New Products

PI3K/Akt/mTOR
Catalog No. Product Name Information Added
S8335 PF-06409577 PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patchBclamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms. Nov 22 2017
A5047 PI3 Kinase p85 alpha Rabbit Recombinant mAb   Nov 13 2017
A5048 PI3 Kinase p55 gamma Rabbit Recombinant mAb   Oct 10 2017
A5008 AMPK alpha 1 Rabbit Recombinant mAb   Oct 09 2017
A5012 PRAS40 Rabbit Recombinant mAb   Oct 09 2017
A5023 AKT1 Rabbit Recombinant mAb   Oct 09 2017
A5025 AMPK gamma 1 Rabbit Recombinant mAb   Oct 09 2017
A5030 Phospho-Akt(Ser473) Rabbit Recombinant mAb   Oct 09 2017
A5031 AKT1/2/3 Rabbit Recombinant mAb   Oct 09 2017
A5033 Phospho-S6K1(T421/S424) Rabbit Recombinant mAb   Oct 09 2017
JAK/STAT
Catalog No. Product Name Information Added
A5042 STAT5a Rabbit Recombinant mAb   Oct 10 2017
A5044 STAT2 Rabbit Recombinant mAb   Oct 10 2017
A5045 STAT4 Rabbit Recombinant mAb   Oct 10 2017
A5003 STAT5b Rabbit Recombinant mAb   Oct 09 2017
A5020 STAT5A/B Rabbit Recombinant mAb   Oct 09 2017
A5024 JAK2 Rabbit Recombinant mAb   Oct 09 2017
S8561 HJC0152 HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility. Sep 19 2017
S7985 PIM447 (LGH447) PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). May 05 2017
S7923 SH5-07 (SH-5-07) SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models. Mar 02 2017
S7769 BP-1-102 BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, binds Stat3 with an affinity Kd of 504 nM and blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM. Feb 22 2017
Cell Cycle
Catalog No. Product Name Information Added
S8469 CCG-203971   Nov 22 2017
S8632 Chk2 Inhibitor II (BML-277) Chk2 Inhibitor II (BML-277) is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM. Nov 02 2017
A5035 Cyclin D1 Rabbit Recombinant mAb   Oct 10 2017
A5004 Chk1 Rabbit Recombinant mAb   Oct 09 2017
A5011 c-Myc Rabbit Recombinant mAb   Oct 09 2017
A5016 Cyclin B1 Rabbit Recombinant mAb   Oct 09 2017
S8499 KRpep-2d KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant. The IC50 value is 1.6 nM. Sep 11 2017
S8387 MSC2530818 MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable. Jul 26 2017
S8520 Senexin A Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively. Jul 11 2017
S7178 Prexasertib (LY2606368) Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM respectively in cell-free assay. Jun 29 2017
DNA Damage
Catalog No. Product Name Information Added
A5037 PARP Rabbit Recombinant mAb   Oct 10 2017
A5039 SIRT6 Rabbit Recombinant mAb   Oct 10 2017
A5049 SIRT1 Rabbit Recombinant mAb   Oct 10 2017
A5034 Cleaved PARP Rabbit Recombinant mAb   Oct 09 2017
S8427 LTURM34 LTURM34 is a specific DNA-PK inhibitor, 170-fold more selective for DNA-PK activity compared to PI3K activity, with IC50 value of 0.034 μM. Jun 13 2017
S8539 TAS-102 TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride. Jun 01 2017
S8379 YU238259 YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays. May 10 2017
S8481 SRT3025 HCl SRT3025 is an orally available small molecule activator of the SIRT1 enzyme. Apr 27 2017
S8434 B02 B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). Apr 21 2017
S8363 NMS-P118 NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively). Apr 21 2017
TGF-beta/smad
Catalog No. Product Name Information Added
S7959 SIS3 HCl SIS3, a novel specific inhibitor of Smad3, inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways. Oct 20 2016
S7663 LY333531 HCl LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively. Oct 10 2016
S7627 LDN-214117 LDN-214117 is a potent and selective BMP type I receptor kinase ALK2 inhibitor with IC50 of 24 nM. Apr 30 2015
S7624 SD-208 SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII. Feb 02 2015
S7658 Kartogenin Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. Nov 27 2014
S7530 EW-7197 EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. Phase 1. Nov 27 2014
S7119 Go6976 Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3. Sep 15 2014
S1421 Staurosporine Staurosporine is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3. Aug 13 2014
S7146 DMH1 DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. May 20 2014
S7147 LDN-212854 LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively. May 20 2014
GPCR & G Protein
Catalog No. Product Name Information Added
S8575 A2AR antagonist 1 A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively. Nov 15 2017
S8637 Ipragliflozin (ASP1941) Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1. Oct 24 2017
S2879 AMD3465 hexahydrobromide AMD3465 is a monomacrocyclic CXCR4 antagonist. Sep 06 2017
S8558 Tofogliflozin(CSG 452) Tofogliflozin is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and Hsglt1, respectively. Aug 29 2017
S8517 Lixisenatide Lixisenatide is a once-daily short-acting glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA) with an IC50 of 1.4 nM for the human GLP-1 receptor in receptor binding studies. Jul 11 2017
S8415 PACAP 1-38 PACAP 1-38 is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis. Mar 31 2017
S8416 PACAP 6-38 PACAP 6-38 is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo. Mar 31 2017
S7182 JTE 013 JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM. Mar 31 2017
S8414 PACAP 1-27 Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist. Feb 22 2017
S8345 ONO-7300243 ONO-7300243 is a novel, potent LPA1(Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM. Dec 08 2016
PTK
Catalog No. Product Name Information Added
S8553 Avapritinib (BLU-285) Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous KIT mutation, D816V in KIT Exon 17 (IC50 = 0.5 nM). Oct 24 2017
S7754 Gilteritinib (ASP2215) Gilteritinib(ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent than the concentration required to inhibit c-KIT (230 nM). Oct 17 2017
A5006 Met (c-Met) Rabbit Recombinant mAb   Oct 09 2017
S8511 Belizatinib (TSR-011) "Belizatinib (TSR-011) is a potent inhibitor of ALK (IC50=0.7 nM) and tropomyosin receptor kinase (TRK) (IC50 values less than 3 nM for TRK A, B, and C). " Sep 19 2017
S8407 PF-06273340 PF-06273340 is a highly potent, kinases elective, well-tolerated pan-Trk inhibitor with IC50 values of 6, 4, 3 nM for TrkA, TrkB, Trk C, respectively. Aug 29 2017
S8583 TPX-0005 TPX-0005 is a novel ALK/ROS1/TRK inhibitor with the IC50 values of 1.01 nM for WT ALK, 1.26 nM for ALK(G1202R), and 1.08 nM for ALK(L1196M); also a potent SRC inhibitor (IC50 5.3 nM). Aug 01 2017
S8573 Sitravatinib (MGCD516) Sitravatinib (MGCD516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl. Jul 26 2017
S2752 HER2-Inhibitor-1 HER2-Inhibitor-1 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR. Phase 1. Jul 13 2017
S8570 RXDX-106 (CEP-40783) RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/MET inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively. Jul 11 2017
S8518 AD80 AD80, a multikinase inhibitor, shows strong activity against human RET, BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM. Jul 03 2017
Epigenetics
Catalog No. Product Name Information Added
S8601 CP2 CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively. Nov 07 2017
S8624 JNJ-64619178 JNJ-64619178 is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties. Nov 02 2017
S8494 PF-06726304 PF-06726304 is a selective EZH2 inhibitor with Ki values of 0.7 nM and 3 nM for WT EZH2 and Y641N respectively; also inhibits H3K27me3 with the IC50 value of 15 nM. Oct 24 2017
S8567 Tucidinostat (Chidamide) Chidamide is a low nanomolar inhibitor of HDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively. Oct 17 2017
A5041 ATF2 Rabbit Recombinant mAb   Oct 10 2017
A5000 HDAC2 Rabbit Recombinant mAb   Oct 09 2017
A5014 CREB Rabbit Recombinant mAb   Oct 09 2017
A5021 HDAC6 Rabbit Recombinant mAb   Oct 09 2017
S8502 TMP195 TMP195 is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays. Jul 19 2017
S8340 SGC2085 SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs. Jul 03 2017
NF-κB
Catalog No. Product Name Information Added
S3633 Pyrrolidinedithiocarbamate ammonium Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor-κB (NF-κB) that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines. Nov 15 2017
S8261 GSK583 GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM. Feb 09 2017
S4712 Diethylmaleate Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. Oct 26 2016
S7948 MRT67307 HCl MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. Apr 25 2016
S7691 PS-1145 PS-1145 is a specific IKK inhibitor with IC50 of 88 nM. Mar 09 2016
S7851 AZD3264 AZD3264 is a novel IKK2 inhibitor. Nov 27 2015
S7672 Omaveloxolone (RTA-408) Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2. Sep 14 2015
S7697 LY2409881 LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases. Apr 20 2015
S7441 WS3 WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Dec 04 2014
S7442 WS6 WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Nov 12 2014
Metabolism
Catalog No. Product Name Information Added
S3652 3-Nitropropionic acid   Nov 22 2017
S8616 PKM2 inhibitor(compound 3k)   Nov 22 2017
S8588 ACSS2 inhibitor ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). Nov 15 2017
S3697 Mafenide hydrochloride Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy. Nov 15 2017
S8619 NCT-503 Gilteritinib(ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent than the concentration required to inhibit c-KIT (230 nM). Oct 17 2017
A5001 FOXO1A Rabbit Recombinant mAb   Oct 09 2017
A5002 Hsp70 Rabbit Recombinant mAb   Oct 09 2017
A5015 Hsp90 alpha/beta Rabbit Recombinant mAb   Oct 09 2017
A5028 GAPDH Rabbit Recombinant mAb   Oct 09 2017
S8611 Vorasidenib (AG-881) Vorasidenib (AG-881) is an orally available inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2). Sep 26 2017
Proteases
Catalog No. Product Name Information Added
S8410 MG-132(S,R,S) MG-132(S,R,S) is a potent, reversible, and cell permeable proteasome inhibitor with IC50 of 0.22 μM, which is the most potent stereoisomer of MG-132. Nov 22 2017
S3692 N-Ethylmaleimide (NEM) N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. Nov 15 2017
S8565 Omarigliptin (MK-3102) Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5). Jul 11 2017
S8457 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). Mar 02 2017
S7420 CA-074 methyl ester (CA-074 Me) CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor. Jan 09 2017
S4697 Saxagliptin hydrate Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. Sep 21 2016
S4636 Teneligliptin hydrobromide Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM. Sep 21 2016
S4662 Atazanavir Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Sep 21 2016
S4666 Sivelestat sodium tetrahydrate Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse. Sep 20 2016
S4571 Hexylresorcinol Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase. The IC50 values of hexylresorcinol for monophenolase is 1.24 μM and for diphenolase is 0.85 μM. Aug 17 2016
Microbiology
Catalog No. Product Name Information Added
S3645 Kitasamycin   Nov 22 2017
S3646 Thimerosal   Nov 22 2017
S3675 Umbelliferone   Nov 22 2017
S3676 Carbendazim   Nov 22 2017
S3667 Imipenem   Nov 22 2017
S3650 Penicillin V potassium salt   Nov 22 2017
S3732 Avibactam sodium   Nov 22 2017
S3621 Pazufloxacin mesylate Pazufloxacin Mesylate, also known as Pazucross and T-3762, is a quinolone antibacterial agent used for the intravenous therapy of several infections. Nov 15 2017
S3618 Acetylspiramycin (ASPM) Acetylspiramycin (ASPM) is a macrolide antimicrobial agent. Nov 07 2017
S8324 ZK756326 2HCl ZK756326 is a full agonist of CCR8(Chemokine receptor 8) with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1. Nov 21 2016
Apoptosis
Catalog No. Product Name Information Added
A2010 Adalimumab Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF, MW: 144.19 KD. Nov 16 2017
S8383 S63845 S63845 is a new, selective MCL-1 inhibitor with the Kd value of 0.19 nM and has no discernible binding to the other BCL-2 members, BCL-2 or BCL-XL. Nov 15 2017
S8304 Azoramide Azoramide is a small-molecule modulator of the unfolded protein response (UPR) that improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress. Oct 17 2017
A5046 TNF Receptor II Rabbit Recombinant mAb   Oct 10 2017
A5010 Bcl-2 Rabbit Recombinant mAb   Oct 09 2017
A5013 Caspase-3 Rabbit Recombinant mAb   Oct 09 2017
S7100 WEHI-539 "WEHI-539 has high affinity (IC50=1.1 nM) and selectivity for BCL-XL and potently kills cells by selectively antagonizing its prosurvival activity. It has more than a 400-fold higher affinity for BCL-XL versus other prosurvival BCL-2 family members." Sep 26 2017
S8465 GSK'872 (GSK2399872A) GSK'872 (GSK2399872A) is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity. Sep 05 2017
S8591 FX1 FX1 is a selective BCL6 BTB inhibitor with an IC50 value of 35 μM in reporter assays. FX1 shows great selectivity against a panel of 50 different kinases. 10 μM FX1 fails to significantly inhibit of any of these kinases. Aug 29 2017
S7126 Marinopyrrole A (Maritoclax) Marinopyrrole A (Maritoclax) is a selective Mcl-1 antagonist. It binds to Mcl-1, but not Bcl-XL, and targets Mcl-1 for proteasomal degradation. Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1 μM. Aug 23 2017
MAPK
Catalog No. Product Name Information Added
S8534 LY3214996 LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines. Nov 02 2017
A5036 Phospho-Erk1(T202/Y204)+Erk2 (T185/Y187) Rabbit Recombinant mAb   Oct 10 2017
A5043 Raf1 Rabbit Recombinant mAb   Oct 10 2017
A5050 MEK3/MEK6 Rabbit Recombinant mAb   Oct 10 2017
A5005 JNK1/2/3 Rabbit Recombinant mAb   Oct 09 2017
A5009 MEK2 Rabbit Recombinant mAb   Oct 09 2017
A5017 p38 MAPK Rabbit Recombinant mAb   Oct 09 2017
A5018 ERK2 Rabbit Recombinant mAb   Oct 09 2017
A5019 MEK1 Rabbit Recombinant mAb   Oct 09 2017
A5026 JNK1/JNK3 Rabbit Recombinant mAb   Oct 09 2017
Angiogenesis
Catalog No. Product Name Information Added
A2006 Bevacizumab Bevacizumab is a humanized anti-VEGF monoclonal antibody which binds to and neutralizes all human VEGF-A isoforms and bioactive proteolytic fragments, MW:149 KD. Nov 16 2017
A2007 Trastuzumab Trastuzumab is a humanized, recombinant monoclonal antibody that binds to the extracellular domain of HER2, MW:145.53 KD. Nov 16 2017
A2008 Pertuzumab Pertuzumab, a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors, impairs the ability of HER2 to bind to other members of the HER family, MW: 148 KD. Nov 16 2017
S8230 Ensartinib (X-396) Ensartinib (X-396) is a novel, potent and specific ALK TKI with the IC50 less than 4 nM in Ambit assays. Oct 09 2017
S8578 PRN1371 PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively. Sep 26 2017
S8441 LW 6 LW6 is a hypoxia-inducible factor 1(HIF) inhibitor which potently inhibits HIF-1α accumulation by degrading HIF-1α without affecting the HIF-1a mRNA levels during hypoxia. It inhibits hypoxia-induced HIF-1α transcription activity with IC50 of 2.64 μM in cell-based HRE-reporter gene assays. Sep 19 2017
S8442 TAK-659 TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3. Aug 08 2017
A2000 Cetuximab Cetuximab, a novel molecular-targeted agent,is an inhibitor of EGFR monoclonal humanized antibody interacting with the extracellular binding site of EGFR to block ligand stimulation. MW : 145.781 KD. Jun 02 2017
S8229 Brigatinib (AP26113) Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy. May 10 2017
S8523 GSK2256098 GSK2256098 is a potent, selective, reversible, and ATP competitive FAK kinase inhibitor with apparent Ki of 0.4 nM. Apr 27 2017
Stem Cell & Wnt
Catalog No. Product Name Information Added
A5038 Beta Catenin Rabbit Recombinant mAb   Oct 10 2017
A5007 GSK3 beta Rabbit Recombinant mAb   Oct 09 2017
S8554 Super-TDU Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction. Sep 19 2017
S8572 Amcasertib (BBI503) Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity. Aug 01 2017
S8474 LF3 LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. Apr 21 2017
S7954 CP21R7 (CP21) CP21R7, also known CP21, is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling. Mar 31 2017
S8392 NCB-0846 NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase) with an IC50 value of 21 nM. Mar 31 2017
S8429 PNU-74654 PNU-75654 disrupts the Wnt signaling pathway via inhibition of the interaction (KD50=450 nM) between β-catenin and Tcf4. Mar 02 2017
S7169 LY3039478 LY3039478 is an oral Notch inhibitor with an IC50 of 0.41 nM. Feb 10 2017
S4747 Jervine Jervine is an inhibitor of Hedgehog signaling (IC50=500-700 nM) that inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jan 24 2017
Ubiquitin
Catalog No. Product Name Information Added
S7109 Pevonedistat (MLN4924) MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM. Aug 31 2017
S8288 VLX1570 VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro. May 19 2017
S7892 Avadomide(CC-122) Avadomide(CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN. Mar 31 2017
S4920 b-AP15 b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM. Mar 30 2015
S7529 ML323 ML323 displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1 with IC50 of 76 nM. Jun 30 2014
S7142 NSC697923 NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. Apr 09 2014
S7285 NMS-873 NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM). Jan 29 2014
S7199 DBeQ DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM. Jul 19 2013
S4921 MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN) MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. Jul 19 2013
S7129 PYR-41 PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. Jul 19 2013
Neuronal Signaling
Catalog No. Product Name Information Added
S3684 Methacholine chloride   Nov 22 2017
S3701 Benactyzine hydrochloride Benactyzine hydrochloride is a centrally acting muscarinic antagonist. It is used as an antidepressant in the treatment of depression and associated anxiety. Nov 15 2017
S8598 S 38093 S 38093 is a histamine H3 antagonist/inverse agonist with a moderate affinity for rat, mouse and human H3 receptors (Ki = 8.8, 1.44 and 1.2 μM, respectively) and no affinity for other histaminergic receptors. Sep 26 2017
S8447 8-OH-DPAT (8-Hydroxy-DPAT) 8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic 5-HT1A agonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous. Aug 08 2017
S8519 A-317491 A-317491 is a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors. Aug 01 2017
S8564 Verubecestat (MK-8931) Verubecestat (MK-8931) is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Jun 29 2017
S4748 Ondansetron Hydrochloride Dihydrate Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist (Ki=6.16 nM), with low affinity for dopamine receptors. Mar 31 2017
S4749 Citalopram HBr Citalopram HBr, an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM. Mar 31 2017
S4751 Cisapride hydrate Cisapride acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic. Mar 31 2017
S8193 Lanabecestat(AZD3293, LY3314814) Lanabecestat(AZD3293, LY3314814)is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. Jan 24 2017
Others
Catalog No. Product Name Information Added
S3677 Cinnamic acid   Nov 22 2017
S3661 2-Methoxy-1,4-naphthoquinone   Nov 22 2017
S3670 Cefsulodin sodium   Nov 22 2017
S3704 4-Methylbenzylidene camphor   Nov 22 2017
S3702 Dihydrothymine   Nov 22 2017
S3611 (+)-Fangchinoline Fangchinoline is a phytochemical that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to possess neuroprotective activity. Nov 15 2017
S3617 (20S)-Protopanaxatriol (20S)-Protopanaxatriol(g-PPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER). Nov 15 2017
S3703 Phenethyl alcohol Phenethyl alcohol is an antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery. Nov 15 2017
S3699 2,3-Butanedione-2-monoxime 2,3-Butanedione monoxime (BDM) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II that inhibits skeletal and cardiac muscle contraction. Nov 15 2017
S3634 6-Hydroxyflavone (6-HF) 6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonist of GABAA receptors. Nov 15 2017