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NU7441 (KU-57788) Chemical Structure
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Biological Activity
NU7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 0.01, 1.7 and 5 μM for DNA-PK, mTOR and PI3-K, respectively. NU7441 (KU-57788) has less inhibitory activity against ATM and ATR (IC50 valuse>100 μM). NU7441 (KU-57788) increased the cytotoxicity of IR and etoposide in V3-YAC cells but not in V3 cells, confirming that DNA-PKcs is the cellular target of NU7441 (KU-57788). NU7441 (KU-57788) alone had no effect on cell cycle distribution, but accumulation in G2/M induced by exposure to IR (2 Gy) or the topoisomerase II poisons, doxorubicin (10 nM) or etoposide (0.1 µM) was increased 1.2 to 2 fold by NU7441 (KU-57788) in SW620 cells. [1][2]
References on NU7441 (KU-57788)
- [1] Proc Amer Assoc Cancer Res 2005;Volume 46
- [2] Cancer Res. 2006 May 15;66(10):5354-62
Chemical Information
| Molecular Weight (WM): | 413.49 |
|---|---|
| Formula: | C25H19NO3S |
| CAS No.: | 503468-95-9 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥5mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
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After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
Data independently produced by Dr. Zhang of Tianjin Medical University NU7441 (KU-57788) purchased from Selleck
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After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF. |
Data independently produced by Dr. Zhang of Tianjin Medical University
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