- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S1629||Orlistat||<1 mg/mL||99 mg/mL||99 mg/mL|
|S4904||JZL184||<1 mg/mL||100 mg/mL||<1 mg/mL|
|S7364||Atglistatin||<1 mg/mL||56 mg/mL||4 mg/mL|
|S7457||XEN445||<1 mg/mL||80 mg/mL||34 mg/mL|
|S4825||Pancreatin||<1 mg/mL||0.01 mg/mL||<1 mg/mL|
|S4930||Cetilistat||<1 mg/mL||3 mg/mL||8 mg/mL|
|S2365||Tanshinone IIA||<1 mg/mL||5 mg/mL||<1 mg/mL|
- Lipase Inhibitors (7)
- New Lipase Products
|Catalog No.||Information||Product Use Citations||Product Validations|
Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice.
JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.
Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.
C, G0s2-null MEFs were transfected with HRAS and the following day treated with either 40 mmol/L of ATGL inhibitor atglistatin or DMSO (Vehicle) every 2 days. Left, representative plates. Right, the average of biologic triplicate determinations. Error bars, SD. The experiment was repeated twice with similar results.
XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.
Pancreatic enzymes also known as pancrelipase and pancreatin, are commercial mixtures of amylase, lipase, and protease. They are used to treat malabsorption syndrome due to pancreatic problems.
Cetilistat is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo
Tanshinone IIA(Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.
Western blotting analysis of b-catenin, TCF3 and LEF1 levels in HT-29 cells. b-actin is the loading control.