RAAS

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S2199

Aliskiren Hemifumarate

Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.

S1657

Enalaprilat Dihydrate

Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.

S1506

Perindopril Erbumine

Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM.

S1284

Benazepril HCl

Benazepril HCl is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.

S1793

Ramipril

Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.

S1941

Enalapril Maleate

Enalapril Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.

S2051

Captopril

Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.

S2076

Lisinopril

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

S2081

Cilazapril Monohydrate

Cilazapril Monohydrate is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

S2079

Moexipril HCl

Moexipril HCl is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.

S2581

Quinapril HCl

Quinapril HCl is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.

S2099

Temocapril HCl

Temocapril HCl is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

S2100

Temocapril

Temocapril is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

S2109

Imidapril HCl

Imidapril HCl is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.

S7678

LCZ696

LCZ696, consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.

S2095

Fosinopril Sodium

Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

S1578

Candesartan

Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.

S1359

Losartan Potassium (DuP 753)

Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

S1738

Telmisartan

Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

S1507

Irbesartan

Irbesartan (SR-47436, BMS-186295) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

S1894

Valsartan

Valsartan is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.

S7098

PD123319

PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

S1604

Olmesartan Medoxomil

Olmesartan Medoxomil (CS-866) is a selective angiotensin II type 1 (AT(1)) receptor antagonist, used in the treatment of high blood pressure.

S2037

Candesartan Cilexetil

Candesartan Cilexetil is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension.

S3057

Azilsartan Medoxomil

Azilsartan Medoxomil is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.

S3046

Azilsartan

Azilsartan is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.

S4102

Eprosartan Mesylate

Eprosartan is a nonpeptide angiotensin II receptor antagonist, [3H]-eprosartan binds to the AT1 receptor with KD of 0.83 nM in rat vascular smooth muscle cells.

Catalog No. Information Product Use Citations Product Validations
S2199

Aliskiren Hemifumarate

Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.

S1657

Enalaprilat Dihydrate

Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.

S1506

Perindopril Erbumine

Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM.

S1284

Benazepril HCl

Benazepril HCl is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.

S1793

Ramipril

Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.

S1941

Enalapril Maleate

Enalapril Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.

S2051

Captopril

Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.

S2076

Lisinopril

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

S2081

Cilazapril Monohydrate

Cilazapril Monohydrate is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

S2079

Moexipril HCl

Moexipril HCl is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.

S2581

Quinapril HCl

Quinapril HCl is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.

S2099

Temocapril HCl

Temocapril HCl is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

S2100

Temocapril

Temocapril is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

S2109

Imidapril HCl

Imidapril HCl is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.

S7678

LCZ696

LCZ696, consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.

S2095

Fosinopril Sodium

Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

Catalog No. Information Product Use Citations Product Validations
S1578

Candesartan

Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.

2015, 5:8116

2015, 47(7), 1–9

2015, 10.1177/1535370215576312

S1359

Losartan Potassium (DuP 753)

Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

2015, 5:8116

2015, 120:140-6

S1738

Telmisartan

Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

2015, 5:8116

S1507

Irbesartan

Irbesartan (SR-47436, BMS-186295) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

2015, 5:8116

2015, 120:140-6

S1894

Valsartan

Valsartan is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.

2015, 5:8116

2014, 68(3):623-9

S7098

PD123319

PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

2015, 47(7), 1–9

2015, 10.1177/1535370215576312

S1604

Olmesartan Medoxomil

Olmesartan Medoxomil (CS-866) is a selective angiotensin II type 1 (AT(1)) receptor antagonist, used in the treatment of high blood pressure.

2015, 5:8116

S2037

Candesartan Cilexetil

Candesartan Cilexetil is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension.

2015, 5:8116

2015, 10.1177/1535370215576312

S3057

Azilsartan Medoxomil

Azilsartan Medoxomil is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.

2015, 5:8116

S3046

Azilsartan

Azilsartan is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.

2015, 5:8116

S4102

Eprosartan Mesylate

Eprosartan is a nonpeptide angiotensin II receptor antagonist, [3H]-eprosartan binds to the AT1 receptor with KD of 0.83 nM in rat vascular smooth muscle cells.

2015, 5:8116

2016, 10.1038/srep25694