Research Area
Product Type
United States ( Change Country )
AMG-073 HCl (Cinacalcet hydrochloride) Chemical Structure
Tetrandrine(Fanchinine)
Tetrandrine (Fanchinine; Hanfangchin A) is a calcium channel blocker with an IC50 of 38.23± 25.77 μM.
Manidipine dihydrochloride (CV-4093)
Manidipine dihydrochloride(CV-4093) is a hydrochloride salt of manidipine that is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM.
Omecamtiv mecarbil (CK-1827452)
Omecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an E50 of 0.6 μM.
NPS-2143 (SB262470)
NPS-2143 (SB262470) is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2+ concentrations and parathyroid hormone secretion, respectively.
Ivacaftor (VX-770)
Ivacaftor (VX-770) is a CFTR potentiator with an IC50 of 43 ± 38 nM
Lacosamide
Lacosamide is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain.
Rufinamide (Banzel)
Rufinamide, a triazole derivative, is an anticonvulsant medication.
Lansoprazole
Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.
Omeprazole (Prilosec)
Omeprazole(Prilosec) is a proton pump inhibitor used in the treatment of dyspepsia.
Ranolazine dihydrochloride
Ranolazine(Ranexa), is an antianginal medication.
Biological Activity
AMG-073 HCl (Cinacalcet hydrochloride) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium. The current study evaluates the efficacy and safety of AMG 073 when added to conventional treatment of secondary hyperparathyroidism in end-stage renal disease (ESRD). [1]
Product Information
| Molecular Weight (WM): | 393.87 |
|---|---|
| Formula: | C22H22F3N.HCl |
| CAS No.: | 364782-34-3 |
| Synonyms: |
Mimpara, Sensipar
|
| Dissolve in (25°C): | DMSO ≥79mg/mL |
| Water ≥1mg/mL | |
| Ethanol ≥33mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Related Inhibitors
Recommended Screening Libraries
Chemical Library
A collection of 864 bioactive compounds
Inhibitor Library
A collection of 481 inhibitors
Kinase Inhibitor Library
A collection of 194 kinase inhibitors
Tyrosine Kinase Inhibitor Library
A collection of 85 tyrosine kinase inhibitors.
FDA Approved Drug Library
A collection of 426 FDA approved drugs
Natural Product Library
A collection of 139 natural products
Chemotherapeutic Agent Library
A collection of 40 chemotherapeutic agents
Epigenetics Compound library
A unique collection of 17 small molecule modulators
Stem Cell Compound library
A unique collection of 47 small molecule inhibitors
GPCR Compound library
A unique collection of 63 GPCR small molecules
Keywords:buy AMG-073 HCl (Cinacalcet hydrochloride) | AMG-073 HCl (Cinacalcet hydrochloride) supplier | purchase AMG-073 HCl (Cinacalcet hydrochloride) | AMG-073 HCl (Cinacalcet hydrochloride) cost | AMG-073 HCl (Cinacalcet hydrochloride) manufacturer | order AMG-073 HCl (Cinacalcet hydrochloride) | AMG-073 HCl (Cinacalcet hydrochloride) distributor