NU7441 (KU-57788)

Catalog No.S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.

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5 Customer Reviews

  • (C) Microirradiation live-cell microscopy of U2OS cells stably expressing mEGFP-MacroD2 full-length construct and treated with KU55933 10 μM, VE-821 1 μM, NU7441 1 μM or DMSO. Scale bar, 10 μm.

    Nucleic Acids Res, 2017, 45(1):244-254. NU7441 (KU-57788) purchased from Selleck.

    Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

  • Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

    Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA-PK Inhibitors

Biological Activity

Description NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays.
Targets
DNA-PK [1]
(Cell-free assay)
14 nM
In vitro

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fheGlEPTB;MD6wNlE1OyEQvF2= M1XDZnNCVkeHUh?=
A172 NGTmVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XuO2lEPTB;MD6xOVMyPiEQvF2= MnPxV2FPT0WU
NCI-H526 NEX6cYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HGVmlEPTB;MD6yPFQxPyEQvF2= NV7aZnE5W0GQR1XS
HDLM-2 MkXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jRN2lEPTB;MD6zNlM1PSEQvF2= MX3TRW5ITVJ?
HuO-3N1 NYfZbpBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrpdXZ3UUN3ME2wMlQ3PjN4IN88US=> MlfMV2FPT0WU
NCI-SNU-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rTdWlEPTB;MD62NFk6PCEQvF2= M3TaSnNCVkeHUh?=
SK-N-AS MkjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nL[2lEPTB;MD62NlIyPiEQvF2= MUfTRW5ITVJ?
LoVo NELQbldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWqzZ|ViUUN3ME2wMlg3PzR7IN88US=> NGThU4xUSU6JRWK=
LAMA-84 MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPaflZkUUN3ME2wMlk5QDN|IN88US=> MYDTRW5ITVJ?
CTB-1 NV;DOZBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3oTWM2OD1zLkGxOVQ3KM7:TR?= MVjTRW5ITVJ?
KP-N-YS NWOxcmlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofRTWM2OD1zLkG0NlMyKM7:TR?= NXO3cVQyW0GQR1XS
HH MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XZdWlEPTB;MT6xPFA6OyEQvF2= MWjTRW5ITVJ?
CHL-1 NV[5PWpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTFwMkGzOlgh|ryP NIXxdHVUSU6JRWK=
NB7 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[4cIxKSzVyPUGuNlQ4PDVizszN NXTZOWZSW0GQR1XS
HL-60 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHkfop{UUN3ME2xMlM5OTlizszN M3rufnNCVkeHUh?=
639-V NYi0VXY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rDdWlEPTB;MT60OFEzQCEQvF2= MVzTRW5ITVJ?
NCI-H1793 NFvKNWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\4XmdKSzVyPUGuOFU5PCEQvF2= NIfxOXVUSU6JRWK=
NEC8 M3O2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTFwNUWzOUDPxE1? NHLCOFFUSU6JRWK=
PA-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7HTWM2OD1zLkW4Nlk1KM7:TR?= NYPGTY9ZW0GQR1XS
D-423MG MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLjeWdxUUN3ME2xMlY6OzZzIN88US=> NVzMZYVLW0GQR1XS
NCI-H292 NWfaenBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEW3PVZKSzVyPUGuO|QxOTNizszN MYLTRW5ITVJ?
SK-MEL-1 NY\Ed45uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnzb5NTUUN3ME2xMlc6PDd7IN88US=> M4frUXNCVkeHUh?=
LB2241-RCC M4fhbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzHOZpLUUN3ME2yMlE1OTR4IN88US=> NV3OfYZnW0GQR1XS
SK-MEL-3 NHX5dYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;CNXdmUUN3ME2yMlE3PDlizszN M3;EVXNCVkeHUh?=
MHH-PREB-1 MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTJwMU[2NFkh|ryP NV;GcHRTW0GQR1XS
BFTC-905 NEPDe5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJwMU[2PFch|ryP NGLWTplUSU6JRWK=
Ramos-2G6-4C10 NFPFOYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:wU2dJUUN3ME2yMlE6QTB7IN88US=> NYTXZlk2W0GQR1XS
G-361 M4DDSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTJwMkG2PEDPxE1? MnTGV2FPT0WU
MOLT-4 MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\LRWV3UUN3ME2yMlIyQDh6IN88US=> Mon2V2FPT0WU
DEL Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\xT2lEPTB;Mj6zOVU3PCEQvF2= MmXvV2FPT0WU
MV-4-11 NX32cVRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vwXWlEPTB;Mj6zO|M6KM7:TR?= MWTTRW5ITVJ?
SK-NEP-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP5TWM2OD1{LkO4O|g{KM7:TR?= MkKwV2FPT0WU
RS4-11 NIr1V4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfGeph3UUN3ME2yMlU3ODJ|IN88US=> NVfSNZRlW0GQR1XS
HuH-7 M3S1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJwNU[3NFIh|ryP NG\3NZlUSU6JRWK=
A101D MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\WTGlEPTB;Mj62NVM{QCEQvF2= MVLTRW5ITVJ?
KG-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m5cmlEPTB;Mj62O|kzPCEQvF2= MYnTRW5ITVJ?
KALS-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPCNlJKSzVyPUKuOlk3OzNizszN NFriS2ZUSU6JRWK=
VMRC-RCZ M3nPWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTTN3kxUUN3ME2yMlc4OzJ6IN88US=> NWrGfYpbW0GQR1XS
SK-UT-1 NGL2RXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjU[oNKSzVyPUOuNVU{OSEQvF2= NID5VpdUSU6JRWK=
SW962 M1y0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP4TWM2OD1|LkKwN|UzKM7:TR?= MknBV2FPT0WU
DBTRG-05MG NXPycG94T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HX[2lEPTB;Mz6yPFA5PSEQvF2= NIHH[XlUSU6JRWK=
PANC-08-13 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e3bWlEPTB;Mz60NVI4QCEQvF2= MXfTRW5ITVJ?
QIMR-WIL MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P3SmlEPTB;Mz60NVM1OSEQvF2= MkDWV2FPT0WU
SK-MEL-30 M{TxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDKWWNIUUN3ME2zMlQzPTl6IN88US=> NVv2T4hlW0GQR1XS
697 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4WzfGlEPTB;Mz60OFk6OyEQvF2= MVjTRW5ITVJ?
NY M1vrfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknFTWM2OD1|LkS1NFIzKM7:TR?= NWXXc4RTW0GQR1XS
ES7 NX7BZYt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTNwNE[3Nlkh|ryP NFj5eohUSU6JRWK=
JVM-3 M3ToPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTNwNEiwO|ch|ryP MXrTRW5ITVJ?
U031 Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzRZpZpUUN3ME2zMlU6OzZ6IN88US=> MWTTRW5ITVJ?
BHT-101 NWXlV|RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTNwNUm5PFUh|ryP NV;aZoNYW0GQR1XS
8305C NIrPOXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEGwSIZKSzVyPUOuOlE4OzZizszN MX\TRW5ITVJ?
MG-63 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTNwNkK2O|Yh|ryP MV;TRW5ITVJ?
NOS-1 NYnkOlJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO1V3hPUUN3ME2zMlY2OzF{IN88US=> NHf1eJdUSU6JRWK=
YH-13 M3zmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXhUWVKSzVyPUOuPFcyQDlizszN Mn24V2FPT0WU
LXF-289 MnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTNwOUGwOFEh|ryP NWjDTHFTW0GQR1XS
GOTO M{i1U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED5R5VKSzVyPUOuPVE1QSEQvF2= NHPEemJUSU6JRWK=
EKVX MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTRwMkK1NlQh|ryP MmewV2FPT0WU
CAL-51 NXHwZmpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17qPGlEPTB;ND6yOFg2PCEQvF2= MkDzV2FPT0WU
AN3-CA M3[5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWwNVI6UUN3ME20MlI2QDF|IN88US=> NXHQNVh{W0GQR1XS
IA-LM NIfqUYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETBc2JKSzVyPUSuNlc6OzVizszN NF7xfWxUSU6JRWK=
KU-19-19 NFHCbWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml30TWM2OD12LkOyPVIyKM7:TR?= NYP5[opRW0GQR1XS
A704 NVv6V5o2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TVV2lEPTB;ND60NFg5QCEQvF2= MljvV2FPT0WU
RH-18 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzBTWM2OD12LkS0PVU{KM7:TR?= NX;mZnVVW0GQR1XS
IST-MEL1 NIW5S5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPPTWM2OD12LkW4NlY{KM7:TR?= MV;TRW5ITVJ?
LU-134-A M{Pqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPvTWM2OD12LkW5Olg2KM7:TR?= MUjTRW5ITVJ?
SF126 NUW3fJdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH34UHNKSzVyPUSuOlA4OTVizszN Mk\wV2FPT0WU
EFO-27 MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{WwSWlEPTB;ND62OlUzPSEQvF2= M1n0NHNCVkeHUh?=
SN12C MmLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1[xd2lEPTB;ND63NVg6QCEQvF2= NHn5fmxUSU6JRWK=
L-363 M3PKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTRwN{exNVYh|ryP NIizTYNUSU6JRWK=
MEL-HO MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTRwN{e5PFkh|ryP NHnpfWVUSU6JRWK=
TYK-nu M1W4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHtdVNvUUN3ME20MlgxOTJ6IN88US=> MoX4V2FPT0WU
MDA-MB-415 NWrwT5RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGX0c|JKSzVyPUWuNFA{OTRizszN NV;hZ2NCW0GQR1XS
HCC70 NEWyfVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3L3V2lEPTB;NT6wN|k{QSEQvF2= NUCzSphHW0GQR1XS
IGROV-1 Mkm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTVwMkWyPVIh|ryP MmHxV2FPT0WU
NCI-H1355 MkH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:2TWM2OD13LkK5OkDPxE1? MlfTV2FPT0WU
23132-87 NWX2XWViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDETWM2OD13LkOyNFI1KM7:TR?= NFj2[ZRUSU6JRWK=
NB69 NEPoTHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPiWpBKSzVyPUWuN|I1OiEQvF2= NX3helRrW0GQR1XS
HSC-2 M3n5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;MTWM2OD13LkSxO|c{KM7:TR?= NGjNcWZUSU6JRWK=
KYSE-410 Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnmyTWM2OD13LkS3OlM3KM7:TR?= NUf0SJV5W0GQR1XS
GCIY NV7uRYxsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nlc2lEPTB;NT61NVM4QCEQvF2= NYrwZ4hOW0GQR1XS
A427 NHPlVWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rjdGlEPTB;NT61N|Y3OSEQvF2= M1vEWHNCVkeHUh?=
ChaGo-K-1 M4DtNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTVwNU[1PVkh|ryP MWDTRW5ITVJ?
PFSK-1 NGTWd4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVraelU4UUN3ME21MlYzOTl2IN88US=> M4\oOnNCVkeHUh?=
MLMA NUTZNnU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTVwOEO2NFYh|ryP MV7TRW5ITVJ?
RVH-421 NWm2eHk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1q5SGlEPTB;Nj6wO|M{QCEQvF2= NXXMVYZRW0GQR1XS
LB1047-RCC Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXWTWM2OD14LkG3OVIzKM7:TR?= MnzTV2FPT0WU
MHH-NB-11 MkPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTZwM{K3NlEh|ryP NXm2N4NOW0GQR1XS
J-RT3-T3-5 M3PJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTZwNkOyPVEh|ryP MkDYV2FPT0WU
UM-UC-3 M4HyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\vWGlEPTB;Nj62OFM{PCEQvF2= NVPnUlZKW0GQR1XS
IST-SL1 M1P2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTZwNkmzOlkh|ryP M{TUbnNCVkeHUh?=
NB14 MlTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK2NohkUUN3ME22Mlc6PzZzIN88US=> NV20[mRjW0GQR1XS
NBsusSR NHr2T2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PZVGlEPTB;Nj64NlUxOiEQvF2= NV3Wd5lZW0GQR1XS
D-263MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HTNmlEPTB;Nj65NVA3QCEQvF2= MkfKV2FPT0WU
NCI-H2347 NUG4[GxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmftTWM2OD14LkmzNlE{KM7:TR?= NIHaVXVUSU6JRWK=
ES8 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXWzZ5BIUUN3ME22Mlk4PTh6IN88US=> MYfTRW5ITVJ?
786-0 NYTPcVVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnXeoEyUUN3ME23MlA6Pzh4IN88US=> NGW1RldUSU6JRWK=
EPLC-272H NWHnSGtjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFe1SXZKSzVyPUeuNVYzPDZizszN NX;5Z3A2W0GQR1XS
CAPAN-1 NEjCXJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nldWlEPTB;Nz6yOFM2QSEQvF2= NILIWoRUSU6JRWK=
NCI-H82 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTdwMk[2OVkh|ryP MVnTRW5ITVJ?
G-402 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTdwM{CwOVEh|ryP M3\odXNCVkeHUh?=
SW982 NVHqeZYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDyUYJKSzVyPUeuN|AzODNizszN M1\lXXNCVkeHUh?=
OVCAR-4 NHLD[mZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\YcnlKSzVyPUeuN|E{OjhizszN NFqwZ5RUSU6JRWK=
KARPAS-299 NVXPVWhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[3RWZlUUN3ME23MlMzPjJ{IN88US=> M4WwSHNCVkeHUh?=
MIA-PaCa-2 MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmq3TWM2OD15LkO2PFI{KM7:TR?= NVnncFNpW0GQR1XS
AU565 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnFSZpKSzVyPUeuOVk5OzNizszN MUjTRW5ITVJ?
GAMG MlPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnaTWM2OD15Lk[0NVMyKM7:TR?= MnvEV2FPT0WU
HuO9 NI\LNm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PyZmlEPTB;Nz63NVc1OyEQvF2= MWjTRW5ITVJ?
ACN MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTdwN{SzN{DPxE1? Ml;2V2FPT0WU
RO82-W-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPsT5hKSzVyPUeuO|Q2OzNizszN Mlv6V2FPT0WU
NKM-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTdwN{S5OVUh|ryP Mn;hV2FPT0WU
CAL-12T Mn[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTdwOUSzOVIh|ryP Mon0V2FPT0WU
FADU MlPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\POmlEPTB;OD6wN|Y2PCEQvF2= NYrscIVlW0GQR1XS
NCI-H28 M2rkTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7Zco5GUUN3ME24MlE3QTZ{IN88US=> MX3TRW5ITVJ?
LCLC-97TM1 NF7ZbJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRThwMkGxNlIh|ryP MXjTRW5ITVJ?
CHP-134 M2\GRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XKZWlEPTB;OD6yOFE5PSEQvF2= MXPTRW5ITVJ?
HT-1080 MnXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRThwMkWwPVMh|ryP NEjINnRUSU6JRWK=
PC-3 M2D6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRThwMkezPVIh|ryP NHP4XYpUSU6JRWK=
SNU-449 M3;kRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRThwMke5N{DPxE1? M{jYZXNCVkeHUh?=
VA-ES-BJ M2jwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2WxSGlEPTB;OD6zOFY5PiEQvF2= M1j4dXNCVkeHUh?=
HT M2Xn[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnm4TWM2OD16LkO2OFkh|ryP MoDtV2FPT0WU
HOS M3u4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzmeIQ1UUN3ME24MlM4PTh7IN88US=> MVLTRW5ITVJ?
KNS-62 NIjjWJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfJTWM2OD16LkO3O|YzKM7:TR?= NHe0VYFUSU6JRWK=
OAW-42 M1nLT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWq0fpZCUUN3ME24Mlk2QTZ2IN88US=> MVTTRW5ITVJ?
A549 MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWT1XGpDUUN3ME25MlA6PjF{IN88US=> NITqUWxUSU6JRWK=
CAKI-1 NXvvbld5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoOwTWM2OD17LkG2OlEh|ryP NEXkbllUSU6JRWK=
HCC1937 NFHXW|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDlTWM2OD17Lk[5PFY2KM7:TR?= M3;KZnNCVkeHUh?=
GI-ME-N NVT4VG53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS5NXFEUUN3ME25MlcxOTN5IN88US=> MkHEV2FPT0WU
DU-4475 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDwTWM2OD17Lkm2PVM6KM7:TR?= MYDTRW5ITVJ?
EM-2 M2\CT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Da[GlEPTB;MUCuNlQzPiEQvF2= MYTTRW5ITVJ?
NCI-H1755 M3LCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV61XWNnUUN3ME2xNE4zPDJ6IN88US=> NYrnTWF{W0GQR1XS
NCI-H1437 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLITWM2OD1zMD61O|I2KM7:TR?= M{LpbnNCVkeHUh?=
VM-CUB-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\ZOWdKSzVyPUGwMlYyPjRizszN NHy1T|JUSU6JRWK=
A2058 NIXy[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjv[VVKSzVyPUGwMlY1ODRizszN MX;TRW5ITVJ?
BPH-1 M3LIXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEL6cWNKSzVyPUGwMlcyPDVizszN NVjle3lKW0GQR1XS
NB5 NX6xZldST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi3dYhHUUN3ME2xNE44PTV7IN88US=> M2LDcXNCVkeHUh?=
G-401 NIrxdG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTFyLke2NlYh|ryP M1:0NHNCVkeHUh?=
CAL-72 NYH2e4xZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTFyLkiwPVQh|ryP NHrPWIpUSU6JRWK=
SK-MEL-28 MkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:wd4ZOUUN3ME2xNE45OjB{IN88US=> NEfM[mNUSU6JRWK=
C32 NVzHVHJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlGxTWM2OD1zMD64N|Q4KM7:TR?= NVnM[mNFW0GQR1XS
NCI-H1155 MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\4WmlEPTB;MUCuPFM4PiEQvF2= M1L2XHNCVkeHUh?=
BB49-HNC MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TzcWlEPTB;MUCuPFU5PiEQvF2= M372UHNCVkeHUh?=
GMS-10 Mm\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LPbWlEPTB;MUCuPFk4OSEQvF2= Mn;YV2FPT0WU
K5 NHzJb2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfPTWM2OD1zMD65NFcyKM7:TR?= MVvTRW5ITVJ?
OS-RC-2 MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTFzLkC1OVkh|ryP MVTTRW5ITVJ?
HTC-C3 MmrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFzLkC3NVQh|ryP NGHoN|VUSU6JRWK=
LB996-RCC M13iPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnqW3YyUUN3ME2xNU4xPzJ|IN88US=> NXXZ[244W0GQR1XS
NCI-H1563 M{Duemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmX3TWM2OD1zMT6xNFEyKM7:TR?= MUjTRW5ITVJ?
CAL-54 NVLyNoVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7ROoZKSzVyPUGxMlQ5OTFizszN MVnTRW5ITVJ?
WM-115 NUn6R|hUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLUS4ZKSzVyPUGxMlY5OjRizszN NG\xZnJUSU6JRWK=
COLO-684 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPNTWM2OD1zMT63NlY4KM7:TR?= NXz0XlRqW0GQR1XS
HOP-62 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzjbIQ2UUN3ME2xNU44PTB6IN88US=> MlW5V2FPT0WU
NCI-H650 NWfWVGg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i5O2lEPTB;MUGuPFk3OSEQvF2= M3GxZ3NCVkeHUh?=
TE-11 Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TnemlEPTB;MUGuPVMyPSEQvF2= MXfTRW5ITVJ?
COLO-679 NHvmNnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPzbZdKSzVyPUGxMlk1PiEQvF2= NIT2dINUSU6JRWK=
FTC-133 M1[1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TWOGlEPTB;MUKuNFA4PiEQvF2= M2\OZXNCVkeHUh?=
D-283MED MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTF{LkC1Olkh|ryP MYPTRW5ITVJ?
SK-PN-DW MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTF{LkG5NFIh|ryP M3qyO3NCVkeHUh?=
BALL-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorLTWM2OD1zMj6yOlYzKM7:TR?= NWfYVmRXW0GQR1XS
GT3TKB MmPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTF{LkOwO|Qh|ryP MmD3V2FPT0WU
HOP-92 NV;kfHhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3z1NGlEPTB;MUKuOVI{OyEQvF2= MmjTV2FPT0WU
M14 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S1U2lEPTB;MUOuNFM{PSEQvF2= M2LIeHNCVkeHUh?=
SKG-IIIa M3vOWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTF|LkC1OVQh|ryP Mn3XV2FPT0WU
Becker M36zNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L2UWlEPTB;MUOuNFU5KM7:TR?= M1\qRXNCVkeHUh?=
ES5 NUjlbWU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLiOVVKSzVyPUGzMlE{PTZizszN MorxV2FPT0WU
NCI-H2030 MoTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jqUWlEPTB;MUOuNlA3OiEQvF2= M4DGN3NCVkeHUh?=
SNU-423 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fqemlEPTB;MUOuN|gyKM7:TR?= NVH2SW5vW0GQR1XS
CP50-MEL-B NFzOeWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDSUXRKSzVyPUGzMlYzOzJizszN M{n4OHNCVkeHUh?=
NCI-H1092 M1;6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT4TW9iUUN3ME2xN{44PDd3IN88US=> MmTQV2FPT0WU
8-MG-BA MonlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjRVHhJUUN3ME2xN{44PTF|IN88US=> MVLTRW5ITVJ?
CAL-27 NYfJXHh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTF2LkC3Nlch|ryP MlnkV2FPT0WU
AGS MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfEZVhnUUN3ME2xOE4yOzF7IN88US=> MkLCV2FPT0WU
MZ2-MEL M3LoSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrsUHNSUUN3ME2xOE4yPDh6IN88US=> MVHTRW5ITVJ?
BFTC-909 MkXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTiWGZDUUN3ME2xOE42ODV3IN88US=> MWnTRW5ITVJ?
D-566MG MlvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3m0O2lEPTB;MUSuO|cxPiEQvF2= NW[w[mdxW0GQR1XS
MZ7-mel Ml7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v6XGlEPTB;MUWuNVA3PyEQvF2= NG[zcGxUSU6JRWK=
TE-5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzhTWM2OD1zNT6yN|M{KM7:TR?= NX3XW2lbW0GQR1XS
647-V M2PzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTF3LkK3NFUh|ryP MkniV2FPT0WU
DMS-114 M3TZNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS2S|VKSzVyPUG1MlMzQTFizszN NGO4[ZFUSU6JRWK=
ME-180 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\PTWM2OD1zNT60O|g{KM7:TR?= MlvlV2FPT0WU
MS-1 Mom0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2W4VGlEPTB;MUWuOVYzOyEQvF2= MW\TRW5ITVJ?
NUGC-3 Mlu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rNUWlEPTB;MUWuOlI1PSEQvF2= MlfFV2FPT0WU
GB-1 NYO5[pd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfnR5hKSzVyPUG1MlY1OzdizszN NHLaNYJUSU6JRWK=
LOXIMVI NUTjT2JsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTF3Lki5NVkh|ryP M2DHS3NCVkeHUh?=
NCI-H1304 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jWVmlEPTB;MUWuPFkzQCEQvF2= NVrsN2V5W0GQR1XS
KURAMOCHI NWLpPHN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvlS|ZKSzVyPUG1Mlk4OSEQvF2= Mo\QV2FPT0WU
SW1783 M2OzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkH5TWM2OD1zNj6wPVk{KM7:TR?= NUK4ZopvW0GQR1XS
EGI-1 MmThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\DUWE3UUN3ME2xOk42OzZ3IN88US=> MWfTRW5ITVJ?
KGN NVPpb|NYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTF4LkW1PFYh|ryP NWrY[FhxW0GQR1XS
PANC-03-27 NF\t[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLDTWM2OD1zNj63OlYzKM7:TR?= MV7TRW5ITVJ?
RH-1 NHvuT2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzUTWM2OD1zNj64NlUh|ryP NX[5N5V4W0GQR1XS
HT-1376 NYiycZNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTF4Lki0OFYh|ryP MnXMV2FPT0WU
ZR-75-30 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTF4LkmzOlEh|ryP NWHzfVVyW0GQR1XS
TI-73 NFmwVmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkflTWM2OD1zNj65OFA5KM7:TR?= MY\TRW5ITVJ?
TK10 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHXN2NKSzVyPUG3MlAxPzlizszN MlzWV2FPT0WU
SW684 M4jvT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHrOmhNUUN3ME2xO{4xOTV2IN88US=> M{K4SXNCVkeHUh?=
RPMI-8866 NW\zN|RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHzTWM2OD1zNz6wOlk6KM7:TR?= NXXFU4ozW0GQR1XS
LNCaP-Clone-FGC M2i0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLTdYdKSzVyPUG3MlUzODFizszN NFXOSVBUSU6JRWK=
NCI-H2291 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XENWlEPTB;MUiuOFM1PSEQvF2= MmrjV2FPT0WU
T47D M3LqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3RNGRzUUN3ME2xPE41QDhizszN M3LDNXNCVkeHUh?=
A204 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXLTWM2OD1zOD61OFUzKM7:TR?= MnLEV2FPT0WU
HT-144 NWm0S3gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfU[JpWUUN3ME2xPE44PDJ5IN88US=> NInRSI1USU6JRWK=
MDA-MB-361 NXHnOGJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr6U4lsUUN3ME2xPU4xPzF2IN88US=> MojiV2FPT0WU
HCC1806 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTF7LkG1PVEh|ryP MoDWV2FPT0WU
NCI-H596 M2W5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYS0cnFZUUN3ME2xPU43OzlzIN88US=> NFziR3dUSU6JRWK=
K-562 M4HMXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3y5PGlEPTB;MUmuPFkzPiEQvF2= NIL6RWlUSU6JRWK=
D-336MG NU\hVZo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DMU2lEPTB;MUmuPVMzOiEQvF2= MVPTRW5ITVJ?
SK-MEL-2 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJyLkG1OVkh|ryP NXzRPFVxW0GQR1XS
HEC-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTJyLkS5O|gh|ryP M{HUT3NCVkeHUh?=
EW-13 NWHieVJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrieoRKSzVyPUKwMlU1PDNizszN NUf1fVRxW0GQR1XS
Hs-578-T NFjBPYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvZTWM2OD1{MD61OVg{KM7:TR?= M4Xm[XNCVkeHUh?=
SJSA-1 NGrMTpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJyLkW2PFgh|ryP MmPnV2FPT0WU
RCC10RGB NXfKeYp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC4cnRKSzVyPUKwMlY4OTlizszN M122WHNCVkeHUh?=
LAN-6 NGfMVW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXWT2NKSzVyPUKxMlA{QTZizszN M2DQW3NCVkeHUh?=
NCI-H1048 MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\XTWM2OD1{MT6yNlU5KM7:TR?= MofjV2FPT0WU
CW-2 NEfOOmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17FXmlEPTB;MkGuNlcxPSEQvF2= NGKwVlBUSU6JRWK=
HCC2157 NH65Oo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF21OlVKSzVyPUKxMlM3KM7:TR?= NX\Wc5FiW0GQR1XS
EW-22 NEPS[5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTnXpJrUUN3ME2yNU4{PzZizszN NHOwVWxUSU6JRWK=
A253 M1L2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\GRmlEPTB;MkGuOFQ5OSEQvF2= MmHnV2FPT0WU
BE-13 NGf5VWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor5TWM2OD1{MT62NVE{KM7:TR?= NFfLXmVUSU6JRWK=
KINGS-1 NHfWfpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJzLk[zNVYh|ryP MnLpV2FPT0WU
ETK-1 Ml\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJzLkixOVIh|ryP NVHnTVFFW0GQR1XS
NCI-H2452 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHOTWM2OD1{MT64OlQ4KM7:TR?= MnXPV2FPT0WU
HPAF-II NHrMXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoCyTWM2OD1{MT64PVI{KM7:TR?= M4HhcnNCVkeHUh?=
D-542MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrVU2pKSzVyPUKxMlkxPjlizszN M3vCWnNCVkeHUh?=
NCI-H630 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnWNWhlUUN3ME2yNk4xOjl4IN88US=> NYrMUolEW0GQR1XS
TGBC11TKB Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLBe|hKSzVyPUKyMlA1QSEQvF2= MXHTRW5ITVJ?
BCPAP M{nmUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjlfIJyUUN3ME2yNk43OTFizszN M2LCUHNCVkeHUh?=
HLE M1HCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnHTWM2OD1{Mj62PVch|ryP MVzTRW5ITVJ?
NCI-H727 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofkTWM2OD1{Mj63N|Uh|ryP MmTzV2FPT0WU
RD MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn2TWM2OD1{Mj63OVE5KM7:TR?= M4LXZ3NCVkeHUh?=
NCI-H522 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ{Lki0N|Eh|ryP NV3JRWlwW0GQR1XS
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KM12 MnjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPzVJl1UUN3ME2yOU42QDB5IN88US=> Mn25V2FPT0WU
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CHP-212 NETNOlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\ncIVVUUN3ME2yPE44PDBzIN88US=> MXPTRW5ITVJ?
KYSE-450 NHm1TXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r2cWlEPTB;MkiuPFA6OSEQvF2= NFewZ2RUSU6JRWK=
RXF393 NVjlOHpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni4TWM2OD1{OT6yPVA3KM7:TR?= NUjZPZh[W0GQR1XS
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Ca9-22 MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJ7LkSyPVkh|ryP MUjTRW5ITVJ?
RT-112 M3HSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPBVHpKSzVyPUK5MlQ3OTFizszN NG\Xb3ZUSU6JRWK=
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HCE-4 M2Gwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJ7Lki3PFYh|ryP MUXTRW5ITVJ?
AM-38 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fLNmlEPTB;M{CuNFYxPiEQvF2= NX;QVZkzW0GQR1XS
AsPC-1 M2PHfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTqTWM2OD1|MD64NFU{KM7:TR?= MlfZV2FPT0WU
TE-9 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHqWWFKSzVyPUOwMlg4OzdizszN NEXoe3RUSU6JRWK=
HuP-T4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTNyLkm2N|gh|ryP MX3TRW5ITVJ?
LB2518-MEL MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi5TWM2OD1|MT6wO|Q1KM7:TR?= MX3TRW5ITVJ?
NCI-H1703 NH;Wdm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFK1ToJKSzVyPUOxMlA6ODVizszN MmTyV2FPT0WU
NCI-H2228 NH\rU45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfQOYlrUUN3ME2zNU41PjVzIN88US=> NUHwblN[W0GQR1XS
SCC-4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DmbmlEPTB;M{GuPVE5OSEQvF2= NEW0cJlUSU6JRWK=
KNS-81-FD MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTN{LkCxNlgh|ryP MVnTRW5ITVJ?
NTERA-S-cl-D1 MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\OTHg5UUN3ME2zNk4xPzN7IN88US=> NGrsR2hUSU6JRWK=
Daoy MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LKSmlEPTB;M{KuNFg{QCEQvF2= MWHTRW5ITVJ?
ES4 NFXOPFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3NNFZKSzVyPUOyMlM6OjJizszN MULTRW5ITVJ?
MHH-ES-1 M3yzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT0TWM2OD1|Mj60PFczKM7:TR?= MYrTRW5ITVJ?
C-33-A NHm1N2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofJTWM2OD1|Mj63O|I5KM7:TR?= NUDPcpRjW0GQR1XS
BHY M{fmNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrGd3RKSzVyPUOyMlk1QTVizszN NWjvdlZrW0GQR1XS
Detroit562 NVjWNoNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTN|Lk[2OVch|ryP MUXTRW5ITVJ?
EW-1 MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4D2O2lEPTB;M{OuPVMzOiEQvF2= M1;WXHNCVkeHUh?=
NCI-H1395 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTN2LkC3PVkh|ryP NVH6dldPW0GQR1XS
KM-H2 NWHzU|hFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH6TWM2OD1|Nj60O|Q{KM7:TR?= MY\TRW5ITVJ?
NCI-H520 M1\iOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTqNplKSzVyPUO2Mlc2PDFizszN NVPYZotkW0GQR1XS
D-392MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PMTGlEPTB;M{euN|M1PCEQvF2= NEn6O5NUSU6JRWK=
NOMO-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2iyXGlEPTB;M{euPFA5QSEQvF2= MYPTRW5ITVJ?
TE-6 NUXaNYxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnoTWM2OD1|OD6xNlQh|ryP MmnZV2FPT0WU
HT-3 MmnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XQSWlEPTB;M{iuOFQ{PiEQvF2= NFvUeWhUSU6JRWK=
RPMI-8226 MkDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHFZZNKSzVyPUO4Mlk2OTlizszN NUPYU|ZtW0GQR1XS
U251 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjWXFFyUUN3ME2zPU4xOTJ2IN88US=> M1Tvb3NCVkeHUh?=
GCT MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojmTWM2OD1|OT6xPFUzKM7:TR?= NGXn[nBUSU6JRWK=
A431 M4nr[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTN7LkG4PVQh|ryP M1;sUnNCVkeHUh?=
TE-12 NYHETmhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXZ[JBKSzVyPUO5MlI1PDhizszN MYrTRW5ITVJ?
HMV-II MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHKw[m9KSzVyPUO5MlUxPDdizszN MkCyV2FPT0WU
IST-MES1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTRyLkG1NFIh|ryP MojPV2FPT0WU
SW13 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTRyLkWxPUDPxE1? Mo\CV2FPT0WU
SF295 NFvFPYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPOTWM2OD12MD64NFY3KM7:TR?= MUXTRW5ITVJ?
MDA-MB-157 NF7jUW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ixbWlEPTB;NECuPVQ3OiEQvF2= MWPTRW5ITVJ?
TE-1 NETWSXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DsWmlEPTB;NEGuPFcyPCEQvF2= NUXOSml3W0GQR1XS
HuCCT1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zwemlEPTB;NEKuOVI5QSEQvF2= M3f5ZXNCVkeHUh?=
KYSE-510 NXrCV|hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jrOWlEPTB;NEOuNVc2PCEQvF2= NVXFNVhbW0GQR1XS
NCI-H358 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIOydXNKSzVyPUS0MlA{ODRizszN MYjTRW5ITVJ?
SW900 NHTFOoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7aTWM2OD12ND6wO|U5KM7:TR?= M1;P[nNCVkeHUh?=
CAS-1 NIf5emVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTnTWM2OD12ND6wPVkyKM7:TR?= NFHq[HFUSU6JRWK=
TE-8 NYn1ZoFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVP5OWg1UUN3ME20OE42PjV6IN88US=> M1;1PHNCVkeHUh?=
P12-ICHIKAWA NEDNXnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP0OIVKSzVyPUS0MlYyOTJizszN NVnPOVdFW0GQR1XS
YKG-1 NVjkcWtFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfUfXVKSzVyPUS0Mlc5OSEQvF2= NInTeI9USU6JRWK=
SNU-C2B M4TzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2flOGlEPTB;NESuO|kxOyEQvF2= MlTlV2FPT0WU
LCLC-103H MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTR2Lki3NFMh|ryP MnPVV2FPT0WU
U-87-MG MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTR3LkGwNlIh|ryP M1r4enNCVkeHUh?=
HAL-01 M3nqemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTR3LkGzO|kh|ryP MnPjV2FPT0WU
OVCAR-8 NWXWfGxsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTU[YJKSzVyPUS1MlM2PjRizszN MkizV2FPT0WU
KYSE-150 NUnVV5lQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\sTWhKSzVyPUS3MlExPTJizszN NWXOPFVRW0GQR1XS
OE33 M2Hlfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTR5LkG0Nlkh|ryP NUfwZlRJW0GQR1XS
CAL-62 NXe4fJJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWn3RpB[UUN3ME20O{41ODZ6IN88US=> NVTLUXY3W0GQR1XS
TCCSUP NW[yNVF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTR5Lk[yOlQh|ryP NY\5eWtXW0GQR1XS
H4 MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvkOo1mUUN3ME20O{43PjJzIN88US=> NF:4T4NUSU6JRWK=
CP66-MEL MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3sbm9KSzVyPUS4MlA4ODRizszN M1fjVXNCVkeHUh?=
SNB75 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;2e2lEPTB;NEiuNVg4PCEQvF2= M3zqWnNCVkeHUh?=
Mo-T M3LpWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTITWM2OD12OD6yO|kh|ryP NFjMS2dUSU6JRWK=
BT-549 NH;nNJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nleWlEPTB;NEiuN|czQSEQvF2= M4GwVnNCVkeHUh?=
IGR-1 MnWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7DdG9KSzVyPUS4MlY3PDVizszN NYLFWIN2W0GQR1XS
NCI-H1299 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fIUWlEPTB;NEiuO|I1QCEQvF2= NHqwbWRUSU6JRWK=
ALL-PO NYLSWoE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DMeGlEPTB;NEmuPVI3QCEQvF2= MXXTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: SW620, LoVo, V3-YAC and V3 cells
  • Concentrations: 0.5 μM or 1 μM
  • Incubation Time: 17 hours
  • Method: The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: Female rude mice bearing SW620 xenografts
  • Formulation: Sterile 0.9% sodium chloride solution
  • Dosages: 10 mg/kg
  • Administration: Intraperitoneally administrated
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
4% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
1mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C25H19NO3S

CAS No. 503468-95-9
Storage powder
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • Answer:

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID