Home Metabolism FAAH inhibitor - Lipase inhibitor JZL195 For research use only.

JZL195

JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.

JZL195 Chemical Structure

JZL195 Chemical Structure

CAS: 1210004-12-8

Purity & Quality Control

Batch: S660901 DMSO] 43 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.99%
99.99

JZL195 Related Products

Signaling Pathway

FAAH Signaling Pathways

FAAH Signaling Pathway

Choose Selective FAAH Inhibitors

Biological Activity

Description JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.
Targets
FAAH [2] MAGL [2]
2 nM 4 nM
In Vivo
In vivo

Systemic administration of JZL195 reduces horizontal and vertical motor activity dose-dependently, and increases time spent in immobility. JZL195 produces a pronounced 2-AG elevation at all doses, and increases brain AEA and OEA levels due to its inhibitory activity at FAAH[1].
Animal Research Animal Models Male Wistar rats
Dosages 5, 15 and 30 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 433.46 Formula

C24H23N3O5
CAS No. 1210004-12-8 SDF --
Smiles C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC4=CC=C(C=C4)[N+](=O)[O-]
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 43 mg/mL ( (99.2 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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