New Microtubule Associated Inhibitors

Catalog No.	Product Name	Information
S0561	Auristatin E	Auristatin E (AE) is a fully synthetic, highly potent antimitotic pentapeptide and a structural analog of dolastatin-10. It inhibits microtubule polymerization, leading to mitotic arrest at the G₂/M phase and subsequent apoptotic cell death in tumor cells. Due to its high toxicity, AE is primarily utilized as a cytotoxic payload in antibody–drug conjugates (ADCs), where targeted delivery minimizes systemic toxicity.
E8284	PM534	PM534 is a potent microtubule-targeting agent (MTA) that binds the colchicine-binding domain (CBD) and inhibits tubulin assembly with IC50 values ranging from 0.8 to 3.2 nM. It also significantly inhibits tumor growth in mouse xenograft models of human non-small cell lung cancer.
S6772	VERU-111	Sabizabulin (VERU-111, ABI-231) is a potent, orally bioavailable inhibitor of tubulin that binds to the colchicine binding site. It inhibits the expression of β tubulin (III, IV) and α tubulin, with the potential to treat prostate cancer. It also exhibits significant anti-proliferative activity, with an average IC50 of 5.2 nM across a broad panel of cancer cell lines.
F0548	MAP2 Antibody [G20G3]	MAP2,MAP-2,Microtubule-Associated Protein 2 (MAP2)
F2687	γ-Tubulin Antibody [J9F14]	gamma Tubulin,gamma-Tubulin,γ Tubulin,γ-Tubulin
≡ All Microtubule Associated Inhibitors