Lipase

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S1629

Orlistat

Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice.

S4904

JZL184

JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.

S7364

Atglistatin

Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.

S7457

XEN445

XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.

S2365

Tanshinone IIA

Tanshinone IIA(Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.

Catalog No. Information Product Use Citations Product Validations
S1629

Orlistat

Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice.

S4904

JZL184

JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.

S7364

Atglistatin

Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.

S7457

XEN445

XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.

S2365

Tanshinone IIA

Tanshinone IIA(Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.