NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.

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4 Customer Reviews

  • Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

    Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.
Targets
DNA-PK [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
PI3K [1]
(Cell-free assay)
ATM [1]
(Cell-free assay)
ATR [1]
(Cell-free assay)
14 nM 1.7 μM 5 μM >100 μM >100 μM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 NHrib5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEKxOFMh|ryP MlHaV2FPT0WU
A172 MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLoTWM2OD1yLkG1N|E3KM7:TR?= NIfkW|FUSU6JRWK=
NCI-H526 NWHnSIg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK2TWM2OD1yLkK4OFA4KM7:TR?= MljGV2FPT0WU
HDLM-2 NELKNoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwM{KzOFUh|ryP MXXTRW5ITVJ?
HuO-3N1 MnPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwNE[2N|Yh|ryP NX3XXpdQW0GQR1XS
NCI-SNU-1 NXHPZYx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LPUGlEPTB;MD62NFk6PCEQvF2= MXfTRW5ITVJ?
SK-N-AS MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwNkKyNVYh|ryP M1HxXXNCVkeHUh?=
LoVo M1jWZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDnTWM2OD1yLki2O|Q6KM7:TR?= NVHGb|Q3W0GQR1XS
LAMA-84 NVf3NWJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwOUi4N|Mh|ryP MY\TRW5ITVJ?
CTB-1 NFq2c25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moj5TWM2OD1zLkGxOVQ3KM7:TR?= NVPvflVVW0GQR1XS
KP-N-YS MmfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnOU3JKSzVyPUGuNVQzOzFizszN M3jYNHNCVkeHUh?=
HH NXHKR5o2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTsdZFQUUN3ME2xMlE5ODl|IN88US=> NUe1UnJYW0GQR1XS
CHL-1 NVu3[YdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWGzXI1mUUN3ME2xMlIyOzZ6IN88US=> MXzTRW5ITVJ?
NB7 M1fvd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rDcWlEPTB;MT6yOFc1PSEQvF2= NYP3[FlKW0GQR1XS
HL-60 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTFwM{ixPUDPxE1? MVLTRW5ITVJ?
639-V NUPreIh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLCfWNxUUN3ME2xMlQ1OTJ6IN88US=> MoGyV2FPT0WU
NCI-H1793 NEHvPHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTKSGFUUUN3ME2xMlQ2QDRizszN MVHTRW5ITVJ?
NEC8 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv5dGVKSzVyPUGuOVU{PSEQvF2= Mo\4V2FPT0WU
PA-1 M2fhPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH0TXRKSzVyPUGuOVgzQTRizszN NWjSTZBSW0GQR1XS
D-423MG M2TYeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP3VVdKSzVyPUGuOlk{PjFizszN NXv4d|J7W0GQR1XS
NCI-H292 M2LyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTFwN{SwNVMh|ryP MljrV2FPT0WU
SK-MEL-1 NXTBW4Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfwfndKSzVyPUGuO|k1PzlizszN NXvGcmFsW0GQR1XS
LB2241-RCC M4rPUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTEUW13UUN3ME2yMlE1OTR4IN88US=> M37Gd3NCVkeHUh?=
SK-MEL-3 NVXtfFVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJwMU[0PUDPxE1? M136PXNCVkeHUh?=
MHH-PREB-1 M17peWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTJwMU[2NFkh|ryP MY\TRW5ITVJ?
BFTC-905 NFzqOoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfqTWM2OD1{LkG2Olg4KM7:TR?= NIDpXG9USU6JRWK=
Ramos-2G6-4C10 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DGcWlEPTB;Mj6xPVkxQSEQvF2= MmPHV2FPT0WU
G-361 NGjCdZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTvUXBSUUN3ME2yMlIyPjhizszN M2TKeHNCVkeHUh?=
MOLT-4 M1TRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DoWGlEPTB;Mj6yNVg5QCEQvF2= MkHiV2FPT0WU
DEL MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4W0UWlEPTB;Mj6zOVU3PCEQvF2= MYPTRW5ITVJ?
MV-4-11 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HWNGlEPTB;Mj6zO|M6KM7:TR?= NEHufHBUSU6JRWK=
SK-NEP-1 M1TJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nvbGlEPTB;Mj6zPFc5OyEQvF2= NX\IO|dFW0GQR1XS
RS4-11 MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJwNU[wNlMh|ryP M2T3d3NCVkeHUh?=
HuH-7 M3fUN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D1Z2lEPTB;Mj61OlcxOiEQvF2= NE\keFVUSU6JRWK=
A101D MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfXTWM2OD1{Lk[xN|M5KM7:TR?= MXnTRW5ITVJ?
KG-1 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjRZpNKSzVyPUKuOlc6OjRizszN NX;wUlVwW0GQR1XS
KALS-1 M3LvR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Dwe2lEPTB;Mj62PVY{OyEQvF2= MoTBV2FPT0WU
VMRC-RCZ M2TvRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S2[WlEPTB;Mj63O|MzQCEQvF2= MVHTRW5ITVJ?
SK-UT-1 NEK1bWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTyTodKSzVyPUOuNVU{OSEQvF2= NYrHV2dKW0GQR1XS
SW962 NVKxR4U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDYTWM2OD1|LkKwN|UzKM7:TR?= M4HwW3NCVkeHUh?=
DBTRG-05MG NEH1T2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTLTWM2OD1|LkK4NFg2KM7:TR?= MX\TRW5ITVJ?
PANC-08-13 MnnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XWbGlEPTB;Mz60NVI4QCEQvF2= MnXrV2FPT0WU
QIMR-WIL NHHORpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTQXFJ[UUN3ME2zMlQyOzRzIN88US=> M2PUVnNCVkeHUh?=
SK-MEL-30 NX:5TG1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTNwNEK1PVgh|ryP M4PmenNCVkeHUh?=
697 MmnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjsWm02UUN3ME2zMlQ1QTl|IN88US=> NWTjXoZzW0GQR1XS
NY MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfNRmRKSzVyPUOuOFUxOjJizszN NVrOOow2W0GQR1XS
ES7 NF:xcJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXMU|hKSzVyPUOuOFY4OjlizszN Mm\xV2FPT0WU
JVM-3 M3PEUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDyTWM2OD1|LkS4NFc4KM7:TR?= NHvVbldUSU6JRWK=
U031 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTNwNUmzOlgh|ryP MnrOV2FPT0WU
BHT-101 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;oUnFlUUN3ME2zMlU6QTh3IN88US=> NGPiUW5USU6JRWK=
8305C MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHRTWM2OD1|Lk[xO|M3KM7:TR?= MYTTRW5ITVJ?
MG-63 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETTdWhKSzVyPUOuOlI3PzZizszN M4H4RXNCVkeHUh?=
NOS-1 NWnhWGozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS0TldmUUN3ME2zMlY2OzF{IN88US=> NWDtRmNGW0GQR1XS
YH-13 NUHBeJVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nVfGlEPTB;Mz64O|E5QSEQvF2= MVvTRW5ITVJ?
LXF-289 M1yzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkOxTWM2OD1|LkmxNFQyKM7:TR?= MnnkV2FPT0WU
GOTO MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmf5TWM2OD1|LkmxOFkh|ryP NIjQZodUSU6JRWK=
EKVX MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrBS3dsUUN3ME20MlIzPTJ2IN88US=> NFHwVZBUSU6JRWK=
CAL-51 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLDXJVKSzVyPUSuNlQ5PTRizszN NH74c4hUSU6JRWK=
AN3-CA MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTLW5NvUUN3ME20MlI2QDF|IN88US=> Ml;TV2FPT0WU
IA-LM NWHTeGFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGO1ZWZKSzVyPUSuNlc6OzVizszN NIHIfWNUSU6JRWK=
KU-19-19 NHu0d|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX3TWM2OD12LkOyPVIyKM7:TR?= M3HPUXNCVkeHUh?=
A704 M1frVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zKWWlEPTB;ND60NFg5QCEQvF2= M4LlWXNCVkeHUh?=
RH-18 NVPHR5VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTRwNES5OVMh|ryP MYnTRW5ITVJ?
IST-MEL1 M3jrPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmi4TWM2OD12LkW4NlY{KM7:TR?= MWnTRW5ITVJ?
LU-134-A MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlWxTWM2OD12LkW5Olg2KM7:TR?= MULTRW5ITVJ?
SF126 NF\YOHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTRwNkC3NVUh|ryP NWfjZXJWW0GQR1XS
EFO-27 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;qRZVCUUN3ME20MlY3PTJ3IN88US=> MUHTRW5ITVJ?
SN12C M3TWPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjvTWM2OD12LkexPFk5KM7:TR?= MXrTRW5ITVJ?
L-363 NFTKbnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHGyWoJKSzVyPUSuO|cyOTZizszN MYjTRW5ITVJ?
MEL-HO MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTRwN{e5PFkh|ryP NVm5T2w2W0GQR1XS
TYK-nu NH7wXJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rj[GlEPTB;ND64NFEzQCEQvF2= MnWzV2FPT0WU
MDA-MB-415 MmjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLyTWM2OD13LkCwN|E1KM7:TR?= MkjlV2FPT0WU
HCC70 NF7lfVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTVwMEO5N|kh|ryP MXTTRW5ITVJ?
IGROV-1 M1nweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLVdIVvUUN3ME21MlI2Ojl{IN88US=> MYHTRW5ITVJ?
NCI-H1355 NITEbpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4X1PGlEPTB;NT6yPVYh|ryP NILuN4JUSU6JRWK=
23132-87 MlHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDPNXZUUUN3ME21MlMzODJ2IN88US=> NHHhdFBUSU6JRWK=
NB69 NFrpWYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXTVY5wUUN3ME21MlMzPDJizszN M2nXTHNCVkeHUh?=
HSC-2 NWDpZ2tmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L0SGlEPTB;NT60NVc4OyEQvF2= MmTzV2FPT0WU
KYSE-410 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLJXVNKSzVyPUWuOFc3OzZizszN MVnTRW5ITVJ?
GCIY M1jr[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTVwNUGzO|gh|ryP NUnxRmtpW0GQR1XS
A427 MojhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIn0OZlKSzVyPUWuOVM3PjFizszN M{TCOXNCVkeHUh?=
ChaGo-K-1 NX3pUJhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TxRmlEPTB;NT61OlU6QSEQvF2= M1PVTnNCVkeHUh?=
PFSK-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXJN|RKSzVyPUWuOlIyQTRizszN NV3lWmN1W0GQR1XS
MLMA MoPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M132U2lEPTB;NT64N|YxPiEQvF2= MULTRW5ITVJ?
RVH-421 MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTEfphKSzVyPU[uNFc{OzhizszN NWG1TlViW0GQR1XS
LB1047-RCC M2rweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjKXoZQUUN3ME22MlE4PTJ{IN88US=> NFLWeGpUSU6JRWK=
MHH-NB-11 M3i4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LVN2lEPTB;Nj6zNlczOSEQvF2= MknkV2FPT0WU
J-RT3-T3-5 NX;IRYo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfOT4dKSzVyPU[uOlMzQTFizszN MlLJV2FPT0WU
UM-UC-3 Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7mfnFKSzVyPU[uOlQ{OzRizszN NV;MfYNQW0GQR1XS
IST-SL1 M4j3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[zemlEPTB;Nj62PVM3QSEQvF2= MUTTRW5ITVJ?
NB14 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzOS2Z6UUN3ME22Mlc6PzZzIN88US=> NYn6eFhiW0GQR1XS
NBsusSR MnnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzrdXRVUUN3ME22MlgzPTB{IN88US=> NXS4codxW0GQR1XS
D-263MG NEfnVGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO3U2VJUUN3ME22MlkyODZ6IN88US=> MWPTRW5ITVJ?
NCI-H2347 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILKUFZKSzVyPU[uPVMzOTNizszN Mlj3V2FPT0WU
ES8 NUDpbItwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXSSGpKSzVyPU[uPVc2QDhizszN M17RTXNCVkeHUh?=
786-0 NWXnSY05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;YTpVKSzVyPUeuNFk4QDZizszN MnfPV2FPT0WU
EPLC-272H NH3ibmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TpVWlEPTB;Nz6xOlI1PiEQvF2= Mmj4V2FPT0WU
CAPAN-1 NHOybZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTdwMkSzOVkh|ryP M3X4OHNCVkeHUh?=
NCI-H82 M1fQW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLpTIdKSzVyPUeuNlY3PTlizszN MYfTRW5ITVJ?
G-402 NGP1ZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{KwPGlEPTB;Nz6zNFA2OSEQvF2= M2nUXnNCVkeHUh?=
SW982 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzFTWM2OD15LkOwNlA{KM7:TR?= NHi1U3hUSU6JRWK=
OVCAR-4 NIHmSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PxUWlEPTB;Nz6zNVMzQCEQvF2= NWm4eWJnW0GQR1XS
KARPAS-299 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTdwM{K2NlIh|ryP NUDHToxUW0GQR1XS
MIA-PaCa-2 NXTlUZF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnTRpdKSzVyPUeuN|Y5OjNizszN MV\TRW5ITVJ?
AU565 MnfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoGzTWM2OD15LkW5PFM{KM7:TR?= NUW0RndEW0GQR1XS
GAMG NFvQN2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\3TWM2OD15Lk[0NVMyKM7:TR?= M4XrdnNCVkeHUh?=
HuO9 NGXWO4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPzR3VKSzVyPUeuO|E4PDNizszN MYLTRW5ITVJ?
ACN M{Ww[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTdwN{SzN{DPxE1? NIr0eGhUSU6JRWK=
RO82-W-1 NUDtboJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TtRWlEPTB;Nz63OFU{OyEQvF2= MlmyV2FPT0WU
NKM-1 MmL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTdwN{S5OVUh|ryP MlTwV2FPT0WU
CAL-12T MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjiZmtKSzVyPUeuPVQ{PTJizszN M3LydHNCVkeHUh?=
FADU Mn;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRThwMEO2OVQh|ryP NFLWbZFUSU6JRWK=
NCI-H28 NGC5fHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XDbGlEPTB;OD6xOlk3OiEQvF2= Mo\BV2FPT0WU
LCLC-97TM1 M1[4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXP6[|FtUUN3ME24MlIyOTJ{IN88US=> MlrvV2FPT0WU
CHP-134 NXXVZ2k{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfLbVh4UUN3ME24MlI1OTh3IN88US=> MlXMV2FPT0WU
HT-1080 NYDaeJIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\lW5EyUUN3ME24MlI2ODl|IN88US=> MmHlV2FPT0WU
PC-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K1b2lEPTB;OD6yO|M6OiEQvF2= Mn[1V2FPT0WU
SNU-449 NX\UTFFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRThwMke5N{DPxE1? NIjxWWVUSU6JRWK=
VA-ES-BJ NFLGdlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRThwM{S2PFYh|ryP M4jaXXNCVkeHUh?=
HT MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\jdGlEPTB;OD6zOlQ6KM7:TR?= Ml64V2FPT0WU
HOS NIHPT|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPwTWM2OD16LkO3OVg6KM7:TR?= NELLV|VUSU6JRWK=
KNS-62 MmTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRThwM{e3OlIh|ryP NU\STIFoW0GQR1XS
OAW-42 MknIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHnTWM2OD16Lkm1PVY1KM7:TR?= NVXFToJuW0GQR1XS
A549 MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;wRmVGUUN3ME25MlA6PjF{IN88US=> Ml\BV2FPT0WU
CAKI-1 NWXpdXFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTlwMU[2NUDPxE1? M3PKTXNCVkeHUh?=
HCC1937 NEjWfmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ezUGlEPTB;OT62PVg3PSEQvF2= Ml:wV2FPT0WU
GI-ME-N NWnaXGlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorMTWM2OD17LkewNVM4KM7:TR?= Mom5V2FPT0WU
DU-4475 M4foTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDkc2ZkUUN3ME25Mlk3QTN7IN88US=> MXPTRW5ITVJ?
EM-2 NX\a[W5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPLc|lpUUN3ME2xNE4zPDJ4IN88US=> MV7TRW5ITVJ?
NCI-H1755 NVP6PZFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nxWGlEPTB;MUCuNlQzQCEQvF2= NX2wNlFqW0GQR1XS
NCI-H1437 NGfreFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTXTWM2OD1zMD61O|I2KM7:TR?= NEDKU3dUSU6JRWK=
VM-CUB-1 NHTBSIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPvTWM2OD1zMD62NVY1KM7:TR?= NHHRb5lUSU6JRWK=
A2058 NXfJXmgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLlOnVKSzVyPUGwMlY1ODRizszN MknRV2FPT0WU
BPH-1 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUGwZYFVUUN3ME2xNE44OTR3IN88US=> MXvTRW5ITVJ?
NB5 NUHFdYRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjzNpZKSzVyPUGwMlc2PTlizszN MkLrV2FPT0WU
G-401 NF3FPGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvxXGlVUUN3ME2xNE44PjJ4IN88US=> NWToPYtQW0GQR1XS
CAL-72 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTFyLkiwPVQh|ryP MYPTRW5ITVJ?
SK-MEL-28 M3uzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\nTWM2OD1zMD64NlAzKM7:TR?= M2LrfHNCVkeHUh?=
C32 NFXpVpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTNTXVSUUN3ME2xNE45OzR5IN88US=> Ml71V2FPT0WU
NCI-H1155 M2C0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPxcWhpUUN3ME2xNE45Ozd4IN88US=> MV\TRW5ITVJ?
BB49-HNC NX;HR2tHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXyO4F7UUN3ME2xNE45PTh4IN88US=> Mo\SV2FPT0WU
GMS-10 M3;DeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr5TWM2OD1zMD64PVcyKM7:TR?= M2\NcnNCVkeHUh?=
K5 MkjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rzZ2lEPTB;MUCuPVA4OSEQvF2= NUD0cokxW0GQR1XS
OS-RC-2 Ml\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fkc2lEPTB;MUGuNFU2QSEQvF2= M4\NOnNCVkeHUh?=
HTC-C3 M13LZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vESGlEPTB;MUGuNFcyPCEQvF2= NXv2Zo5sW0GQR1XS
LB996-RCC NGLGR|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTFzLkC3NlMh|ryP M3H4VnNCVkeHUh?=
NCI-H1563 MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTFzLkGwNVEh|ryP NYXuXlZ{W0GQR1XS
CAL-54 MnHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTFzLkS4NVEh|ryP NFjOUnBUSU6JRWK=
WM-115 NVHW[ppHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr4b|hKSzVyPUGxMlY5OjRizszN MmrWV2FPT0WU
COLO-684 M3:1S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXznNFlQUUN3ME2xNU44OjZ5IN88US=> MmTwV2FPT0WU
HOP-62 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX30ToxFUUN3ME2xNU44PTB6IN88US=> M4LkS3NCVkeHUh?=
NCI-H650 MnTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfmTWM2OD1zMT64PVYyKM7:TR?= NXG2T49LW0GQR1XS
TE-11 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYe2ZmFuUUN3ME2xNU46OzF3IN88US=> MVnTRW5ITVJ?
COLO-679 NH7oUZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXybY5wUUN3ME2xNU46PDZizszN NY\pbnlsW0GQR1XS
FTC-133 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnJTWM2OD1zMj6wNFc3KM7:TR?= MUDTRW5ITVJ?
D-283MED NVHhbYZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTF{LkC1Olkh|ryP Mn[xV2FPT0WU
SK-PN-DW NGrlc3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXxcnVKSzVyPUGyMlE6ODJizszN NVqxb|RSW0GQR1XS
BALL-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fJXGlEPTB;MUKuNlY3OiEQvF2= NGnkWZJUSU6JRWK=
GT3TKB NELmVGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojZTWM2OD1zMj6zNFc1KM7:TR?= NFG0bXpUSU6JRWK=
HOP-92 NHPnXlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLlTWM2OD1zMj61NlM{KM7:TR?= NVX1VWtHW0GQR1XS
M14 M3LlZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLCe|JRUUN3ME2xN{4xOzN3IN88US=> NUW0Tmc3W0GQR1XS
SKG-IIIa MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnyVXBKSzVyPUGzMlA2PTRizszN M1;pNnNCVkeHUh?=
Becker MnfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3r3VmlEPTB;MUOuNFU5KM7:TR?= NWCySXlZW0GQR1XS
ES5 MnT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXDXJNKSzVyPUGzMlE{PTZizszN NWW2U4ZSW0GQR1XS
NCI-H2030 NIPkUINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTF|LkKwOlIh|ryP NGPLfFBUSU6JRWK=
SNU-423 M2\Vb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTEdlNKSzVyPUGzMlM5OSEQvF2= M1fId3NCVkeHUh?=
CP50-MEL-B Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDaTnZuUUN3ME2xN{43OjN{IN88US=> MnvYV2FPT0WU
NCI-H1092 M2ruN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTF|Lke0O|Uh|ryP M{\VdnNCVkeHUh?=
8-MG-BA MlX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF|Lke1NVMh|ryP MW\TRW5ITVJ?
CAL-27 NITpZmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r5XWlEPTB;MUSuNFczPyEQvF2= NGPIXI9USU6JRWK=
AGS Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[1c3g6UUN3ME2xOE4yOzF7IN88US=> MYPTRW5ITVJ?
MZ2-MEL NUnPXGZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jvNmlEPTB;MUSuNVQ5QCEQvF2= NUPoS|BtW0GQR1XS
BFTC-909 M4j6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[2TWM2OD1zND61NFU2KM7:TR?= NHzpeGRUSU6JRWK=
D-566MG NEDp[5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH5WlZKSzVyPUG0Mlc4ODZizszN MWXTRW5ITVJ?
MZ7-mel NGXGZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTF3LkGwOlch|ryP M4rXe3NCVkeHUh?=
TE-5 MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PpTmlEPTB;MUWuNlM{OyEQvF2= MmqwV2FPT0WU
647-V NUnmbXp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfPTWM2OD1zNT6yO|A2KM7:TR?= Mnu1V2FPT0WU
DMS-114 M1qxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTF3LkOyPVEh|ryP NWHuWIhWW0GQR1XS
ME-180 NFvSSpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTF3LkS3PFMh|ryP MmDtV2FPT0WU
MS-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF3LkW2NlMh|ryP Mn;wV2FPT0WU
NUGC-3 NX;aT2c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PrS2lEPTB;MUWuOlI1PSEQvF2= MU\TRW5ITVJ?
GB-1 NIHnfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PmUmlEPTB;MUWuOlQ{PyEQvF2= M4HWfHNCVkeHUh?=
LOXIMVI M1zX[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml71TWM2OD1zNT64PVE6KM7:TR?= NUj1OlR3W0GQR1XS
NCI-H1304 NIPGVYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13NbGlEPTB;MUWuPFkzQCEQvF2= NWPmUFU4W0GQR1XS
KURAMOCHI Mo\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPsTWM2OD1zNT65O|Eh|ryP MWHTRW5ITVJ?
SW1783 MknNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTF4LkC5PVMh|ryP MYTTRW5ITVJ?
EGI-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvOdFdKSzVyPUG2MlU{PjVizszN NIjX[3FUSU6JRWK=
KGN NFjmNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjJRXdKSzVyPUG2MlU2QDZizszN NID4S5hUSU6JRWK=
PANC-03-27 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPtdJlKSzVyPUG2Mlc3PjJizszN Mn3HV2FPT0WU
RH-1 NWj5cnQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;TV2NyUUN3ME2xOk45OjVizszN NFroTlJUSU6JRWK=
HT-1376 NIrYPFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XtSWlEPTB;MU[uPFQ1PiEQvF2= M2fkdXNCVkeHUh?=
ZR-75-30 NVmyZZplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LhWmlEPTB;MU[uPVM3OSEQvF2= MX\TRW5ITVJ?
TI-73 Mk\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXrVoVKSzVyPUG2Mlk1ODhizszN NI\ZRWVUSU6JRWK=
TK10 NEjFNFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PqSWlEPTB;MUeuNFA4QSEQvF2= MV\TRW5ITVJ?
SW684 M37KZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTjTWM2OD1zNz6wNVU1KM7:TR?= NFfue2hUSU6JRWK=
RPMI-8866 Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vSWWlEPTB;MUeuNFY6QSEQvF2= MUPTRW5ITVJ?
LNCaP-Clone-FGC NEPYSYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLLTWM2OD1zNz61NlAyKM7:TR?= MUfTRW5ITVJ?
NCI-H2291 M{PZeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrWVJRKSzVyPUG4MlQ{PDVizszN M1T0eHNCVkeHUh?=
T47D NYXlXINET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV23Vm1DUUN3ME2xPE41QDhizszN MlvhV2FPT0WU
A204 M1[4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFq2eHNKSzVyPUG4MlU1PTJizszN NVPncoh1W0GQR1XS
HT-144 NIXFUGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF6Lke0Nlch|ryP NFzGeHpUSU6JRWK=
MDA-MB-361 Mmj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTiWYVKSzVyPUG5MlA4OTRizszN M3\LS3NCVkeHUh?=
HCC1806 MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP1TWM2OD1zOT6xOVkyKM7:TR?= M{\PbHNCVkeHUh?=
NCI-H596 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz5TWM2OD1zOT62N|kyKM7:TR?= NVzJWFZsW0GQR1XS
K-562 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELQfmlKSzVyPUG5Mlg6OjZizszN NV70RphmW0GQR1XS
D-336MG MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnzOo9sUUN3ME2xPU46OzJ{IN88US=> Mof3V2FPT0WU
SK-MEL-2 M3vBSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTCTWM2OD1{MD6xOVU6KM7:TR?= MX7TRW5ITVJ?
HEC-1 M4PFdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfLTWM2OD1{MD60PVc5KM7:TR?= NHrySWdUSU6JRWK=
EW-13 NWLvfVRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTJyLkW0OFMh|ryP MVXTRW5ITVJ?
Hs-578-T NUOxW5pJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DpbmlEPTB;MkCuOVU5OyEQvF2= NVLiRoVPW0GQR1XS
SJSA-1 NFzFfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnmTWM2OD1{MD61Olg5KM7:TR?= NIe3cGtUSU6JRWK=
RCC10RGB NWrXZnI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzPcZdKSzVyPUKwMlY4OTlizszN NUT1VG1tW0GQR1XS
LAN-6 MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPqTWM2OD1{MT6wN|k3KM7:TR?= NFy3WXVUSU6JRWK=
NCI-H1048 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJzLkKyOVgh|ryP M2XueXNCVkeHUh?=
CW-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTJzLkK3NFUh|ryP MWXTRW5ITVJ?
HCC2157 NEnidYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\Xe4txUUN3ME2yNU4{PiEQvF2= MXrTRW5ITVJ?
EW-22 NV3xdYUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTJzLkO3OkDPxE1? M1qyS3NCVkeHUh?=
A253 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJzLkS0PFEh|ryP NGr6NIJUSU6JRWK=
BE-13 MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:4TWM2OD1{MT62NVE{KM7:TR?= NUDYU5M5W0GQR1XS
KINGS-1 M3vRcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLVOZFKSzVyPUKxMlY{OTZizszN NF;L[YpUSU6JRWK=
ETK-1 M{Xxdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEe1UoJKSzVyPUKxMlgyPTJizszN M2nYR3NCVkeHUh?=
NCI-H2452 NUTCcYxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPrZVFKSzVyPUKxMlg3PDdizszN M3XFVXNCVkeHUh?=
HPAF-II NIH2RWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NICzRVNKSzVyPUKxMlg6OjNizszN NVyydY9VW0GQR1XS
D-542MG NXrGOpN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInYNVRKSzVyPUKxMlkxPjlizszN NIf6VYpUSU6JRWK=
NCI-H630 MlWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\mOnpKSzVyPUKyMlAzQTZizszN NWOwfI83W0GQR1XS
TGBC11TKB M2HxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;mfmlEPTB;MkKuNFQ6KM7:TR?= M4rWeXNCVkeHUh?=
BCPAP NUjJbYUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHX0fFVKSzVyPUKyMlYyOSEQvF2= M2fjUnNCVkeHUh?=
HLE NGO4TZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHFTWM2OD1{Mj62PVch|ryP NF\VNIFUSU6JRWK=
NCI-H727 NWO2SZZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLVU4Z1UUN3ME2yNk44OzVizszN NHPyN4pUSU6JRWK=
RD M3vLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zR[mlEPTB;MkKuO|UyQCEQvF2= MlXyV2FPT0WU
NCI-H522 M{DveWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\TfFM2UUN3ME2yNk45PDNzIN88US=> MY\TRW5ITVJ?
CGTH-W-1 MnnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXaN|BCUUN3ME2yN{4xPjRzIN88US=> M1vWPHNCVkeHUh?=
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BB65-RCC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfpTWM2OD1{Mz63PFY{KM7:TR?= MkDIV2FPT0WU
HSC-3 NHS3U4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJ|Lki1Nlch|ryP NX7zfZNHW0GQR1XS
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MKN1 M2D4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlToTWM2OD1{ND62PEDPxE1? MWnTRW5ITVJ?
MN-60 MlvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nOWmlEPTB;MkSuPFUyQSEQvF2= NFvGUmtUSU6JRWK=
8505C M37pRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJ3LkG4OFUh|ryP NX;NUFAxW0GQR1XS
COLO-320-HSR NUDKNIFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTJ3LkKyNFgh|ryP MYXTRW5ITVJ?
BB30-HNC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fwW2lEPTB;MkWuNlQ5OyEQvF2= M3LLTnNCVkeHUh?=
KM12 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJ3LkW4NFch|ryP MXPTRW5ITVJ?
NB13 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJ3LkW4PVgh|ryP MmTiV2FPT0WU
HCC2998 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfqTWM2OD1{Nj6wNlg{KM7:TR?= MYTTRW5ITVJ?
U-118-MG NFP4VmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzGTWM2OD1{Nj6wPFA5KM7:TR?= MXvTRW5ITVJ?
NB10 M1vMVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\qTWM2OD1{Nj6yN|Qh|ryP MnnDV2FPT0WU
SK-LMS-1 MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LaXmlEPTB;MkeuNFcxPCEQvF2= NFnBXJpUSU6JRWK=
SW1573 MoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3faW2lEPTB;MkeuNVEh|ryP MYPTRW5ITVJ?
LB373-MEL-D NEW1PFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXFeY1KSzVyPUK3MlEzQTRizszN NUTIUZFmW0GQR1XS
DK-MG M3XMSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJ5LkG4NVch|ryP NUTxSJA2W0GQR1XS
RMG-I NYTTUFM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJ5LkKwNlkh|ryP MnzwV2FPT0WU
SW1088 NX\uXGhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;nXmlEPTB;MkeuOVA1OiEQvF2= MYLTRW5ITVJ?
SK-OV-3 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXruTZY{UUN3ME2yO{44PTl|IN88US=> NF;MepBUSU6JRWK=
KP-N-YN MmjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjBfJJKSzVyPUK3MlgxPDNizszN MYLTRW5ITVJ?
RPMI-7951 NYi0VYVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTJ6LkK0OVYh|ryP NGPzcoxUSU6JRWK=
CaR-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJ6LkW1PFIh|ryP MkjVV2FPT0WU
MKN7 NE\lUVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r3UmlEPTB;MkiuOVk3PCEQvF2= M4DLU3NCVkeHUh?=
CHP-212 NF3wemNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUeyUGN1UUN3ME2yPE44PDBzIN88US=> MkCxV2FPT0WU
KYSE-450 NX2wXWt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfwUXNKSzVyPUK4MlgxQTFizszN Mn30V2FPT0WU
RXF393 NUjreJRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHftfo9KSzVyPUK5MlI6ODZizszN NH;JO|NUSU6JRWK=
P30-OHK NI\LXYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nrOmlEPTB;MkmuN|A1QCEQvF2= Ml7xV2FPT0WU
Ca9-22 NV24V25nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHGRpJuUUN3ME2yPU41Ojl7IN88US=> M3HGTnNCVkeHUh?=
RT-112 NXHMU|BwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHSwUoJKSzVyPUK5MlQ3OTFizszN MnrvV2FPT0WU
ES1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTHTWFTUUN3ME2yPU45PTR2IN88US=> NHzpVmFUSU6JRWK=
HCE-4 MoThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfOboZKSzVyPUK5Mlg4QDZizszN MlnaV2FPT0WU
AM-38 MnvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjHbIhKSzVyPUOwMlA3ODZizszN NXLaZlYzW0GQR1XS
AsPC-1 MljkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzCT2RKSzVyPUOwMlgxPTNizszN NI[5T5hUSU6JRWK=
TE-9 NWrSN29WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHjN4p2UUN3ME2zNE45PzN5IN88US=> NXPKWlg{W0GQR1XS
HuP-T4 NUDlb3hQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknCTWM2OD1|MD65OlM5KM7:TR?= M1TmRXNCVkeHUh?=
LB2518-MEL MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjJTWM2OD1|MT6wO|Q1KM7:TR?= NESyZpRUSU6JRWK=
NCI-H1703 NHn1UFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPJTWM2OD1|MT6wPVA2KM7:TR?= M2TwTXNCVkeHUh?=
NCI-H2228 NH\aRZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\XPHVRUUN3ME2zNU41PjVzIN88US=> MlHQV2FPT0WU
SCC-4 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG4eVVKSzVyPUOxMlkyQDFizszN MWTTRW5ITVJ?
KNS-81-FD NYe1TIxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjtTWM2OD1|Mj6wNVI5KM7:TR?= M3jFc3NCVkeHUh?=
NTERA-S-cl-D1 M{jvOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVGwNGltUUN3ME2zNk4xPzN7IN88US=> MkjQV2FPT0WU
Daoy MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTN{LkC4N|gh|ryP MYDTRW5ITVJ?
ES4 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17pOWlEPTB;M{KuN|kzOiEQvF2= NHv4XYFUSU6JRWK=
MHH-ES-1 NHXoPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHniSG1KSzVyPUOyMlQ5PzJizszN NFz2XppUSU6JRWK=
C-33-A Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TPRWlEPTB;M{KuO|czQCEQvF2= MV7TRW5ITVJ?
BHY NVLZSVlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPhTWM2OD1|Mj65OFk2KM7:TR?= MVXTRW5ITVJ?
Detroit562 M3LoTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPwTWM2OD1|Mz62OlU4KM7:TR?= NUWyWoNbW0GQR1XS
EW-1 NH76dJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTN|LkmzNlIh|ryP NGrD[nVUSU6JRWK=
NCI-H1395 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TOUWlEPTB;M{SuNFc6QSEQvF2= MXrTRW5ITVJ?
KM-H2 M{HxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTN4LkS3OFMh|ryP M2[xeXNCVkeHUh?=
NCI-H520 NXTUd2MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjkTWM2OD1|Nj63OVQyKM7:TR?= MkDYV2FPT0WU
D-392MG MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHJN49KSzVyPUO3MlM{PDRizszN NEPLeXpUSU6JRWK=
NOMO-1 MnjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPmV3FbUUN3ME2zO{45ODh7IN88US=> NIPxNYRUSU6JRWK=
TE-6 NELsS3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7RO2F5UUN3ME2zPE4yOjRizszN NF[1XYxUSU6JRWK=
HT-3 NYfNcmJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTN6LkS0N|Yh|ryP MWPTRW5ITVJ?
RPMI-8226 NHXIdYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHEUXk4UUN3ME2zPE46PTF7IN88US=> NUHSbW17W0GQR1XS
U251 NWjMeZhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPpW4JIUUN3ME2zPU4xOTJ2IN88US=> MmfKV2FPT0WU
GCT NXLyNXNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HocmlEPTB;M{muNVg2OiEQvF2= Ml62V2FPT0WU
A431 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjLN5hKSzVyPUO5MlE5QTRizszN MkPZV2FPT0WU
TE-12 NGXNd3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj3cpRKSzVyPUO5MlI1PDhizszN NIDEW49USU6JRWK=
HMV-II Mkf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUm1bJVvUUN3ME2zPU42ODR5IN88US=> MoDxV2FPT0WU
IST-MES1 M1PMemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTRyLkG1NFIh|ryP M3jKVXNCVkeHUh?=
SW13 NGD1S2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXmWngyUUN3ME20NE42OTlizszN NUD5Z3FyW0GQR1XS
SF295 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYeyNpdqUUN3ME20NE45ODZ4IN88US=> Mo[xV2FPT0WU
MDA-MB-157 NVLyZnB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFe0WY1KSzVyPUSwMlk1PjJizszN M3;pOXNCVkeHUh?=
TE-1 Ml7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknSTWM2OD12MT64O|E1KM7:TR?= NHvvUmVUSU6JRWK=
HuCCT1 NIXBcZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2L6O2lEPTB;NEKuOVI5QSEQvF2= M2njO3NCVkeHUh?=
KYSE-510 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLiTWM2OD12Mz6xO|U1KM7:TR?= NI\0RW1USU6JRWK=
NCI-H358 NFzGcohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWj3[GtMUUN3ME20OE4xOzB2IN88US=> MlTRV2FPT0WU
SW900 MmXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TVZWlEPTB;NESuNFc2QCEQvF2= NHvYNVlUSU6JRWK=
CAS-1 MkfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n0VWlEPTB;NESuNFk6OSEQvF2= NH65TWxUSU6JRWK=
TE-8 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnoXJlKSzVyPUS0MlU3PThizszN NXvROnoxW0GQR1XS
P12-ICHIKAWA MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\6N441UUN3ME20OE43OTF{IN88US=> MoHSV2FPT0WU
YKG-1 NFT6dYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPXeYxKSzVyPUS0Mlc5OSEQvF2= NEPSSnNUSU6JRWK=
SNU-C2B MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTR2Lke5NFMh|ryP MX\TRW5ITVJ?
LCLC-103H NFL4NHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XLfGlEPTB;NESuPFcxOyEQvF2= NVrv[nE1W0GQR1XS
U-87-MG M1LIWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGKyV3BKSzVyPUS1MlExOjJizszN Mni3V2FPT0WU
HAL-01 NGPSeWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTR3LkGzO|kh|ryP Mk\YV2FPT0WU
OVCAR-8 NHPzTndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jXeWlEPTB;NEWuN|U3PCEQvF2= MYDTRW5ITVJ?
KYSE-150 NFjVN2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfHTWM2OD12Nz6xNFUzKM7:TR?= MXTTRW5ITVJ?
OE33 NIr2bpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfKdG55UUN3ME20O{4yPDJ7IN88US=> MVPTRW5ITVJ?
CAL-62 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P5dGlEPTB;NEeuOFA3QCEQvF2= NE\iUHVUSU6JRWK=
TCCSUP NIe4VGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPydYY6UUN3ME20O{43OjZ2IN88US=> M4jFcnNCVkeHUh?=
H4 NVGwVoVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXyZow6UUN3ME20O{43PjJzIN88US=> M1f4S3NCVkeHUh?=
CP66-MEL M1PTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLWOohuUUN3ME20PE4xPzB2IN88US=> Mkf4V2FPT0WU
SNB75 MojSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrrc2ZKSzVyPUS4MlE5PzRizszN NH3qd|dUSU6JRWK=
Mo-T MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NID0SG1KSzVyPUS4MlI4QSEQvF2= MkD0V2FPT0WU
BT-549 NUnNfm82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnUSoRKSzVyPUS4MlM4OjlizszN Mn7yV2FPT0WU
IGR-1 MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjiW3pKSzVyPUS4MlY3PDVizszN M{LYWXNCVkeHUh?=
NCI-H1299 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjad4FKSzVyPUS4MlczPDhizszN MYLTRW5ITVJ?
ALL-PO M1HNSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTPWYdKSzVyPUS5MlkzPjhizszN MYPTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method: The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
4% DMSO+30% PEG 300+5% Tween 80+ddH2O
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID