Lisinopril

Catalog No.S2076

Lisinopril  Chemical Structure

Molecular Weight(MW): 405.49

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

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Biological Activity

Description Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
Targets
ACE [1]
In vitro

Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. [1] Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain. Lisinopril inhibits Angiotensin-converting enzyme (ACE) in vitro, as well as after parenteral and oral administration to humans; its oral bioavailability is only 25-29%, but it has a longer duration of action than enalapril. [2]

In vivo Lisinopril treated SHR rats has significantly raised total cholesterol levels compared to untreated spontaneously hypertensive rats (SHR) rats (+27%), but not compared to lisinopril treated Wistar Kyoto rats (WKY) rats. [3] Lisinopril is a long-acting angiotensin-converting enzyme inhibitor which blocks the renin-angiotensin system (RAS) and reduces systemic blood pressure in rats. Lisinopril reduces the hydroxyproline level and inhibits accumulation of collagens in the pulmonary tissue of the treatment group (paraquat + lisinopril) and per-treatment group (lisinopril + paraquat) in rats. [4] Lisinopril results in preserved ultrafiltration volume (UF), glucose reabsorption (D 1 /D 0 glucose) and peritoneal thickness in rats. [5] Lisinopril (0.2 mg/kg twice a day for 10 days) protects the cell membrane integrity and lessens free radical-induced oxidant stress in guinea pig hearts. [6]

Protocol

Solubility (25°C)

In vitro Water 20 mg/mL (49.32 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 405.49
Formula

C21H31N3O5

CAS No. 83915-83-7
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02847338 Not yet recruiting Hypertension Cambridge University Hospitals NHS Foundation Trust|Medical Research Council November 2016 Phase 4
NCT02682459 Recruiting Extracapillary Glomerulonephritis Monia Lorini|Istituto Di Ricerche Farmacologiche Mario Negri|A.O. Ospedale Papa Giovanni XXIII February 2016 Phase 2
NCT02641899 Completed Healthy Intarcia Therapeutics December 2015 Phase 1
NCT02603809 Active, not recruiting Essential Hypertension Actelion December 2015 Phase 2
NCT02623036 Recruiting Hypertension, Resistant to Conventional Therapy Memorial Health University Medical Center November 2015 Phase 1
NCT01984164 Recruiting Hypertension|Mild Cognitive Impairment Ihab M. Hajjar|National Institute on Aging (NIA)|Emory University August 2014 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID