New Topoisomerase Inhibitors

Catalog No.	Product Name	Information
S0557	PNU-159682	PNU-159682, a metabolite of the anthracycline nemorubicin, is a potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 is used as a highly potent cytotoxic payload for antibody-drug conjugates (ADCs). PNU-159682 can be used in EDV nanocell technology to overcome drug resistance.
E6719	IID432	IID432 is a highly efficacious and safe oral cyanotriazole inhibitor of Trypanosoma cruzi topoisomerase II, with an EC50 of 8 nM. It achieved relapse-free (sterile) parasite clearance in wash-out assays and a single 25 mg/kg dose cleared infection in mice. IID432 has potential as a curative, short-course treatment for Chagas disease.
E0858	Lavofloxacin lactate	Lavofloxacin lactate, the lactate salt of levofloxacin, is a fluoroquinolone antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria. It inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair, leading to double-strand DNA breaks and bacterial cell death.
S0035	Zoliflodacin(ETX0914; AZD0914)	Zoliflodacin (ETX0914; AZD0914) is a first‑in‑class, single‑dose oral spiropyrimidinetrione antibiotic that inhibits bacterial type II topoisomerases, specifically DNA gyrase B (GyrB) and topoisomerase IV, and exhibits high efficacy against multidrug‑resistant Neisseria gonorrhoeae.
≡ All Topoisomerase Inhibitors