New Topoisomerase Inhibitors

Catalog No.	Product Name	Information
E0858	Lavofloxacin lactate	Lavofloxacin lactate, the lactate salt of levofloxacin, is a fluoroquinolone antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria. It inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair, leading to double-strand DNA breaks and bacterial cell death.
S0035	Zoliflodacin(ETX0914; AZD0914)	Zoliflodacin (ETX0914; AZD0914) is a first‑in‑class, single‑dose oral spiropyrimidinetrione antibiotic that inhibits bacterial type II topoisomerases, specifically DNA gyrase B (GyrB) and topoisomerase IV, and exhibits high efficacy against multidrug‑resistant Neisseria gonorrhoeae.
E4708	Etoposide phosphate	Etoposide phosphate a phosphate ester proagent of etoposide, is a selective inhibitor of topoisomerase II and a potent anti-cancer chemotherapy agent. This compound also induces cell cycle arrest, apoptosis, and autophagy.
E6461	Cholesteryl hemisuccinate	Cholesteryl hemisuccinate is a cholesterol derivative and a potent inhibior of DNA polymerase and DNA topoisomerase with an IC50 of 2.9 μM, 6.3 μM, 25 μM for Rat DNA polymerase β, Human DNA polymerase λ and Human DNA topoisomerase I respectively. It exhibits anticancer effect due to its ability to inhibit DNA replication, repair and cell division and can be used in cancer cell growth research.
E8306	ABBV-969 Payload	ABBV-969 Payload is an agent-linker conjugate with a potent inhibitor of topoisomerase I and a linker designed for use in the antibody-drug conjugate (ADC) ABBV-969. It can be used in non-small cell lung cancer research.
≡ All Topoisomerase Inhibitors