CAS No. 1135242-13-5

Batch: Purity:99.80
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VU0357017 Hydrochloride Chemical Structure
Chemical Structure
Check the VU0357017 Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1135242-13-5
Molecular Formula

C18H28ClN3O3
Molecular Weight (MW) 369.89
SMILES CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C.Cl

Biological Activity

VU0357017 hydrochloride is a potent, highly selective, and CNS-penetrant allosteric agonist of the M1 muscarinic acetylcholine receptor. By binding to an allosteric site on the M1 receptor, it selectively activates muscarinic cholinergic signaling pathways without activating other receptor subtypes. This activation enhances downstream central cholinergic neurotransmission, promoting functional responses associated with cognitive processing and synaptic plasticity in the central nervous system.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 38 mg/mL (102.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 10 mg/mL
Ethanol 2 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.