CaSR

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S1260

Cinacalcet HCl

Cinacalcet HCl represents a new class of compounds for the treatment of hyperparathyroidism.

S2633

NPS-2143

NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.

Catalog No. Information Product Use Citations Product Validations
S1260

Cinacalcet HCl

Cinacalcet HCl represents a new class of compounds for the treatment of hyperparathyroidism.

Catalog No. Information Product Use Citations Product Validations
S2633

NPS-2143

NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.

2016, 10.1007/s00204-016-1693-z

2014, 289(42):28835-45