New TLR Inhibitors

Catalog No.	Product Name	Information
E2758	Robinin	Robinin is a flavonoid that acts by inhibiting TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin reduces oxidized-LDL-induced TLR2 and TLR4 expression at the mRNA level and prevents NF-κB p65 nuclear translocation by regulating TLR-NF-κB signaling. Robinin exhibits anti-inflammatory and anti-tumor effects.
S0835	TH1020	TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist, with an IC50 value of 0.85 μM. TH1020 inhibits downstream signaling pathways activated by the TLR5/Flagellin complex. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8.
E5922	Enpatoran	Enpatoran is a potent, selective inhibitor of Toll-like receptors 7 and 8 (TLR7/8), with IC50 of 11.1 nM and 24.1 nM, respectively, in HEK293 cells. It also demonstrates potential for treating autoimmune diseases.
E5893	MTT5	MTT5 is an agonist of TLR7 that activates dendritic cells and CD8⁺ T cells, enhancing immune responses in the tumor microenvironment. When linked to an ADC, it enhances antitumor efficacy through combined immune stimulation and cytotoxicity.
E5909	CL075	CL075 (3M002) is a selective agonist of TLR8 with immunomodulatory properties. It primes human neutrophils by activating signaling pathways, including p47phox phosphorylation and p38MAPK, leading to enhanced reactive oxygen species (ROS) production and contributing to immune defense.
≡ All TLR Inhibitors