NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.

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6 Customer Reviews

  • (C) Microirradiation live-cell microscopy of U2OS cells stably expressing mEGFP-MacroD2 full-length construct and treated with KU55933 10 μM, VE-821 1 μM, NU7441 1 μM or DMSO. Scale bar, 10 μm.

    Nucleic Acids Res, 2017, 45(1):244-254. NU7441 (KU-57788) purchased from Selleck.

    Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

  • Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

    (C) Immunohistochemically detection of Cleaved Caspase-3 48 h after treatment to measure apoptosis in vivo, induced levels of apoptosis in xenografts treated with radiation in combination with DNA-PKcsi and HT compared to radiation alone. Necrotic areas were observed in xenograft of triple treatment. DNA-PKcsi:NU7441

    Oncotarget, 2016, 7(40): 65504-65513. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 NYXsPYtlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHjTWM2OD1yLkCyNVQ{KM7:TR?= NH:0dmZUSU6JRWK=
A172 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n3R2lEPTB;MD6xOVMyPiEQvF2= MYrTRW5ITVJ?
NCI-H526 NWroR2lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHweGg6UUN3ME2wMlI5PDB5IN88US=> NH\tUXJUSU6JRWK=
HDLM-2 NGK0ZYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwM{KzOFUh|ryP NIHufppUSU6JRWK=
HuO-3N1 NXm5PFRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TZWGlEPTB;MD60OlY{PiEQvF2= MV3TRW5ITVJ?
NCI-SNU-1 NV7oZWw{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTXPIlFUUN3ME2wMlYxQTl2IN88US=> MoLUV2FPT0WU
SK-N-AS Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnU[IFMUUN3ME2wMlYzOjF4IN88US=> NX;1S2FMW0GQR1XS
LoVo NYLjbYpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHUTpVKSzVyPUCuPFY4PDlizszN NV\J[GY5W0GQR1XS
LAMA-84 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwOUi4N|Mh|ryP NG[3NmtUSU6JRWK=
CTB-1 NEn5OG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTFwMUG1OFYh|ryP NIn0bpJUSU6JRWK=
KP-N-YS MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7ONlFKSzVyPUGuNVQzOzFizszN M3X1fHNCVkeHUh?=
HH NYTLbFlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPHT4dKSzVyPUGuNVgxQTNizszN MWTTRW5ITVJ?
CHL-1 NEDnXm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XnN2lEPTB;MT6yNVM3QCEQvF2= NYDBSG9sW0GQR1XS
NB7 NIDjV2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTFwMkS3OFUh|ryP M1\KeXNCVkeHUh?=
HL-60 MoXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fRR2lEPTB;MT6zPFE6KM7:TR?= Mn;qV2FPT0WU
639-V MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofETWM2OD1zLkS0NVI5KM7:TR?= Mn\KV2FPT0WU
NCI-H1793 M4TzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTxTWM2OD1zLkS1PFQh|ryP MmHmV2FPT0WU
NEC8 NW\aW25IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPPTWM2OD1zLkW1N|Uh|ryP M37BfXNCVkeHUh?=
PA-1 NUD0XJg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\weGlEPTB;MT61PFI6PCEQvF2= NYXJTYJwW0GQR1XS
D-423MG NUfwXXI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\1TWM2OD1zLk[5N|YyKM7:TR?= MVXTRW5ITVJ?
NCI-H292 NYXiNFZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[yTFJKSzVyPUGuO|QxOTNizszN M2fTWXNCVkeHUh?=
SK-MEL-1 NUTwb41rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH0TY1jUUN3ME2xMlc6PDd7IN88US=> Mn3BV2FPT0WU
LB2241-RCC NHPFe|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\HcGlEPTB;Mj6xOFE1PiEQvF2= Moq4V2FPT0WU
SK-MEL-3 NVHYbG1MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfP[5pKSzVyPUKuNVY1QSEQvF2= M{W2b3NCVkeHUh?=
MHH-PREB-1 MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\Od5FKSzVyPUKuNVY3ODlizszN MoPCV2FPT0WU
BFTC-905 NFGxbVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HTbGlEPTB;Mj6xOlY5PyEQvF2= NHztTmRUSU6JRWK=
Ramos-2G6-4C10 M2\tcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmq4TWM2OD1{LkG5PVA6KM7:TR?= NHPQbFNUSU6JRWK=
G-361 M1[0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTwTWM2OD1{LkKxOlgh|ryP MmPqV2FPT0WU
MOLT-4 M13Nemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDwT5hTUUN3ME2yMlIyQDh6IN88US=> NWWyUIhnW0GQR1XS
DEL Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXBe2xKSzVyPUKuN|U2PjRizszN NUfMSJljW0GQR1XS
MV-4-11 MkPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIL6TpBKSzVyPUKuN|c{QSEQvF2= NGi3WmZUSU6JRWK=
SK-NEP-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJwM{i3PFMh|ryP MV3TRW5ITVJ?
RS4-11 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\ncIRKSzVyPUKuOVYxOjNizszN NFvwfZNUSU6JRWK=
HuH-7 NGLBeXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LNe2lEPTB;Mj61OlcxOiEQvF2= M2fEfHNCVkeHUh?=
A101D M13Dbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3S5dWlEPTB;Mj62NVM{QCEQvF2= MWHTRW5ITVJ?
KG-1 NUjyTmxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;TRVhKSzVyPUKuOlc6OjRizszN M1TCTnNCVkeHUh?=
KALS-1 NIPaWXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDzcWlKSzVyPUKuOlk3OzNizszN M3TGS3NCVkeHUh?=
VMRC-RCZ MlPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLaTWM2OD1{Lke3N|I5KM7:TR?= MkfvV2FPT0WU
SK-UT-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrKTWM2OD1|LkG1N|Eh|ryP MoHzV2FPT0WU
SW962 M2nGTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nBR2lEPTB;Mz6yNFM2OiEQvF2= M3GwTHNCVkeHUh?=
DBTRG-05MG NI[zWFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTNwMkiwPFUh|ryP NEHLZphUSU6JRWK=
PANC-08-13 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTNwNEGyO|gh|ryP M{DkOnNCVkeHUh?=
QIMR-WIL MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\3SVF{UUN3ME2zMlQyOzRzIN88US=> M4HxVHNCVkeHUh?=
SK-MEL-30 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;sfmlEPTB;Mz60NlU6QCEQvF2= MmO0V2FPT0WU
697 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DXW2lEPTB;Mz60OFk6OyEQvF2= NXqzcoloW0GQR1XS
NY M1i5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnjTWM2OD1|LkS1NFIzKM7:TR?= NInrd5hUSU6JRWK=
ES7 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPCc|ZKSzVyPUOuOFY4OjlizszN NW[yNIJCW0GQR1XS
JVM-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PYd2lEPTB;Mz60PFA4PyEQvF2= M1zjdXNCVkeHUh?=
U031 MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3Pe3VsUUN3ME2zMlU6OzZ6IN88US=> NX25WphKW0GQR1XS
BHT-101 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTNwNUm5PFUh|ryP NVPoTWxJW0GQR1XS
8305C NIO2UpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTNwNkG3N|Yh|ryP MWfTRW5ITVJ?
MG-63 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrhTWM2OD1|Lk[yOlc3KM7:TR?= M4PYUHNCVkeHUh?=
NOS-1 M3rQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPEWnExUUN3ME2zMlY2OzF{IN88US=> MWDTRW5ITVJ?
YH-13 Ml3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXSTWM2OD1|Lki3NVg6KM7:TR?= NV;CW5dOW0GQR1XS
LXF-289 NFjuNWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXwTWM2OD1|LkmxNFQyKM7:TR?= M2CyZ3NCVkeHUh?=
GOTO MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon3TWM2OD1|LkmxOFkh|ryP M1f6S3NCVkeHUh?=
EKVX NFTQdmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPU[oMxUUN3ME20MlIzPTJ2IN88US=> MofyV2FPT0WU
CAL-51 NWCzb2p6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTRwMkS4OVQh|ryP MYTTRW5ITVJ?
AN3-CA NX3GZnZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFT3d|FKSzVyPUSuNlU5OTNizszN M4W1OHNCVkeHUh?=
IA-LM M3fzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTRwMke5N|Uh|ryP MnniV2FPT0WU
KU-19-19 NWnOWXRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{f6e2lEPTB;ND6zNlkzOSEQvF2= M{jWXXNCVkeHUh?=
A704 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ixdWlEPTB;ND60NFg5QCEQvF2= Mn7MV2FPT0WU
RH-18 NVPvTlUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PvbWlEPTB;ND60OFk2OyEQvF2= M1[yZ3NCVkeHUh?=
IST-MEL1 NHvrNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTRwNUiyOlMh|ryP NHrGdWNUSU6JRWK=
LU-134-A MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jFdGlEPTB;ND61PVY5PSEQvF2= MnvXV2FPT0WU
SF126 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITGeXhKSzVyPUSuOlA4OTVizszN NHLwVI5USU6JRWK=
EFO-27 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2WwO2lEPTB;ND62OlUzPSEQvF2= MmfmV2FPT0WU
SN12C NIDOV4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTRwN{G4PVgh|ryP MoLvV2FPT0WU
L-363 NWPVUZRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTRwN{exNVYh|ryP NIXpVYxUSU6JRWK=
MEL-HO MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH64e2VKSzVyPUSuO|c6QDlizszN MXXTRW5ITVJ?
TYK-nu NW[5Zpc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi5eYc1UUN3ME20MlgxOTJ6IN88US=> NVrQdmhzW0GQR1XS
MDA-MB-415 M{nBXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\BTWlEPTB;NT6wNFMyPCEQvF2= MlT2V2FPT0WU
HCC70 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTjTWM2OD13LkCzPVM6KM7:TR?= NFz2N41USU6JRWK=
IGROV-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Ts[GlEPTB;NT6yOVI6OiEQvF2= NV\vUGhZW0GQR1XS
NCI-H1355 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfyd29KSzVyPUWuNlk3KM7:TR?= NEPNb25USU6JRWK=
23132-87 M{jYNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fZT2lEPTB;NT6zNlAzPCEQvF2= NUT4e4M4W0GQR1XS
NB69 M{POV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjSe|lKSzVyPUWuN|I1OiEQvF2= M3jjbHNCVkeHUh?=
HSC-2 NUm0[FVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTVwNEG3O|Mh|ryP NVPVNYF{W0GQR1XS
KYSE-410 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\SN4hUUUN3ME21MlQ4PjN4IN88US=> MUfTRW5ITVJ?
GCIY M3m4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTVwNUGzO|gh|ryP MWTTRW5ITVJ?
A427 NUfXXZB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTlVWxKSzVyPUWuOVM3PjFizszN MVrTRW5ITVJ?
ChaGo-K-1 M{L4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm0NYZKSzVyPUWuOVY2QTlizszN MmjhV2FPT0WU
PFSK-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzj[pd4UUN3ME21MlYzOTl2IN88US=> M2rIWXNCVkeHUh?=
MLMA MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\He3ZKSzVyPUWuPFM3ODZizszN NV74VoZEW0GQR1XS
RVH-421 MmnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\acJA{UUN3ME22MlA4OzN6IN88US=> NXvGV5JyW0GQR1XS
LB1047-RCC MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfxTWM2OD14LkG3OVIzKM7:TR?= NIjiTlBUSU6JRWK=
MHH-NB-11 Mn3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrxV5M3UUN3ME22MlMzPzJzIN88US=> NVnkTGkzW0GQR1XS
J-RT3-T3-5 NIThV5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTZwNkOyPVEh|ryP NX;nUGZtW0GQR1XS
UM-UC-3 NEHocHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTZwNkSzN|Qh|ryP MYLTRW5ITVJ?
IST-SL1 NIHHcZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnTNWlKSzVyPU[uOlk{PjlizszN NETEeW1USU6JRWK=
NB14 NXfKRWhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXITWM2OD14Lke5O|YyKM7:TR?= MXfTRW5ITVJ?
NBsusSR NF[2[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnt[4FKSzVyPU[uPFI2ODJizszN NE\ITFFUSU6JRWK=
D-263MG MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrEZ2pKSzVyPU[uPVExPjhizszN MknEV2FPT0WU
NCI-H2347 M3nDSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXmXJJOUUN3ME22Mlk{OjF|IN88US=> MkHhV2FPT0WU
ES8 M1LqW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\JO4NKSzVyPU[uPVc2QDhizszN M37kb3NCVkeHUh?=
786-0 NGHHPVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7qTWM2OD15LkC5O|g3KM7:TR?= NHzvWHNUSU6JRWK=
EPLC-272H M1rZ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlGwTWM2OD15LkG2NlQ3KM7:TR?= MW\TRW5ITVJ?
CAPAN-1 M{LjdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXhWmRqUUN3ME23MlI1OzV7IN88US=> NELk[JdUSU6JRWK=
NCI-H82 NFrWVJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTdwMk[2OVkh|ryP NYj3OnRIW0GQR1XS
G-402 MoXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTdwM{CwOVEh|ryP MXXTRW5ITVJ?
SW982 MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\4S2lEPTB;Nz6zNFIxOyEQvF2= M3n3ZnNCVkeHUh?=
OVCAR-4 NVGzNJU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTdwM{GzNlgh|ryP NH6xU49USU6JRWK=
KARPAS-299 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv5VIVKSzVyPUeuN|I3OjJizszN MmiwV2FPT0WU
MIA-PaCa-2 M2\IRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnyO|RGUUN3ME23MlM3QDJ|IN88US=> MoX2V2FPT0WU
AU565 NHTpO3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTdwNUm4N|Mh|ryP NVXjfmNFW0GQR1XS
GAMG M2XGXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\B[oFKSzVyPUeuOlQyOzFizszN MVvTRW5ITVJ?
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HLE NXW4SHdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TVXGlEPTB;MkKuOlk4KM7:TR?= MULTRW5ITVJ?
NCI-H727 NWXUNos6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HyS2lEPTB;MkKuO|M2KM7:TR?= Ml;GV2FPT0WU
RD MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4G2bWlEPTB;MkKuO|UyQCEQvF2= Mn75V2FPT0WU
NCI-H522 M2\1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDFUIo3UUN3ME2yNk45PDNzIN88US=> MUfTRW5ITVJ?
CGTH-W-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXkZXlKSzVyPUKzMlA3PDFizszN MYTTRW5ITVJ?
SK-LU-1 NVrRRYVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4njdmlEPTB;MkOuOFY5OyEQvF2= NWnEO5FuW0GQR1XS
BB65-RCC Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33nbGlEPTB;MkOuO|g3OyEQvF2= MkDrV2FPT0WU
HSC-3 NXnhR|RlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{KyWmlEPTB;MkOuPFUzPyEQvF2= NVzYNlVqW0GQR1XS
SK-MES-1 NIHvNlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\GOY9RUUN3ME2yOE4xOTZzIN88US=> NEDCcYJUSU6JRWK=
DB NXfSXphWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDZTWM2OD1{ND6xNFI5KM7:TR?= NVLvfHM5W0GQR1XS
HO-1-N-1 M3fFe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\oTWM2OD1{ND6zNFk{KM7:TR?= MmTYV2FPT0WU
MKN1 NGfDb|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LsbWlEPTB;MkSuOlgh|ryP NGXxS4NUSU6JRWK=
MN-60 MoHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXGTWM2OD1{ND64OVE6KM7:TR?= MWHTRW5ITVJ?
8505C NXraSFJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX65[nZvUUN3ME2yOU4yQDR3IN88US=> NXy4OphvW0GQR1XS
COLO-320-HSR MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJ3LkKyNFgh|ryP M4LFdnNCVkeHUh?=
BB30-HNC M{G2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3WTWM2OD1{NT6yOFg{KM7:TR?= MWDTRW5ITVJ?
KM12 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWm4VmJRUUN3ME2yOU42QDB5IN88US=> NXWwVHZ4W0GQR1XS
NB13 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJ3LkW4PVgh|ryP M3XYRXNCVkeHUh?=
HCC2998 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{e3UGlEPTB;Mk[uNFI5OyEQvF2= MXHTRW5ITVJ?
U-118-MG NGLvbpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETVPYRKSzVyPUK2MlA5ODhizszN M17UNXNCVkeHUh?=
NB10 M2DRWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIKzZ4pKSzVyPUK2MlI{PCEQvF2= MXzTRW5ITVJ?
SK-LMS-1 NVe2OVZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX2TWM2OD1{Nz6wO|A1KM7:TR?= Mo\4V2FPT0WU
SW1573 MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jKOmlEPTB;MkeuNVEh|ryP NUfyPHhsW0GQR1XS
LB373-MEL-D NX;a[GtkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTUTWM2OD1{Nz6xNlk1KM7:TR?= Mnf4V2FPT0WU
DK-MG NWO5UZdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fq[2lEPTB;MkeuNVgyPyEQvF2= NXfDOXBkW0GQR1XS
RMG-I NYD3fmFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7pS|JKUUN3ME2yO{4zODJ7IN88US=> M4DY[XNCVkeHUh?=
SW1088 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTJ5LkWwOFIh|ryP NF\YXHhUSU6JRWK=
SK-OV-3 NH\BVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NES2XYpKSzVyPUK3Mlc2QTNizszN M2LqVXNCVkeHUh?=
KP-N-YN NU\YUXViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1K3PWlEPTB;MkeuPFA1OyEQvF2= M4n3TnNCVkeHUh?=
RPMI-7951 NXuwNGFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLFTWM2OD1{OD6yOFU3KM7:TR?= MorVV2FPT0WU
CaR-1 NEO1fVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS2TWM2OD1{OD61OVgzKM7:TR?= MnHJV2FPT0WU
MKN7 NX3yZohwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLqelR6UUN3ME2yPE42QTZ2IN88US=> MmO5V2FPT0WU
CHP-212 M1PZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP3TWM2OD1{OD63OFAyKM7:TR?= NYC5RWdnW0GQR1XS
KYSE-450 NUTTcnFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTHTWM2OD1{OD64NFkyKM7:TR?= NFvUN2pUSU6JRWK=
RXF393 NG\iUGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnxTWM2OD1{OT6yPVA3KM7:TR?= NULRTpk4W0GQR1XS
P30-OHK NYC2WmloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnqZWQyUUN3ME2yPU4{ODR6IN88US=> MkTCV2FPT0WU
Ca9-22 M{fE[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfJOldKSzVyPUK5MlQzQTlizszN M{\oXHNCVkeHUh?=
RT-112 NWHCS2xST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTGWY1KSzVyPUK5MlQ3OTFizszN MluyV2FPT0WU
ES1 NH;sUWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnroTWM2OD1{OT64OVQ1KM7:TR?= Mm\EV2FPT0WU
HCE-4 NFz6dWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLzTWM2OD1{OT64O|g3KM7:TR?= NHfId|FUSU6JRWK=
AM-38 M{DTV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vJOWlEPTB;M{CuNFYxPiEQvF2= M{[yNXNCVkeHUh?=
AsPC-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXoTWM2OD1|MD64NFU{KM7:TR?= M2nxV3NCVkeHUh?=
TE-9 MljXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDDUVVKSzVyPUOwMlg4OzdizszN MVPTRW5ITVJ?
HuP-T4 NVrlR21OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\Fd404UUN3ME2zNE46PjN6IN88US=> MYXTRW5ITVJ?
LB2518-MEL NEHPNXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTQTWM2OD1|MT6wO|Q1KM7:TR?= MmjNV2FPT0WU
NCI-H1703 NG\Eb5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTNzLkC5NFUh|ryP Mmi4V2FPT0WU
NCI-H2228 M3z6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIixNXpKSzVyPUOxMlQ3PTFizszN NX3tZpB{W0GQR1XS
SCC-4 M1K4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTNzLkmxPFEh|ryP M{fFenNCVkeHUh?=
KNS-81-FD MoXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjkVWsxUUN3ME2zNk4xOTJ6IN88US=> NG\kPGtUSU6JRWK=
NTERA-S-cl-D1 M1zQUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTN{LkC3N|kh|ryP MV7TRW5ITVJ?
Daoy NFn5d|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTN{LkC4N|gh|ryP MWHTRW5ITVJ?
ES4 NYrRWm1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rTbmlEPTB;M{KuN|kzOiEQvF2= NHO0WmlUSU6JRWK=
MHH-ES-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn1U3U{UUN3ME2zNk41QDd{IN88US=> Mn7VV2FPT0WU
C-33-A MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfscW5KSzVyPUOyMlc4OjhizszN NXrpZ2dTW0GQR1XS
BHY NHXpToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXyTWM2OD1|Mj65OFk2KM7:TR?= MmjvV2FPT0WU
Detroit562 M2nZe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzxN2tIUUN3ME2zN{43PjV5IN88US=> NIT0OmhUSU6JRWK=
EW-1 Ml;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlL5TWM2OD1|Mz65N|IzKM7:TR?= NEXEemFUSU6JRWK=
NCI-H1395 M2LTOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vXVGlEPTB;M{SuNFc6QSEQvF2= NF\tclhUSU6JRWK=
KM-H2 NWOwXYtnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXXTWM2OD1|Nj60O|Q{KM7:TR?= MmXWV2FPT0WU
NCI-H520 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlG1TWM2OD1|Nj63OVQyKM7:TR?= NVX0Z|BFW0GQR1XS
D-392MG M1X2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;SbWlEPTB;M{euN|M1PCEQvF2= NXe4PFdnW0GQR1XS
NOMO-1 M3;jV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTN5LkiwPFkh|ryP Mlz6V2FPT0WU
TE-6 MnXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTN6LkGyOEDPxE1? M1zxUnNCVkeHUh?=
HT-3 NEfTdXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvG[GxKSzVyPUO4MlQ1OzZizszN MXTTRW5ITVJ?
RPMI-8226 NFrkdGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TTR2lEPTB;M{iuPVUyQSEQvF2= NWL0UmdCW0GQR1XS
U251 NF\jPYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTN7LkCxNlQh|ryP MmS2V2FPT0WU
GCT MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXSO|hQUUN3ME2zPU4yQDV{IN88US=> NWizUFFwW0GQR1XS
A431 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorPTWM2OD1|OT6xPFk1KM7:TR?= MUHTRW5ITVJ?
TE-12 NH7EdZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfXNGdpUUN3ME2zPU4zPDR6IN88US=> MY\TRW5ITVJ?
HMV-II MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f0d2lEPTB;M{muOVA1PyEQvF2= NH3TNG1USU6JRWK=
IST-MES1 NEjkTIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHVUFNlUUN3ME20NE4yPTB{IN88US=> M4KyTHNCVkeHUh?=
SW13 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\5eGlEPTB;NECuOVE6KM7:TR?= MWnTRW5ITVJ?
SF295 NVKw[ZpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTRyLkiwOlYh|ryP M4nqR3NCVkeHUh?=
MDA-MB-157 M17LW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M16zfGlEPTB;NECuPVQ3OiEQvF2= NVnXdGsxW0GQR1XS
TE-1 MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTWTWM2OD12MT64O|E1KM7:TR?= MonLV2FPT0WU
HuCCT1 M2nvV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG5dnNKSzVyPUSyMlUzQDlizszN NWO0b|N7W0GQR1XS
KYSE-510 NULHWYx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HlfWlEPTB;NEOuNVc2PCEQvF2= MnrIV2FPT0WU
NCI-H358 Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HkdGlEPTB;NESuNFMxPCEQvF2= NWWzcIJ{W0GQR1XS
SW900 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvVTWM2OD12ND6wO|U5KM7:TR?= M2KyenNCVkeHUh?=
CAS-1 MkTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPETWM2OD12ND6wPVkyKM7:TR?= NET3bFJUSU6JRWK=
TE-8 M{TNcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDZXVJKSzVyPUS0MlU3PThizszN NEK0U41USU6JRWK=
P12-ICHIKAWA NFviU|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTR2Lk[xNVIh|ryP NED0XlhUSU6JRWK=
YKG-1 NIDBPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF6wcmxKSzVyPUS0Mlc5OSEQvF2= M33mfnNCVkeHUh?=
SNU-C2B M4rWcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTR2Lke5NFMh|ryP NIDrcJNUSU6JRWK=
LCLC-103H NGXJT|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXlTWM2OD12ND64O|A{KM7:TR?= Mni1V2FPT0WU
U-87-MG NYHJNY5zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIO5epZKSzVyPUS1MlExOjJizszN M1zvfHNCVkeHUh?=
HAL-01 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkK0TWM2OD12NT6xN|c6KM7:TR?= MlrJV2FPT0WU
OVCAR-8 NILkRZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;ZNY9KSzVyPUS1MlM2PjRizszN M3i4ZXNCVkeHUh?=
KYSE-150 NY\wd|BrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPyeJdXUUN3ME20O{4yODV{IN88US=> NFHuZ|VUSU6JRWK=
OE33 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjSTVNKSzVyPUS3MlE1OjlizszN Mn33V2FPT0WU
CAL-62 NFe0NpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHWTWM2OD12Nz60NFY5KM7:TR?= NIDOelNUSU6JRWK=
TCCSUP NYPJSlFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1ntSmlEPTB;NEeuOlI3PCEQvF2= NUP3O2JPW0GQR1XS
H4 Moj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nVNGlEPTB;NEeuOlYzOSEQvF2= MlzHV2FPT0WU
CP66-MEL M3vi[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITRcJZKSzVyPUS4MlA4ODRizszN MV\TRW5ITVJ?
SNB75 NXj6UZVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW3d3VKSzVyPUS4MlE5PzRizszN NV7WRZNyW0GQR1XS
Mo-T MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;NTWM2OD12OD6yO|kh|ryP NF7qcZBUSU6JRWK=
BT-549 NX[1TnVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnoZ2xUUUN3ME20PE4{PzJ7IN88US=> MmnpV2FPT0WU
IGR-1 NUPPVVZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkD2TWM2OD12OD62OlQ2KM7:TR?= Mo[wV2FPT0WU
NCI-H1299 M2S1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTR6LkeyOFgh|ryP M1PoT3NCVkeHUh?=
ALL-PO NHHQe4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnM[YZ2UUN3ME20PU46OjZ6IN88US=> NVLk[GZJW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method: The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
4% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID