New Products

PI3K/Akt/mTOR
Catalog No. Product Name Information Added
A5269 Tuberin Rabbit Recombinant mAb   Dec 21 2017
S8335 PF-06409577 PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms. Nov 22 2017
A5047 PI3 Kinase p85 alpha Rabbit Recombinant mAb   Nov 13 2017
A5048 PI3 Kinase p55 gamma Rabbit Recombinant mAb   Oct 10 2017
A5008 AMPK alpha 1 Rabbit Recombinant mAb   Oct 09 2017
A5012 PRAS40 Rabbit Recombinant mAb   Oct 09 2017
A5023 AKT1 Rabbit Recombinant mAb   Oct 09 2017
A5025 AMPK gamma 1 Rabbit Recombinant mAb   Oct 09 2017
A5030 Phospho-Akt(Ser473) Rabbit Recombinant mAb   Oct 09 2017
A5031 AKT1/2/3 Rabbit Recombinant mAb   Oct 09 2017
JAK/STAT
Catalog No. Product Name Information Added
S8605 C188-9 C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors. Jan 10 2018
S8541 FM-381 FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively. Dec 27 2017
A5042 STAT5a Rabbit Recombinant mAb   Oct 10 2017
A5044 STAT2 Rabbit Recombinant mAb   Oct 10 2017
A5045 STAT4 Rabbit Recombinant mAb   Oct 10 2017
A5003 STAT5b Rabbit Recombinant mAb   Oct 09 2017
A5020 STAT5A/B Rabbit Recombinant mAb   Oct 09 2017
A5024 JAK2 Rabbit Recombinant mAb   Oct 09 2017
S8561 HJC0152 HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility. Sep 19 2017
S7985 PIM447 (LGH447) PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). May 05 2017
Cell Cycle
Catalog No. Product Name Information Added
A5268 p57 Kip2 Rabbit Recombinant mAb   Dec 21 2017
A5276 Chk2 Rabbit Recombinant mAb   Dec 21 2017
A5305 SOS1 Rabbit Recombinant mAb   Dec 21 2017
S2284 Colchicine Colchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM. Dec 04 2017
S8469 CCG-203971 CCG-203971 is a novel small-molecule inhibitor of the Rho/MRTF/SRF pathway with the IC50 value of 0.64 μM for SRE.L. It inhibits Rho-mediated gene transcription. Nov 22 2017
S8632 Chk2 Inhibitor II (BML-277) Chk2 Inhibitor II (BML-277) is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM. It is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases. Nov 02 2017
A5035 Cyclin D1 Rabbit Recombinant mAb   Oct 10 2017
A5004 Chk1 Rabbit Recombinant mAb   Oct 09 2017
A5011 c-Myc Rabbit Recombinant mAb   Oct 09 2017
A5016 Cyclin B1 Rabbit Recombinant mAb   Oct 09 2017
DNA Damage
Catalog No. Product Name Information Added
S8666 BAY 1895344 (BAY-1895344) BAY 1895344 is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM. Jan 16 2018
A5238 RPS3 Rabbit Recombinant mAb WBELISA Dec 21 2017
A5242 DGCR8 Rabbit Recombinant mAb WBELISA Dec 21 2017
A5245 Phospho-p95/NBS1 (S343) Rabbit Recombinant mAb WBELISA Dec 21 2017
A5252 ERG Rabbit Recombinant mAb WBELISA Dec 21 2017
A5274 MSI2 Rabbit Recombinant mAb   Dec 21 2017
A5275 hnRNP K Rabbit Recombinant mAb   Dec 21 2017
A5279 Ku80 Rabbit Recombinant mAb   Dec 21 2017
A5283 SMC3 Rabbit Recombinant mAb   Dec 21 2017
A5294 Mre11 Rabbit Recombinant mAb   Dec 21 2017
TGF-beta/smad
Catalog No. Product Name Information Added
S7959 SIS3 HCl SIS3, a novel specific inhibitor of Smad3, inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways. Oct 20 2016
S7663 LY333531 HCl LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively. Oct 10 2016
S7627 LDN-214117 LDN-214117 is a potent and selective BMP type I receptor kinase ALK2 inhibitor with IC50 of 24 nM. Apr 30 2015
S7624 SD-208 SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII. Feb 02 2015
S7658 Kartogenin Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. Nov 27 2014
S7530 Vactosertib  (TEW-7197) Vactosertib  (TEW-7197) is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. Phase 1. Nov 27 2014
S7119 Go6976 Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3. Sep 15 2014
S1421 Staurosporine Staurosporine is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3. Aug 13 2014
S7146 DMH1 DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. May 20 2014
S7147 LDN-212854 LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively. May 20 2014
GPCR & G Protein
Catalog No. Product Name Information Added
A5270 GRK2 Rabbit Recombinant mAb   Dec 21 2017
S3734 Albiglutide Albiglutide is a glucagon-like peptide-1 agonist (GLP-1 agonist). Dec 19 2017
S8575 A2AR antagonist 1 A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively. Nov 15 2017
S8637 Ipragliflozin (ASP1941) Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1. Oct 24 2017
S2879 AMD3465 hexahydrobromide AMD3465 is a monomacrocyclic CXCR4 antagonist. Sep 06 2017
S8558 Tofogliflozin(CSG 452) Tofogliflozin is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and Hsglt1, respectively. Aug 29 2017
S8517 Lixisenatide Lixisenatide is a once-daily short-acting glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA) with an IC50 of 1.4 nM for the human GLP-1 receptor in receptor binding studies. Jul 11 2017
S8415 PACAP 1-38 PACAP 1-38 is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis. Mar 31 2017
S8416 PACAP 6-38 PACAP 6-38 is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo. Mar 31 2017
S7182 JTE 013 JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM. Mar 31 2017
PTK
Catalog No. Product Name Information Added
S3759 Norcantharidin Norcantharidin is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. Feb 07 2018
S8553 Avapritinib (BLU-285) Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous KIT mutation, D816V in KIT Exon 17 (IC50 = 0.5 nM). Oct 24 2017
S7754 Gilteritinib (ASP2215) Gilteritinib(ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent than the concentration required to inhibit c-KIT (230 nM). Oct 17 2017
A5006 Met (c-Met) Rabbit Recombinant mAb   Oct 09 2017
S8511 Belizatinib (TSR-011) "Belizatinib (TSR-011) is a potent inhibitor of ALK (IC50=0.7 nM) and tropomyosin receptor kinase (TRK) (IC50 values less than 3 nM for TRK A, B, and C). " Sep 19 2017
S8407 PF-06273340 PF-06273340 is a highly potent, kinases elective, well-tolerated pan-Trk inhibitor with IC50 values of 6, 4, 3 nM for TrkA, TrkB, Trk C, respectively. Aug 29 2017
S8583 TPX-0005 TPX-0005 is a novel ALK/ROS1/TRK inhibitor with the IC50 values of 1.01 nM for WT ALK, 1.26 nM for ALK(G1202R), and 1.08 nM for ALK(L1196M); also a potent SRC inhibitor (IC50 5.3 nM). Aug 01 2017
S8573 Sitravatinib (MGCD516) Sitravatinib (MGCD516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl. Jul 26 2017
S2752 HER2-Inhibitor-1 HER2-Inhibitor-1 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR. Phase 1. Jul 13 2017
S8570 RXDX-106 (CEP-40783) RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/MET inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively. Jul 11 2017
Epigenetics
Catalog No. Product Name Information Added
S8071 UNC0638 UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. Feb 08 2018
S3944 Valproic acid Valproic acid is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase inhibitor and is under investigation for treatment of HIV and various cancers. Jan 25 2018
S8664 GSK3326595 (EPZ015938) GSK3326595 (EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) that potently inhibits tumor growth in vitro and in vivo in animal models. Jan 03 2018
A5240 ASH2L Rabbit Recombinant mAb WBELISA Dec 21 2017
A5247 PRMT5 Rabbit Recombinant mAb WBELISA Dec 21 2017
A5251 PHD1/prolyl hydroxylase Rabbit Recombinant mAb WBELISA Dec 21 2017
S8648 ACY-738 ACY-738 inhibits HDAC6 with low nanomolar potency (IC50=1.7 nM) and a selectivity of 60- to 1500-fold over class I HDACs. Dec 05 2017
S8601 CP2 CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively. Nov 07 2017
S8624 JNJ-64619178 JNJ-64619178 is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties. Nov 02 2017
S8494 PF-06726304 PF-06726304 is a selective EZH2 inhibitor with Ki values of 0.7 nM and 3 nM for WT EZH2 and Y641N respectively; also inhibits H3K27me3 with the IC50 value of 15 nM. Oct 24 2017
NF-κB
Catalog No. Product Name Information Added
S3633 Pyrrolidinedithiocarbamate ammonium Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor-κB (NF-κB) that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines. Nov 15 2017
S8261 GSK583 GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM. Feb 09 2017
S4712 Diethylmaleate Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. Oct 26 2016
S7948 MRT67307 HCl MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. Apr 25 2016
S7691 PS-1145 PS-1145 is a specific IKK inhibitor with IC50 of 88 nM. Mar 09 2016
S7851 AZD3264 AZD3264 is a novel IKK2 inhibitor. Nov 27 2015
S7672 Omaveloxolone (RTA-408) Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2. Sep 14 2015
S7697 LY2409881 LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases. Apr 20 2015
S7441 WS3 WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Dec 04 2014
S7442 WS6 WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Nov 12 2014
Metabolism
Catalog No. Product Name Information Added
S3945 L-Cycloserine L-Cycloserine is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity. Feb 07 2018
S5146 3-Methylpyrazole 3-Methylpyrazole (3-MP) is a weak or non-inhibitor of alcohol dehydrogenase. Jan 16 2018
S8608 Adenosine Dialdehyde (ADOX) Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM. Jan 10 2018
S8657 PF-06840003 PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor. Although it has moderate hIDO1 enzyme inhibition (IC50 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size. Jan 03 2018
A5229 LRP1 Rabbit Recombinant mAb WBELISA Dec 21 2017
A5232 SCARB1 Rabbit Recombinant mAb WBELISA Dec 21 2017
A5239 Alas1 Rabbit Recombinant mAb WBELISA Dec 21 2017
A5248 PGK1 Rabbit Recombinant mAb WBELISA Dec 21 2017
A5260 Phospho-HSF1(S326) Rabbit Recombinant mAb   Dec 21 2017
A5261 Lactate Dehydrogenase Rabbit Recombinant mAb   Dec 21 2017
Proteases
Catalog No. Product Name Information Added
A5284 Cathepsin L/V/K/H Rabbit Recombinant mAb   Dec 21 2017
A5287 Cathepsin B Rabbit Recombinant mAb   Dec 21 2017
S3733 Boceprevir Boceprevir is an oral, direct acting hepatitis C virus (HCV) protease inhibitor with Ki value of 14 nM for NS3. It is used in combination with other antiviral agents in the treatment of chronic hepatitis C, genotype 1. Dec 05 2017
S3724 Velpatasvir Velpatasvir is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication. Nov 29 2017
S3728 Grazoprevir Grazoprevir anhydrous is a Hepatitis C Virus NS3/4A Protease inhibitor with IC50 values of 7pM, 4pM, and 62pM for HCV genotype 1a, 1B, and 4 respectively. Nov 23 2017
S3692 N-Ethylmaleimide (NEM) N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. Nov 15 2017
S8565 Omarigliptin (MK-3102) Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5). Jul 11 2017
S8457 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). Mar 02 2017
S7420 CA-074 methyl ester (CA-074 Me) CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor. Jan 09 2017
S4697 Saxagliptin hydrate Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. Sep 21 2016
Microbiology
Catalog No. Product Name Information Added
S4759 p-Coumaric Acid p-Coumaric acid is a hydroxy derivative of cinnamic acid found in a variety of edible plants that is reported to have antioxidant, anti-inflammatory, and antimicrobial activity. Jan 03 2018
S3741 Benznidazole Benznidazole is a nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis. Dec 19 2017
S3707 Ethopabate Ethopabate (ETP) is a coccidiostat that is frequently used to prevent and treat coccidiosis in chickens. Nov 30 2017
S3708 Sulfachloropyridazine Sulfachloropyridazine is an antibiotic used to treat a variety of bacterial infections. Nov 30 2017
S3709 Furagin Furagin is 2-substituted 5-nitrofuran, chemically and structurally similar to well-known antibacterial compound nitrofurantoin with antimicrobial activities. Nov 30 2017
S3746 Lumefantrine Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. Nov 30 2017
S3705 Chlorobutanol Chlorobutanol (trichloro-2-methyl-2-propanol) is a preservative, sedative, hypnotic and weak local anesthetic with antibacterial and antifungal properties. Nov 29 2017
S3710 Fosfomycin calcium Fosfomycin is bactericidal and inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase, also known as MurA. It enters the bacterial cell through the glycerophosphate transporter. Nov 29 2017
S3722 Isavuconazole Isavuconazole is a new extended-spectrum triazole with activity against yeasts, molds, and dimorphic fungi that inhibits cytochrome P450 (CYP)-dependent 14α-lanosterol demethylation, which is essential for fungal cell membrane ergosterol synthesis. Nov 29 2017
S3695 Cystamine dihydrochloride Cystamine dihydrochloride acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes. Nov 27 2017
Apoptosis
Catalog No. Product Name Information Added
S8483 CBL0137 (CBL-0137) CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex). Jan 16 2018
A5259 APAF1 Rabbit Recombinant mAb   Dec 21 2017
A5262 Phospho-PAK1/2/3(S144/S141/S139) Rabbit Recombinant mAb   Dec 21 2017
A5264 Phospho-RSK1 (S380) Rabbit Recombinant mAb   Dec 21 2017
A5272 p73 Rabbit Recombinant mAb   Dec 21 2017
A5273 STK3 Rabbit Recombinant mAb   Dec 21 2017
A5293 Bid Rabbit Recombinant mAb   Dec 21 2017
S8580 COTI-2 COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity. Dec 19 2017
A2010 Adalimumab Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD. Nov 16 2017
S8383 S63845 S63845 is a new, selective MCL-1 inhibitor with the Kd value of 0.19 nM and has no discernible binding to the other BCL-2 members, BCL-2 or BCL-XL. Nov 15 2017
MAPK
Catalog No. Product Name Information Added
S8534 LY3214996 LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines. Nov 02 2017
A5036 Phospho-Erk1(T202/Y204)+Erk2 (T185/Y187) Rabbit Recombinant mAb   Oct 10 2017
A5043 Raf1 Rabbit Recombinant mAb   Oct 10 2017
A5050 MEK3/MEK6 Rabbit Recombinant mAb   Oct 10 2017
A5005 JNK1/2/3 Rabbit Recombinant mAb   Oct 09 2017
A5009 MEK2 Rabbit Recombinant mAb   Oct 09 2017
A5017 p38 MAPK Rabbit Recombinant mAb   Oct 09 2017
A5018 ERK2 Rabbit Recombinant mAb   Oct 09 2017
A5019 MEK1 Rabbit Recombinant mAb   Oct 09 2017
A5026 JNK1/JNK3 Rabbit Recombinant mAb   Oct 09 2017
Angiogenesis
Catalog No. Product Name Information Added
A2006 Bevacizumab Bevacizumab is a humanized anti-VEGF monoclonal antibody which binds to and neutralizes all human VEGF-A isoforms and bioactive proteolytic fragments, MW:149 KD. Nov 16 2017
A2007 Trastuzumab Trastuzumab is a humanized, recombinant monoclonal antibody that binds to the extracellular domain of HER2, MW:145.53 KD. Nov 16 2017
A2008 Pertuzumab Pertuzumab, a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors, impairs the ability of HER2 to bind to other members of the HER family, MW: 148 KD. Nov 16 2017
S8230 Ensartinib (X-396) Ensartinib (X-396) is a novel, potent and specific ALK TKI with the IC50 less than 4 nM in Ambit assays. Oct 09 2017
S8578 PRN1371 PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively. Sep 26 2017
S8441 LW 6 LW6 is a hypoxia-inducible factor 1(HIF) inhibitor which potently inhibits HIF-1α accumulation by degrading HIF-1α without affecting the HIF-1a mRNA levels during hypoxia. It inhibits hypoxia-induced HIF-1α transcription activity with IC50 of 2.64 μM in cell-based HRE-reporter gene assays. Sep 19 2017
S8442 TAK-659 TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3. Aug 08 2017
A2000 Cetuximab Cetuximab, a novel molecular-targeted agent,is an inhibitor of EGFR monoclonal humanized antibody interacting with the extracellular binding site of EGFR to block ligand stimulation. MW : 145.781 KD. Jun 02 2017
S8229 Brigatinib (AP26113) Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy. May 10 2017
S8523 GSK2256098 GSK2256098 is a potent, selective, reversible, and ATP competitive FAK kinase inhibitor with apparent Ki of 0.4 nM. Apr 27 2017
Stem Cell & Wnt
Catalog No. Product Name Information Added
S8647 iCRT3 iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays. Jan 10 2018
A5254 YAP1 Rabbit Recombinant mAb WBELISA Dec 21 2017
A5298 ADAM10 Rabbit Recombinant mAb   Dec 21 2017
S8597 LYN-1604 LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants. Dec 05 2017
S8644 GNF-6231 GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM. Dec 05 2017
A5038 Beta Catenin Rabbit Recombinant mAb   Oct 10 2017
A5007 GSK3 beta Rabbit Recombinant mAb   Oct 09 2017
S8554 Super-TDU Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction. Sep 19 2017
S8572 Amcasertib (BBI503) Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity. Aug 01 2017
S8474 LF3 LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. Apr 21 2017
Ubiquitin
Catalog No. Product Name Information Added
A5265 UBE2I Rabbit Recombinant mAb   Dec 21 2017
A5316 PIAS1/PIAS2/PIAS3 Rabbit Recombinant mAb   Dec 21 2017
A5320 USP14 Rabbit Recombinant mAb   Dec 21 2017
S7109 Pevonedistat (MLN4924) MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM. Aug 31 2017
S8288 VLX1570 VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro. May 19 2017
S7892 Avadomide(CC-122) Avadomide(CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN. Mar 31 2017
S4920 b-AP15 b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM. Mar 30 2015
S7529 ML323 ML323 displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1 with IC50 of 76 nM. Jun 30 2014
S7142 NSC697923 NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. Apr 09 2014
S7285 NMS-873 NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM). Jan 29 2014
Neuronal Signaling
Catalog No. Product Name Information Added
S3643 Amitraz Amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide. Dec 27 2017
S4760 (2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD) HP-β-cyclodextrin (HP-β-CD), a well-known sugar used in drug delivery, genetic vector, environmental protection and treatment of Niemann-Pick disease type C1 (NPC1), is an inhibitor of amyloid-β aggregation. Dec 27 2017
A5308 GDNF Rabbit Recombinant mAb   Dec 21 2017
A5315 EAAT2 Rabbit Recombinant mAb   Dec 21 2017
A5317 Amyloid beta A4 Rabbit Recombinant mAb   Dec 21 2017
A5319 NUR77 Rabbit Recombinant mAb   Dec 21 2017
S3664 Flupenthixol dihydrochloride Flupentixol, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist. Dec 19 2017
S3639 Tacrine hydrochloride hydrate Tacrine is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. It also acts as a histamine N-methyltransferase inhibitor. Dec 19 2017
S3706 Sarpogrelate hydrochloride Sarpogrelate is a selective 5-HT2A antagonist with pKi values of 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively. Nov 30 2017
S3716 Flibanserin Flibanserin is a nonhormonal, centrally acting molecule that acts as an agonist at postsynaptic 5-HT1A receptors and as an antagonist at 5-HT2A receptors. Nov 30 2017
Others
Catalog No. Product Name Information Added
S8667 JPH203 JPH203, a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells. Feb 07 2018
S8673 ONC212 ONC212, a fluorinated-ONC201 analogue, is broadly efficacious across most solid tumors and hematological malignancies in the low nanomolar range and has robust anti-leukemic activity. Feb 07 2018
S3947 Hydroumbellic acid Hydroumbellic acid is used as pharmaceutical intermediates. Feb 07 2018
S3946 Mesterolone Mesterolone is a synthetic steroid with anabolic and androgenic activities. Feb 07 2018
S3933 10-deacetyl-paclitaxel 10-deacetyl-paclitaxel (10-DAT) is a semi-synthetic precursor of Paclitaxel. Feb 07 2018
S3918 4',7-Dimethoxy-5-Hydroxyflavone 4',7-Dimethoxy-5-Hydroxyflavone (apigenin dimethylether) inhibits α-glucosidase and α-amylase enzymes and enhanced 2-NBDG uptake in L6 cells. Feb 07 2018
S5173 2'-Hydroxy-4'-methylacetophenone 2'-Hydroxy-4'-methylacetophenone may be used in the preparation of 4'-methyl-2'-[(p-tolylsulfonyl)oxy]acetophenone and possesses acaricidal property. Jan 31 2018
S3953 L-Lysine hydrochloride L-Lysine hydrochloride is an essential amino acid. It is often added to animal feed used as a dietary supplement and plays a major role in calcium absorption, building muscle protein, recovering from surgery or sports injuries, and the body's production of hormones, enzymes, and antibodies. Jan 25 2018
S3961 Homoveratrumic acid Homoveratrumic acid (Homoveratric acid) is the main metabolite of 3,4-dimethoxyphenylethylamine (DMPEA) in urine. Jan 25 2018
S3965 Vanillyl Butyl Ether Vanillyl butyl ether, an ether of monohydroxybenzoic acid, is added to food products as a flavoring agent. It is also present in cosmetics and personal care products as a fragrance ingredient, oral care agent, hair conditioning agent, and warming or cooling agent. Jan 25 2018