RAAS

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RAAS Inhibitors | Antagonists (27)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2199 Aliskiren Hemifumarate Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.
S1578 Candesartan Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.
  • Sci Rep, 2015, 5:8116
  • Acta Biochim Biophys Sin, 2015, 47(7), 1–9
  • Exp Biol Med, 2015, 10.1177/1535370215576312
S1359 Losartan Potassium (DuP 753) Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
  • Sci Rep, 2015, 5:8116
  • Sci Rep, 2015, 5:8116
  • Antiviral Res, 2015, 120:140-6
S1657 Enalaprilat Dihydrate Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.
S1738 Telmisartan Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
  • Sci Rep, 2015, 5:8116
  • Sci Rep, 2015, 5:8116
S1507 Irbesartan Irbesartan (SR-47436, BMS-186295) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.
  • Sci Rep, 2015, 5:8116
  • Antiviral Res, 2015, 120:140-6
S1894 Valsartan Valsartan is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.
  • Sci Rep, 2015, 5:8116
  • J Nat Med, 2014, 68(3):623-9
S1506 Perindopril Erbumine Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM.
S7098 PD123319 PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
  • Acta Biochim Biophys Sin, 2015, 47(7), 1–9
  • Exp Biol Med, 2015, 10.1177/1535370215576312
S1284 Benazepril HCl Benazepril HCl is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1604 Olmesartan Medoxomil Olmesartan Medoxomil (CS-866) is a selective angiotensin II type 1 (AT(1)) receptor antagonist, used in the treatment of high blood pressure.
  • Sci Rep, 2015, 5:8116
S1793 Ramipril Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
S2037 Candesartan Cilexetil Candesartan Cilexetil is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension.
  • Sci Rep, 2015, 5:8116
  • Exp Biol Med, 2015, 10.1177/1535370215576312
S1941 Enalapril Maleate Enalapril Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
S2076 Lisinopril Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
S2051 Captopril Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.
S2081 Cilazapril Monohydrate Cilazapril Monohydrate is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
S3057 Azilsartan Medoxomil Azilsartan Medoxomil is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.
  • Sci Rep, 2015, 5:8116
S2079 Moexipril HCl Moexipril HCl is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.
S2100 Temocapril Temocapril is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2581 Quinapril HCl Quinapril HCl is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.
S2109 Imidapril HCl Imidapril HCl is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
S2099 Temocapril HCl Temocapril HCl is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
S3046 Azilsartan Azilsartan is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.
  • Sci Rep, 2015, 5:8116
S2095 Fosinopril Sodium Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
S4102 Eprosartan Mesylate Eprosartan is a nonpeptide angiotensin II receptor antagonist, [3H]-eprosartan binds to the AT1 receptor with KD of 0.83 nM in rat vascular smooth muscle cells.
  • Sci Rep, 2015, 5:8116
  • Sci Rep, 2015, 5:8116
S7678 LCZ696 LCZ696, consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
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All RAAS Products

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S2199 Aliskiren Hemifumarate 100 mg/mL 100 mg/mL 100 mg/mL
S1578 Candesartan <1 mg/mL 88 mg/mL 1 mg/mL
S1359 Losartan Potassium (DuP 753) 92 mg/mL 92 mg/mL 92 mg/mL
S1657 Enalaprilat Dihydrate <1 mg/mL 70 mg/mL <1 mg/mL
S1738 Telmisartan <1 mg/mL 13 mg/mL <1 mg/mL
S1507 Irbesartan <1 mg/mL 1 mg/mL 3 mg/mL
S1894 Valsartan <1 mg/mL 87 mg/mL 87 mg/mL
S1506 Perindopril Erbumine 88 mg/mL <1 mg/mL 88 mg/mL
S7098 PD123319 100 mg/mL 100 mg/mL 100 mg/mL
S1284 Benazepril HCl 19 mg/mL 92 mg/mL 92 mg/mL
S1604 Olmesartan Medoxomil <1 mg/mL 89 mg/mL <1 mg/mL
S1793 Ramipril <1 mg/mL 83 mg/mL 83 mg/mL
S2037 Candesartan Cilexetil <1 mg/mL 122 mg/mL 4 mg/mL
S1941 Enalapril Maleate <1 mg/mL 99 mg/mL 4 mg/mL
S2076 Lisinopril 20 mg/mL <1 mg/mL <1 mg/mL
S2051 Captopril 2 mg/mL 43 mg/mL 43 mg/mL
S2081 Cilazapril Monohydrate <1 mg/mL 87 mg/mL 87 mg/mL
S3057 Azilsartan Medoxomil <1 mg/mL 114 mg/mL <1 mg/mL
S2079 Moexipril HCl <1 mg/mL 20 mg/mL <1 mg/mL
S2581 Quinapril HCl 95 mg/mL 18 mg/mL 95 mg/mL
S2109 Imidapril HCl 54 mg/mL 88 mg/mL 29 mg/mL
S2099 Temocapril HCl <1 mg/mL 103 mg/mL 103 mg/mL
S3046 Azilsartan <1 mg/mL 91 mg/mL <1 mg/mL
S2095 Fosinopril Sodium 117 mg/mL <1 mg/mL 4 mg/mL
S4102 Eprosartan Mesylate <1 mg/mL 104 mg/mL 4 mg/mL
S7678 LCZ696 100 mg/mL 30 mg/mL 9 mg/mL
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