CAS No. 249296-44-4
Batch:
Purity:99.99
Chemical Structure
Check the
Varenicline
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 249296-44-4 | |
|---|---|---|
| Molecular Formula |
C13H13N3 |
|
| Molecular Weight (MW) | 211.26 | |
| SMILES | C1NCC2CC1C3=CC4=NC=CN=C4C=C23 |
Biological Activity
Varenicline (CP-526555) is a highly selective nicotinic acetylcholine receptor partial agonist targeting α4β2 receptors, exhibiting high selectivity over α3β4, α7, and muscle-type nAChRs, while also acting as a 5-HT3 receptor agonist. By partially activating α4β2 nAChRs, varenicline modulates cholinergic signaling and stimulates mesolimbic dopamine release, while simultaneously blocking full agonist binding to diminish nicotine-induced reward phenotypes. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
42 mg/mL
(198.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 42 mg/mL |
| Water | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.