRW5ITVJ?
HO-1-N-1 MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIC2VJRKSzVyPUK0MlMxQTNizszN MkiyV2FPT0WU
MKN1 NYn1OWxwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXSTWM2OD1{ND62PEDPxE1? MYrTRW5ITVJ?
MN-60 NGjVZWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJ2Lki1NVkh|ryP MYnTRW5ITVJ?
8505C MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvYNJliUUN3ME2yOU4yQDR3IN88US=> NXjhT4tZW0GQR1XS
COLO-320-HSR NI\ET3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HUZmlEPTB;MkWuNlIxQCEQvF2= MWrTRW5ITVJ?
BB30-HNC MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH0WXZCUUN3ME2yOU4zPDh|IN88US=> MknFV2FPT0WU
KM12 MkHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zIS2lEPTB;MkWuOVgxPyEQvF2= MVzTRW5ITVJ?
NB13 NXfpc25qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjudWxQUUN3ME2yOU42QDl6IN88US=> M{m1fXNCVkeHUh?=
HCC2998 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrBWHVKSzVyPUK2MlAzQDNizszN MVnTRW5ITVJ?
U-118-MG M4HwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13weWlEPTB;Mk[uNFgxQCEQvF2= M{TiUXNCVkeHUh?=
NB10 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nCUmlEPTB;Mk[uNlM1KM7:TR?= NUHUOWsyW0GQR1XS
SK-LMS-1 NF;QepBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLhV3JKSzVyPUK3MlA4ODRizszN Ml7TV2FPT0WU
SW1573 NUPVTXh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJ5LkGxJO69VQ>? NF;uOI1USU6JRWK=
LB373-MEL-D Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfKbJpLUUN3ME2yO{4yOjl2IN88US=> MorCV2FPT0WU
DK-MG M3HQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1u5N2lEPTB;MkeuNVgyPyEQvF2= M2PFTXNCVkeHUh?=
RMG-I MnKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXOwbWlOUUN3ME2yO{4zODJ7IN88US=> NYiyNVhwW0GQR1XS
SW1088 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NID5d|lKSzVyPUK3MlUxPDJizszN NWnGfYI4W0GQR1XS
SK-OV-3 NYXuZpNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TuPWlEPTB;MkeuO|U6OyEQvF2= NGDtVpJUSU6JRWK=
KP-N-YN MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJ5LkiwOFMh|ryP Mm\tV2FPT0WU
RPMI-7951 M1TIS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nJTWlEPTB;MkiuNlQ2PiEQvF2= NWXWZ5dUW0GQR1XS
CaR-1 MkDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnf5TWM2OD1{OD61OVgzKM7:TR?= NX:xN4pWW0GQR1XS
MKN7 NWH5OZpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHwTWM2OD1{OD61PVY1KM7:TR?= NH7LW5lUSU6JRWK=
CHP-212 NFXRV5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnn[m1KSzVyPUK4Mlc1ODFizszN NEW5W4pUSU6JRWK=
KYSE-450 M4X1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjve41mUUN3ME2yPE45ODlzIN88US=> NELVfG1USU6JRWK=
RXF393 MlPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnpTWM2OD1{OT6yPVA3KM7:TR?= NFjGW3pUSU6JRWK=
P30-OHK MmrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L3bWlEPTB;MkmuN|A1QCEQvF2= MVXTRW5ITVJ?
Ca9-22 M2CzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1iyfmlEPTB;MkmuOFI6QSEQvF2= NEPV[ZNUSU6JRWK=
RT-112 NH\1TJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjWdW11UUN3ME2yPU41PjFzIN88US=> NEm5dJhUSU6JRWK=
ES1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\TTWM2OD1{OT64OVQ1KM7:TR?= MXrTRW5ITVJ?
HCE-4 MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED3U2NKSzVyPUK5Mlg4QDZizszN NHjsbXVUSU6JRWK=
AM-38 NHTxfZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTNyLkC2NFYh|ryP MnntV2FPT0WU
AsPC-1 MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDTTWM2OD1|MD64NFU{KM7:TR?= NVPUXIZ2W0GQR1XS
TE-9 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjtTXJOUUN3ME2zNE45PzN5IN88US=> NH;Hc2xUSU6JRWK=
HuP-T4 Mmi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInGWHJKSzVyPUOwMlk3OzhizszN NHTQV3NUSU6JRWK=
LB2518-MEL MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTNzLkC3OFQh|ryP MnjnV2FPT0WU
NCI-H1703 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTNzLkC5NFUh|ryP NG\Mc4pUSU6JRWK=
NCI-H2228 NGf2dHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITic2tKSzVyPUOxMlQ3PTFizszN M1H3R3NCVkeHUh?=
SCC-4 MmnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TQU2lEPTB;M{GuPVE5OSEQvF2= MWXTRW5ITVJ?
KNS-81-FD MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIOxS3FKSzVyPUOyMlAyOjhizszN M3nRNXNCVkeHUh?=
NTERA-S-cl-D1 NF3wUmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[5TWM2OD1|Mj6wO|M6KM7:TR?= Moq3V2FPT0WU
Daoy NXLVZlVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPpflZKSzVyPUOyMlA5OzhizszN M1L6fHNCVkeHUh?=
ES4 NIXqPI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nNWGlEPTB;M{KuN|kzOiEQvF2= NIrpZXVUSU6JRWK=
MHH-ES-1 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr1TWM2OD1|Mj60PFczKM7:TR?= MYLTRW5ITVJ?
C-33-A MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTN{Lke3Nlgh|ryP NXvNOoY5W0GQR1XS
BHY NHTB[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEK2dWNKSzVyPUOyMlk1QTVizszN NFW5TmZUSU6JRWK=
Detroit562 NWX2[I9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W0[2lEPTB;M{OuOlY2PyEQvF2= M3LSW3NCVkeHUh?=
EW-1 NX\DVW5rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTN|LkmzNlIh|ryP MXTTRW5ITVJ?
NCI-H1395 M3rDcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTN2LkC3PVkh|ryP NInlbFJUSU6JRWK=
KM-H2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrhNpE2UUN3ME2zOk41PzR|IN88US=> MVLTRW5ITVJ?
NCI-H520 MmD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTN4Lke1OFEh|ryP NVv5SllWW0GQR1XS
D-392MG NXK4[IdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn5eYFKSzVyPUO3MlM{PDRizszN M4nsSHNCVkeHUh?=
NOMO-1 M2n0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X1PGlEPTB;M{euPFA5QSEQvF2= M17EOnNCVkeHUh?=
TE-6 NHO2cm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HlVWlEPTB;M{iuNVI1KM7:TR?= NU[2[ItKW0GQR1XS
HT-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjQcoxRUUN3ME2zPE41PDN4IN88US=> NInSNWFUSU6JRWK=
RPMI-8226 M{fFc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1uzNmlEPTB;M{iuPVUyQSEQvF2= M2X1WnNCVkeHUh?=
U251 MorrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rFUGlEPTB;M{muNFEzPCEQvF2= NFjVfohUSU6JRWK=
GCT NUPyUow2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H6[WlEPTB;M{muNVg2OiEQvF2= MYXTRW5ITVJ?
A431 NXPNS4h2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLOWHdQUUN3ME2zPU4yQDl2IN88US=> MVnTRW5ITVJ?
TE-12 M1XofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIi5R2dKSzVyPUO5MlI1PDhizszN NHzKcoZUSU6JRWK=
HMV-II MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEC2eY1KSzVyPUO5MlUxPDdizszN M2\NWXNCVkeHUh?=
IST-MES1 NVmw[G96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1S5R2lEPTB;NECuNVUxOiEQvF2= MVvTRW5ITVJ?
SW13 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXVZ3VKSzVyPUSwMlUyQSEQvF2= NEf3UWJUSU6JRWK=
SF295 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUizO2JWUUN3ME20NE45ODZ4IN88US=> NHO4PIxUSU6JRWK=
MDA-MB-157 NGH3N5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTRyLkm0OlIh|ryP M2HsPHNCVkeHUh?=
TE-1 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzM[JNKSzVyPUSxMlg4OTRizszN MmTQV2FPT0WU
HuCCT1 NEjXToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37sdWlEPTB;NEKuOVI5QSEQvF2= M2PVPXNCVkeHUh?=
KYSE-510 NXfVeXdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWr2Z2ZWUUN3ME20N{4yPzV2IN88US=> M{fxeXNCVkeHUh?=
NCI-H358 NFi4TnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H4O2lEPTB;NESuNFMxPCEQvF2= M1XFTXNCVkeHUh?=
SW900 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTR2LkC3OVgh|ryP MX;TRW5ITVJ?
CAS-1 M1y1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLnTWM2OD12ND6wPVkyKM7:TR?= NVX2OHJLW0GQR1XS
TE-8 NVLPW2k5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTR2LkW2OVgh|ryP MYPTRW5ITVJ?
P12-ICHIKAWA M3Hkemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO0SpBKSzVyPUS0MlYyOTJizszN NVLhRWR5W0GQR1XS
YKG-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\zT3o6UUN3ME20OE44QDFizszN MW\TRW5ITVJ?
SNU-C2B MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTR2Lke5NFMh|ryP M37XPHNCVkeHUh?=
LCLC-103H NVzFNlJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7sV4F4UUN3ME20OE45PzB|IN88US=> M{fDRXNCVkeHUh?=
U-87-MG NVnxbZNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTR3LkGwNlIh|ryP NX\JTZZDW0GQR1XS
HAL-01 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTR3LkGzO|kh|ryP M4Tz[nNCVkeHUh?=
OVCAR-8 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTR3LkO1OlQh|ryP M1vWUnNCVkeHUh?=
KYSE-150 MkHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzwdlVKSzVyPUS3MlExPTJizszN NHLvTnJUSU6JRWK=
OE33 MmDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml76TWM2OD12Nz6xOFI6KM7:TR?= Mn\1V2FPT0WU
CAL-62 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET2SIZKSzVyPUS3MlQxPjhizszN MmDaV2FPT0WU
TCCSUP MmLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHicJd4UUN3ME20O{43OjZ2IN88US=> NGPQOXFUSU6JRWK=
H4 NY\wZmJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrlenFKSzVyPUS3MlY3OjFizszN MlHhV2FPT0WU
CP66-MEL NWrSeG84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3id2gxUUN3ME20PE4xPzB2IN88US=> NFzQbW9USU6JRWK=
SNB75 M3PGOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTR6LkG4O|Qh|ryP MnnzV2FPT0WU
Mo-T MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXnTWM2OD12OD6yO|kh|ryP M2DHU3NCVkeHUh?=
BT-549 MkPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHnTWM2OD12OD6zO|I6KM7:TR?= M1TuXHNCVkeHUh?=
IGR-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWiwWGhTUUN3ME20PE43PjR3IN88US=> NXrGSJN3W0GQR1XS
NCI-H1299 NVHUNIVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTZTWM2OD12OD63NlQ5KM7:TR?= MoTVV2FPT0WU
ALL-PO NXTvRnEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTR7LkmyOlgh|ryP NGL4NmRUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method: The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
4% DMSO+30% PEG 300+5% Tween 80+ddH2O
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID